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Items: 25


Antiphospholipid antibodies induce thrombosis by PP2A activation via apoER2-Dab2-SHC1 complex formation in endothelium.

Sacharidou A, Chambliss KL, Ulrich V, Salmon JE, Shen YM, Herz J, Hui DY, Terada LS, Shaul PW, Mineo C.

Blood. 2018 May 10;131(19):2097-2110. doi: 10.1182/blood-2017-11-814681. Epub 2018 Mar 2.


Hyposialylated IgG activates endothelial IgG receptor FcγRIIB to promote obesity-induced insulin resistance.

Tanigaki K, Sacharidou A, Peng J, Chambliss KL, Yuhanna IS, Ghosh D, Ahmed M, Szalai AJ, Vongpatanasin W, Mattrey RF, Chen Q, Azadi P, Lingvay I, Botto M, Holland WL, Kohler JJ, Sirsi SR, Hoyt K, Shaul PW, Mineo C.

J Clin Invest. 2018 Jan 2;128(1):309-322. doi: 10.1172/JCI89333. Epub 2017 Nov 27.


New Insights in the Pathophysiology of Antiphospholipid Syndrome.

Sacharidou A, Shaul PW, Mineo C.

Semin Thromb Hemost. 2018 Jul;44(5):475-482. doi: 10.1055/s-0036-1597286. Epub 2017 Jan 27. Review.


Identification of a Monoclonal Antibody That Attenuates Antiphospholipid Syndrome-Related Pregnancy Complications and Thrombosis.

Mineo C, Lanier L, Jung E, Sengupta S, Ulrich V, Sacharidou A, Tarango C, Osunbunmi O, Shen YM, Salmon JE, Brekken RA, Huang X, Thorpe PE, Shaul PW.

PLoS One. 2016 Jul 27;11(7):e0158757. doi: 10.1371/journal.pone.0158757. eCollection 2016.


Endothelial Fcγ Receptor IIB Activation Blunts Insulin Delivery to Skeletal Muscle to Cause Insulin Resistance in Mice.

Tanigaki K, Chambliss KL, Yuhanna IS, Sacharidou A, Ahmed M, Atochin DN, Huang PL, Shaul PW, Mineo C.

Diabetes. 2016 Jul;65(7):1996-2005. doi: 10.2337/db15-1605. Epub 2016 Apr 26.


ApoE Receptor 2 Mediation of Trophoblast Dysfunction and Pregnancy Complications Induced by Antiphospholipid Antibodies in Mice.

Ulrich V, Gelber SE, Vukelic M, Sacharidou A, Herz J, Urbanus RT, de Groot PG, Natale DR, Harihara A, Redecha P, Abrahams VM, Shaul PW, Salmon JE, Mineo C.

Arthritis Rheumatol. 2016 Mar;68(3):730-739. doi: 10.1002/art.39453.


A Protein Kinase C Phosphorylation Motif in GLUT1 Affects Glucose Transport and is Mutated in GLUT1 Deficiency Syndrome.

Lee EE, Ma J, Sacharidou A, Mi W, Salato VK, Nguyen N, Jiang Y, Pascual JM, North PE, Shaul PW, Mettlen M, Wang RC.

Mol Cell. 2015 Jun 4;58(5):845-53. doi: 10.1016/j.molcel.2015.04.015. Epub 2015 May 14.


PDZK1 prevents neointima formation via suppression of breakpoint cluster region kinase in vascular smooth muscle.

Lee WR, Sacharidou A, Behling-Kelly E, Oltmann SC, Zhu W, Ahmed M, Gerard RD, Hui DY, Abe J, Shaul PW, Mineo C.

PLoS One. 2015 Apr 17;10(4):e0124494. doi: 10.1371/journal.pone.0124494. eCollection 2015.


ETS-related gene (ERG) controls endothelial cell permeability via transcriptional regulation of the claudin 5 (CLDN5) gene.

Yuan L, Le Bras A, Sacharidou A, Itagaki K, Zhan Y, Kondo M, Carman CV, Davis GE, Aird WC, Oettgen P.

J Biol Chem. 2012 Feb 24;287(9):6582-91. doi: 10.1074/jbc.M111.300236. Epub 2012 Jan 10.


Molecular mechanisms controlling vascular lumen formation in three-dimensional extracellular matrices.

Sacharidou A, Stratman AN, Davis GE.

Cells Tissues Organs. 2012;195(1-2):122-43. doi: 10.1159/000331410. Epub 2011 Oct 13. Review.


RhoJ is an endothelial cell-restricted Rho GTPase that mediates vascular morphogenesis and is regulated by the transcription factor ERG.

Yuan L, Sacharidou A, Stratman AN, Le Bras A, Zwiers PJ, Spokes K, Bhasin M, Shih SC, Nagy JA, Molema G, Aird WC, Davis GE, Oettgen P.

Blood. 2011 Jul 28;118(4):1145-53. doi: 10.1182/blood-2010-10-315275. Epub 2011 May 31.


Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice.

Chan AC, Drakos SG, Ruiz OE, Smith AC, Gibson CC, Ling J, Passi SF, Stratman AN, Sacharidou A, Revelo MP, Grossmann AH, Diakos NA, Davis GE, Metzstein MM, Whitehead KJ, Li DY.

J Clin Invest. 2011 May;121(5):1871-81. doi: 10.1172/JCI44393. Epub 2011 Apr 1. Erratum in: J Clin Invest. 2012 May 1;122(5):1948.


Molecular basis for endothelial lumen formation and tubulogenesis during vasculogenesis and angiogenic sprouting.

Davis GE, Stratman AN, Sacharidou A, Koh W.

Int Rev Cell Mol Biol. 2011;288:101-65. doi: 10.1016/B978-0-12-386041-5.00003-0. Review.


Blood vessel tubulogenesis requires Rasip1 regulation of GTPase signaling.

Xu K, Sacharidou A, Fu S, Chong DC, Skaug B, Chen ZJ, Davis GE, Cleaver O.

Dev Cell. 2011 Apr 19;20(4):526-39. doi: 10.1016/j.devcel.2011.02.010. Epub 2011 Mar 10.


Endothelial lumen signaling complexes control 3D matrix-specific tubulogenesis through interdependent Cdc42- and MT1-MMP-mediated events.

Sacharidou A, Koh W, Stratman AN, Mayo AM, Fisher KE, Davis GE.

Blood. 2010 Jun 24;115(25):5259-69. doi: 10.1182/blood-2009-11-252692. Epub 2010 Mar 9.


MT1-MMP- and Cdc42-dependent signaling co-regulate cell invasion and tunnel formation in 3D collagen matrices.

Fisher KE, Sacharidou A, Stratman AN, Mayo AM, Fisher SB, Mahan RD, Davis MJ, Davis GE.

J Cell Sci. 2009 Dec 15;122(Pt 24):4558-69. doi: 10.1242/jcs.050724. Epub 2009 Nov 24.


Formation of endothelial lumens requires a coordinated PKCepsilon-, Src-, Pak- and Raf-kinase-dependent signaling cascade downstream of Cdc42 activation.

Koh W, Sachidanandam K, Stratman AN, Sacharidou A, Mayo AM, Murphy EA, Cheresh DA, Davis GE.

J Cell Sci. 2009 Jun 1;122(Pt 11):1812-22. doi: 10.1242/jcs.045799. Epub 2009 May 12.


Endothelial cell lumen and vascular guidance tunnel formation requires MT1-MMP-dependent proteolysis in 3-dimensional collagen matrices.

Stratman AN, Saunders WB, Sacharidou A, Koh W, Fisher KE, Zawieja DC, Davis MJ, Davis GE.

Blood. 2009 Jul 9;114(2):237-47. doi: 10.1182/blood-2008-12-196451. Epub 2009 Apr 1.


In vitro three dimensional collagen matrix models of endothelial lumen formation during vasculogenesis and angiogenesis.

Koh W, Stratman AN, Sacharidou A, Davis GE.

Methods Enzymol. 2008;443:83-101. doi: 10.1016/S0076-6879(08)02005-3.


Determinants for association and guide RNA-directed endonuclease cleavage by purified RNA editing complexes from Trypanosoma brucei.

Hernandez A, Panigrahi A, Cifuentes-Rojas C, Sacharidou A, Stuart K, Cruz-Reyes J.

J Mol Biol. 2008 Aug 1;381(1):35-48. doi: 10.1016/j.jmb.2008.05.003. Epub 2008 May 8.


Preferential interaction of a 25kDa protein with an A6 pre-mRNA substrate for RNA editing in Trypanosoma brucei.

Halbig K, Sacharidou A, De Nova-Ocampo M, Cruz-Reyes J.

Int J Parasitol. 2006 Oct;36(12):1295-304. Epub 2006 Jun 19.


RNA editing complex interactions with a site for full-round U deletion in Trypanosoma brucei.

Sacharidou A, Cifuentes-Rojas C, Halbig K, Hernandez A, Dangott LJ, De Nova-Ocampo M, Cruz-Reyes J.

RNA. 2006 Jul;12(7):1219-28. Epub 2006 May 11.


Minimal pre-mRNA substrates with natural and converted sites for full-round U insertion and U deletion RNA editing in trypanosomes.

Cifuentes-Rojas C, Halbig K, Sacharidou A, De Nova-Ocampo M, Cruz-Reyes J.

Nucleic Acids Res. 2005 Nov 23;33(20):6610-20. Print 2005.


Expression of mdm-2 protein in neoplastic, preneoplastic, and normal bronchial mucosa specimens: comparative study with p53 expression.

Rasidakis A, Orphanidou D, Kalomenidis J, Papamichalis G, Toumbis M, Lambaditis J, Sacharidou A, Papastamatiou H, Jordanoglou J.

Hybridoma. 1998 Aug;17(4):339-45.


Immunohistochemical detection of p53 protein in neoplastic, preneoplastic and normal bronchial mucosa specimens obtained during diagnostic bronchoscopy.

Orfanidou D, Kalomenidis J, Rasidakis A, Papamichalis G, Toumbis M, Labaditis J, Sacharidou A, Papastamatiou H, Jordanoglou J.

Oncol Rep. 1998 May-Jun;5(3):763-9.


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