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Items: 1 to 50 of 67

1.

Cellular immune response to DNA and vaccinia prime-boost immunization kills Plasmodium yoelii-infected hepatocytes in vitro.

Sacci JB Jr, Hollingdale MR, Sedegah M.

Pathog Dis. 2017 Jun 1;75(4). doi: 10.1093/femspd/ftx051.

PMID:
28475711
2.

Mosquito bite immunization with radiation-attenuated Plasmodium falciparum sporozoites: safety, tolerability, protective efficacy and humoral immunogenicity.

Hickey BW, Lumsden JM, Reyes S, Sedegah M, Hollingdale MR, Freilich DA, Luke TC, Charoenvit Y, Goh LM, Berzins MP, Bebris L, Sacci JB Jr, De La Vega P, Wang R, Ganeshan H, Abot EN, Carucci DJ, Doolan DL, Brice GT, Kumar A, Aguiar J, Nutman TB, Leitman SF, Hoffman SL, Epstein JE, Richie TL.

Malar J. 2016 Jul 22;15(1):377. doi: 10.1186/s12936-016-1435-y.

3.

Overexpression of Plasmodium berghei ATG8 by Liver Forms Leads to Cumulative Defects in Organelle Dynamics and to Generation of Noninfectious Merozoites.

Voss C, Ehrenman K, Mlambo G, Mishra S, Kumar KA, Sacci JB Jr, Sinnis P, Coppens I.

mBio. 2016 Jun 28;7(3). pii: e00682-16. doi: 10.1128/mBio.00682-16.

4.

Discovery of Novel Plasmodium falciparum Pre-Erythrocytic Antigens for Vaccine Development.

Aguiar JC, Bolton J, Wanga J, Sacci JB, Iriko H, Mazeika JK, Han ET, Limbach K, Patterson NB, Sedegah M, Cruz AM, Tsuboi T, Hoffman SL, Carucci D, Hollingdale MR, Villasante ED, Richie TL.

PLoS One. 2015 Aug 20;10(8):e0136109. doi: 10.1371/journal.pone.0136109. eCollection 2015.

5.

Clinical trial in healthy malaria-naïve adults to evaluate the safety, tolerability, immunogenicity and efficacy of MuStDO5, a five-gene, sporozoite/hepatic stage Plasmodium falciparum DNA vaccine combined with escalating dose human GM-CSF DNA.

Richie TL, Charoenvit Y, Wang R, Epstein JE, Hedstrom RC, Kumar S, Luke TC, Freilich DA, Aguiar JC, Sacci JB Jr, Sedegah M, Nosek RA Jr, De La Vega P, Berzins MP, Majam VF, Abot EN, Ganeshan H, Richie NO, Banania JG, Baraceros MF, Geter TG, Mere R, Bebris L, Limbach K, Hickey BW, Lanar DE, Ng J, Shi M, Hobart PM, Norman JA, Soisson LA, Hollingdale MR, Rogers WO, Doolan DL, Hoffman SL.

Hum Vaccin Immunother. 2012 Nov 1;8(11):1564-84. doi: 10.4161/hv.22129. Epub 2012 Nov 1.

6.

Disruption of the Plasmodium falciparum liver-stage antigen-1 locus causes a differentiation defect in late liver-stage parasites.

Mikolajczak SA, Sacci JB Jr, De La Vega P, Camargo N, VanBuskirk K, Krzych U, Cao J, Jacobs-Lorena M, Cowman AF, Kappe SH.

Cell Microbiol. 2011 Aug;13(8):1250-60. doi: 10.1111/j.1462-5822.2011.01617.x. Epub 2011 Jun 24.

7.

Plasmodium falciparum liver stage antigen-1 is cross-linked by tissue transglutaminase.

Nicoll WS, Sacci JB, Rodolfo C, Di Giacomo G, Piacentini M, Holland ZJ, Doerig C, Hollingdale MR, Lanar DE.

Malar J. 2011 Jan 21;10:14. doi: 10.1186/1475-2875-10-14.

8.

Plasmodium falciparum PF10_0164 (ETRAMP10.3) is an essential parasitophorous vacuole and exported protein in blood stages.

Mackellar DC, O'Neill MT, Aly AS, Sacci JB Jr, Cowman AF, Kappe SH.

Eukaryot Cell. 2010 May;9(5):784-94. doi: 10.1128/EC.00336-09. Epub 2010 Mar 12.

9.

Characterization of immunoglobulin G antibodies to Plasmodium falciparum sporozoite surface antigen MB2 in malaria exposed individuals.

Nguyen TV, Sacci JB Jr, de la Vega P, John CC, James AA, Kang AS.

Malar J. 2009 Oct 23;8:235. doi: 10.1186/1475-2875-8-235.

10.

Functional immunoassays using an in-vitro malaria liver-stage infection model: where do we go from here?

House BL, Hollingdale MR, Sacci JB Jr, Richie TL.

Trends Parasitol. 2009 Nov;25(11):525-33. doi: 10.1016/j.pt.2009.08.004. Epub 2009 Sep 9. Review.

PMID:
19747878
11.

Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by design.

VanBuskirk KM, O'Neill MT, De La Vega P, Maier AG, Krzych U, Williams J, Dowler MG, Sacci JB Jr, Kangwanrangsan N, Tsuboi T, Kneteman NM, Heppner DG Jr, Murdock BA, Mikolajczak SA, Aly AS, Cowman AF, Kappe SH.

Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):13004-9. doi: 10.1073/pnas.0906387106. Epub 2009 Jul 22.

12.

CD8+ T lymphocytes protective against malaria liver stages are primed in skin-draining lymph nodes.

Chakravarty S, Cockburn IA, Kuk S, Overstreet MG, Sacci JB, Zavala F.

Nat Med. 2007 Sep;13(9):1035-41. Epub 2007 Aug 19.

PMID:
17704784
13.

Plasmodium falciparum infection and exoerythrocytic development in mice with chimeric human livers.

Sacci JB Jr, Alam U, Douglas D, Lewis J, Tyrrell DL, Azad AF, Kneteman NM.

Int J Parasitol. 2006 Mar;36(3):353-60.

PMID:
16442544
14.

Plasmodium yoelii: axenic development of the parasite mosquito stages.

Porter-Kelley JM, Dinglasan RR, Alam U, Ndeta GA, Sacci JB Jr, Azad AF.

Exp Parasitol. 2006 Feb;112(2):99-108. Epub 2005 Nov 14.

PMID:
16289466
15.

Transcriptional analysis of in vivo Plasmodium yoelii liver stage gene expression.

Sacci JB Jr, Ribeiro JM, Huang F, Alam U, Russell JA, Blair PL, Witney A, Carucci DJ, Azad AF, Aguiar JC.

Mol Biochem Parasitol. 2005 Aug;142(2):177-83. Epub 2005 Apr 26.

PMID:
15876462
16.

High-throughput generation of P. falciparum functional molecules by recombinational cloning.

Aguiar JC, LaBaer J, Blair PL, Shamailova VY, Koundinya M, Russell JA, Huang F, Mar W, Anthony RM, Witney A, Caruana SR, Brizuela L, Sacci JB Jr, Hoffman SL, Carucci DJ.

Genome Res. 2004 Oct;14(10B):2076-82.

17.

Monoclonal antibody MG96 completely blocks Plasmodium yoelii development in Anopheles stephensi.

Dinglasan RR, Fields I, Shahabuddin M, Azad AF, Sacci JB Jr.

Infect Immun. 2003 Dec;71(12):6995-7001.

18.

Molecular mechanism of host specificity in Plasmodium falciparum infection: role of circumsporozoite protein.

Rathore D, Hrstka SC, Sacci JB Jr, De la Vega P, Linhardt RJ, Kumar S, McCutchan TF.

J Biol Chem. 2003 Oct 17;278(42):40905-10. Epub 2003 Aug 6.

19.

Subcellular localization of rickettsial invasion protein, InvA.

Gaywee J, Sacci JB Jr, Radulovic S, Beier MS, Azad AF.

Am J Trop Med Hyg. 2003 Jan;68(1):92-6.

PMID:
12556155
20.

Gene expression analysis during liver stage development of Plasmodium.

Sacci JB Jr, Azad AF.

Int J Parasitol. 2002 Dec 4;32(13):1551-7. Review.

PMID:
12435439
21.

A proteomic view of the Plasmodium falciparum life cycle.

Florens L, Washburn MP, Raine JD, Anthony RM, Grainger M, Haynes JD, Moch JK, Muster N, Sacci JB, Tabb DL, Witney AA, Wolters D, Wu Y, Gardner MJ, Holder AA, Sinden RE, Yates JR, Carucci DJ.

Nature. 2002 Oct 3;419(6906):520-6.

PMID:
12368866
22.

Inhibition of liver-stage development assay.

Sacci JB Jr.

Methods Mol Med. 2002;72:517-20. No abstract available.

PMID:
12125149
23.

Hepatocyte perfusion, isolation, and culture.

Sacci JB Jr.

Methods Mol Med. 2002;72:503-5. No abstract available.

PMID:
12125147
24.

Hepatic portal branch inoculation.

Sacci JB Jr.

Methods Mol Med. 2002;72:499-501. No abstract available.

PMID:
12125146
25.

Laser capture microdissection and molecular analysis of Plasmodium yoelii liver-stage parasites.

Sacci JB Jr, Aguiar JC, Lau AO, Hoffman SL.

Mol Biochem Parasitol. 2002 Feb;119(2):285-9. No abstract available.

PMID:
11814581
26.

Binding and invasion of liver cells by Plasmodium falciparum sporozoites. Essential involvement of the amino terminus of circumsporozoite protein.

Rathore D, Sacci JB, de la Vega P, McCutchan TF.

J Biol Chem. 2002 Mar 1;277(9):7092-8. Epub 2001 Dec 20.

27.

Two-step chromatographic purification of recombinant Plasmodium falciparum circumsporozoite protein from Escherichia coli.

Kolodny N, Kitov S, Vassell MA, Miller VL, Ware LA, Fegeding K, De La Vega P, Sacci JB Jr, Lanar DE.

J Chromatogr B Biomed Sci Appl. 2001 Oct 5;762(1):77-86.

PMID:
11589461
28.

Enhancement of the immune response in rabbits to a malaria DNA vaccine by immunization with a needle-free jet device.

Aguiar JC, Hedstrom RC, Rogers WO, Charoenvit Y, Sacci JB Jr, Lanar DE, Majam VF, Stout RR, Hoffman SL.

Vaccine. 2001 Oct 12;20(1-2):275-80.

PMID:
11567774
29.

Anti-mosquito midgut antibodies block development of Plasmodium falciparum and Plasmodium vivax in multiple species of Anopheles mosquitoes and reduce vector fecundity and survivorship.

Lal AA, Patterson PS, Sacci JB, Vaughan JA, Paul C, Collins WE, Wirtz RA, Azad AF.

Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5228-33. Epub 2001 Apr 17.

30.

Detection of Plasmodium yoelii stage mRNA in BALB/c mice.

Lau AO, Sacci JB Jr, Azad AF.

J Parasitol. 2001 Feb;87(1):19-23.

PMID:
11227890
31.

Host responses to Plasmodium yoelii hepatic stages: a paradigm in host-parasite interaction.

Lau AO, Sacci JB Jr, Azad AF.

J Immunol. 2001 Feb 1;166(3):1945-50.

32.

Mercury exposure and murine response to Plasmodium yoelii infection and immunization.

Silbergeld EK, Sacci JB Jr, Azad AF.

Immunopharmacol Immunotoxicol. 2000 Nov;22(4):685-95.

PMID:
11105781
33.

Retrieving parasite specific liver stage gene products in Plasmodium yoelii infected livers using differential display.

Lau AO, Sacci JB Jr, Azad AF.

Mol Biochem Parasitol. 2000 Nov;111(1):143-51.

PMID:
11087924
34.

Antigens cross reactive with Plasmodium falciparum merozoite surface protein 4 are found in pre-erythrocytic and sexual stages.

Wang L, Menting JG, Stowers A, Charoenvit Y, Sacci JB Jr, Coppel RL.

Mol Biochem Parasitol. 2000 Jul;109(2):189-94. No abstract available.

PMID:
10960179
35.

Improving protective immunity induced by DNA-based immunization: priming with antigen and GM-CSF-encoding plasmid DNA and boosting with antigen-expressing recombinant poxvirus.

Sedegah M, Weiss W, Sacci JB Jr, Charoenvit Y, Hedstrom R, Gowda K, Majam VF, Tine J, Kumar S, Hobart P, Hoffman SL.

J Immunol. 2000 Jun 1;164(11):5905-12.

36.

gammadelta T cells are a component of early immunity against preerythrocytic malaria parasites.

McKenna KC, Tsuji M, Sarzotti M, Sacci JB Jr, Witney AA, Azad AF.

Infect Immun. 2000 Apr;68(4):2224-30.

37.

CD4(+) T-cell- and gamma interferon-dependent protection against murine malaria by immunization with linear synthetic peptides from a Plasmodium yoelii 17-kilodalton hepatocyte erythrocyte protein.

Charoenvit Y, Majam VF, Corradin G, Sacci JB Jr, Wang R, Doolan DL, Jones TR, Abot E, Patarroyo ME, Guzman F, Hoffman SL.

Infect Immun. 1999 Nov;67(11):5604-14.

38.

Pan DR binding sequence provides T-cell help for induction of protective antibodies against Plasmodium yoelii sporozoites.

Franke ED, Hoffman SL, Sacci JB Jr, Wang R, Charoenvit Y, Appella E, Chesnut R, Alexander J, Del Guercio MF, Sette A.

Vaccine. 1999 Mar 5;17(9-10):1201-5.

PMID:
10195633
39.

Plasmodium falciparum and Plasmodium yoelii: effect of the iron chelation prodrug dexrazoxane on in vitro cultures.

Loyevsky M, Sacci JB Jr, Boehme P, Weglicki W, John C, Gordeuk VR.

Exp Parasitol. 1999 Feb;91(2):105-14.

PMID:
9990337
40.

Immunogenicity and in vitro protective efficacy of a recombinant multistage Plasmodium falciparum candidate vaccine.

Shi YP, Hasnain SE, Sacci JB, Holloway BP, Fujioka H, Kumar N, Wohlhueter R, Hoffman SL, Collins WE, Lal AA.

Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1615-20.

41.

In vitro expression and in vivo immunogenicity of Plasmodium falciparum pre-erythrocytic stage DNA vaccines.

Hedstrom RC, Doolan DL, Wang R, Kumar A, Sacci JB Jr, Gardner MJ, Aguiar JC, Charoenvit Y, Sedegah M, Tine JA, Margalith M, Hobart P, Hoffman SL.

Int J Mol Med. 1998 Jul;2(1):29-38.

PMID:
9854139
42.

Simultaneous induction of multiple antigen-specific cytotoxic T lymphocytes in nonhuman primates by immunization with a mixture of four Plasmodium falciparum DNA plasmids.

Wang R, Doolan DL, Charoenvit Y, Hedstrom RC, Gardner MJ, Hobart P, Tine J, Sedegah M, Fallarme V, Sacci JB Jr, Kaur M, Klinman DM, Hoffman SL, Weiss WR.

Infect Immun. 1998 Sep;66(9):4193-202.

43.

Development of two monoclonal antibodies against Plasmodium falciparum sporozoite surface protein 2 and mapping of B-cell epitopes.

Charoenvit Y, Fallarme V, Rogers WO, Sacci JB Jr, Kaur M, Aguiar JC, Yuan LF, Corradin G, Andersen E, Wizel B, Houghten RA, Oloo A, De la Vega P, Hoffman SL.

Infect Immun. 1997 Aug;65(8):3430-7.

44.

The development of a multivalent DNA vaccine for malaria.

Hedstrom RC, Doolan DL, Wang R, Gardner MJ, Kumar A, Sedegah M, Gramzinski RA, Sacci JB Jr, Charoenvit Y, Weiss WR, Margalith M, Norman JA, Hobart P, Hoffman SL.

Springer Semin Immunopathol. 1997;19(2):147-59. Review. No abstract available.

PMID:
9406343
45.

Rationale and approaches to constructing preerythrocytic malaria vaccines.

Hoffman SL, Sacci JB Jr.

Pharm Biotechnol. 1995;6:787-802. Review. No abstract available.

PMID:
7551248
46.

Murine typhus: updated roles of multiple urban components and a second typhuslike rickettsia.

Schriefer ME, Sacci JB Jr, Taylor JP, Higgins JA, Azad AF.

J Med Entomol. 1994 Sep;31(5):681-5.

PMID:
7966170
47.

Identification of a novel rickettsial infection in a patient diagnosed with murine typhus.

Schriefer ME, Sacci JB Jr, Dumler JS, Bullen MG, Azad AF.

J Clin Microbiol. 1994 Apr;32(4):949-54.

48.

Molecular identification of rickettsia-like microorganisms associated with colonized cat fleas (Ctenocephalides felis).

Higgins JA, Sacci JB Jr, Schriefer ME, Endris RG, Azad AF.

Insect Mol Biol. 1994 Feb;3(1):27-33.

PMID:
8069413
49.

Inhibition of malaria parasite development in mosquitoes by anti-mosquito-midgut antibodies.

Lal AA, Schriefer ME, Sacci JB, Goldman IF, Louis-Wileman V, Collins WE, Azad AF.

Infect Immun. 1994 Jan;62(1):316-8.

50.

Expression of members of the heat-shock protein 70 family in the exoerythrocytic stages of Plasmodium berghei and Plasmodium falciparum.

Kumar N, Nagasawa H, Sacci JB Jr, Sina BJ, Aikawa M, Atkinson C, Uparanukraw P, Kubiak LB, Azad AF, Hollingdale MR.

Parasitol Res. 1993;79(2):109-13.

PMID:
8475027

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