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Structural and functional insight into the Mycobacterium tuberculosis protein PrpR reveals a novel type of transcription factor.

Tang S, Hicks ND, Cheng YS, Silva A, Fortune SM, Sacchettini JC.

Nucleic Acids Res. 2019 Oct 10;47(18):9934-9949. doi: 10.1093/nar/gkz724.


Genome-wide Phenotypic Profiling Identifies and Categorizes Genes Required for Mycobacterial Low Iron Fitness.

Dragset MS, Ioerger TR, Zhang YJ, Mærk M, Ginbot Z, Sacchettini JC, Flo TH, Rubin EJ, Steigedal M.

Sci Rep. 2019 Aug 6;9(1):11394. doi: 10.1038/s41598-019-47905-y.


Correction: TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities.

Carey AF, Rock JM, Krieger IV, Chase MR, Fernandez-Suarez M, Gagneux S, Sacchettini JC, Ioerger TR, Fortune SM.

PLoS Pathog. 2019 Jun 4;15(6):e1007846. doi: 10.1371/journal.ppat.1007846. eCollection 2019 Jun.


A DNA-Binding Protein Tunes Septum Placement during Bacillus subtilis Sporulation.

Brown EE, Miller AK, Krieger IV, Otto RM, Sacchettini JC, Herman JK.

J Bacteriol. 2019 Jul 24;201(16). pii: e00287-19. doi: 10.1128/JB.00287-19. Print 2019 Aug 15.


Structure-Guided Drug Design of 6-Substituted Adenosine Analogues as Potent Inhibitors of Mycobacterium tuberculosis Adenosine Kinase.

Crespo RA, Dang Q, Zhou NE, Guthrie LM, Snavely TC, Dong W, Loesch KA, Suzuki T, You L, Wang W, O'Malley T, Parish T, Olsen DB, Sacchettini JC.

J Med Chem. 2019 May 9;62(9):4483-4499. doi: 10.1021/acs.jmedchem.9b00020. Epub 2019 Apr 19.


Minocycline and Silver Dual-Loaded Polyphosphoester-Based Nanoparticles for Treatment of Resistant Pseudomonas aeruginosa.

Chen Q, Shah KN, Zhang F, Salazar AJ, Shah PN, Li R, Sacchettini JC, Wooley KL, Cannon CL.

Mol Pharm. 2019 Apr 1;16(4):1606-1619. doi: 10.1021/acs.molpharmaceut.8b01288. Epub 2019 Mar 12.


R pyocin tail fiber structure reveals a receptor-binding domain with a lectin fold.

Salazar AJ, Sherekar M, Tsai J, Sacchettini JC.

PLoS One. 2019 Feb 5;14(2):e0211432. doi: 10.1371/journal.pone.0211432. eCollection 2019.


Mycobacterium tuberculosis SatS is a chaperone for the SecA2 protein export pathway.

Miller BK, Hughes R, Ligon LS, Rigel NW, Malik S, Anjuwon-Foster BR, Sacchettini JC, Braunstein M.

Elife. 2019 Jan 3;8. pii: e40063. doi: 10.7554/eLife.40063.


Advancing Translational Science for Pulmonary Nontuberculous Mycobacterial Infections. A Road Map for Research.

Daniel-Wayman S, Abate G, Barber DL, Bermudez LE, Coler RN, Cynamon MH, Daley CL, Davidson RM, Dick T, Floto RA, Henkle E, Holland SM, Jackson M, Lee RE, Nuermberger EL, Olivier KN, Ordway DJ, Prevots DR, Sacchettini JC, Salfinger M, Sassetti CM, Sizemore CF, Winthrop KL, Zelazny AM.

Am J Respir Crit Care Med. 2019 Apr 15;199(8):947-951. doi: 10.1164/rccm.201807-1273PP. No abstract available.


A Lysine Acetyltransferase Contributes to the Metabolic Adaptation to Hypoxia in Mycobacterium tuberculosis.

Rittershaus ESC, Baek SH, Krieger IV, Nelson SJ, Cheng YS, Nambi S, Baker RE, Leszyk JD, Shaffer SA, Sacchettini JC, Sassetti CM.

Cell Chem Biol. 2018 Dec 20;25(12):1495-1505.e3. doi: 10.1016/j.chembiol.2018.09.009. Epub 2018 Oct 11.


Anion-π Interactions in Computer-Aided Drug Design: Modeling the Inhibition of Malate Synthase by Phenyl-Diketo Acids.

Ellenbarger JF, Krieger IV, Huang HL, Gómez-Coca S, Ioerger TR, Sacchettini JC, Wheeler SE, Dunbar KR.

J Chem Inf Model. 2018 Oct 22;58(10):2085-2091. doi: 10.1021/acs.jcim.8b00417. Epub 2018 Sep 12.


Structure-guided design of a potent peptide inhibitor targeting the interaction between CRK and ABL kinase.

Shen Q, Bhatt VS, Krieger I, Sacchettini JC, Cho JH.

Medchemcomm. 2018 Feb 1;9(3):519-524. doi: 10.1039/c7md00619e. eCollection 2018 Mar 1.


Identification of cyclic hexapeptides natural products with inhibitory potency against Mycobacterium tuberculosis.

Singh SB, Odingo J, Bailey MA, Sunde B, Korkegian A, O'Malley T, Ovechkina Y, Ioerger TR, Sacchettini JC, Young K, Olsen DB, Parish T.

BMC Res Notes. 2018 Jun 28;11(1):416. doi: 10.1186/s13104-018-3526-z.


Discovery of Antimicrobial Lipodepsipeptides Produced by a Serratia sp. within Mosquito Microbiomes.

Ganley JG, Carr G, Ioerger TR, Sacchettini JC, Clardy J, Derbyshire ER.

Chembiochem. 2018 Aug 6;19(15):1590-1594. doi: 10.1002/cbic.201800124. Epub 2018 Jun 10.


Targeting protein biotinylation enhances tuberculosis chemotherapy.

Tiwari D, Park SW, Essawy MM, Dawadi S, Mason A, Nandakumar M, Zimmerman M, Mina M, Ho HP, Engelhart CA, Ioerger T, Sacchettini JC, Rhee K, Ehrt S, Aldrich CC, Dartois V, Schnappinger D.

Sci Transl Med. 2018 Apr 25;10(438). pii: eaal1803. doi: 10.1126/scitranslmed.aal1803.


TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities.

Carey AF, Rock JM, Krieger IV, Chase MR, Fernandez-Suarez M, Gagneux S, Sacchettini JC, Ioerger TR, Fortune SM.

PLoS Pathog. 2018 Mar 5;14(3):e1006939. doi: 10.1371/journal.ppat.1006939. eCollection 2018 Mar. Erratum in: PLoS Pathog. 2019 Jun 4;15(6):e1007846.


Identification of a Mycothiol-Dependent Nitroreductase from Mycobacterium tuberculosis.

Negri A, Javidnia P, Mu R, Zhang X, Vendome J, Gold B, Roberts J, Barman D, Ioerger T, Sacchettini JC, Jiang X, Burns-Huang K, Warrier T, Ling Y, Warren JD, Oren DA, Beuming T, Wang H, Wu J, Li H, Rhee KY, Nathan CF, Liu G, Somersan-Karakaya S.

ACS Infect Dis. 2018 May 11;4(5):771-787. doi: 10.1021/acsinfecdis.7b00111. Epub 2018 Feb 21.


An Antibacterial β-Lactone Kills Mycobacterium tuberculosis by Disrupting Mycolic Acid Biosynthesis.

Lehmann J, Cheng TY, Aggarwal A, Park AS, Zeiler E, Raju RM, Akopian T, Kandror O, Sacchettini JC, Moody DB, Rubin EJ, Sieber SA.

Angew Chem Int Ed Engl. 2018 Jan 2;57(1):348-353. doi: 10.1002/anie.201709365. Epub 2017 Dec 5.


Structural insights into species-specific features of the ribosome from the human pathogen Mycobacterium tuberculosis.

Yang K, Chang JY, Cui Z, Li X, Meng R, Duan L, Thongchol J, Jakana J, Huwe CM, Sacchettini JC, Zhang J.

Nucleic Acids Res. 2017 Oct 13;45(18):10884-10894. doi: 10.1093/nar/gkx785.


Identification of a novel class of small compounds with anti-tuberculosis activity by in silico structure-based drug screening.

Taira J, Morita K, Kawashima S, Umei T, Baba H, Maruoka T, Komatsu H, Sakamoto H, Sacchettini JC, Aoki S.

J Antibiot (Tokyo). 2017 Nov;70(11):1057-1064. doi: 10.1038/ja.2017.106. Epub 2017 Sep 27.


A comprehensive characterization of PncA polymorphisms that confer resistance to pyrazinamide.

Yadon AN, Maharaj K, Adamson JH, Lai YP, Sacchettini JC, Ioerger TR, Rubin EJ, Pym AS.

Nat Commun. 2017 Sep 19;8(1):588. doi: 10.1038/s41467-017-00721-2.


Tetraterpene Synthase Substrate and Product Specificity in the Green Microalga Botryococcus braunii Race L.

Thapa HR, Tang S, Sacchettini JC, Devarenne TP.

ACS Chem Biol. 2017 Sep 15;12(9):2408-2416. doi: 10.1021/acschembio.7b00457. Epub 2017 Aug 25.


Mechanism-based inactivator of isocitrate lyases 1 and 2 from Mycobacterium tuberculosis.

Pham TV, Murkin AS, Moynihan MM, Harris L, Tyler PC, Shetty N, Sacchettini JC, Huang HL, Meek TD.

Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):7617-7622. doi: 10.1073/pnas.1706134114. Epub 2017 Jul 5.


Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.

Aggarwal A, Parai MK, Shetty N, Wallis D, Woolhiser L, Hastings C, Dutta NK, Galaviz S, Dhakal RC, Shrestha R, Wakabayashi S, Walpole C, Matthews D, Floyd D, Scullion P, Riley J, Epemolu O, Norval S, Snavely T, Robertson GT, Rubin EJ, Ioerger TR, Sirgel FA, van der Merwe R, van Helden PD, Keller P, Böttger EC, Karakousis PC, Lenaerts AJ, Sacchettini JC.

Cell. 2017 Jul 13;170(2):249-259.e25. doi: 10.1016/j.cell.2017.06.025. Epub 2017 Jun 29.


Erratum for Perkowski et al., "The EXIT Strategy: an Approach for Identifying Bacterial Proteins Exported during Host Infection".

Perkowski EF, Zulauf KE, Weerakoon D, Hayden JD, Ioerger TR, Oreper D, Gomez SM, Sacchettini JC, Braunstein M.

MBio. 2017 Jun 20;8(3). pii: e00872-17. doi: 10.1128/mBio.00872-17. No abstract available.


The EXIT Strategy: an Approach for Identifying Bacterial Proteins Exported during Host Infection.

Perkowski EF, Zulauf KE, Weerakoon D, Hayden JD, Ioerger TR, Oreper D, Gomez SM, Sacchettini JC, Braunstein M.

MBio. 2017 Apr 25;8(2). pii: e00333-17. doi: 10.1128/mBio.00333-17. Erratum in: MBio. 2017 Jun 20;8(3):.


A strategy for dual inhibition of the proteasome and fatty acid synthase with belactosin C-orlistat hybrids.

Zhu M, Harshbarger WD, Robles O, Krysiak J, Hull KG, Cho SW, Richardson RD, Yang Y, Garcia A, Spiegelman L, Ramirez B, Wilson CT, Yau JA, Moore JT, Walker CB, Sacchettini JC, Liu WR, Sieber SA, Smith JW, Romo D.

Bioorg Med Chem. 2017 Jun 1;25(11):2901-2916. doi: 10.1016/j.bmc.2017.01.020. Epub 2017 Jan 19.


Ribosomal mutations promote the evolution of antibiotic resistance in a multidrug environment.

Gomez JE, Kaufmann-Malaga BB, Wivagg CN, Kim PB, Silvis MR, Renedo N, Ioerger TR, Ahmad R, Livny J, Fishbein S, Sacchettini JC, Carr SA, Hung DT.

Elife. 2017 Feb 21;6. pii: e20420. doi: 10.7554/eLife.20420.


Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange.

Huang HL, Krieger IV, Parai MK, Gawandi VB, Sacchettini JC.

J Biol Chem. 2016 Dec 30;291(53):27421-27432. doi: 10.1074/jbc.M116.750877. Epub 2016 Oct 13.


Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase.

Palencia A, Li X, Bu W, Choi W, Ding CZ, Easom EE, Feng L, Hernandez V, Houston P, Liu L, Meewan M, Mohan M, Rock FL, Sexton H, Zhang S, Zhou Y, Wan B, Wang Y, Franzblau SG, Woolhiser L, Gruppo V, Lenaerts AJ, O'Malley T, Parish T, Cooper CB, Waters MG, Ma Z, Ioerger TR, Sacchettini JC, Rullas J, Angulo-Barturen I, Pérez-Herrán E, Mendoza A, Barros D, Cusack S, Plattner JJ, Alley MR.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):6271-80. doi: 10.1128/AAC.01339-16. Print 2016 Oct.


Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor.

Martínez-Hoyos M, Perez-Herran E, Gulten G, Encinas L, Álvarez-Gómez D, Alvarez E, Ferrer-Bazaga S, García-Pérez A, Ortega F, Angulo-Barturen I, Rullas-Trincado J, Blanco Ruano D, Torres P, Castañeda P, Huss S, Fernández Menéndez R, González Del Valle S, Ballell L, Barros D, Modha S, Dhar N, Signorino-Gelo F, McKinney JD, García-Bustos JF, Lavandera JL, Sacchettini JC, Jimenez MS, Martín-Casabona N, Castro-Pichel J, Mendoza-Losana A.

EBioMedicine. 2016 Jun;8:291-301. doi: 10.1016/j.ebiom.2016.05.006. Epub 2016 May 8.


Binding Mechanism of the N-Terminal SH3 Domain of CrkII and Proline-Rich Motifs in cAbl.

Bhatt VS, Zeng D, Krieger I, Sacchettini JC, Cho JH.

Biophys J. 2016 Jun 21;110(12):2630-2641. doi: 10.1016/j.bpj.2016.05.008.


N-Benzyl-4-((heteroaryl)methyl)benzamides: A New Class of Direct NADH-Dependent 2-trans Enoyl-Acyl Carrier Protein Reductase (InhA) Inhibitors with Antitubercular Activity.

Guardia A, Gulten G, Fernandez R, Gómez J, Wang F, Convery M, Blanco D, Martínez M, Pérez-Herrán E, Alonso M, Ortega F, Rullás J, Calvo D, Mata L, Young R, Sacchettini JC, Mendoza-Losana A, Remuiñán M, Ballell Pages L, Castro-Pichel J.

ChemMedChem. 2016 Apr 5;11(7):687-701. doi: 10.1002/cmdc.201600020. Epub 2016 Mar 2.


High Throughput Screen for Escherichia coli Twin Arginine Translocation (Tat) Inhibitors.

Bageshwar UK, VerPlank L, Baker D, Dong W, Hamsanathan S, Whitaker N, Sacchettini JC, Musser SM.

PLoS One. 2016 Feb 22;11(2):e0149659. doi: 10.1371/journal.pone.0149659. eCollection 2016.


Structural Similarities and Differences between Two Functionally Distinct SecA Proteins, Mycobacterium tuberculosis SecA1 and SecA2.

Swanson S, Ioerger TR, Rigel NW, Miller BK, Braunstein M, Sacchettini JC.

J Bacteriol. 2015 Dec 14;198(4):720-30. doi: 10.1128/JB.00696-15.


Structure of Ribosomal Silencing Factor Bound to Mycobacterium tuberculosis Ribosome.

Li X, Sun Q, Jiang C, Yang K, Hung LW, Zhang J, Sacchettini JC.

Structure. 2015 Dec 1;23(12):2387. doi: 10.1016/j.str.2015.11.002. Epub 2015 Dec 1. No abstract available.


The identification of novel Mycobacterium tuberculosis DHFR inhibitors and the investigation of their binding preferences by using molecular modelling.

Hong W, Wang Y, Chang Z, Yang Y, Pu J, Sun T, Kaur S, Sacchettini JC, Jung H, Lin Wong W, Fah Yap L, Fong Ngeow Y, Paterson IC, Wang H.

Sci Rep. 2015 Oct 16;5:15328. doi: 10.1038/srep15328.


Peptidoglycan synthesis in Mycobacterium tuberculosis is organized into networks with varying drug susceptibility.

Kieser KJ, Baranowski C, Chao MC, Long JE, Sassetti CM, Waldor MK, Sacchettini JC, Ioerger TR, Rubin EJ.

Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):13087-92. doi: 10.1073/pnas.1514135112. Epub 2015 Oct 5.


Structure of Ribosomal Silencing Factor Bound to Mycobacterium tuberculosis Ribosome.

Li X, Sun Q, Jiang C, Yang K, Hung LW, Zhang J, Sacchettini JC.

Structure. 2015 Oct 6;23(10):1858-1865. doi: 10.1016/j.str.2015.07.014. Epub 2015 Aug 20. Erratum in: Structure. 2015 Dec 1;23(12):2387. Structure. 2015 Dec 1;23 (12 ):2387.


Functional genomics screening utilizing mutant mouse embryonic stem cells identifies novel radiation-response genes.

Loesch K, Galaviz S, Hamoui Z, Clanton R, Akabani G, Deveau M, DeJesus M, Ioerger T, Sacchettini JC, Wallis D.

PLoS One. 2015 Apr 8;10(4):e0120534. doi: 10.1371/journal.pone.0120534. eCollection 2015.


Discovery of InhA inhibitors with anti-mycobacterial activity through a matched molecular pair approach.

Kanetaka H, Koseki Y, Taira J, Umei T, Komatsu H, Sakamoto H, Gulten G, Sacchettini JC, Kitamura M, Aoki S.

Eur J Med Chem. 2015 Apr 13;94:378-85. doi: 10.1016/j.ejmech.2015.02.062. Epub 2015 Mar 5.


High-Throughput Differentiation and Screening of a Library of Mutant Stem Cell Clones Defines New Host-Based Genes Involved in Rabies Virus Infection.

Wallis D, Loesch K, Galaviz S, Sun Q, DeJesus M, Ioerger T, Sacchettini JC.

Stem Cells. 2015 Aug;33(8):2509-22. doi: 10.1002/stem.1983. Epub 2015 May 12.


A novel antimycobacterial compound acts as an intracellular iron chelator.

Dragset MS, Poce G, Alfonso S, Padilla-Benavides T, Ioerger TR, Kaneko T, Sacchettini JC, Biava M, Parish T, Argüello JM, Steigedal M, Rubin EJ.

Antimicrob Agents Chemother. 2015 Apr;59(4):2256-64. doi: 10.1128/AAC.05114-14. Epub 2015 Feb 2.


Subfamily-specific adaptations in the structures of two penicillin-binding proteins from Mycobacterium tuberculosis.

Prigozhin DM, Krieger IV, Huizar JP, Mavrici D, Waldo GS, Hung LW, Sacchettini JC, Terwilliger TC, Alber T.

PLoS One. 2014 Dec 31;9(12):e116249. doi: 10.1371/journal.pone.0116249. eCollection 2014.


Structure, activity, and inhibition of the Carboxyltransferase β-subunit of acetyl coenzyme A carboxylase (AccD6) from Mycobacterium tuberculosis.

Reddy MC, Breda A, Bruning JB, Sherekar M, Valluru S, Thurman C, Ehrenfeld H, Sacchettini JC.

Antimicrob Agents Chemother. 2014 Oct;58(10):6122-32. doi: 10.1128/AAC.02574-13. Epub 2014 Aug 4.


Folate pathway disruption leads to critical disruption of methionine derivatives in Mycobacterium tuberculosis.

Nixon MR, Saionz KW, Koo MS, Szymonifka MJ, Jung H, Roberts JP, Nandakumar M, Kumar A, Liao R, Rustad T, Sacchettini JC, Rhee KY, Freundlich JS, Sherman DR.

Chem Biol. 2014 Jul 17;21(7):819-30. doi: 10.1016/j.chembiol.2014.04.009. Epub 2014 Jun 19.


The copper-responsive RicR regulon contributes to Mycobacterium tuberculosis virulence.

Shi X, Festa RA, Ioerger TR, Butler-Wu S, Sacchettini JC, Darwin KH, Samanovic MI.

MBio. 2014 Feb 18;5(1). pii: e00876-13. doi: 10.1128/mBio.00876-13.


Tryptophan biosynthesis protects mycobacteria from CD4 T-cell-mediated killing.

Zhang YJ, Reddy MC, Ioerger TR, Rothchild AC, Dartois V, Schuster BM, Trauner A, Wallis D, Galaviz S, Huttenhower C, Sacchettini JC, Behar SM, Rubin EJ.

Cell. 2013 Dec 5;155(6):1296-308. doi: 10.1016/j.cell.2013.10.045.


High-throughput sequencing enhanced phage display identifies peptides that bind mycobacteria.

Ngubane NA, Gresh L, Ioerger TR, Sacchettini JC, Zhang YJ, Rubin EJ, Pym A, Khati M.

PLoS One. 2013 Nov 12;8(11):e77844. doi: 10.1371/journal.pone.0077844. eCollection 2013.

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