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Items: 44


Similarities and differences between helminth parasites and cancer cell lines in shaping human monocytes: Insights into parallel mechanisms of immune evasion.

Narasimhan PB, Akabas L, Tariq S, Huda N, Bennuru S, Sabzevari H, Hofmeister R, Nutman TB, Tolouei Semnani R.

PLoS Negl Trop Dis. 2018 Apr 18;12(4):e0006404. doi: 10.1371/journal.pntd.0006404. eCollection 2018 Apr.


Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-β.

Lan Y, Zhang D, Xu C, Hance KW, Marelli B, Qi J, Yu H, Qin G, Sircar A, Hernández VM, Jenkins MH, Fontana RE, Deshpande A, Locke G, Sabzevari H, Radvanyi L, Lo KM.

Sci Transl Med. 2018 Jan 17;10(424). pii: eaan5488. doi: 10.1126/scitranslmed.aan5488.


Programed death-1/programed death-ligand 1 expression in lymph nodes of HIV infected patients: results of a pilot safety study in rhesus macaques using anti-programed death-ligand 1 (Avelumab).

Gill AL, Green SA, Abdullah S, Le Saout C, Pittaluga S, Chen H, Turnier R, Lifson J, Godin S, Qin J, Sneller MC, Cuillerot JM, Sabzevari H, Lane HC, Catalfamo M.

AIDS. 2016 Oct 23;30(16):2487-2493.


Systemic Immunotherapy of Non-Muscle Invasive Mouse Bladder Cancer with Avelumab, an Anti-PD-L1 Immune Checkpoint Inhibitor.

Vandeveer AJ, Fallon JK, Tighe R, Sabzevari H, Schlom J, Greiner JW.

Cancer Immunol Res. 2016 May;4(5):452-62. doi: 10.1158/2326-6066.CIR-15-0176. Epub 2016 Feb 26.


Cutting edge: epigenetic regulation of Foxp3 defines a stable population of CD4+ regulatory T cells in tumors from mice and humans.

Waight JD, Takai S, Marelli B, Qin G, Hance KW, Zhang D, Tighe R, Lan Y, Lo KM, Sabzevari H, Hofmeister R, Wilson NS.

J Immunol. 2015 Feb 1;194(3):878-82. doi: 10.4049/jimmunol.1402725. Epub 2014 Dec 29.


The immunocytokine NHS-IL12 as a potential cancer therapeutic.

Fallon J, Tighe R, Kradjian G, Guzman W, Bernhardt A, Neuteboom B, Lan Y, Sabzevari H, Schlom J, Greiner JW.

Oncotarget. 2014 Apr 15;5(7):1869-84.


Distinct effects of saracatinib on memory CD8+ T cell differentiation.

Takai S, Sabzevari H, Farsaci B, Schlom J, Greiner JW.

J Immunol. 2012 May 1;188(9):4323-33. doi: 10.4049/jimmunol.1101439. Epub 2012 Mar 26.


Development of an IL-15-autocrine CD8 T-cell leukemia in IL-15-transgenic mice requires the cis expression of IL-15Rα.

Sato N, Sabzevari H, Fu S, Ju W, Petrus MN, Bamford RN, Waldmann TA, Tagaya Y.

Blood. 2011 Apr 14;117(15):4032-40. doi: 10.1182/blood-2010-09-307504. Epub 2011 Feb 8.


Effect of a small molecule BCL-2 inhibitor on immune function and use with a recombinant vaccine.

Farsaci B, Sabzevari H, Higgins JP, Di Bari MG, Takai S, Schlom J, Hodge JW.

Int J Cancer. 2010 Oct 1;127(7):1603-13. doi: 10.1002/ijc.25177.


TGF-beta modulates the functionality of tumor-infiltrating CD8+ T cells through effects on TCR signaling and Spred1 expression.

di Bari MG, Lutsiak ME, Takai S, Mostböck S, Farsaci B, Semnani RT, Wakefield LM, Schlom J, Sabzevari H.

Cancer Immunol Immunother. 2009 Nov;58(11):1809-18. doi: 10.1007/s00262-009-0692-9. Epub 2009 Mar 25.


Human dendritic cell maturation and activation by a heat-killed recombinant yeast (Saccharomyces cerevisiae) vector encoding carcinoembryonic antigen.

Remondo C, Cereda V, Mostböck S, Sabzevari H, Franzusoff A, Schlom J, Tsang KY.

Vaccine. 2009 Feb 11;27(7):987-94. doi: 10.1016/j.vaccine.2008.12.002. Epub 2008 Dec 25.


Chronic lymphocytic leukemia (CLL) cells genetically modified to express B7-1, ICAM-1, and LFA-3 confer APC capacity to T cells from CLL patients.

Litzinger MT, Foon KA, Sabzevari H, Tsang KY, Schlom J, Palena C.

Cancer Immunol Immunother. 2009 Jun;58(6):955-65. doi: 10.1007/s00262-008-0611-5. Epub 2008 Nov 14.


Inhibition of TLR3 and TLR4 function and expression in human dendritic cells by helminth parasites.

Semnani RT, Venugopal PG, Leifer CA, Mostböck S, Sabzevari H, Nutman TB.

Blood. 2008 Aug 15;112(4):1290-8. doi: 10.1182/blood-2008-04-149856. Epub 2008 Jun 9.


An anti-transforming growth factor beta antibody suppresses metastasis via cooperative effects on multiple cell compartments.

Nam JS, Terabe M, Mamura M, Kang MJ, Chae H, Stuelten C, Kohn E, Tang B, Sabzevari H, Anver MR, Lawrence S, Danielpour D, Lonning S, Berzofsky JA, Wakefield LM.

Cancer Res. 2008 May 15;68(10):3835-43. doi: 10.1158/0008-5472.CAN-08-0215.


Tumor-induced impairment of TCR signaling results in compromised functionality of tumor-infiltrating regulatory T cells.

Lutsiak ME, Tagaya Y, Adams AJ, Schlom J, Sabzevari H.

J Immunol. 2008 May 1;180(9):5871-81.


Fc-mOX40L fusion protein produces complete remission and enhanced survival in 2 murine tumor models.

Sadun RE, Hsu WE, Zhang N, Nien YC, Bergfeld SA, Sabzevari H, Lutsiak ME, Khawli L, Hu P, Epstein AL.

J Immunother. 2008 Apr;31(3):235-45. doi: 10.1097/CJI.0b013e31816a88e0.


Construction and preclinical characterization of Fc-mGITRL for the immunotherapy of cancer.

Hu P, Arias RS, Sadun RE, Nien YC, Zhang N, Sabzevari H, Lutsiak ME, Khawli LA, Epstein AL.

Clin Cancer Res. 2008 Jan 15;14(2):579-88. doi: 10.1158/1078-0432.CCR-07-0940.


Recombinant Saccharomyces cerevisiae (yeast-CEA) as a potent activator of murine dendritic cells.

Bernstein MB, Chakraborty M, Wansley EK, Guo Z, Franzusoff A, Mostböck S, Sabzevari H, Schlom J, Hodge JW.

Vaccine. 2008 Jan 24;26(4):509-21. Epub 2007 Dec 3.


Enhanced levels of costimulation lead to reduced effector/memory CD8+ T cell functionality.

Mostböck S, Vidal S, Schlom J, Sabzevari H.

J Immunol. 2007 Sep 15;179(6):3524-34.


Acquisition of antigen presentasome (APS), an MHC/costimulatory complex, is a checkpoint of memory T-cell homeostasis.

Mostböck S, Catalfamo M, Tagaya Y, Schlom J, Sabzevari H.

Blood. 2007 Mar 15;109(6):2488-95. Epub 2006 Nov 14.


Activation-associated phenotype of CD3 T cells in acute graft-versus-host disease.

Paz Morante M, Briones J, Canto E, Sabzevari H, Martino R, Sierra J, Rodriguez-Sanchez JL, Vidal S.

Clin Exp Immunol. 2006 Jul;145(1):36-43.


Costimulatory molecules as adjuvants for immunotherapy.

Hodge JW, Greiner JW, Tsang KY, Sabzevari H, Kudo-Saito C, Grosenbach DW, Gulley JL, Arlen PM, Marshall JL, Panicali D, Schlom J.

Front Biosci. 2006 Jan 1;11:788-803. Review.


Physiological relevance of antigen presentasome (APS), an acquired MHC/costimulatory complex, in the sustained activation of CD4+ T cells in the absence of APCs.

Zhou J, Tagaya Y, Tolouei-Semnani R, Schlom J, Sabzevari H.

Blood. 2005 Apr 15;105(8):3238-46. Epub 2005 Jan 6.


Combinatorial vaccine strategies and the use of molecular arrays to characterize T-cell activation.

Schlom J, Palena C, Greiner JW, Tsang KY, Grosenbach DW, Sabzevari H, Gulley JL, Arlen PM, Kass E, Hodge JW.

Dev Biol (Basel). 2004;116:27-47. No abstract available.


Inhibition of CD4(+)25+ T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide.

Lutsiak ME, Semnani RT, De Pascalis R, Kashmiri SV, Schlom J, Sabzevari H.

Blood. 2005 Apr 1;105(7):2862-8. Epub 2004 Dec 9.


Role of trans-cellular IL-15 presentation in the activation of NK cell-mediated killing, which leads to enhanced tumor immunosurveillance.

Kobayashi H, Dubois S, Sato N, Sabzevari H, Sakai Y, Waldmann TA, Tagaya Y.

Blood. 2005 Jan 15;105(2):721-7. Epub 2004 Sep 14.


Amplification of the lytic potential of effector/memory CD8+ cells by vector-based enhancement of ICAM-1 (CD54) in target cells: implications for intratumoral vaccine therapy.

Slavin-Chiorini DC, Catalfamo M, Kudo-Saito C, Hodge JW, Schlom J, Sabzevari H.

Cancer Gene Ther. 2004 Oct;11(10):665-80.


A triad of costimulatory molecules synergize to amplify T-cell activation in both vector-based and vector-infected dendritic cell vaccines.

Schlom J, Sabzevari H, Grosenbach DW, Hodge JW.

Artif Cells Blood Substit Immobil Biotechnol. 2003 May;31(2):193-228.


Acquisition of CD80 by human T cells at early stages of activation: functional involvement of CD80 acquisition in T cell to T cell interaction.

Tatari-Calderone Z, Semnani RT, Nutman TB, Schlom J, Sabzevari H.

J Immunol. 2002 Dec 1;169(11):6162-9.


Proliferative arrest and cell cycle regulation in CD8(+)CD28(-) versus CD8(+)CD28(+) T cells.

Scheuring UJ, Sabzevari H, Theofilopoulos AN.

Hum Immunol. 2002 Nov;63(11):1000-9.


Filarial antigens impair the function of human dendritic cells during differentiation.

Semnani RT, Sabzevari H, Iyer R, Nutman TB.

Infect Immun. 2001 Sep;69(9):5813-22.


Enhancing the potency of peptide-pulsed antigen presenting cells by vector-driven hyperexpression of a triad of costimulatory molecules.

Hodge JW, Grosenbach DW, Rad AN, Giuliano M, Sabzevari H, Schlom J.

Vaccine. 2001 May 14;19(25-26):3552-67.


Acquisition of CD80 (B7-1) by T cells.

Sabzevari H, Kantor J, Jaigirdar A, Tagaya Y, Naramura M, Hodge J, Bernon J, Schlom J.

J Immunol. 2001 Feb 15;166(4):2505-13.


IL-2-induced activation-induced cell death is inhibited in IL-15 transgenic mice.

Marks-Konczalik J, Dubois S, Losi JM, Sabzevari H, Yamada N, Feigenbaum L, Waldmann TA, Tagaya Y.

Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11445-50.


Enhanced activation of T cells by dendritic cells engineered to hyperexpress a triad of costimulatory molecules.

Hodge JW, Rad AN, Grosenbach DW, Sabzevari H, Yafal AG, Gritz L, Schlom J.

J Natl Cancer Inst. 2000 Aug 2;92(15):1228-39.


A triad of costimulatory molecules synergize to amplify T-cell activation.

Hodge JW, Sabzevari H, Yafal AG, Gritz L, Lorenz MG, Schlom J.

Cancer Res. 1999 Nov 15;59(22):5800-7.


Differential expression profiles of apoptosis-affecting genes in HIV-infected cell lines and patient T cells.

Scheuring UJ, Sabzevari H, Corbeil J, Theofilopoulos AN.

AIDS. 1999 Feb 4;13(2):167-75.


A recombinant antibody-interleukin 2 fusion protein suppresses growth of hepatic human neuroblastoma metastases in severe combined immunodeficiency mice.

Sabzevari H, Gillies SD, Mueller BM, Pancook JD, Reisfeld RA.

Proc Natl Acad Sci U S A. 1994 Sep 27;91(20):9626-30.


Production and regulation of gelatinase B by human T-cells.

Montgomery AM, Sabzevari H, Reisfeld RA.

Biochim Biophys Acta. 1993 Apr 16;1176(3):265-8.


Metastasis of ocular and flank implants of the 13762NF mammary adenocarcinoma in syngeneic rats.

Szalay J, Sabzevari H.

J Natl Cancer Inst. 1987 Oct;79(4):837-45.


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