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Physician narratives of illness.

Wilson A, Millard C, Sabroe I.

Lancet. 2019 Jul 6;394(10192):20-21. doi: 10.1016/S0140-6736(19)31501-6. Epub 2019 Jul 4. No abstract available.


The incremental shuttle walk test predicts mortality in non-group 1 pulmonary hypertension: results from the ASPIRE Registry.

Billings CG, Lewis R, Hurdman JA, Condliffe R, Elliot CA, Thompson AAR, Smith IA, Austin M, Armstrong IJ, Hamilton N, Charalampopoulos A, Sabroe I, Swift AJ, Rothman AM, Wild JM, Lawrie A, Waterhouse JC, Kiely DG.

Pulm Circ. 2019 Apr-Jun;9(2):2045894019848649. doi: 10.1177/2045894019848649.


The care of dying people in 16th- and 17th-century England.

Germain L, Sabroe I.

Death Stud. 2019 Feb 1:1-8. doi: 10.1080/07481187.2018.1541941. [Epub ahead of print]


A method for transplantation of human HSCs into zebrafish, to replace humanised murine transplantation models.

Hamilton N, Sabroe I, Renshaw SA.

Version 2. F1000Res. 2018 May 15 [revised 2018 Jan 1];7:594. doi: 10.12688/f1000research.14507.2. eCollection 2018.


Human Rhinovirus Inhibits Macrophage Phagocytosis of Bacteria in Chronic Obstructive Pulmonary Disease. More Than a Common Cold.

Sabroe I, Ho A, Dockrell DH.

Am J Respir Crit Care Med. 2019 Jun 15;199(12):1451-1452. doi: 10.1164/rccm.201812-2283ED. No abstract available.


Diagnosis of Pulmonary Hypertension with Cardiac MRI: Derivation and Validation of Regression Models.

Johns CS, Kiely DG, Rajaram S, Hill C, Thomas S, Karunasaagarar K, Garg P, Hamilton N, Solanki R, Capener DA, Elliot C, Sabroe I, Charalamopopoulos A, Condliffe R, Wild JM, Swift AJ.

Radiology. 2019 Jan;290(1):61-68. doi: 10.1148/radiol.2018180603. Epub 2018 Oct 23.


DUSP10 Negatively Regulates the Inflammatory Response to Rhinovirus through Interleukin-1β Signaling.

Manley GCA, Stokes CA, Marsh EK, Sabroe I, Parker LC.

J Virol. 2019 Jan 4;93(2). pii: e01659-18. doi: 10.1128/JVI.01659-18. Print 2019 Jan 15.


Effect of Hypoglycemia on Inflammatory Responses and the Response to Low-Dose Endotoxemia in Humans.

Iqbal A, Prince LR, Novodvorsky P, Bernjak A, Thomas MR, Birch L, Lambert D, Kay LJ, Wright FJ, Macdonald IA, Jacques RM, Storey RF, McCrimmon RJ, Francis S, Heller SR, Sabroe I.

J Clin Endocrinol Metab. 2019 Apr 1;104(4):1187-1199. doi: 10.1210/jc.2018-01168.


Toll-like Receptor 3 Is a Therapeutic Target for Pulmonary Hypertension.

Farkas D, Thompson AAR, Bhagwani AR, Hultman S, Ji H, Kotha N, Farr G, Arnold ND, Braithwaite A, Casbolt H, Cole JE, Sabroe I, Monaco C, Cool CD, Goncharova EA, Lawrie A, Farkas L.

Am J Respir Crit Care Med. 2019 Jan 15;199(2):199-210. doi: 10.1164/rccm.201707-1370OC.


The impact of patient choice on survival in chronic thromboembolic pulmonary hypertension.

Quadery SR, Swift AJ, Billings CG, Thompson AAR, Elliot CA, Hurdman J, Charalampopoulos A, Sabroe I, Armstrong IJ, Hamilton N, Sephton P, Garrad S, Pepke-Zaba J, Jenkins DP, Screaton N, Rothman AM, Lawrie A, Cleveland T, Thomas S, Rajaram S, Hill C, Davies C, Johns CS, Wild JM, Condliffe R, Kiely DG.

Eur Respir J. 2018 Sep 16;52(3). pii: 1800589. doi: 10.1183/13993003.00589-2018. Print 2018 Sep.


Incremental Shuttle Walking Test Distance Is Reduced in Patients With Pulmonary Hypertension in World Health Organisation Functional Class I.

Billings CG, Lewis R, Armstrong IJ, Hurdman JA, Smith IA, Austin M, Elliot CA, Charalampopoulos A, Sabroe I, Lawrie A, Thompson AAR, Condliffe R, Kiely DG.

Front Med (Lausanne). 2018 Jun 21;5:172. doi: 10.3389/fmed.2018.00172. eCollection 2018.


Pathophysiology and Diagnosis of Pulmonary Hypertension Due to Left Heart Disease.

Charalampopoulos A, Lewis R, Hickey P, Durrington C, Elliot C, Condliffe R, Sabroe I, Kiely DG.

Front Med (Lausanne). 2018 Jun 6;5:174. doi: 10.3389/fmed.2018.00174. eCollection 2018. Review.


DP1 receptor signaling prevents the onset of intrinsic apoptosis in eosinophils and functions as a transcriptional modulator.

Peinhaupt M, Roula D, Theiler A, Sedej M, Schicho R, Marsche G, Sturm EM, Sabroe I, Rothenberg ME, Heinemann A.

J Leukoc Biol. 2018 Jul;104(1):159-171. doi: 10.1002/JLB.3MA1017-404R. Epub 2018 Apr 1.


Combining creative writing and narrative analysis to deliver new insights into the impact of pulmonary hypertension.

Goddard JC, Armstrong IJ, Kiely DG, Elliot CA, Charalampopoulos A, Condliffe R, Stone BJ, Sabroe I.

BMJ Open Respir Res. 2017 Jun 5;4(1):e000184. doi: 10.1136/bmjresp-2017-000184. eCollection 2017.


NR4A orphan nuclear receptor family members, NR4A2 and NR4A3, regulate neutrophil number and survival.

Prince LR, Prosseda SD, Higgins K, Carlring J, Prestwich EC, Ogryzko NV, Rahman A, Basran A, Falciani F, Taylor P, Renshaw SA, Whyte MKB, Sabroe I.

Blood. 2017 Aug 24;130(8):1014-1025. doi: 10.1182/blood-2017-03-770164. Epub 2017 Jun 21.


Incremental shuttle walk test distance and autonomic dysfunction predict survival in pulmonary arterial hypertension.

Billings CG, Hurdman JA, Condliffe R, Elliot CA, Smith IA, Austin M, Armstrong IJ, Hamilton N, Charalampopoulos A, Sabroe I, Swift AJ, Rothman AM, Wild JM, Lawrie A, Waterhouse JC, Kiely DG.

J Heart Lung Transplant. 2017 Aug;36(8):871-879. doi: 10.1016/j.healun.2017.04.008. Epub 2017 Apr 24.


Human rhinovirus-induced inflammatory responses are inhibited by phosphatidylserine containing liposomes.

Stokes CA, Kaur R, Edwards MR, Mondhe M, Robinson D, Prestwich EC, Hume RD, Marshall CA, Perrie Y, O'Donnell VB, Harwood JL, Sabroe I, Parker LC.

Mucosal Immunol. 2017 May;10(3):829. doi: 10.1038/mi.2017.40. No abstract available.


Idiopathic and Systemic Sclerosis-Associated Pulmonary Arterial Hypertension: A Comparison of Demographic, Hemodynamic, and MRI Characteristics and Outcomes.

Ramjug S, Hussain N, Hurdman J, Billings C, Charalampopoulos A, Elliot CA, Kiely DG, Sabroe I, Rajaram S, Swift AJ, Condliffe R.

Chest. 2017 Jul;152(1):92-102. doi: 10.1016/j.chest.2017.02.010. Epub 2017 Feb 20.


Bosutinib therapy resulting in severe deterioration of pre-existing pulmonary arterial hypertension.

Hickey PM, Thompson AA, Charalampopoulos A, Elliot CA, Hamilton N, Kiely DG, Lawrie A, Sabroe I, Condliffe R.

Eur Respir J. 2016 Nov;48(5):1514-1516. doi: 10.1183/13993003.01004-2016. Epub 2016 Sep 22. No abstract available.


A social-technological epistemology of clinical decision-making as mediated by imaging.

van Baalen S, Carusi A, Sabroe I, Kiely DG.

J Eval Clin Pract. 2017 Oct;23(5):949-958. doi: 10.1111/jep.12637. Epub 2016 Oct 3.


Long-term outcomes of domiciliary intravenous iloprost in idiopathic and connective tissue disease-associated pulmonary arterial hypertension.

Ramjug S, Hussain N, Hurdman J, Elliot CA, Sabroe I, Armstrong IJ, Billings C, Hamilton N, Kiely DG, Condliffe R.

Respirology. 2017 Feb;22(2):372-377. doi: 10.1111/resp.12899. Epub 2016 Sep 20.


Human rhinovirus-induced inflammatory responses are inhibited by phosphatidylserine containing liposomes.

Stokes CA, Kaur R, Edwards MR, Mondhe M, Robinson D, Prestwich EC, Hume RD, Marshall CA, Perrie Y, O'Donnell VB, Harwood JL, Sabroe I, Parker LC.

Mucosal Immunol. 2016 Sep;9(5):1303-16. doi: 10.1038/mi.2015.137. Epub 2016 Feb 24.


Pulmonary arterial hypertension associated with congenital heart disease: Comparison of clinical and anatomic-pathophysiologic classification.

Ramjug S, Hussain N, Hurdman J, Billings C, Charalampopoulos A, Elliot CA, Sabroe I, Kiely DG, Condliffe R.

J Heart Lung Transplant. 2016 May;35(5):610-8. doi: 10.1016/j.healun.2015.12.016. Epub 2016 Jan 7.


A matter of time: study of circadian clocks and their role in inflammation.

Carter SJ, Durrington HJ, Gibbs JE, Blaikley J, Loudon AS, Ray DW, Sabroe I.

J Leukoc Biol. 2016 Apr;99(4):549-60. doi: 10.1189/jlb.3RU1015-451R. Epub 2016 Feb 8. Review.


Platelet P2Y12 Inhibitors Reduce Systemic Inflammation and Its Prothrombotic Effects in an Experimental Human Model.

Thomas MR, Outteridge SN, Ajjan RA, Phoenix F, Sangha GK, Faulkner RE, Ecob R, Judge HM, Khan H, West LE, Dockrell DH, Sabroe I, Storey RF.

Arterioscler Thromb Vasc Biol. 2015 Dec;35(12):2562-70. doi: 10.1161/ATVBAHA.115.306528. Epub 2015 Oct 29.


Management of acute pulmonary embolism.

Quadery R, Elliot CA, Hurdman J, Kiely DG, Maclean RM, Sabroe I, van Veen JJ, Condliffe R.

Br J Hosp Med (Lond). 2015 Oct;76(10):C150-5. doi: 10.12968/hmed.2015.76.10.C150. No abstract available.


Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK).

Heaney LG, Djukanovic R, Woodcock A, Walker S, Matthews JG, Pavord ID, Bradding P, Niven R, Brightling CE, Chaudhuri R, Arron JR, Choy DF, Cowan D, Mansur A, Menzies-Gow A, Adcock I, Chung KF, Corrigan C, Coyle P, Harrison T, Johnston S, Howarth P, Lordan J, Sabroe I, Bigler J, Smith D, Catley M, May R, Pierre L, Stevenson C, Crater G, Keane F, Costello RW, Hudson V, Supple D, Hardman T.

Thorax. 2016 Feb;71(2):187-9. doi: 10.1136/thoraxjnl-2015-207326. Epub 2015 Jul 23. Review.


Ticagrelor potentiates adenosine-induced stimulation of neutrophil chemotaxis and phagocytosis.

Alsharif KF, Thomas MR, Judge HM, Khan H, Prince LR, Sabroe I, Ridger VC, Storey RF.

Vascul Pharmacol. 2015 Aug;71:201-7. doi: 10.1016/j.vph.2015.02.006. Epub 2015 Apr 11.


Phosphoinositide-3 kinase inhibition modulates responses to rhinovirus by mechanisms that are predominantly independent of autophagy.

Ismail S, Stokes CA, Prestwich EC, Roberts RL, Juss JK, Sabroe I, Parker LC.

PLoS One. 2014 Dec 26;9(12):e116055. doi: 10.1371/journal.pone.0116055. eCollection 2014.


CT features of pulmonary arterial hypertension and its major subtypes: a systematic CT evaluation of 292 patients from the ASPIRE Registry.

Rajaram S, Swift AJ, Condliffe R, Johns C, Elliot CA, Hill C, Davies C, Hurdman J, Sabroe I, Wild JM, Kiely DG.

Thorax. 2015 Apr;70(4):382-7. doi: 10.1136/thoraxjnl-2014-206088. Epub 2014 Dec 18.


Editorial: RSV: a new box of delights for an old enemy.

Sabroe I, Dockrell DH, Culley FJ.

J Leukoc Biol. 2014 Dec;96(6):945-7. doi: 10.1189/jlb.4CE0714-341R. No abstract available.


Macrophage phenotype is associated with disease severity in preterm infants with chronic lung disease.

Prince LR, Maxwell NC, Gill SK, Dockrell DH, Sabroe I, McGreal EP, Kotecha S, Whyte MK.

PLoS One. 2014 Aug 12;9(8):e103059. doi: 10.1371/journal.pone.0103059. eCollection 2014.


Ambrisentan therapy in pulmonary hypertension: clinical use and tolerability in a referral centre.

Condliffe R, Elliot CA, Hurdman J, Sabroe I, Billings C, Kiely DG, Hamilton N.

Ther Adv Respir Dis. 2014 Jun;8(3):71-77. Epub 2014 Apr 30.


Rhinoviral infection and asthma: the detection and management of rhinoviruses by airway epithelial cells.

Parker LC, Stokes CA, Sabroe I.

Clin Exp Allergy. 2014 Jan;44(1):20-8. doi: 10.1111/cea.12182. Review.


Management dilemmas in acute pulmonary embolism.

Condliffe R, Elliot CA, Hughes RJ, Hurdman J, Maclean RM, Sabroe I, van Veen JJ, Kiely DG.

Thorax. 2014 Feb;69(2):174-80. doi: 10.1136/thoraxjnl-2013-204667. Epub 2013 Dec 16. Review.


Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish.

Thompson AA, Elks PM, Marriott HM, Eamsamarng S, Higgins KR, Lewis A, Williams L, Parmar S, Shaw G, McGrath EE, Formenti F, Van Eeden FJ, Kinnula VL, Pugh CW, Sabroe I, Dockrell DH, Chilvers ER, Robbins PA, Percy MJ, Simon MC, Johnson RS, Renshaw SA, Whyte MK, Walmsley SR.

Blood. 2014 Jan 16;123(3):366-76. doi: 10.1182/blood-2013-05-500207. Epub 2013 Nov 6.


The yin and the yang of immunosuppression with inhaled corticosteroids.

Sabroe I, Postma D, Heijink I, Dockrell DH.

Thorax. 2013 Dec;68(12):1085-7. doi: 10.1136/thoraxjnl-2013-203773. Epub 2013 Aug 8. No abstract available.


Muckle-Wells syndrome without mutation in exon 3 of the NLRP3 gene, identified by evidence of excessive monocyte production of functional interleukin 1β and rapid response to anakinra.

Sabroe RA, Stokes CA, Parker LC, Higgins K, Prince LR, Sabroe I.

Clin Exp Dermatol. 2013 Dec;38(8):874-7. doi: 10.1111/ced.12186. Epub 2013 Jul 25.


Practical phenotyping of difficult asthma.

Thomas A, Green RH, Niven RM, Saha S, Hall I, Heaney LG, Sabroe I.

Thorax. 2014 Mar;69(3):299-301. doi: 10.1136/thoraxjnl-2013-203568. Epub 2013 May 31. No abstract available.


The role of interleukin-1 and interleukin-18 in pro-inflammatory and anti-viral responses to rhinovirus in primary bronchial epithelial cells.

Piper SC, Ferguson J, Kay L, Parker LC, Sabroe I, Sleeman MA, Briend E, Finch DK.

PLoS One. 2013 May 28;8(5):e63365. doi: 10.1371/journal.pone.0063365. Print 2013.


Pulmonary hypertension: diagnosis and management.

Kiely DG, Elliot CA, Sabroe I, Condliffe R.

BMJ. 2013 Apr 16;346:f2028. doi: 10.1136/bmj.f2028. No abstract available.


Central venous catheter-related blood stream infections in patients receiving intravenous iloprost for pulmonary hypertension.

Sammut D, Elliot CA, Kiely DG, Armstrong IJ, Martin L, Wilkinson J, Sephton P, Jones J, Hamilton N, Hurdman J, McLellan E, Sabroe I, Condliffe R.

Eur J Clin Microbiol Infect Dis. 2013 Jul;32(7):883-9. doi: 10.1007/s10096-013-1822-z. Epub 2013 Feb 7.


Diesel exhaust particle exposure in vitro alters monocyte differentiation and function.

Chaudhuri N, Jary H, Lea S, Khan N, Piddock KC, Dockrell DH, Donaldson K, Duffin R, Singh D, Parker LC, Sabroe I.

PLoS One. 2012;7(12):e51107. doi: 10.1371/journal.pone.0051107. Epub 2012 Dec 7.


Pulmonary hypertension in COPD: results from the ASPIRE registry.

Hurdman J, Condliffe R, Elliot CA, Swift A, Rajaram S, Davies C, Hill C, Hamilton N, Armstrong IJ, Billings C, Pollard L, Wild JM, Lawrie A, Lawson R, Sabroe I, Kiely DG.

Eur Respir J. 2013 Jun;41(6):1292-301. doi: 10.1183/09031936.00079512. Epub 2012 Sep 27.


Roles of neutrophils in the regulation of the extent of human inflammation through delivery of IL-1 and clearance of chemokines.

Basran A, Jabeen M, Bingle L, Stokes CA, Dockrell DH, Whyte MK, Walmsley SR, Higgins KR, Vogel SN, Wilson HL, Prince LR, Prestwich EC, Sabroe RA, Parker LC, Sabroe I.

J Leukoc Biol. 2013 Jan;93(1):7-19. doi: 10.1189/jlb.0512250. Epub 2012 Aug 17.


Pellino-1 selectively regulates epithelial cell responses to rhinovirus.

Bennett JA, Prince LR, Parker LC, Stokes CA, de Bruin HG, van den Berge M, Heijink IH, Whyte MK, Sabroe I.

J Virol. 2012 Jun;86(12):6595-604. doi: 10.1128/JVI.06755-11. Epub 2012 Apr 18.


Deficiency of tumour necrosis factor-related apoptosis-inducing ligand exacerbates lung injury and fibrosis.

McGrath EE, Lawrie A, Marriott HM, Mercer P, Cross SS, Arnold N, Singleton V, Thompson AA, Walmsley SR, Renshaw SA, Sabroe I, Chambers RC, Dockrell DH, Whyte MK.

Thorax. 2012 Sep;67(9):796-803. doi: 10.1136/thoraxjnl-2011-200863. Epub 2012 Apr 11.


Staphylococcus aureus induces eosinophil cell death mediated by α-hemolysin.

Prince LR, Graham KJ, Connolly J, Anwar S, Ridley R, Sabroe I, Foster SJ, Whyte MK.

PLoS One. 2012;7(2):e31506. doi: 10.1371/journal.pone.0031506. Epub 2012 Feb 15.


Interleukin-1β regulates CXCL8 release and influences disease outcome in response to Streptococcus pneumoniae, defining intercellular cooperation between pulmonary epithelial cells and macrophages.

Marriott HM, Gascoyne KA, Gowda R, Geary I, Nicklin MJ, Iannelli F, Pozzi G, Mitchell TJ, Whyte MK, Sabroe I, Dockrell DH.

Infect Immun. 2012 Mar;80(3):1140-9. doi: 10.1128/IAI.05697-11. Epub 2011 Dec 12.


ASPIRE registry: assessing the Spectrum of Pulmonary hypertension Identified at a REferral centre.

Hurdman J, Condliffe R, Elliot CA, Davies C, Hill C, Wild JM, Capener D, Sephton P, Hamilton N, Armstrong IJ, Billings C, Lawrie A, Sabroe I, Akil M, O'Toole L, Kiely DG.

Eur Respir J. 2012 Apr;39(4):945-55. doi: 10.1183/09031936.00078411. Epub 2011 Sep 1.

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