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Items: 21


Generation of focal mutations and large genomic deletions in the pancreas using inducible in vivo genome editing.

Mishra A, Emamgholi F, Erlangga Z, Hartleben B, Unger K, Wolff K, Teichmann U, Kessel M, Woller N, Kühnel F, Dow LE, Manns MP, Vogel A, Lowe SW, Saborowski A, Saborowski M.

Carcinogenesis. 2019 Jun 6. pii: bgz108. doi: 10.1093/carcin/bgz108. [Epub ahead of print]


Murine Liver Organoids as a Genetically Flexible System to Study Liver Cancer In Vivo and In Vitro.

Saborowski A, Wolff K, Spielberg S, Beer B, Hartleben B, Erlangga Z, Becker D, Dow LE, Marhenke S, Woller N, Unger K, Schirmacher P, Manns MP, Marquardt JU, Vogel A, Saborowski M.

Hepatol Commun. 2019 Feb 5;3(3):423-436. doi: 10.1002/hep4.1312. eCollection 2019 Mar.


Clinical characteristics of patients with liver cirrhosis and spontaneous portosystemic shunts detected by ultrasound in a tertiary care and transplantation centre.

Lipinski M, Saborowski M, Heidrich B, Attia D, Kasten P, Manns MP, Gebel M, Potthoff A.

Scand J Gastroenterol. 2018 Sep;53(9):1107-1113. doi: 10.1080/00365521.2018.1498913. Epub 2018 Sep 29.


Arid1a restrains Kras-dependent changes in acinar cell identity.

Livshits G, Alonso-Curbelo D, Morris JP 4th, Koche R, Saborowski M, Wilkinson JE, Lowe SW.

Elife. 2018 Jul 17;7. pii: e35216. doi: 10.7554/eLife.35216.


Lipid-lowering therapy with PCSK9-inhibitors in the management of cardiovascular high-risk patients: Effectiveness, therapy adherence and safety in a real world cohort.

Saborowski M, Dölle M, Manns MP, Leitolf H, Zender S.

Cardiol J. 2018;25(1):32-41. doi: 10.5603/CJ.a2017.0137. Epub 2017 Nov 23.


CD4 and CD8 T lymphocyte interplay in controlling tumor growth.

Ostroumov D, Fekete-Drimusz N, Saborowski M, Kühnel F, Woller N.

Cell Mol Life Sci. 2018 Feb;75(4):689-713. doi: 10.1007/s00018-017-2686-7. Epub 2017 Oct 14. Review.


Tailored Tumor Immunogenicity Reveals Regulation of CD4 and CD8 T Cell Responses against Cancer.

Knocke S, Fleischmann-Mundt B, Saborowski M, Manns MP, Kühnel F, Wirth TC, Woller N.

Cell Rep. 2016 Nov 22;17(9):2234-2246. doi: 10.1016/j.celrep.2016.10.086.


Administration of Gemcitabine After Pancreatic Tumor Resection in Mice Induces an Antitumor Immune Response Mediated by Natural Killer Cells.

Gürlevik E, Fleischmann-Mundt B, Brooks J, Demir IE, Steiger K, Ribback S, Yevsa T, Woller N, Kloos A, Ostroumov D, Armbrecht N, Manns MP, Dombrowski F, Saborowski M, Kleine M, Wirth TC, Oettle H, Ceyhan GO, Esposito I, Calvisi DF, Kubicka S, Kühnel F.

Gastroenterology. 2016 Aug;151(2):338-350.e7. doi: 10.1053/j.gastro.2016.05.004. Epub 2016 May 20.


Viral Infection of Tumors Overcomes Resistance to PD-1-immunotherapy by Broadening Neoantigenome-directed T-cell Responses.

Woller N, Gürlevik E, Fleischmann-Mundt B, Schumacher A, Knocke S, Kloos AM, Saborowski M, Geffers R, Manns MP, Wirth TC, Kubicka S, Kühnel F.

Mol Ther. 2015 Oct;23(10):1630-40. doi: 10.1038/mt.2015.115. Epub 2015 Jun 26.


Optimizing sparse sequencing of single cells for highly multiplex copy number profiling.

Baslan T, Kendall J, Ward B, Cox H, Leotta A, Rodgers L, Riggs M, D'Italia S, Sun G, Yong M, Miskimen K, Gilmore H, Saborowski M, Dimitrova N, Krasnitz A, Harris L, Wigler M, Hicks J.

Genome Res. 2015 May;25(5):714-24. doi: 10.1101/gr.188060.114. Epub 2015 Apr 9.


Surface-enhanced resonance Raman scattering nanostars for high-precision cancer imaging.

Harmsen S, Huang R, Wall MA, Karabeber H, Samii JM, Spaliviero M, White JR, Monette S, O'Connor R, Pitter KL, Sastra SA, Saborowski M, Holland EC, Singer S, Olive KP, Lowe SW, Blasberg RG, Kircher MF.

Sci Transl Med. 2015 Jan 21;7(271):271ra7. doi: 10.1126/scitranslmed.3010633.


Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors.

Lito P, Saborowski A, Yue J, Solomon M, Joseph E, Gadal S, Saborowski M, Kastenhuber E, Fellmann C, Ohara K, Morikami K, Miura T, Lukacs C, Ishii N, Lowe S, Rosen N.

Cancer Cell. 2014 May 12;25(5):697-710. doi: 10.1016/j.ccr.2014.03.011. Epub 2014 Apr 17.


Conditional reverse tet-transactivator mouse strains for the efficient induction of TRE-regulated transgenes in mice.

Dow LE, Nasr Z, Saborowski M, Ebbesen SH, Manchado E, Tasdemir N, Lee T, Pelletier J, Lowe SW.

PLoS One. 2014 Apr 17;9(4):e95236. doi: 10.1371/journal.pone.0095236. eCollection 2014.


Mutant p53 drives pancreatic cancer metastasis through cell-autonomous PDGF receptor β signaling.

Weissmueller S, Manchado E, Saborowski M, Morris JP 4th, Wagenblast E, Davis CA, Moon SH, Pfister NT, Tschaharganeh DF, Kitzing T, Aust D, Markert EK, Wu J, Grimmond SM, Pilarsky C, Prives C, Biankin AV, Lowe SW.

Cell. 2014 Apr 10;157(2):382-394. doi: 10.1016/j.cell.2014.01.066.


A modular and flexible ESC-based mouse model of pancreatic cancer.

Saborowski M, Saborowski A, Morris JP 4th, Bosbach B, Dow LE, Pelletier J, Klimstra DS, Lowe SW.

Genes Dev. 2014 Jan 1;28(1):85-97. doi: 10.1101/gad.232082.113.


Mouse model of intrahepatic cholangiocarcinoma validates FIG-ROS as a potent fusion oncogene and therapeutic target.

Saborowski A, Saborowski M, Davare MA, Druker BJ, Klimstra DS, Lowe SW.

Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19513-8. doi: 10.1073/pnas.1311707110. Epub 2013 Oct 23.


Antitumoral immune response by recruitment and expansion of dendritic cells in tumors infected with telomerase-dependent oncolytic viruses.

Edukulla R, Woller N, Mundt B, Knocke S, Gürlevik E, Saborowski M, Malek N, Manns MP, Wirth T, Kühnel F, Kubicka S.

Cancer Res. 2009 Feb 15;69(4):1448-58. doi: 10.1158/0008-5472.CAN-08-1160. Epub 2009 Feb 3. Erratum in: Cancer Res. 2011 Mar 1;71(5):2021. Ramakrishna, Edukulla [corrected to Edukulla, Ramakrishna].


Expression of the chick Sizzled gene in progenitors of the cardiac outflow tract.

Wittler L, Saborowski M, Kessel M.

Gene Expr Patterns. 2008 Jul;8(6):471-6. doi: 10.1016/j.gep.2008.02.004. Epub 2008 Feb 29.


The human organic cation transporter-1 gene is transactivated by hepatocyte nuclear factor-4alpha.

Saborowski M, Kullak-Ublick GA, Eloranta JJ.

J Pharmacol Exp Ther. 2006 May;317(2):778-85. Epub 2006 Jan 25.


The human organic anion transporter 2 gene is transactivated by hepatocyte nuclear factor-4 alpha and suppressed by bile acids.

Popowski K, Eloranta JJ, Saborowski M, Fried M, Meier PJ, Kullak-Ublick GA.

Mol Pharmacol. 2005 May;67(5):1629-38. Epub 2005 Feb 3.


[Chloral hydrate and diarrhea. A 76-year-old retired administration employee].

Saborowski M, Gubler Ch, Jochum W, Bauerfeind P.

Praxis (Bern 1994). 2004 Sep 22;93(39):1600-2. German. No abstract available.


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