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Items: 41

1.

p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1.

Quiñones M, Al-Massadi O, Folgueira C, Bremser S, Gallego R, Torres-Leal L, Haddad-Tóvolli R, García-Caceres C, Hernandez-Bautista R, Lam BYH, Beiroa D, Sanchez-Rebordelo E, Senra A, Malagon JA, Valerio P, Fondevila MF, Fernø J, Malagon MM, Contreras R, Pfluger P, Brüning JC, Yeo G, Tschöp M, Diéguez C, López M, Claret M, Kloppenburg P, Sabio G, Nogueiras R.

Nat Commun. 2018 Aug 24;9(1):3432. doi: 10.1038/s41467-018-05711-6.

2.

p38α blocks brown adipose tissue thermogenesis through p38δ inhibition.

Matesanz N, Nikolic I, Leiva M, Pulgarín-Alfaro M, Santamans AM, Bernardo E, Mora A, Herrera-Melle L, Rodríguez E, Beiroa D, Caballero A, Martín-García E, Acín-Pérez R, Hernández-Cosido L, Leiva-Vega L, Torres JL, Centeno F, Nebreda AR, Enríquez JA, Nogueiras R, Marcos M, Sabio G.

PLoS Biol. 2018 Jul 6;16(7):e2004455. doi: 10.1371/journal.pbio.2004455. eCollection 2018 Jul.

3.

Anti-CD69 therapy induces rapid mobilization and high proliferation of HSPCs through S1P and mTOR.

Notario L, Alari-Pahissa E, Albentosa A, Leiva M, Sabio G, Lauzurica P.

Leukemia. 2018 Jun;32(6):1445-1457. doi: 10.1038/s41375-018-0052-x. Epub 2018 Feb 27.

PMID:
29483712
4.

Pharmacological stimulation of p53 with low-dose doxorubicin ameliorates diet-induced nonalcoholic steatosis and steatohepatitis.

Porteiro B, Fondevila MF, Buque X, Gonzalez-Rellan MJ, Fernandez U, Mora A, Beiroa D, Senra A, Gallego R, Fernø J, López M, Sabio G, Dieguez C, Aspichueta P, Nogueiras R.

Mol Metab. 2018 Feb;8:132-143. doi: 10.1016/j.molmet.2017.12.005. Epub 2017 Dec 15.

5.

MKK6 controls T3-mediated browning of white adipose tissue.

Matesanz N, Bernardo E, Acín-Pérez R, Manieri E, Pérez-Sieira S, Hernández-Cosido L, Montalvo-Romeral V, Mora A, Rodríguez E, Leiva-Vega L, Lechuga-Vieco AV, Ruiz-Cabello J, Torres JL, Crespo-Ruiz M, Centeno F, Álvarez CV, Marcos M, Enríquez JA, Nogueiras R, Sabio G.

Nat Commun. 2017 Oct 11;8(1):856. doi: 10.1038/s41467-017-00948-z.

6.

Street floods in Metro Manila and possible solutions.

Lagmay AM, Mendoza J, Cipriano F, Delmendo PA, Lacsamana MN, Moises MA, Pellejera N 3rd, Punay KN, Sabio G, Santos L, Serrano J, Taniza HJ, Tingin NE.

J Environ Sci (China). 2017 Sep;59:39-47. doi: 10.1016/j.jes.2017.03.004. Epub 2017 Mar 10.

PMID:
28888237
7.

Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance.

Martínez-Sánchez N, Seoane-Collazo P, Contreras C, Varela L, Villarroya J, Rial-Pensado E, Buqué X, Aurrekoetxea I, Delgado TC, Vázquez-Martínez R, González-García I, Roa J, Whittle AJ, Gomez-Santos B, Velagapudi V, Tung YCL, Morgan DA, Voshol PJ, Martínez de Morentin PB, López-González T, Liñares-Pose L, Gonzalez F, Chatterjee K, Sobrino T, Medina-Gómez G, Davis RJ, Casals N, Orešič M, Coll AP, Vidal-Puig A, Mittag J, Tena-Sempere M, Malagón MM, Diéguez C, Martínez-Chantar ML, Aspichueta P, Rahmouni K, Nogueiras R, Sabio G, Villarroya F, López M.

Cell Metab. 2017 Jul 5;26(1):212-229.e12. doi: 10.1016/j.cmet.2017.06.014.

8.

Corrigendum: Hepatic p63 regulates steatosis via IKKβ/ER stress.

Porteiro B, Fondevila MF, Delgado TC, Iglesias C, Imbernon M, Iruzubieta P, Crespo J, Zabala-Letona A, Fernø J, González-Terán B, Matesanz N, Hernández-Cosido L, Marcos M, Tovar S, Vidal A, Sánchez-Ceinos J, Malagon MM, Pombo C, Zalvide J, Carracedo A, Buque X, Dieguez C, Sabio G, López M, Aspichueta P, Martínez-Chantar ML, Nogueiras R.

Nat Commun. 2017 Jun 16;8:16059. doi: 10.1038/ncomms16059.

9.

Hepatic p63 regulates steatosis via IKKβ/ER stress.

Porteiro B, Fondevila MF, Delgado TC, Iglesias C, Imbernon M, Iruzubieta P, Crespo J, Zabala-Letona A, Fernø J, González-Terán B, Matesanz N, Hernández-Cosido L, Marcos M, Tovar S, Vidal A, Sánchez-Ceinos J, Malagon MM, Pombo C, Zalvide J, Carracedo A, Buque X, Dieguez C, Sabio G, López M, Aspichueta P, Martínez-Chantar ML, Nogueiras R.

Nat Commun. 2017 May 8;8:15111. doi: 10.1038/ncomms15111. Erratum in: Nat Commun. 2017 Jun 16;8:16059.

10.

p38γ and p38δ reprogram liver metabolism by modulating neutrophil infiltration.

González-Terán B, Matesanz N, Nikolic I, Verdugo MA, Sreeramkumar V, Hernández-Cosido L, Mora A, Crainiciuc G, Sáiz ML, Bernardo E, Leiva-Vega L, Rodríguez E, Bondía V, Torres JL, Perez-Sieira S, Ortega L, Cuenda A, Sanchez-Madrid F, Nogueiras R, Hidalgo A, Marcos M, Sabio G.

EMBO J. 2016 Mar 1;35(5):536-52. doi: 10.15252/embj.201591857. Epub 2016 Feb 3.

11.

p38γ and δ promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation.

González-Terán B, López JA, Rodríguez E, Leiva L, Martínez-Martínez S, Bernal JA, Jiménez-Borreguero LJ, Redondo JM, Vazquez J, Sabio G.

Nat Commun. 2016 Jan 22;7:10477. doi: 10.1038/ncomms10477.

12.

Stress kinases in the modulation of metabolism and energy balance.

Manieri E, Sabio G.

J Mol Endocrinol. 2015 Oct;55(2):R11-22. doi: 10.1530/JME-15-0146. Review.

13.

The PPARα-FGF21 hormone axis contributes to metabolic regulation by the hepatic JNK signaling pathway.

Vernia S, Cavanagh-Kyros J, Garcia-Haro L, Sabio G, Barrett T, Jung DY, Kim JK, Xu J, Shulha HP, Garber M, Gao G, Davis RJ.

Cell Metab. 2014 Sep 2;20(3):512-25. doi: 10.1016/j.cmet.2014.06.010. Epub 2014 Jul 17.

14.

TNF and MAP kinase signalling pathways.

Sabio G, Davis RJ.

Semin Immunol. 2014 Jun;26(3):237-45. doi: 10.1016/j.smim.2014.02.009. Epub 2014 Mar 16. Review.

15.

Specific calcineurin targeting in macrophages confers resistance to inflammation via MKP-1 and p38.

Escolano A, Martínez-Martínez S, Alfranca A, Urso K, Izquierdo HM, Delgado M, Martín F, Sabio G, Sancho D, Gómez-del Arco P, Redondo JM.

EMBO J. 2014 May 16;33(10):1117-33. doi: 10.1002/embj.201386369. Epub 2014 Mar 3.

16.

Eukaryotic elongation factor 2 controls TNF-α translation in LPS-induced hepatitis.

González-Terán B, Cortés JR, Manieri E, Matesanz N, Verdugo Á, Rodríguez ME, González-Rodríguez Á, Valverde ÁM, Martín P, Davis RJ, Sabio G.

J Clin Invest. 2013 Jan;123(1):164-78. doi: 10.1172/JCI65124. Epub 2012 Dec 3. Erratum in: J Clin Invest. 2014 Apr 1;124(4):1869. Valverde, Ángela [corrected to Valverde, Ángela M].

17.

Central melanin-concentrating hormone influences liver and adipose metabolism via specific hypothalamic nuclei and efferent autonomic/JNK1 pathways.

Imbernon M, Beiroa D, Vázquez MJ, Morgan DA, Veyrat-Durebex C, Porteiro B, Díaz-Arteaga A, Senra A, Busquets S, Velásquez DA, Al-Massadi O, Varela L, Gándara M, López-Soriano FJ, Gallego R, Seoane LM, Argiles JM, López M, Davis RJ, Sabio G, Rohner-Jeanrenaud F, Rahmouni K, Dieguez C, Nogueiras R.

Gastroenterology. 2013 Mar;144(3):636-649.e6. doi: 10.1053/j.gastro.2012.10.051. Epub 2012 Nov 6.

18.

Activation of p38 MAPK in CD4 T cells controls IL-17 production and autoimmune encephalomyelitis.

Noubade R, Krementsov DN, Del Rio R, Thornton T, Nagaleekar V, Saligrama N, Spitzack A, Spach K, Sabio G, Davis RJ, Rincon M, Teuscher C.

Blood. 2011 Sep 22;118(12):3290-300. doi: 10.1182/blood-2011-02-336552. Epub 2011 Jul 25.

19.

Constitutive expression and enzymatic activity of Tan protein in brain and epidermis of Ceratitis capitata and of Drosophila melanogaster wild-type and tan mutants.

Pérez MM, Sabio G, Badaracco A, Quesada-Allué LA.

Insect Biochem Mol Biol. 2011 Sep;41(9):653-9. doi: 10.1016/j.ibmb.2011.04.007. Epub 2011 May 7.

PMID:
21571070
20.

Translational control of NKT cell cytokine production by p38 MAPK.

Nagaleekar VK, Sabio G, Aktan I, Chant A, Howe IW, Thornton TM, Benoit PJ, Davis RJ, Rincon M, Boyson JE.

J Immunol. 2011 Apr 1;186(7):4140-6. doi: 10.4049/jimmunol.1002614. Epub 2011 Mar 2.

21.

Requirement of c-Jun NH(2)-terminal kinase for Ras-initiated tumor formation.

Cellurale C, Sabio G, Kennedy NJ, Das M, Barlow M, Sandy P, Jacks T, Davis RJ.

Mol Cell Biol. 2011 Apr;31(7):1565-76. doi: 10.1128/MCB.01122-10. Epub 2011 Jan 31.

22.

p38gamma regulates interaction of nuclear PSF and RNA with the tumour-suppressor hDlg in response to osmotic shock.

Sabio G, Cerezo-Guisado MI, Del Reino P, Iñesta-Vaquera FA, Rousseau S, Arthur JS, Campbell DG, Centeno F, Cuenda A.

J Cell Sci. 2010 Aug 1;123(Pt 15):2596-604. doi: 10.1242/jcs.066514. Epub 2010 Jul 6.

23.

cJun NH2-terminal kinase 1 (JNK1): roles in metabolic regulation of insulin resistance.

Sabio G, Davis RJ.

Trends Biochem Sci. 2010 Sep;35(9):490-6. doi: 10.1016/j.tibs.2010.04.004. Epub 2010 May 7. Review.

24.

Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1.

Sabio G, Cavanagh-Kyros J, Barrett T, Jung DY, Ko HJ, Ong H, Morel C, Mora A, Reilly J, Kim JK, Davis RJ.

Genes Dev. 2010 Feb 1;24(3):256-64. doi: 10.1101/gad.1878510. Epub 2010 Jan 15.

25.

Differential activation of p38MAPK isoforms by MKK6 and MKK3.

Remy G, Risco AM, Iñesta-Vaquera FA, González-Terán B, Sabio G, Davis RJ, Cuenda A.

Cell Signal. 2010 Apr;22(4):660-7. doi: 10.1016/j.cellsig.2009.11.020. Epub 2009 Dec 11.

PMID:
20004242
26.

Prevention of steatosis by hepatic JNK1.

Sabio G, Cavanagh-Kyros J, Ko HJ, Jung DY, Gray S, Jun JY, Barrett T, Mora A, Kim JK, Davis RJ.

Cell Metab. 2009 Dec;10(6):491-8. doi: 10.1016/j.cmet.2009.09.007.

27.

Role of muscle c-Jun NH2-terminal kinase 1 in obesity-induced insulin resistance.

Sabio G, Kennedy NJ, Cavanagh-Kyros J, Jung DY, Ko HJ, Ong H, Barrett T, Kim JK, Davis RJ.

Mol Cell Biol. 2010 Jan;30(1):106-15. doi: 10.1128/MCB.01162-09.

28.

Nuclear localization of p38 MAPK in response to DNA damage.

Wood CD, Thornton TM, Sabio G, Davis RA, Rincon M.

Int J Biol Sci. 2009 Jun 16;5(5):428-37.

29.

Induction of hepatitis by JNK-mediated expression of TNF-alpha.

Das M, Sabio G, Jiang F, Rincón M, Flavell RA, Davis RJ.

Cell. 2009 Jan 23;136(2):249-60. doi: 10.1016/j.cell.2008.11.017.

30.

A stress signaling pathway in adipose tissue regulates hepatic insulin resistance.

Sabio G, Das M, Mora A, Zhang Z, Jun JY, Ko HJ, Barrett T, Kim JK, Davis RJ.

Science. 2008 Dec 5;322(5907):1539-43. doi: 10.1126/science.1160794.

31.

Proteolysis of the tumour suppressor hDlg in response to osmotic stress is mediated by caspases and independent of phosphorylation.

Iñesta-Vaquera FA, Centeno F, del Reino P, Sabio G, Peggie M, Cuenda A.

FEBS J. 2009 Jan;276(2):387-400. doi: 10.1111/j.1742-4658.2008.06783.x. Epub 2008 Nov 28.

32.

Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation.

Thornton TM, Pedraza-Alva G, Deng B, Wood CD, Aronshtam A, Clements JL, Sabio G, Davis RJ, Matthews DE, Doble B, Rincon M.

Science. 2008 May 2;320(5876):667-70. doi: 10.1126/science.1156037.

33.

Crystal structure of human arginase I at 1.29-A resolution and exploration of inhibition in the immune response.

Di Costanzo L, Sabio G, Mora A, Rodriguez PC, Ochoa AC, Centeno F, Christianson DW.

Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13058-63. Epub 2005 Sep 2.

34.

BIRB796 inhibits all p38 MAPK isoforms in vitro and in vivo.

Kuma Y, Sabio G, Bain J, Shpiro N, Márquez R, Cuenda A.

J Biol Chem. 2005 May 20;280(20):19472-9. Epub 2005 Mar 8.

35.

p38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP.

Sabio G, Arthur JS, Kuma Y, Peggie M, Carr J, Murray-Tait V, Centeno F, Goedert M, Morrice NA, Cuenda A.

EMBO J. 2005 Mar 23;24(6):1134-45. Epub 2005 Feb 24.

36.

Stress- and mitogen-induced phosphorylation of the synapse-associated protein SAP90/PSD-95 by activation of SAPK3/p38gamma and ERK1/ERK2.

Sabio G, Reuver S, Feijoo C, Hasegawa M, Thomas GM, Centeno F, Kuhlendahl S, Leal-Ortiz S, Goedert M, Garner C, Cuenda A.

Biochem J. 2004 May 15;380(Pt 1):19-30.

37.

Different dependence of lithium and valproate on PI3K/PKB pathway.

Mora A, Sabio G, Alonso JC, Soler G, Centeno F.

Bipolar Disord. 2002 Jun;4(3):195-200.

PMID:
12180274
38.

Lithium blocks the PKB and GSK3 dephosphorylation induced by ceramide through protein phosphatase-2A.

Mora A, Sabio G, Risco AM, Cuenda A, Alonso JC, Soler G, Centeno F.

Cell Signal. 2002 Jun;14(6):557-62.

PMID:
11897496
39.

Mechanisms of MPP(+) incorporation into cerebellar granule cells.

González-Polo RA, Mora A, Clemente N, Sabio G, Centeno F, Soler G, Fuentes JM.

Brain Res Bull. 2001 Sep 15;56(2):119-23.

PMID:
11704348
40.

Glu-256 is a main structural determinant for oligomerisation of human arginase I.

Sabio G, Mora A, Rangel MA, Quesada A, Marcos CF, Alonso JC, Soler G, Centeno F.

FEBS Lett. 2001 Jul 20;501(2-3):161-5.

41.

Lithium inhibits caspase 3 activation and dephosphorylation of PKB and GSK3 induced by K+ deprivation in cerebellar granule cells.

Mora A, Sabio G, González-Polo RA, Cuenda A, Alessi DR, Alonso JC, Fuentes JM, Soler G, Centeno F.

J Neurochem. 2001 Jul;78(1):199-206.

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