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Items: 29

1.

Mouse model of severe recessive RYR1-related myopathy.

Brennan S, Garcia-Castañeda M, Michelucci A, Sabha N, Malik S, Groom L, Wei LaPierre L, Dowling JJ, Dirksen RT.

Hum Mol Genet. 2019 Sep 15;28(18):3024-3036. doi: 10.1093/hmg/ddz105.

PMID:
31107960
2.

Tamoxifen therapy in a murine model of myotubular myopathy.

Maani N, Sabha N, Rezai K, Ramani A, Groom L, Eltayeb N, Mavandadnejad F, Pang A, Russo G, Brudno M, Haucke V, Dirksen RT, Dowling JJ.

Nat Commun. 2018 Nov 19;9(1):4849. doi: 10.1038/s41467-018-07057-5.

3.

Characterization of a Clival Chordoma Xenograft Model Reveals Tumor Genomic Instability.

Diaz RJ, Luck A, Bondoc A, Golbourn B, Picard D, Remke M, Loukides J, Sabha N, Smith C, Cusimano MD, Rutka JT.

Am J Pathol. 2018 Dec;188(12):2902-2911. doi: 10.1016/j.ajpath.2018.08.004. Epub 2018 Sep 22.

PMID:
30248342
4.

Brainstem blood brain barrier disruption using focused ultrasound: A demonstration of feasibility and enhanced doxorubicin delivery.

Alli S, Figueiredo CA, Golbourn B, Sabha N, Wu MY, Bondoc A, Luck A, Coluccia D, Maslink C, Smith C, Wurdak H, Hynynen K, O'Reilly M, Rutka JT.

J Control Release. 2018 Jul 10;281:29-41. doi: 10.1016/j.jconrel.2018.05.005. Epub 2018 May 16.

5.

PIK3C2B inhibition improves function and prolongs survival in myotubular myopathy animal models.

Sabha N, Volpatti JR, Gonorazky H, Reifler A, Davidson AE, Li X, Eltayeb NM, Dall'Armi C, Di Paolo G, Brooks SV, Buj-Bello A, Feldman EL, Dowling JJ.

J Clin Invest. 2016 Sep 1;126(9):3613-25. doi: 10.1172/JCI86841. Epub 2016 Aug 22.

6.

A role for activated Cdc42 in glioblastoma multiforme invasion.

Okura H, Golbourn BJ, Shahzad U, Agnihotri S, Sabha N, Krieger JR, Figueiredo CA, Chalil A, Landon-Brace N, Riemenschneider A, Arai H, Smith CA, Xu S, Kaluz S, Marcus AI, Van Meir EG, Rutka JT.

Oncotarget. 2016 Aug 30;7(35):56958-56975. doi: 10.18632/oncotarget.10925.

7.

Study of the biodistribution of fluorescein in glioma-infiltrated mouse brain and histopathological correlation of intraoperative findings in high-grade gliomas resected under fluorescein fluorescence guidance.

Diaz RJ, Dios RR, Hattab EM, Burrell K, Rakopoulos P, Sabha N, Hawkins C, Zadeh G, Rutka JT, Cohen-Gadol AA.

J Neurosurg. 2015 Jun;122(6):1360-9. doi: 10.3171/2015.2.JNS132507. Epub 2015 Apr 3.

PMID:
25839919
8.

A preclinical study demonstrating the efficacy of nilotinib in inhibiting the growth of pediatric high-grade glioma.

Au K, Singh SK, Burrell K, Sabha N, Hawkins C, Huang A, Zadeh G.

J Neurooncol. 2015 May;122(3):471-80. doi: 10.1007/s11060-015-1744-y. Epub 2015 Mar 4.

9.

Response.

Zadeh G, Agnihotri S, Gugel I, Remke M, Bornemann A, Pantazis G, Mack SC, Shih D, Singh SK, Sabha N, Taylor MD, Tatagiba M, Krischek B.

J Neurosurg. 2014 Dec;121(6):1433. No abstract available.

PMID:
25584369
10.

Foretinib is effective therapy for metastatic sonic hedgehog medulloblastoma.

Faria CC, Golbourn BJ, Dubuc AM, Remke M, Diaz RJ, Agnihotri S, Luck A, Sabha N, Olsen S, Wu X, Garzia L, Ramaswamy V, Mack SC, Wang X, Leadley M, Reynaud D, Ermini L, Post M, Northcott PA, Pfister SM, Croul SE, Kool M, Korshunov A, Smith CA, Taylor MD, Rutka JT.

Cancer Res. 2015 Jan 1;75(1):134-46. doi: 10.1158/0008-5472.CAN-13-3629. Epub 2014 Nov 12.

11.

Gene-expression profiling elucidates molecular signaling networks that can be therapeutically targeted in vestibular schwannoma.

Agnihotri S, Gugel I, Remke M, Bornemann A, Pantazis G, Mack SC, Shih D, Singh SK, Sabha N, Taylor MD, Tatagiba M, Zadeh G, Krischek B.

J Neurosurg. 2014 Dec;121(6):1434-45. doi: 10.3171/2014.6.JNS131433. Epub 2014 Sep 23.

PMID:
25245477
12.

Transcriptional profiling of GBM invasion genes identifies effective inhibitors of the LIM kinase-Cofilin pathway.

Park JB, Agnihotri S, Golbourn B, Bertrand KC, Luck A, Sabha N, Smith CA, Byron S, Zadeh G, Croul S, Berens M, Rutka JT.

Oncotarget. 2014 Oct 15;5(19):9382-95.

13.

ATM regulates 3-methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents.

Agnihotri S, Burrell K, Buczkowicz P, Remke M, Golbourn B, Chornenkyy Y, Gajadhar A, Fernandez NA, Clarke ID, Barszczyk MS, Pajovic S, Ternamian C, Head R, Sabha N, Sobol RW, Taylor MD, Rutka JT, Jones C, Dirks PB, Zadeh G, Hawkins C.

Cancer Discov. 2014 Oct;4(10):1198-213. doi: 10.1158/2159-8290.CD-14-0157. Epub 2014 Aug 6.

14.

Conditional knockout of pik3c3 causes a murine muscular dystrophy.

Reifler A, Li X, Archambeau AJ, McDade JR, Sabha N, Michele DE, Dowling JJ.

Am J Pathol. 2014 Jun;184(6):1819-30. doi: 10.1016/j.ajpath.2014.02.012. Epub 2014 Apr 13.

15.

Analysis of IDH mutation, 1p/19q deletion, and PTEN loss delineates prognosis in clinical low-grade diffuse gliomas.

Sabha N, Knobbe CB, Maganti M, Al Omar S, Bernstein M, Cairns R, Çako B, von Deimling A, Capper D, Mak TW, Kiehl TR, Carvalho P, Garrett E, Perry A, Zadeh G, Guha A, Sidney Croul.

Neuro Oncol. 2014 Jul;16(7):914-23.

16.

The role of drebrin in glioma migration and invasion.

Terakawa Y, Agnihotri S, Golbourn B, Nadi M, Sabha N, Smith CA, Croul SE, Rutka JT.

Exp Cell Res. 2013 Feb 15;319(4):517-28. doi: 10.1016/j.yexcr.2012.11.008. Epub 2012 Nov 29.

PMID:
23201135
17.

Conditional astroglial Rictor overexpression induces malignant glioma in mice.

Bashir T, Cloninger C, Artinian N, Anderson L, Bernath A, Holmes B, Benavides-Serrato A, Sabha N, Nishimura RN, Guha A, Gera J.

PLoS One. 2012;7(10):e47741. doi: 10.1371/journal.pone.0047741. Epub 2012 Oct 15.

18.

Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations.

Liu XY, Gerges N, Korshunov A, Sabha N, Khuong-Quang DA, Fontebasso AM, Fleming A, Hadjadj D, Schwartzentruber J, Majewski J, Dong Z, Siegel P, Albrecht S, Croul S, Jones DT, Kool M, Tonjes M, Reifenberger G, Faury D, Zadeh G, Pfister S, Jabado N.

Acta Neuropathol. 2012 Nov;124(5):615-25. doi: 10.1007/s00401-012-1031-3. Epub 2012 Aug 12.

PMID:
22886134
19.

Investigation of the in vitro therapeutic efficacy of nilotinib in immortalized human NF2-null vestibular schwannoma cells.

Sabha N, Au K, Agnihotri S, Singh S, Mangat R, Guha A, Zadeh G.

PLoS One. 2012;7(6):e39412. doi: 10.1371/journal.pone.0039412. Epub 2012 Jun 20.

20.

Comparisons of [18F]-1-deoxy-1-fluoro-scyllo-inositol with [18F]-FDG for PET imaging of inflammation, breast and brain cancer xenografts in athymic mice.

McLarty K, Moran MD, Scollard DA, Chan C, Sabha N, Mukherjee J, Guha A, McLaurin J, Nitz M, Houle S, Wilson AA, Reilly RM, Vasdev N.

Nucl Med Biol. 2011 Oct;38(7):953-9. doi: 10.1016/j.nucmedbio.2011.02.017. Epub 2011 May 6.

PMID:
21982567
21.

Uropathogenic E. coli infection provokes epigenetic downregulation of CDKN2A (p16INK4A) in uroepithelial cells.

Tolg C, Sabha N, Cortese R, Panchal T, Ahsan A, Soliman A, Aitken KJ, Petronis A, Bägli DJ.

Lab Invest. 2011 Jun;91(6):825-36. doi: 10.1038/labinvest.2010.197. Epub 2011 Jan 17.

22.

Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme.

Wolf A, Agnihotri S, Micallef J, Mukherjee J, Sabha N, Cairns R, Hawkins C, Guha A.

J Exp Med. 2011 Feb 14;208(2):313-26. doi: 10.1084/jem.20101470. Epub 2011 Jan 17.

23.

Mammalian target of rapamycin (mTOR) induces proliferation and de-differentiation responses to three coordinate pathophysiologic stimuli (mechanical strain, hypoxia, and extracellular matrix remodeling) in rat bladder smooth muscle.

Aitken KJ, Tolg C, Panchal T, Leslie B, Yu J, Elkelini M, Sabha N, Tse DJ, Lorenzo AJ, Hassouna M, Bägli DJ.

Am J Pathol. 2010 Jan;176(1):304-19. doi: 10.2353/ajpath.2010.080834. Epub 2009 Dec 17.

24.

High-grade glioma formation results from postnatal pten loss or mutant epidermal growth factor receptor expression in a transgenic mouse glioma model.

Wei Q, Clarke L, Scheidenhelm DK, Qian B, Tong A, Sabha N, Karim Z, Bock NA, Reti R, Swoboda R, Purev E, Lavoie JF, Bajenaru ML, Shannon P, Herlyn D, Kaplan D, Henkelman RM, Gutmann DH, Guha A.

Cancer Res. 2006 Aug 1;66(15):7429-37.

25.
27.

Role of signal transducer and activator of transcription 3 (STAT3) in stretch injury to bladder smooth muscle cells.

Halachmi S, Aitken KJ, Szybowska M, Sabha N, Dessouki S, Lorenzo A, Tse D, Bagli DJ.

Cell Tissue Res. 2006 Oct;326(1):149-58. Epub 2006 May 17.

PMID:
16705451
28.

Pathological and molecular progression of astrocytomas in a GFAP:12 V-Ha-Ras mouse astrocytoma model.

Shannon P, Sabha N, Lau N, Kamnasaran D, Gutmann DH, Guha A.

Am J Pathol. 2005 Sep;167(3):859-67.

29.

Targeting the Tie2/Tek receptor in astrocytomas.

Zadeh G, Qian B, Okhowat A, Sabha N, Kontos CD, Guha A.

Am J Pathol. 2004 Feb;164(2):467-76.

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