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Items: 1 to 50 of 126

1.

Linoleic acid improves assembly of the CII subunit and CIII2/CIV complex of the mitochondrial oxidative phosphorylation system in heart failure.

Maekawa S, Takada S, Nambu H, Furihata T, Kakutani N, Setoyama D, Ueyanagi Y, Kang D, Sabe H, Kinugawa S.

Cell Commun Signal. 2019 Oct 16;17(1):128. doi: 10.1186/s12964-019-0445-0.

2.

ARF6 and AMAP1 are major targets of KRAS and TP53 mutations to promote invasion, PD-L1 dynamics, and immune evasion of pancreatic cancer.

Hashimoto S, Furukawa S, Hashimoto A, Tsutaho A, Fukao A, Sakamura Y, Parajuli G, Onodera Y, Otsuka Y, Handa H, Oikawa T, Hata S, Nishikawa Y, Mizukami Y, Kodama Y, Murakami M, Fujiwara T, Hirano S, Sabe H.

Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17450-17459. doi: 10.1073/pnas.1901765116. Epub 2019 Aug 9.

3.

Statins may have double-edged effects in patients with lung adenocarcinoma after lung resection.

Nishikawa S, Menju T, Takahashi K, Miyata R, Chen-Yoshikawa TF, Sonobe M, Yoshizawa A, Sabe H, Sato T, Date H.

Cancer Manag Res. 2019 Apr 18;11:3419-3432. doi: 10.2147/CMAR.S200819. eCollection 2019.

4.

Mitofusin 2 is involved in chemotaxis of neutrophil-like differentiated HL-60 cells.

Mazaki Y, Takada S, Nio-Kobayashi J, Maekawa S, Higashi T, Onodera Y, Sabe H.

Biochem Biophys Res Commun. 2019 Jun 4;513(3):708-713. doi: 10.1016/j.bbrc.2019.04.037. Epub 2019 Apr 12.

PMID:
30987827
5.

Epithelial-specific histone modification of the miR-96/182 locus targeting AMAP1 mRNA predisposes p53 to suppress cell invasion in epithelial cells.

Handa H, Hashimoto A, Hashimoto S, Sugino H, Oikawa T, Sabe H.

Cell Commun Signal. 2018 Dec 4;16(1):94. doi: 10.1186/s12964-018-0302-6.

6.

Brain-Derived Neurotrophic Factor Improves Limited Exercise Capacity in Mice With Heart Failure.

Matsumoto J, Takada S, Kinugawa S, Furihata T, Nambu H, Kakutani N, Tsuda M, Fukushima A, Yokota T, Tanaka S, Takahashi H, Watanabe M, Hatakeyama S, Matsumoto M, Nakayama KI, Otsuka Y, Sabe H, Tsutsui H, Anzai T.

Circulation. 2018 Oct 30;138(18):2064-2066. doi: 10.1161/CIRCULATIONAHA.118.035212. No abstract available.

PMID:
30372141
7.

Arf6-driven cell invasion is intrinsically linked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe.

Onodera Y, Nam JM, Horikawa M, Shirato H, Sabe H.

Nat Commun. 2018 Jul 11;9(1):2682. doi: 10.1038/s41467-018-05087-7.

8.

p53-Dependent and -Independent Epithelial Integrity: Beyond miRNAs and Metabolic Fluctuations.

Oikawa T, Otsuka Y, Sabe H.

Cancers (Basel). 2018 May 25;10(6). pii: E162. doi: 10.3390/cancers10060162. Review.

9.

Small-conductance Ca2+-activated K+ channel activation deteriorates hypoxic ventricular arrhythmias via CaMKII in cardiac hypertrophy.

Tenma T, Mitsuyama H, Watanabe M, Kakutani N, Otsuka Y, Mizukami K, Kamada R, Takahashi M, Takada S, Sabe H, Tsutsui H, Yokoshiki H.

Am J Physiol Heart Circ Physiol. 2018 Aug 1;315(2):H262-H272. doi: 10.1152/ajpheart.00636.2017. Epub 2018 Apr 6.

10.

Necessity of p53-binding to the CDH1 locus for its expression defines two epithelial cell types differing in their integrity.

Oikawa T, Otsuka Y, Onodera Y, Horikawa M, Handa H, Hashimoto S, Suzuki Y, Sabe H.

Sci Rep. 2018 Jan 25;8(1):1595. doi: 10.1038/s41598-018-20043-7.

11.

Frequent overexpression of AMAP1, an Arf6 effector in cell invasion, is characteristic of the MMTV-PyMT rather than the MMTV-Neu human breast cancer model.

Otsuka Y, Oikawa T, Yoshino H, Hashimoto S, Handa H, Yamamoto H, Hashimoto A, Sabe H.

Cell Commun Signal. 2018 Jan 5;16(1):1. doi: 10.1186/s12964-017-0212-z.

12.

ARF1 recruits RAC1 to leading edge in neutrophil chemotaxis.

Mazaki Y, Onodera Y, Higashi T, Horinouchi T, Oikawa T, Sabe H.

Cell Commun Signal. 2017 Oct 2;15(1):36. doi: 10.1186/s12964-017-0193-y.

13.

Prognostic significance of erythrocyte protein band 4.1-like5 expression in upper urinary tract urothelial carcinoma.

Daimon T, Kosaka T, Kikuchi E, Mikami S, Miyazaki Y, Hashimoto A, Hashimoto S, Mizuno R, Miyajima A, Okada Y, Sabe H, Oya M.

Urol Oncol. 2017 Sep;35(9):543.e17-543.e24. doi: 10.1016/j.urolonc.2017.04.008. Epub 2017 May 5.

PMID:
28483476
14.

High expression of EPB41L5, an integral component of the Arf6-driven mesenchymal program, correlates with poor prognosis of squamous cell carcinoma of the tongue.

Otsuka Y, Sato H, Oikawa T, Onodera Y, Nam JM, Hashimoto A, Fukunaga K, Hatanaka KC, Hatanaka Y, Matsuno Y, Fukuda S, Sabe H.

Cell Commun Signal. 2016 Nov 21;14(1):28.

15.

Acquired platinum resistance involves epithelial to mesenchymal transition through ubiquitin ligase FBXO32 dysregulation.

Tanaka N, Kosaka T, Miyazaki Y, Mikami S, Niwa N, Otsuka Y, Minamishima YA, Mizuno R, Kikuchi E, Miyajima A, Sabe H, Okada Y, Uhlén P, Suematsu M, Oya M.

JCI Insight. 2016 Nov 3;1(18):e83654. doi: 10.1172/jci.insight.83654.

16.

Arf6 and its ZEB1-EPB41L5 mesenchymal axis are required for both mesenchymal- and amoeboid-type invasion of cancer cells.

Handa H, Hashimoto A, Hashimoto S, Sabe H.

Small GTPases. 2018 Sep 3;9(5):420-426. doi: 10.1080/21541248.2016.1249043. Epub 2017 Sep 26.

17.

Tumor responsiveness to statins requires overexpression of the ARF6 pathway.

Sabe H, Hashimoto A, Hashimoto S, Oikawa T.

Mol Cell Oncol. 2016 May 13;3(4):e1185564. doi: 10.1080/23723556.2016.1185564. eCollection 2016 Jul.

18.

ZEB1 induces EPB41L5 in the cancer mesenchymal program that drives ARF6-based invasion, metastasis and drug resistance.

Hashimoto A, Hashimoto S, Sugino H, Yoshikawa A, Onodera Y, Handa H, Oikawa T, Sabe H.

Oncogenesis. 2016 Sep 12;5(9):e259. doi: 10.1038/oncsis.2016.60.

19.

The Rho guanine nucleotide exchange factor ARHGEF5 promotes tumor malignancy via epithelial-mesenchymal transition.

Komiya Y, Onodera Y, Kuroiwa M, Nomimura S, Kubo Y, Nam JM, Kajiwara K, Nada S, Oneyama C, Sabe H, Okada M.

Oncogenesis. 2016 Sep 12;5(9):e258. doi: 10.1038/oncsis.2016.59.

20.

P53- and mevalonate pathway-driven malignancies require Arf6 for metastasis and drug resistance.

Hashimoto A, Oikawa T, Hashimoto S, Sugino H, Yoshikawa A, Otsuka Y, Handa H, Onodera Y, Nam JM, Oneyama C, Okada M, Fukuda M, Sabe H.

J Cell Biol. 2016 Apr 11;213(1):81-95. doi: 10.1083/jcb.201510002. Epub 2016 Apr 4.

21.

Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer.

Hashimoto S, Mikami S, Sugino H, Yoshikawa A, Hashimoto A, Onodera Y, Furukawa S, Handa H, Oikawa T, Okada Y, Oya M, Sabe H.

Nat Commun. 2016 Feb 8;7:10656. doi: 10.1038/ncomms10656.

22.

AMAP1 as a negative-feedback regulator of nuclear factor-κB under inflammatory conditions.

Tien DN, Kishihata M, Yoshikawa A, Hashimoto A, Sabe H, Nishi E, Kamei K, Arai H, Kita T, Kimura T, Yokode M, Ashida N.

Sci Rep. 2014 May 28;4:5094. doi: 10.1038/srep05094.

23.

High level expression of AMAP1 protein correlates with poor prognosis and survival after surgery of head and neck squamous cell carcinoma patients.

Sato H, Hatanaka KC, Hatanaka Y, Hatakeyama H, Hashimoto A, Matsuno Y, Fukuda S, Sabe H.

Cell Commun Signal. 2014 Mar 12;12:17. doi: 10.1186/1478-811X-12-17.

24.

Co-overexpression of GEP100 and AMAP1 proteins correlates with rapid local recurrence after breast conservative therapy.

Kinoshita R, Nam JM, Ito YM, Hatanaka KC, Hashimoto A, Handa H, Otsuka Y, Hashimoto S, Onodera Y, Hosoda M, Onodera S, Shimizu S, Tanaka S, Shirato H, Tanino M, Sabe H.

PLoS One. 2013 Oct 7;8(10):e76791. doi: 10.1371/journal.pone.0076791. eCollection 2013.

25.

β1-Integrin via NF-κB signaling is essential for acquisition of invasiveness in a model of radiation treated in situ breast cancer.

Nam JM, Ahmed KM, Costes S, Zhang H, Onodera Y, Olshen AB, Hatanaka KC, Kinoshita R, Ishikawa M, Sabe H, Shirato H, Park CC.

Breast Cancer Res. 2013;15(4):R60.

26.

Intracellular trafficking of integrins in cancer cells.

Onodera Y, Nam JM, Sabe H.

Pharmacol Ther. 2013 Oct;140(1):1-9. doi: 10.1016/j.pharmthera.2013.05.007. Epub 2013 May 24. Review.

PMID:
23711790
27.

Involvement of EphA2-mediated tyrosine phosphorylation of Shp2 in Shp2-regulated activation of extracellular signal-regulated kinase.

Miura K, Wakayama Y, Tanino M, Orba Y, Sawa H, Hatakeyama M, Tanaka S, Sabe H, Mochizuki N.

Oncogene. 2013 Nov 7;32(45):5292-301. doi: 10.1038/onc.2012.571. Epub 2013 Jan 14.

PMID:
23318428
28.

Rab5c promotes AMAP1-PRKD2 complex formation to enhance β1 integrin recycling in EGF-induced cancer invasion.

Onodera Y, Nam JM, Hashimoto A, Norman JC, Shirato H, Hashimoto S, Sabe H.

J Cell Biol. 2012 Jun 25;197(7):983-96. doi: 10.1083/jcb.201201065.

29.

Grp1 plays a key role in linking insulin signaling to glut4 recycling.

Li J, Malaby AW, Famulok M, Sabe H, Lambright DG, Hsu VW.

Dev Cell. 2012 Jun 12;22(6):1286-98. doi: 10.1016/j.devcel.2012.03.004. Epub 2012 May 17.

30.
31.

EphrinA1-EphA2 signal induces compaction and polarization of Madin-Darby canine kidney cells by inactivating Ezrin through negative regulation of RhoA.

Wakayama Y, Miura K, Sabe H, Mochizuki N.

J Biol Chem. 2011 Dec 23;286(51):44243-53. doi: 10.1074/jbc.M111.267047. Epub 2011 Oct 6.

32.

Engagement of overexpressed Her2 with GEP100 induces autonomous invasive activities and provides a biomarker for metastases of lung adenocarcinoma.

Menju T, Hashimoto S, Hashimoto A, Otsuka Y, Handa H, Ogawa E, Toda Y, Wada H, Date H, Sabe H.

PLoS One. 2011;6(9):e25301. doi: 10.1371/journal.pone.0025301. Epub 2011 Sep 22.

33.

GEP100-Arf6-AMAP1-cortactin pathway frequently used in cancer invasion is activated by VEGFR2 to promote angiogenesis.

Hashimoto A, Hashimoto S, Ando R, Noda K, Ogawa E, Kotani H, Hirose M, Menju T, Morishige M, Manabe T, Toda Y, Ishida S, Sabe H.

PLoS One. 2011;6(8):e23359. doi: 10.1371/journal.pone.0023359. Epub 2011 Aug 15.

34.

Modification and implementation of NCCN guidelines on non-small cell lung cancer in the Middle East and North Africa region.

Jazieh AR, Bamefleh H, Demirkazik A, Gaafar RM, Geara FB, Javaid M, Khader J, Khodadad K, Omar W, Saadeddin A, Sabe HA, Shadmehr MB, El Sherif A, Uddin N, Jahanzeb M, Ettinger D; MENA Lung Cancer Regional Guidelines Committee.

J Natl Compr Canc Netw. 2010 Jul;8 Suppl 3:S16-21.

PMID:
20697125
35.

Cancer early dissemination: cancerous epithelial-mesenchymal transdifferentiation and transforming growth factor β signalling.

Sabe H.

J Biochem. 2011 Jun;149(6):633-9. doi: 10.1093/jb/mvr044. Epub 2011 Apr 7. Review.

36.

Zyxin mediates actin fiber reorganization in epithelial-mesenchymal transition and contributes to endocardial morphogenesis.

Mori M, Nakagami H, Koibuchi N, Miura K, Takami Y, Koriyama H, Hayashi H, Sabe H, Mochizuki N, Morishita R, Kaneda Y.

Mol Biol Cell. 2009 Jul;20(13):3115-24. doi: 10.1091/mbc.E09-01-0046. Epub 2009 May 13.

37.

The EGFR-GEP100-Arf6-AMAP1 signaling pathway specific to breast cancer invasion and metastasis.

Sabe H, Hashimoto S, Morishige M, Ogawa E, Hashimoto A, Nam JM, Miura K, Yano H, Onodera Y.

Traffic. 2009 Aug;10(8):982-93. doi: 10.1111/j.1600-0854.2009.00917.x. Epub 2009 Apr 21. Review.

38.

The EGFR-GEP100-Arf6 pathway in breast cancer: Full invasiveness is not from the inside.

Sabe H, Hashimoto S, Morishige M, Hashimoto A, Ogawa E.

Cell Adh Migr. 2008 Apr-May;2(2):71-3. Epub 2008 Apr 23.

39.

EphA2 engages Git1 to suppress Arf6 activity modulating epithelial cell-cell contacts.

Miura K, Nam JM, Kojima C, Mochizuki N, Sabe H.

Mol Biol Cell. 2009 Apr;20(7):1949-59. doi: 10.1091/mbc.E08-06-0549. Epub 2009 Feb 4.

40.

IRES-mediated translational control of AMAP1 expression during differentiation of monocyte U937 cells.

Miyata M, Raven JF, Baltzis D, Koromilas AE, Sabe H.

Cell Cycle. 2008 Oct;7(20):3273-81. Epub 2008 Oct 28.

PMID:
18843202
41.

EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition.

Hirano M, Hashimoto S, Yonemura S, Sabe H, Aizawa S.

J Cell Biol. 2008 Sep 22;182(6):1217-30. doi: 10.1083/jcb.200712086. Epub 2008 Sep 15.

42.

Clathrin dependent endocytosis of E-cadherin is regulated by the Arf6GAP isoform SMAP1.

Kon S, Tanabe K, Watanabe T, Sabe H, Satake M.

Exp Cell Res. 2008 Apr 15;314(7):1415-28. doi: 10.1016/j.yexcr.2007.11.006. Epub 2007 Nov 17.

PMID:
18331728
43.

Dynamic rearrangement of surface proteins is essential for cytokinesis.

Bauer T, Motosugi N, Miura K, Sabe H, Hiiragi T.

Genesis. 2008 Mar;46(3):152-62. doi: 10.1002/dvg.20377.

PMID:
18327789
44.

Fbx8 makes Arf6 refractory to function via ubiquitination.

Yano H, Kobayashi I, Onodera Y, Luton F, Franco M, Mazaki Y, Hashimoto S, Iwai K, Ronai Z, Sabe H.

Mol Biol Cell. 2008 Mar;19(3):822-32. Epub 2007 Dec 19.

45.

GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion.

Morishige M, Hashimoto S, Ogawa E, Toda Y, Kotani H, Hirose M, Wei S, Hashimoto A, Yamada A, Yano H, Mazaki Y, Kodama H, Nio Y, Manabe T, Wada H, Kobayashi H, Sabe H.

Nat Cell Biol. 2008 Jan;10(1):85-92. Epub 2007 Dec 16.

PMID:
18084281
46.

CIN85, a Cbl-interacting protein, is a component of AMAP1-mediated breast cancer invasion machinery.

Nam JM, Onodera Y, Mazaki Y, Miyoshi H, Hashimoto S, Sabe H.

EMBO J. 2007 Feb 7;26(3):647-56. Epub 2007 Jan 25.

47.

ArfGAP family proteins in cell adhesion, migration and tumor invasion.

Sabe H, Onodera Y, Mazaki Y, Hashimoto S.

Curr Opin Cell Biol. 2006 Oct;18(5):558-64. Epub 2006 Aug 9. Review.

PMID:
16904307
48.

Neutrophil direction sensing and superoxide production linked by the GTPase-activating protein GIT2.

Mazaki Y, Hashimoto S, Tsujimura T, Morishige M, Hashimoto A, Aritake K, Yamada A, Nam JM, Kiyonari H, Nakao K, Sabe H.

Nat Immunol. 2006 Jul;7(7):724-31. Epub 2006 May 21.

PMID:
16715100
49.

Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis.

Hashimoto S, Hirose M, Hashimoto A, Morishige M, Yamada A, Hosaka H, Akagi K, Ogawa E, Oneyama C, Agatsuma T, Okada M, Kobayashi H, Wada H, Nakano H, Ikegami T, Nakagawa A, Sabe H.

Proc Natl Acad Sci U S A. 2006 May 2;103(18):7036-41. Epub 2006 Apr 24.

50.

Assays and properties of the ArfGAPs, AMAP1 and AMAP2, in Arf6 function.

Hashimoto S, Hashimoto A, Yamada A, Onodera Y, Sabe H.

Methods Enzymol. 2005;404:216-31.

PMID:
16413272

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