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p53-Related Transcription Targets of TAp73 in Cancer Cells-Bona Fide or Distorted Reality?

Wang C, Teo CR, Sabapathy K.

Int J Mol Sci. 2020 Feb 17;21(4). pii: E1346. doi: 10.3390/ijms21041346. Review.


Corrigendum to 'Understanding p53 functions through p53 antibodies'.

Sabapathy K, Lane DP.

J Mol Cell Biol. 2019 Dec 19;11(12):1105. doi: 10.1093/jmcb/mjz110. No abstract available.


RNF4-A Paradigm for SUMOylation-Mediated Ubiquitination.

Kumar R, Sabapathy K.

Proteomics. 2019 Nov;19(21-22):e1900185. doi: 10.1002/pmic.201900185. Epub 2019 Oct 29. Review.


Effect of Universal Testing and Treatment on HIV Incidence - HPTN 071 (PopART).

Hayes RJ, Donnell D, Floyd S, Mandla N, Bwalya J, Sabapathy K, Yang B, Phiri M, Schaap A, Eshleman SH, Piwowar-Manning E, Kosloff B, James A, Skalland T, Wilson E, Emel L, Macleod D, Dunbar R, Simwinga M, Makola N, Bond V, Hoddinott G, Moore A, Griffith S, Deshmane Sista N, Vermund SH, El-Sadr W, Burns DN, Hargreaves JR, Hauck K, Fraser C, Shanaube K, Bock P, Beyers N, Ayles H, Fidler S; HPTN 071 (PopART) Study Team.

N Engl J Med. 2019 Jul 18;381(3):207-218. doi: 10.1056/NEJMoa1814556.


Understanding p53 functions through p53 antibodies.

Sabapathy K, Lane DP.

J Mol Cell Biol. 2019 Apr 1;11(4):317-329. doi: 10.1093/jmcb/mjz010. Erratum in: J Mol Cell Biol. 2019 Dec 19;11(12):1105.


Cancer therapeutic targeting using mutant-p53-specific siRNAs.

Ubby I, Krueger C, Rosato R, Qian W, Chang J, Sabapathy K.

Oncogene. 2019 May;38(18):3415-3427. doi: 10.1038/s41388-018-0652-y. Epub 2019 Jan 14.


Understanding the Time Needed to Link to Care and Start ART in Seven HPTN 071 (PopART) Study Communities in Zambia and South Africa.

Seeley J, Bond V, Yang B, Floyd S, MacLeod D, Viljoen L, Phiri M, Simuyaba M, Hoddinott G, Shanaube K, Bwalya C, de Villiers L, Jennings K, Mwanza M, Schaap A, Dunbar R, Sabapathy K, Ayles H, Bock P, Hayes R, Fidler S; HPTN 071 (PopART) study team.

AIDS Behav. 2019 Apr;23(4):929-946. doi: 10.1007/s10461-018-2335-7.


Context-dependent AMPK activation distinctly regulates TAp73 stability and transcriptional activity.

Li D, Dulloo I, Sabapathy K.

Signal Transduct Target Ther. 2018 Jul 27;3:20. doi: 10.1038/s41392-018-0020-y. eCollection 2018.


The cascade of care following community-based detection of HIV in sub-Saharan Africa - A systematic review with 90-90-90 targets in sight.

Sabapathy K, Hensen B, Varsaneux O, Floyd S, Fidler S, Hayes R.

PLoS One. 2018 Jul 27;13(7):e0200737. doi: 10.1371/journal.pone.0200737. eCollection 2018.


Is home-based HIV testing universally acceptable? Findings from a case-control study nested within the HPTN 071 (PopART) trial.

Sabapathy K, Mulubwa C, Mathema H, Mubekapi-Musadaidzwa C, Schaap A, Hoddinott G, Hargreaves J, Floyd S, Ayles H, Hayes R; HPTN 071 (PopART) Study Team.

Trop Med Int Health. 2018 Jun;23(6):678-690. doi: 10.1111/tmi.13055. Epub 2018 Apr 16.


Comparative assessment of five trials of universal HIV testing and treatment in sub-Saharan Africa.

Perriat D, Balzer L, Hayes R, Lockman S, Walsh F, Ayles H, Floyd S, Havlir D, Kamya M, Lebelonyane R, Mills LA, Okello V, Petersen M, Pillay D, Sabapathy K, Wirth K, Orne-Gliemann J, Dabis F; Universal Test and Treat Trials Consortium (UT3C).

J Int AIDS Soc. 2018 Jan;21(1). doi: 10.1002/jia2.25048.


Monoclonal Antibodies against Specific p53 Hotspot Mutants as Potential Tools for Precision Medicine.

Hwang LA, Phang BH, Liew OW, Iqbal J, Koh XH, Koh XY, Othman R, Xue Y, Richards AM, Lane DP, Sabapathy K.

Cell Rep. 2018 Jan 2;22(1):299-312. doi: 10.1016/j.celrep.2017.11.112.


Predictors of timely linkage-to-ART within universal test and treat in the HPTN 071 (PopART) trial in Zambia and South Africa: findings from a nested case-control study.

Sabapathy K, Mubekapi-Musadaidzwa C, Mulubwa C, Schaap A, Hoddinott G, Stangl A, Floyd S, Ayles H, Fidler S, Hayes R; HPTN 071 (PopART) study team.

J Int AIDS Soc. 2017 Dec;20(4). doi: 10.1002/jia2.25037.


Hospital-based routine HIV testing in high-income countries: a systematic literature review.

Elgalib A, Fidler S, Sabapathy K.

HIV Med. 2018 Mar;19(3):195-205. doi: 10.1111/hiv.12568. Epub 2017 Nov 23.


Therapeutic targeting of p53: all mutants are equal, but some mutants are more equal than others.

Sabapathy K, Lane DP.

Nat Rev Clin Oncol. 2018 Jan;15(1):13-30. doi: 10.1038/nrclinonc.2017.151. Epub 2017 Sep 26. Review.


Genome-scale mutational signatures of aflatoxin in cells, mice, and human tumors.

Huang MN, Yu W, Teoh WW, Ardin M, Jusakul A, Ng AWT, Boot A, Abedi-Ardekani B, Villar S, Myint SS, Othman R, Poon SL, Heguy A, Olivier M, Hollstein M, Tan P, Teh BT, Sabapathy K, Zavadil J, Rozen SG.

Genome Res. 2017 Sep;27(9):1475-1486. doi: 10.1101/gr.220038.116. Epub 2017 Jul 24.


A universal testing and treatment intervention to improve HIV control: One-year results from intervention communities in Zambia in the HPTN 071 (PopART) cluster-randomised trial.

Hayes R, Floyd S, Schaap A, Shanaube K, Bock P, Sabapathy K, Griffith S, Donnell D, Piwowar-Manning E, El-Sadr W, Beyers N, Ayles H, Fidler S; HPTN 071 (PopART) Study Team.

PLoS Med. 2017 May 2;14(5):e1002292. doi: 10.1371/journal.pmed.1002292. eCollection 2017 May.


Baseline CD4 Count and Adherence to Antiretroviral Therapy: A Systematic Review and Meta-Analysis.

Bock P, James A, Nikuze A, Peton N, Sabapathy K, Mills E, Fidler S, Ford N.

J Acquir Immune Defic Syndr. 2016 Dec 15;73(5):514-521. Review.


HIV-related stigma and universal testing and treatment for HIV prevention and care: design of an implementation science evaluation nested in the HPTN 071 (PopART) cluster-randomized trial in Zambia and South Africa.

Hargreaves JR, Stangl A, Bond V, Hoddinott G, Krishnaratne S, Mathema H, Moyo M, Viljoen L, Brady L, Sievwright K, Horn L, Sabapathy K, Ayles H, Beyers N, Bock P, Fidler S, Griffith S, Seeley J, Hayes R; HPTN 071 (PopART) study team.

Health Policy Plan. 2016 Dec;31(10):1342-1354. Epub 2016 Jul 3.


Transcription-associated mutation of lasR in Pseudomonas aeruginosa.

Wang C, McPherson JR, Zhang LH, Rozen S, Sabapathy K.

DNA Repair (Amst). 2016 Oct;46:9-19. doi: 10.1016/j.dnarep.2016.09.001. Epub 2016 Sep 13.


MOAP-1 Mediates Fas-Induced Apoptosis in Liver by Facilitating tBid Recruitment to Mitochondria.

Tan CT, Zhou QL, Su YC, Fu NY, Chang HC, Tao RN, Sukumaran SK, Baksh S, Tan YJ, Sabapathy K, Yu CD, Yu VC.

Cell Rep. 2016 Jun 28;16(1):174-185. doi: 10.1016/j.celrep.2016.05.068. Epub 2016 Jun 16.


Linkage to care: a step on the path, but not the destination.

Sabapathy K, Hayes R.

Lancet HIV. 2016 May;3(5):e193-4. doi: 10.1016/S2352-3018(16)00038-2. Epub 2016 Mar 10. No abstract available.


Longitudinal metabolic imaging of hepatocellular carcinoma in transgenic mouse models identifies acylcarnitine as a potential biomarker for early detection.

Yaligar J, Teoh WW, Othman R, Verma SK, Phang BH, Lee SS, Wang WW, Toh HC, Gopalan V, Sabapathy K, Velan SS.

Sci Rep. 2016 Feb 2;6:20299. doi: 10.1038/srep20299.


p73: a Positive or Negative Regulator of Angiogenesis, or Both?

Sabapathy K.

Mol Cell Biol. 2015 Dec 28;36(6):848-54. doi: 10.1128/MCB.00929-15. Review.


The Contrived Mutant p53 Oncogene - Beyond Loss of Functions.

Sabapathy K.

Front Oncol. 2015 Dec 10;5:276. doi: 10.3389/fonc.2015.00276. eCollection 2015. Review.


Amino-terminal p53 mutations lead to expression of apoptosis proficient p47 and prognosticate better survival, but predispose to tumorigenesis.

Phang BH, Othman R, Bougeard G, Chia RH, Frebourg T, Tang CL, Cheah PY, Sabapathy K.

Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):E6349-58. doi: 10.1073/pnas.1510043112. Epub 2015 Nov 2.


Hypoxia-induced DNp73 stabilization regulates Vegf-A expression and tumor angiogenesis similar to TAp73.

Dulloo I, Hooi PB, Sabapathy K.

Cell Cycle. 2015;14(22):3533-9. doi: 10.1080/15384101.2015.1078038.


Molecular characterization of hepatocarcinogenesis using mouse models.

Teoh WW, Xie M, Vijayaraghavan A, Yaligar J, Tong WM, Goh LK, Sabapathy K.

Dis Model Mech. 2015 Jul 1;8(7):743-53. doi: 10.1242/dmm.017624. Epub 2015 May 5.


Interplay between TAp73 Protein and Selected Activator Protein-1 (AP-1) Family Members Promotes AP-1 Target Gene Activation and Cellular Growth.

Subramanian D, Bunjobpol W, Sabapathy K.

J Biol Chem. 2015 Jul 24;290(30):18636-49. doi: 10.1074/jbc.M115.636548. Epub 2015 May 27.


Hypoxia-inducible TAp73 supports tumorigenesis by regulating the angiogenic transcriptome.

Dulloo I, Phang BH, Othman R, Tan SY, Vijayaraghavan A, Goh LK, Martin-Lopez M, Marques MM, Li CW, Wang de Y, Marín MC, Xian W, McKeon F, Sabapathy K.

Nat Cell Biol. 2015 Apr;17(4):511-23. doi: 10.1038/ncb3130. Epub 2015 Mar 16.


Suppression of acetylpolyamine oxidase by selected AP-1 members regulates DNp73 abundance: mechanistic insights for overcoming DNp73-mediated resistance to chemotherapeutic drugs.

Bunjobpol W, Dulloo I, Igarashi K, Concin N, Matsuo K, Sabapathy K.

Cell Death Differ. 2014 Aug;21(8):1240-9. doi: 10.1038/cdd.2014.41. Epub 2014 Apr 11.


HPTN 071 (PopART): rationale and design of a cluster-randomised trial of the population impact of an HIV combination prevention intervention including universal testing and treatment - a study protocol for a cluster randomised trial.

Hayes R, Ayles H, Beyers N, Sabapathy K, Floyd S, Shanaube K, Bock P, Griffith S, Moore A, Watson-Jones D, Fraser C, Vermund SH, Fidler S; HPTN 071 (PopART) Study Team.

Trials. 2014 Feb 13;15:57. doi: 10.1186/1745-6215-15-57.


HPTN 071 (PopART): a cluster-randomized trial of the population impact of an HIV combination prevention intervention including universal testing and treatment: mathematical model.

Cori A, Ayles H, Beyers N, Schaap A, Floyd S, Sabapathy K, Eaton JW, Hauck K, Smith P, Griffith S, Moore A, Donnell D, Vermund SH, Fidler S, Hayes R, Fraser C; HPTN 071 PopART Study Team.

PLoS One. 2014 Jan 15;9(1):e84511. doi: 10.1371/journal.pone.0084511. eCollection 2014.


The 6th International p63/p73 Workshop: the C(ancer) and D(evelopmental) roles of p63 and p73.

Sabapathy K, Nagakawara A, Aberdam D.

Cell Death Differ. 2014 Aug;21(8):1340-2. doi: 10.1038/cdd.2013.192. Epub 2014 Jan 17. No abstract available.


Oppositional regulation of Noxa by JNK1 and JNK2 during apoptosis induced by proteasomal inhibitors.

Pietkiewicz S, Sohn D, Piekorz RP, Grether-Beck S, Budach W, Sabapathy K, Jänicke RU.

PLoS One. 2013 Apr 11;8(4):e61438. doi: 10.1371/journal.pone.0061438. Print 2013.


Cell-type, dose, and mutation-type specificity dictate mutant p53 functions in vivo.

Lee MK, Teoh WW, Phang BH, Tong WM, Wang ZQ, Sabapathy K.

Cancer Cell. 2012 Dec 11;22(6):751-64. doi: 10.1016/j.ccr.2012.10.022.


Uptake of home-based voluntary HIV testing in sub-Saharan Africa: a systematic review and meta-analysis.

Sabapathy K, Van den Bergh R, Fidler S, Hayes R, Ford N.

PLoS Med. 2012;9(12):e1001351. doi: 10.1371/journal.pmed.1001351. Epub 2012 Dec 4. Review.


Role of the JNK pathway in human diseases.

Sabapathy K.

Prog Mol Biol Transl Sci. 2012;106:145-69. doi: 10.1016/B978-0-12-396456-4.00013-4. Review.


Treatment outcomes from the largest antiretroviral treatment program in Myanmar (Burma): a cohort analysis of retention after scale-up.

Sabapathy K, Ford N, Chan KN, Kyaw MK, Elema R, Smithuis F, Floyd S.

J Acquir Immune Defic Syndr. 2012 Jun 1;60(2):e53-62. doi: 10.1097/QAI.0b013e31824d5689.


The 5th International p63/p73 Workshop: much more than just tumour suppression.

Kadakia MP, Caron de Fromentel C, Sabapathy K.

Cell Death Differ. 2012 Mar;19(3):549-50. doi: 10.1038/cdd.2011.204. Epub 2012 Jan 13. No abstract available. Erratum in: Cell Death Differ. 2012 Sep;19(9):1572. de-Fromentel, C C [corrected to Caron de Fromentel, C].


The mitogen-activated protein kinase (MAPK) cascade controls phosphatase and tensin homolog (PTEN) expression through multiple mechanisms.

Ciuffreda L, Di Sanza C, Cesta Incani U, Eramo A, Desideri M, Biagioni F, Passeri D, Falcone I, Sette G, Bergamo P, Anichini A, Sabapathy K, McCubrey JA, Ricciardi MR, Tafuri A, Blandino G, Orlandi A, De Maria R, Cognetti F, Del Bufalo D, Milella M.

J Mol Med (Berl). 2012 Jun;90(6):667-79. doi: 10.1007/s00109-011-0844-1. Epub 2012 Jan 4.


Nucleotide excision repair factor XPC enhances DNA damage-induced apoptosis by downregulating the antiapoptotic short isoform of caspase-2.

Wang QE, Han C, Zhang B, Sabapathy K, Wani AA.

Cancer Res. 2012 Feb 1;72(3):666-75. doi: 10.1158/0008-5472.CAN-11-2774. Epub 2011 Dec 15.


Similar mortality and reduced loss to follow-up in integrated compared with vertical programs providing antiretroviral treatment in sub-saharan Africa.

Greig J, O'Brien DP, Ford N, Spelman T, Sabapathy K, Shanks L.

J Acquir Immune Defic Syndr. 2012 Apr 15;59(5):e92-8. doi: 10.1097/QAI.0b013e31824206c7.


Robustness of non-Gaussian entanglement against noisy amplifier and attenuator environments.

Sabapathy KK, Ivan JS, Simon R.

Phys Rev Lett. 2011 Sep 23;107(13):130501. Epub 2011 Sep 19.


Keloid fibroblasts are more sensitive to Wnt3a treatment in terms of elevated cellular growth and fibronectin expression.

Chua AW, Gan SU, Ting Y, Fu Z, Lim CK, Song C, Sabapathy K, Phan TT.

J Dermatol Sci. 2011 Dec;64(3):199-209. doi: 10.1016/j.jdermsci.2011.09.008. Epub 2011 Sep 29.


Universal testing and treatment as an HIV prevention strategy: research questions and methods.

Hayes R, Sabapathy K, Fidler S.

Curr HIV Res. 2011 Sep;9(6):429-45. Review.


Oncogenic ras-induced down-regulation of pro-apoptotic protease caspase-2 is required for malignant transformation of intestinal epithelial cells.

Yoo BH, Wang Y, Erdogan M, Sasazuki T, Shirasawa S, Corcos L, Sabapathy K, Rosen KV.

J Biol Chem. 2011 Nov 11;286(45):38894-903. doi: 10.1074/jbc.M111.290692. Epub 2011 Sep 8.


JNK1 and JNK2 play redundant functions in Myc-induced B cell lymphoma formation.

Anbalagan M, Sabapathy K.

Int J Cancer. 2012 Apr 15;130(8):1967-9. doi: 10.1002/ijc.26207. Epub 2011 Aug 16. No abstract available.


p53 promotes cellular survival in a context-dependent manner by directly inducing the expression of haeme-oxygenase-1.

Nam SY, Sabapathy K.

Oncogene. 2011 Nov 3;30(44):4476-86. doi: 10.1038/onc.2011.150. Epub 2011 May 9.


Incidence of tuberculosis in HIV-infected patients before and after starting combined antiretroviral therapy in 8 sub-Saharan African HIV programs.

Nicholas S, Sabapathy K, Ferreyra C, Varaine F, Pujades-Rodríguez M; AIDS Working Group of Médecins Sans Frontières.

J Acquir Immune Defic Syndr. 2011 Aug 1;57(4):311-8. doi: 10.1097/QAI.0b013e318218a713.


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