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Items: 1 to 50 of 64

1.

Large-scale death of retinal astrocytes during normal development is non-apoptotic and implemented by microglia.

Puñal VM, Paisley CE, Brecha FS, Lee MA, Perelli RM, Wang J, O'Koren EG, Ackley CR, Saban DR, Reese BE, Kay JN.

PLoS Biol. 2019 Oct 18;17(10):e3000492. doi: 10.1371/journal.pbio.3000492. eCollection 2019 Oct.

2.

scDAPA: detection and visualization of dynamic alternative polyadenylation from single cell RNA-seq data.

Ye C, Zhou Q, Wu X, Yu C, Ji G, Saban DR, Li QQ.

Bioinformatics. 2019 Sep 6. pii: btz701. doi: 10.1093/bioinformatics/btz701. [Epub ahead of print]

PMID:
31557285
3.

Complement and CD4+ T cells drive context-specific corneal sensory neuropathy.

Royer DJ, Echegaray-Mendez J, Lin L, Gmyrek GB, Mathew R, Saban DR, Perez VL, Carr DJ.

Elife. 2019 Aug 15;8. pii: e48378. doi: 10.7554/eLife.48378.

4.

PRCD is essential for high-fidelity photoreceptor disc formation.

Spencer WJ, Ding JD, Lewis TR, Yu C, Phan S, Pearring JN, Kim KY, Thor A, Mathew R, Kalnitsky J, Hao Y, Travis AM, Biswas SK, Lo WK, Besharse JC, Ellisman MH, Saban DR, Burns ME, Arshavsky VY.

Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):13087-13096. doi: 10.1073/pnas.1906421116. Epub 2019 Jun 12.

PMID:
31189593
5.

Microglial Function Is Distinct in Different Anatomical Locations during Retinal Homeostasis and Degeneration.

O'Koren EG, Yu C, Klingeborn M, Wong AYW, Prigge CL, Mathew R, Kalnitsky J, Msallam RA, Silvin A, Kay JN, Bowes Rickman C, Arshavsky VY, Ginhoux F, Merad M, Saban DR.

Immunity. 2019 Mar 19;50(3):723-737.e7. doi: 10.1016/j.immuni.2019.02.007. Epub 2019 Mar 5.

PMID:
30850344
6.

Immune cells in the retina and choroid: Two different tissue environments that require different defenses and surveillance.

McMenamin PG, Saban DR, Dando SJ.

Prog Retin Eye Res. 2019 May;70:85-98. doi: 10.1016/j.preteyeres.2018.12.002. Epub 2018 Dec 12. Review.

PMID:
30552975
7.

Fate Mapping In Vivo to Distinguish Bona Fide Microglia Versus Recruited Monocyte-Derived Macrophages in Retinal Disease.

Reyes NJ, Mathew R, Saban DR.

Methods Mol Biol. 2019;1834:153-164. doi: 10.1007/978-1-4939-8669-9_11.

PMID:
30324443
8.

SYK inhibitor entospletinib prevents ocular and skin GVHD in mice.

Poe JC, Jia W, Di Paolo JA, Reyes NJ, Kim JY, Su H, Sundy JS, Cardones AR, Perez VL, Chen BJ, Chao NJ, Cardona DM, Saban DR, Sarantopoulos S.

JCI Insight. 2018 Oct 4;3(19). pii: 122430. doi: 10.1172/jci.insight.122430.

9.

Resolvin D1 treatment on goblet cell mucin and immune responses in the chronic allergic eye disease (AED) model.

Saban DR, Hodges RR, Mathew R, Reyes NJ, Yu C, Kaye R, Swift W, Botten N, Serhan CN, Dartt DA.

Mucosal Immunol. 2019 Jan;12(1):145-153. doi: 10.1038/s41385-018-0089-1. Epub 2018 Oct 2.

10.

Neutrophils cause obstruction of eyelid sebaceous glands in inflammatory eye disease in mice.

Reyes NJ, Yu C, Mathew R, Kunnen CM, Kalnitsky J, Redfern RL, Leonardi A, Perez VL, MacLeod AS, Gupta PK, Saban DR.

Sci Transl Med. 2018 Jul 25;10(451). pii: eaas9164. doi: 10.1126/scitranslmed.aas9164.

11.

Induction and Characterization of the Allergic Eye Disease Mouse Model.

Reyes NJ, Mathew R, Saban DR.

Methods Mol Biol. 2018;1799:49-57. doi: 10.1007/978-1-4939-7896-0_5.

PMID:
29956143
12.

New concepts in macrophage ontogeny in the adult neural retina.

Saban DR.

Cell Immunol. 2018 Aug;330:79-85. doi: 10.1016/j.cellimm.2018.04.008. Epub 2018 Apr 22. Review.

PMID:
29703455
13.

Effect of Anti-C5a Therapy in a Murine Model of Early/Intermediate Dry Age-Related Macular Degeneration.

Toomey CB, Landowski M, Klingeborn M, Kelly U, Deans J, Dong H, Harrabi O, Van Blarcom T, Yeung YA, Grishanin R, Lin JC, Saban DR, Bowes Rickman C.

Invest Ophthalmol Vis Sci. 2018 Feb 1;59(2):662-673. doi: 10.1167/iovs.17-23134.

14.

Interleukin-6 neutralization prolongs corneal allograft survival.

Kodati S, Chauhan SK, Chen Y, Emami-Naeini P, Omoto M, Dohlman TH, Stevenson W, Amouzegar A, Tummala G, Saban DR, Dana R.

Curr Trends Immunol. 2018;19:105-113.

15.

Gene Therapy for Modulation of T-Cell-Mediated Immune Response Provoked by Corneal Transplantation.

Pastak M, Kleff V, Saban DR, Czugala M, Steuhl KP, Ergün S, Singer BB, Fuchsluger TA.

Hum Gene Ther. 2018 Apr;29(4):467-479. doi: 10.1089/hum.2017.044. Epub 2017 Oct 6.

16.

The Mechanism of Diabetic Retinopathy Pathogenesis Unifying Key Lipid Regulators, Sirtuin 1 and Liver X Receptor.

Hammer SS, Beli E, Kady N, Wang Q, Wood K, Lydic TA, Malek G, Saban DR, Wang XX, Hazra S, Levi M, Busik JV, Grant MB.

EBioMedicine. 2017 Aug;22:181-190. doi: 10.1016/j.ebiom.2017.07.008. Epub 2017 Jul 11.

17.

A Commencement for Eye Commensals.

Reyes NJ, Saban DR.

Immunity. 2017 Jul 18;47(1):6-8. doi: 10.1016/j.immuni.2017.07.006.

18.

Erratum to: CX3CR1 deficiency accelerates the development of retinopathy in a rodent model of type 1 diabetes.

Beli E, Dominguez JM 2nd, Hu P, Thinschmidt JS, Caballero S, Calzi SL, Luo D, Shanmugam S, Salazar TE, Duan Y, Boulton ME, Mohr S, Abcouwer SF, Saban DR, Harrison JK, Grant MB.

J Mol Med (Berl). 2017 May;95(5):565-566. doi: 10.1007/s00109-017-1530-8. No abstract available.

PMID:
28421250
19.

New insights into mononuclear phagocyte biology from the visual system.

Reyes NJ, O'Koren EG, Saban DR.

Nat Rev Immunol. 2017 May;17(5):322-332. doi: 10.1038/nri.2017.13. Epub 2017 Mar 27. Review.

20.

CX3CR1 deficiency accelerates the development of retinopathy in a rodent model of type 1 diabetes.

Beli E, Dominguez JM 2nd, Hu P, Thinschmidt JS, Caballero S, Li Calzi S, Luo D, Shanmugam S, Salazar TE, Duan Y, Boulton ME, Mohr S, Abcouwer SF, Saban DR, Harrison JK, Grant MB.

J Mol Med (Berl). 2016 Nov;94(11):1255-1265. doi: 10.1007/s00109-016-1433-0. Epub 2016 Jun 25. Erratum in: J Mol Med (Berl). 2017 May;95(5):565-566.

21.

Aldehyde dehydrogenase inhibition blocks mucosal fibrosis in human and mouse ocular scarring.

Ahadome SD, Abraham DJ, Rayapureddi S, Saw VP, Saban DR, Calder VL, Norman JT, Ponticos M, Daniels JT, Dart JK.

JCI Insight. 2016 Aug 4;1(12):e87001. doi: 10.1172/jci.insight.87001.

22.

Classical dendritic cells mediate fibrosis directly via the retinoic acid pathway in severe eye allergy.

Ahadome SD, Mathew R, Reyes NJ, Mettu PS, Cousins SW, Calder VL, Saban DR.

JCI Insight. 2016 Aug 4;1(12). pii: 87012. doi: 10.1172/jci.insight.87012.

23.

Method for single illumination source combined optical coherence tomography and fluorescence imaging of fluorescently labeled ocular structures in transgenic mice.

McNabb RP, Blanco T, Bomze HM, Tseng HC, Saban DR, Izatt JA, Kuo AN.

Exp Eye Res. 2016 Oct;151:68-74. doi: 10.1016/j.exer.2016.08.003. Epub 2016 Aug 9.

24.

Secondary allergic T cell responses are regulated by dendritic cell-derived thrombospondin-1 in the setting of allergic eye disease.

Smith RE, Reyes NJ, Khandelwal P, Schlereth SL, Lee HS, Masli S, Saban DR.

J Leukoc Biol. 2016 Aug;100(2):371-80. doi: 10.1189/jlb.3A0815-357RR. Epub 2016 Feb 8.

25.
26.

Partial denervation of sub-basal axons persists following debridement wounds to the mouse cornea.

Pajoohesh-Ganji A, Pal-Ghosh S, Tadvalkar G, Kyne BM, Saban DR, Stepp MA.

Lab Invest. 2015 Nov;95(11):1305-18. doi: 10.1038/labinvest.2015.113. Epub 2015 Aug 17.

27.

Linking immune responses with fibrosis in allergic eye disease.

Dale SB, Saban DR.

Curr Opin Allergy Clin Immunol. 2015 Oct;15(5):467-75. doi: 10.1097/ACI.0000000000000197. Review.

28.

Involvement of corneal lymphangiogenesis in a mouse model of allergic eye disease.

Lee HS, Hos D, Blanco T, Bock F, Reyes NJ, Mathew R, Cursiefen C, Dana R, Saban DR.

Invest Ophthalmol Vis Sci. 2015 May;56(5):3140-8. doi: 10.1167/iovs.14-16186.

29.

Regulation of age-related macular degeneration-like pathology by complement factor H.

Toomey CB, Kelly U, Saban DR, Bowes Rickman C.

Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):E3040-9. doi: 10.1073/pnas.1424391112. Epub 2015 May 19.

30.

The cornea has "the nerve" to encourage immune rejection.

Blanco T, Saban DR.

Am J Transplant. 2015 Jun;15(6):1453-4. doi: 10.1111/ajt.13238. Epub 2015 Apr 14. No abstract available.

31.

T helper subsets in allergic eye disease.

Reyes NJ, Saban DR.

Curr Opin Allergy Clin Immunol. 2014 Oct;14(5):477-84. doi: 10.1097/ACI.0000000000000088. Review.

32.

The chemokine receptor CCR7 expressed by dendritic cells: a key player in corneal and ocular surface inflammation.

Saban DR.

Ocul Surf. 2014 Apr;12(2):87-99. doi: 10.1016/j.jtos.2013.10.007. Epub 2013 Dec 31. Review.

33.

Cytokine deposition alters leukocyte morphology and initial recruitment of monocytes and γδT cells after corneal injury.

Pal-Ghosh S, Pajoohesh-Ganji A, Menko AS, Oh HY, Tadvalkar G, Saban DR, Stepp MA.

Invest Ophthalmol Vis Sci. 2014 Apr 28;55(4):2757-65. doi: 10.1167/iovs.13-13557.

34.

CCL-21 conditioned regulatory T cells induce allotolerance through enhanced homing to lymphoid tissue.

Chauhan SK, Saban DR, Dohlman TH, Dana R.

J Immunol. 2014 Jan 15;192(2):817-23. doi: 10.4049/jimmunol.1203469. Epub 2013 Dec 11.

35.

CNS inflammation and bone marrow neuropathy in type 1 diabetes.

Hu P, Thinschmidt JS, Yan Y, Hazra S, Bhatwadekar A, Caballero S, Salazar T, Miyan JA, Li W, Derbenev A, Zsombok A, Tikhonenko M, Dominguez JM 2nd, McGorray SP, Saban DR, Boulton ME, Busik JV, Raizada MK, Chan-Ling T, Grant MB.

Am J Pathol. 2013 Nov;183(5):1608-20. doi: 10.1016/j.ajpath.2013.07.009.

36.

Ocular allergy modulation to hi-dose antigen sensitization is a Treg-dependent process.

Lee HS, Schlereth S, Khandelwal P, Saban DR.

PLoS One. 2013 Sep 27;8(9):e75769. doi: 10.1371/journal.pone.0075769. eCollection 2013.

37.

Ocular mucosal CD11b+ and CD103+ mouse dendritic cells under normal conditions and in allergic immune responses.

Khandelwal P, Blanco-Mezquita T, Emami P, Lee HS, Reyes NJ, Mathew R, Huang R, Saban DR.

PLoS One. 2013 May 14;8(5):e64193. doi: 10.1371/journal.pone.0064193. Print 2013.

38.

Chronic dry eye disease is principally mediated by effector memory Th17 cells.

Chen Y, Chauhan SK, Lee HS, Saban DR, Dana R.

Mucosal Immunol. 2014 Jan;7(1):38-45. doi: 10.1038/mi.2013.20. Epub 2013 Apr 10.

39.

Effect of desiccating environmental stress versus systemic muscarinic AChR blockade on dry eye immunopathogenesis.

Chen Y, Chauhan SK, Lee HS, Stevenson W, Schaumburg CS, Sadrai Z, Saban DR, Kodati S, Stern ME, Dana R.

Invest Ophthalmol Vis Sci. 2013 Apr 3;54(4):2457-64. doi: 10.1167/iovs.12-11121.

40.

New twists to an old story: novel concepts in the pathogenesis of allergic eye disease.

Saban DR, Calder V, Kuo CH, Reyes NJ, Dartt DA, Ono SJ, Niederkorn JY.

Curr Eye Res. 2013 Mar;38(3):317-30. doi: 10.3109/02713683.2012.747617. Epub 2013 Jan 2. Review.

41.

Long-term type 1 diabetes influences haematopoietic stem cells by reducing vascular repair potential and increasing inflammatory monocyte generation in a murine model.

Hazra S, Jarajapu YP, Stepps V, Caballero S, Thinschmidt JS, Sautina L, Bengtsson N, Licalzi S, Dominguez J, Kern TS, Segal MS, Ash JD, Saban DR, Bartelmez SH, Grant MB.

Diabetologia. 2013 Mar;56(3):644-53. doi: 10.1007/s00125-012-2781-0. Epub 2012 Nov 29.

42.

Gamma-irradiation reduces the allogenicity of donor corneas.

Stevenson W, Cheng SF, Emami-Naeini P, Hua J, Paschalis EI, Dana R, Saban DR.

Invest Ophthalmol Vis Sci. 2012 Oct 1;53(11):7151-8. doi: 10.1167/iovs.12-9609.

43.

Blocking CCR7 at the ocular surface impairs the pathogenic contribution of dendritic cells in allergic conjunctivitis.

Schlereth S, Lee HS, Khandelwal P, Saban DR.

Am J Pathol. 2012 Jun;180(6):2351-60. doi: 10.1016/j.ajpath.2012.02.015. Epub 2012 Apr 14.

44.

Donor-derived, tolerogenic dendritic cells suppress immune rejection in the indirect allosensitization-dominant setting of corneal transplantation.

Hattori T, Saban DR, Emami-Naeini P, Chauhan SK, Funaki T, Ueno H, Dana R.

J Leukoc Biol. 2012 Apr;91(4):621-7. doi: 10.1189/jlb.1011500. Epub 2012 Jan 30.

45.

Dependence of corneal stem/progenitor cells on ocular surface innervation.

Ueno H, Ferrari G, Hattori T, Saban DR, Katikireddy KR, Chauhan SK, Dana R.

Invest Ophthalmol Vis Sci. 2012 Feb 21;53(2):867-72. doi: 10.1167/iovs.11-8438.

46.

Corneal penetration of topical and subconjunctival bevacizumab.

Dastjerdi MH, Sadrai Z, Saban DR, Zhang Q, Dana R.

Invest Ophthalmol Vis Sci. 2011 Nov 7;52(12):8718-23. doi: 10.1167/iovs.11-7871.

47.

Suppression of inflammatory corneal lymphangiogenesis by application of topical corticosteroids.

Hos D, Saban DR, Bock F, Regenfuss B, Onderka J, Masli S, Cursiefen C.

Arch Ophthalmol. 2011 Apr;129(4):445-52. doi: 10.1001/archophthalmol.2011.42.

PMID:
21482870
48.

Characterization of Langerin-expressing dendritic cell subsets in the normal cornea.

Hattori T, Chauhan SK, Lee H, Ueno H, Dana R, Kaplan DH, Saban DR.

Invest Ophthalmol Vis Sci. 2011 Jun 28;52(7):4598-604. doi: 10.1167/iovs.10-6741.

49.

Interferon-γ-secreting NK cells promote induction of dry eye disease.

Chen Y, Chauhan SK, Saban DR, Sadrai Z, Okanobo A, Dana R.

J Leukoc Biol. 2011 Jun;89(6):965-72. doi: 10.1189/jlb.1110611. Epub 2011 Mar 14.

50.

Effect of topical azithromycin on corneal innate immune responses.

Sadrai Z, Hajrasouliha AR, Chauhan S, Saban DR, Dastjerdi MH, Dana R.

Invest Ophthalmol Vis Sci. 2011 Apr 19;52(5):2525-31. doi: 10.1167/iovs.10-5658.

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