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Detection of Taenia solium DNA in the Urine of Neurocysticercosis Patients.

Toribio L, de Los Angeles Romano M, Scott AL, Gonzales I, Saavedra H, Garcia HH, Shiff C, For The Cysticercosis Working Group In Peru.

Am J Trop Med Hyg. 2018 Dec 10. doi: 10.4269/ajtmh.18-0706. [Epub ahead of print]


Centrosome aberrations and chromosome instability contribute to tumorigenesis and intra-tumor heterogeneity.

Jusino S, Fernández-Padín FM, Saavedra HI.

J Cancer Metastasis Treat. 2018;4. pii: 43. doi: 10.20517/2394-4722.2018.24. Epub 2018 Aug 7.


TTK promotes mesenchymal signaling via multiple mechanisms in triple negative breast cancer.

King JL, Zhang B, Li Y, Li KP, Ni JJ, Saavedra HI, Dong JT.

Oncogenesis. 2018 Sep 12;7(9):69. doi: 10.1038/s41389-018-0077-z.


Use of Simulation to Improve the Comfort of Pediatric Residents Managing Critically Ill Emergency Department Patients.

Saavedra HR, Turner JS, Cooper DD.

Pediatr Emerg Care. 2018 Sep;34(9):633-635. doi: 10.1097/PEC.0000000000001596.


Clinical topography relationship in patients with parenchymal neurocysticercosis and seizures.

Duque KR, Escalaya AL, Zapata W, Burneo JG, Bustos JA, Gonzales I, Saavedra H, Pretell EJ, Garcia HH; Cysticercosis Working Group in Peru.

Epilepsy Res. 2018 Sep;145:145-152. doi: 10.1016/j.eplepsyres.2018.06.011. Epub 2018 Jun 28.


Dynamic allostery can drive cold adaptation in enzymes.

Saavedra HG, Wrabl JO, Anderson JA, Li J, Hilser VJ.

Nature. 2018 Jun;558(7709):324-328. doi: 10.1038/s41586-018-0183-2. Epub 2018 Jun 6.


Inflammation is a key risk factor for persistent seizures in neurocysticercosis.

Herrick JA, Maharathi B, Kim JS, Abundis GG, Garg A, Gonzales I, Saavedra H, Bustos JA, Garcia HH, Loeb JA; Cysticercosis Working Group in Peru.

Ann Clin Transl Neurol. 2018 Apr 10;5(5):630-639. doi: 10.1002/acn3.562. eCollection 2018 May.


Detection of E2F-DNA Complexes Using Chromatin Immunoprecipitation Assays.

Lee M, Gudas LJ, Saavedra HI.

Methods Mol Biol. 2018;1726:143-151. doi: 10.1007/978-1-4939-7565-5_13.


Correction: Genetically tunable frustration controls allostery in an intrinsically disordered transcription factor.

Li J, White JT, Saavedra H, Wrabl JO, Motlagh HN, Liu K, Sowers J, Schroer TA, Thompson EB, Hilser VJ.

Elife. 2018 Feb 12;7. pii: e35768. doi: 10.7554/eLife.35768. No abstract available.


Nudt19 is a renal CoA diphosphohydrolase with biochemical and regulatory properties that are distinct from the hepatic Nudt7 isoform.

Shumar SA, Kerr EW, Geldenhuys WJ, Montgomery GE, Fagone P, Thirawatananond P, Saavedra H, Gabelli SB, Leonardi R.

J Biol Chem. 2018 Mar 16;293(11):4134-4148. doi: 10.1074/jbc.RA117.001358. Epub 2018 Jan 29.


Low sensitivity and frequent cross-reactions in commercially available antibody detection ELISA assays for Taenia solium cysticercosis.

Garcia HH, Castillo Y, Gonzales I, Bustos JA, Saavedra H, Jacob L, Del Brutto OH, Wilkins PP, Gonzalez AE, Gilman RH; Cysticercosis Working Group in Peru.

Trop Med Int Health. 2018 Jan;23(1):101-105. doi: 10.1111/tmi.13010. Epub 2017 Dec 7.


The E2F activators control multiple mitotic regulators and maintain genomic integrity through Sgo1 and BubR1.

Lee M, Rivera-Rivera Y, Moreno CS, Saavedra HI.

Oncotarget. 2017 Sep 8;8(44):77649-77672. doi: 10.18632/oncotarget.20765. eCollection 2017 Sep 29.


Genetically tunable frustration controls allostery in an intrinsically disordered transcription factor.

Li J, White JT, Saavedra H, Wrabl JO, Motlagh HN, Liu K, Sowers J, Schroer TA, Thompson EB, Hilser VJ.

Elife. 2017 Oct 12;6. pii: e30688. doi: 10.7554/eLife.30688. Erratum in: Elife. 2018 Feb 12;7:.


Antibody Banding Patterns of the Enzyme-Linked Immunoelectrotransfer Blot and Brain Imaging Findings in Patients With Neurocysticercosis.

Arroyo G, Rodriguez S, Lescano AG, Alroy KA, Bustos JA, Santivañez S, Gonzales I, Saavedra H, Pretell EJ, Gonzalez AE, Gilman RH, Tsang VCW, Garcia HH; Cysticercosis Working Group in Peru .

Clin Infect Dis. 2018 Jan 6;66(2):282-288. doi: 10.1093/cid/cix774.


Structural insight into the inactivation of Mycobacterium tuberculosis non-classical transpeptidase LdtMt2 by biapenem and tebipenem.

Bianchet MA, Pan YH, Basta LAB, Saavedra H, Lloyd EP, Kumar P, Mattoo R, Townsend CA, Lamichhane G.

BMC Biochem. 2017 May 25;18(1):8. doi: 10.1186/s12858-017-0082-4.


Centrosome - a promising anti-cancer target.

Rivera-Rivera Y, Saavedra HI.

Biologics. 2016 Dec 13;10:167-176. doi: 10.2147/BTT.S87396. eCollection 2016. Review.


Association studies to transporting proteins of fac-ReI(CO)3(pterin)(H2O) complex.

Ragone F, Saavedra HH, García PF, Wolcan E, Argüello GA, Ruiz GT.

J Biol Inorg Chem. 2017 Jan;22(1):99-108. doi: 10.1007/s00775-016-1410-7. Epub 2016 Nov 4.


Cysticidal Efficacy of Combined Treatment With Praziquantel and Albendazole for Parenchymal Brain Cysticercosis.

Garcia HH, Lescano AG, Gonzales I, Bustos JA, Pretell EJ, Horton J, Saavedra H, Gonzalez AE, Gilman RH; Cysticercosis Working Group in Peru.

Clin Infect Dis. 2016 Jun 1;62(11):1375-9. doi: 10.1093/cid/ciw134. Epub 2016 Mar 16.


A large silent cysticercus occupying most of the medulla oblongata.

Meneses JP, Salas C, Saavedra H, Esteban D, Garcia HH; Cysticercosis Working Group in Perú.

Eur J Neurol. 2016 Feb;23(2):e6-7. doi: 10.1111/ene.12765. No abstract available.


Occasional resolution of multiple parenchymal brain calcifications in patients with neurocysticercosis.

Meneses Quiroz LJ, Gonzales I, Pretell EJ, Saavedra H, Garcia HH; Cysticercosis Working Group in Perú.

Neurol Clin Pract. 2015 Dec;5(6):531-533. No abstract available.


Silencing of E2F3 suppresses tumor growth of Her2+ breast cancer cells by restricting mitosis.

Lee M, Oprea-Ilies G, Saavedra HI.

Oncotarget. 2015 Nov 10;6(35):37316-34. doi: 10.18632/oncotarget.5686.


Combined antiparasitic treatment for neurocysticercosis - Authors' reply.

Garcia HH, Gonzales I, Bustos JA, Saavedra H, Gavidia M, Rodriguez L, Najar E, Umeres H, Pretell EJ.

Lancet Infect Dis. 2015 Mar;15(3):266-7. doi: 10.1016/S1473-3099(15)70047-2. No abstract available.


Identification of HIBCH gene mutations causing autosomal recessive Leigh syndrome: a gene involved in valine metabolism.

Soler-Alfonso C, Enns GM, Koenig MK, Saavedra H, Bonfante-Mejia E, Northrup H.

Pediatr Neurol. 2015 Mar;52(3):361-5. doi: 10.1016/j.pediatrneurol.2014.10.023. Epub 2014 Nov 7.


Chromosome instability in diffuse large B cell lymphomas is suppressed by activation of the noncanonical NF-κB pathway.

Ramachandiran S, Adon A, Guo X, Wang Y, Wang H, Chen Z, Kowalski J, Sunay UR, Young AN, Brown T, Mar JC, Du Y, Fu H, Mann KP, Natkunam Y, Boise LH, Saavedra HI, Lossos IS, Bernal-Mizrachi L.

Int J Cancer. 2015 May 15;136(10):2341-51. doi: 10.1002/ijc.29301. Epub 2014 Nov 11.


Differential expression of centrosome regulators in Her2+ breast cancer cells versus non-tumorigenic MCF10A cells.

Lee MY, Marina M, King JL, Saavedra HI.

Cell Div. 2014 Sep 25;9:3. doi: 10.1186/1747-1028-9-3. eCollection 2014.


Enhanced steroid dosing reduces seizures during antiparasitic treatment for cysticercosis and early after.

Garcia HH, Gonzales I, Lescano AG, Bustos JA, Pretell EJ, Saavedra H, Nash TE; Cysticercosis Working Group in Peru.

Epilepsia. 2014 Sep;55(9):1452-9. doi: 10.1111/epi.12739. Epub 2014 Aug 4.


Efficacy of combined antiparasitic therapy with praziquantel and albendazole for neurocysticercosis: a double-blind, randomised controlled trial.

Garcia HH, Gonzales I, Lescano AG, Bustos JA, Zimic M, Escalante D, Saavedra H, Gavidia M, Rodriguez L, Najar E, Umeres H, Pretell EJ; Cysticercosis Working Group in Peru.

Lancet Infect Dis. 2014 Aug;14(8):687-695. doi: 10.1016/S1473-3099(14)70779-0. Epub 2014 Jul 3.


Poldip2 knockout results in perinatal lethality, reduced cellular growth and increased autophagy of mouse embryonic fibroblasts.

Brown DI, Lassègue B, Lee M, Zafari R, Long JS, Saavedra HI, Griendling KK.

PLoS One. 2014 May 5;9(5):e96657. doi: 10.1371/journal.pone.0096657. eCollection 2014.


E2F activators signal and maintain centrosome amplification in breast cancer cells.

Lee MY, Moreno CS, Saavedra HI.

Mol Cell Biol. 2014 Jul;34(14):2581-99.


Nek2 and Plk4: prognostic markers, drivers of breast tumorigenesis and drug resistance.

Marina M, Saavedra HI.

Front Biosci (Landmark Ed). 2014 Jan 1;19:352-65. Review.


Silencing CDK4 radiosensitizes breast cancer cells by promoting apoptosis.

Hagen KR, Zeng X, Lee MY, Tucker Kahn S, Harrison Pitner MK, Zaky SS, Liu Y, O'Regan RM, Deng X, Saavedra HI.

Cell Div. 2013 Jul 25;8(1):10. doi: 10.1186/1747-1028-8-10.


Cdk4 and nek2 signal binucleation and centrosome amplification in a her2+ breast cancer model.

Harrison Pitner MK, Saavedra HI.

PLoS One. 2013 Jun 11;8(6):e65971. doi: 10.1371/journal.pone.0065971. Print 2013.


Synthesis, structure and band gap energy of covalently linked cluster-assembled materials.

Mandal S, Reber AC, Qian M, Liu R, Saavedra HM, Sen S, Weiss PS, Khanna SN, Sen A.

Dalton Trans. 2012 Oct 28;41(40):12365-77.


On the stability of an unsupported mercury-mercury bond linking group 15 Zintl clusters.

Mandal S, Reber AC, Qian M, Liu R, Saavedra HM, Sen S, Weiss PS, Khanna SN, Sen A.

Dalton Trans. 2012 May 14;41(18):5454-7. doi: 10.1039/c2dt30083d. Epub 2012 Mar 6.


Pharmacokinetics of combined treatment with praziquantel and albendazole in neurocysticercosis.

Garcia HH, Lescano AG, Lanchote VL, Pretell EJ, Gonzales I, Bustos JA, Takayanagui OM, Bonato PS, Horton J, Saavedra H, Gonzalez AE, Gilman RH; Cysticercosis Working Group in Peru.

Br J Clin Pharmacol. 2011 Jul;72(1):77-84. doi: 10.1111/j.1365-2125.2011.03945.x.


[Neurocysticercosis diagnosis and management in Peru].

Saavedra H, Gonzales I, Alvarado MA, Porras MA, Vargas V, Cjuno RA, Garcia HH, Martinez SM.

Rev Peru Med Exp Salud Publica. 2010 Oct-Dec;27(4):586-91. Review. Spanish.


The G1 phase Cdks regulate the centrosome cycle and mediate oncogene-dependent centrosome amplification.

Harrison MK, Adon AM, Saavedra HI.

Cell Div. 2011 Jan 27;6:2. doi: 10.1186/1747-1028-6-2.


The Zintl ion [As7]2-: an example of an electron-deficient As(x) radical anion.

Mandal S, Liu R, Reber AC, Qian M, Saavedra HM, Ke X, Schiffer P, Sen S, Weiss PS, Khanna SN, Sen A.

Chem Commun (Camb). 2011 Mar 21;47(11):3126-8. doi: 10.1039/c0cc03219k. Epub 2011 Jan 25.


Controlling band gap energies in cluster-assembled ionic solids through internal electric fields.

Chaki NK, Mandal S, Reber AC, Qian M, Saavedra HM, Weiss PS, Khanna SN, Sen A.

ACS Nano. 2010 Oct 26;4(10):5813-8. doi: 10.1021/nn101640r.


The Ras oncogene signals centrosome amplification in mammary epithelial cells through cyclin D1/Cdk4 and Nek2.

Zeng X, Shaikh FY, Harrison MK, Adon AM, Trimboli AJ, Carroll KA, Sharma N, Timmers C, Chodosh LA, Leone G, Saavedra HI.

Oncogene. 2010 Sep 9;29(36):5103-12. doi: 10.1038/onc.2010.253. Epub 2010 Jun 28.


Cluster-assembled materials: toward nanomaterials with precise control over properties.

Qian M, Reber AC, Ugrinov A, Chaki NK, Mandal S, Saavedra HM, Khanna SN, Sen A, Weiss PS.

ACS Nano. 2010 Jan 26;4(1):235-40. doi: 10.1021/nn9010297.


Cdk2 and Cdk4 regulate the centrosome cycle and are critical mediators of centrosome amplification in p53-null cells.

Adon AM, Zeng X, Harrison MK, Sannem S, Kiyokawa H, Kaldis P, Saavedra HI.

Mol Cell Biol. 2010 Feb;30(3):694-710. doi: 10.1128/MCB.00253-09. Epub 2009 Nov 23.


Gastrostomy tube-related complaints in the pediatric emergency department: identifying opportunities for improvement.

Saavedra H, Losek JD, Shanley L, Titus MO.

Pediatr Emerg Care. 2009 Nov;25(11):728-32. doi: 10.1097/PEC.0b013e3181bec847.


Reversible lability by in situ reaction of self-assembled monolayers.

Saavedra HM, Thompson CM, Hohman JN, Crespi VH, Weiss PS.

J Am Chem Soc. 2009 Feb 18;131(6):2252-9. doi: 10.1021/ja807648g.


Mortality of a wireworm, Agriotes obscurus (Coleoptera: Elateridae), after topical application of various insecticides.

Van Herk WG, Vernon RS, Tolman JH, Saavedra HO.

J Econ Entomol. 2008 Apr;101(2):375-83.


Transitional sublethal and lethal effects of insecticides after dermal exposures to five economic species of wireworms (Coleoptera: Elateridae).

Vernon RS, Van Herk W, Tolman J, Saavedra HO, Clodius M, Gage B.

J Econ Entomol. 2008 Apr;101(2):365-74.


1-Adamantanethiolate monolayer displacement kinetics follow a universal form.

Saavedra HM, Barbu CM, Dameron AA, Mullen TJ, Crespi VH, Weiss PS.

J Am Chem Soc. 2007 Sep 5;129(35):10741-6. Epub 2007 Aug 9.


E2f1, E2f2, and E2f3 control E2F target expression and cellular proliferation via a p53-dependent negative feedback loop.

Timmers C, Sharma N, Opavsky R, Maiti B, Wu L, Wu J, Orringer D, Trikha P, Saavedra HI, Leone G.

Mol Cell Biol. 2007 Jan;27(1):65-78. Erratum in: Mol Cell Biol. 2012 May;32(9):1758.


Control of the p53-p21CIP1 Axis by E2f1, E2f2, and E2f3 is essential for G1/S progression and cellular transformation.

Sharma N, Timmers C, Trikha P, Saavedra HI, Obery A, Leone G.

J Biol Chem. 2006 Nov 24;281(47):36124-31. Epub 2006 Sep 27.


Aberrant regulation of survivin by the RB/E2F family of proteins.

Jiang Y, Saavedra HI, Holloway MP, Leone G, Altura RA.

J Biol Chem. 2004 Sep 24;279(39):40511-20. Epub 2004 Jul 22.

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