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Items: 1 to 50 of 246

1.

Pre-α-pro-GDNF and Pre-β-pro-GDNF Isoforms Are Neuroprotective in the 6-hydroxydopamine Rat Model of Parkinson's Disease.

Penttinen AM, Parkkinen I, Voutilainen MH, Koskela M, Bäck S, Their A, Richie CT, Domanskyi A, Harvey BK, Tuominen RK, Nevalaita L, Saarma M, Airavaara M.

Front Neurol. 2018 Jun 20;9:457. doi: 10.3389/fneur.2018.00457. eCollection 2018.

2.

Combination of CDNF and Deep Brain Stimulation Decreases Neurological Deficits in Late-stage Model Parkinson's Disease.

Huotarinen A, Penttinen AM, Bäck S, Voutilainen MH, Julku U, Piepponen TP, Männistö PT, Saarma M, Tuominen R, Laakso A, Airavaara M.

Neuroscience. 2018 Mar 15;374:250-263. doi: 10.1016/j.neuroscience.2018.01.052. Epub 2018 Feb 3.

3.

Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Elevates Stimulus-Evoked Release of Dopamine in Freely-Moving Rats.

Renko JM, Bäck S, Voutilainen MH, Piepponen TP, Reenilä I, Saarma M, Tuominen RK.

Mol Neurobiol. 2018 Jan 18. doi: 10.1007/s12035-018-0872-8. [Epub ahead of print]

PMID:
29349573
4.

Development and plasticity of meningeal lymphatic vessels.

Antila S, Karaman S, Nurmi H, Airavaara M, Voutilainen MH, Mathivet T, Chilov D, Li Z, Koppinen T, Park JH, Fang S, Aspelund A, Saarma M, Eichmann A, Thomas JL, Alitalo K.

J Exp Med. 2017 Dec 4;214(12):3645-3667. doi: 10.1084/jem.20170391. Epub 2017 Nov 15.

5.

MANF Is Essential for Neurite Extension and Neuronal Migration in the Developing Cortex.

Tseng KY, Danilova T, Domanskyi A, Saarma M, Lindahl M, Airavaara M.

eNeuro. 2017 Sep 29;4(5). pii: ENEURO.0214-17.2017. doi: 10.1523/ENEURO.0214-17.2017. eCollection 2017 Sep-Oct.

6.

Obesity: Receptors identified for a weight regulator.

Saarma M, Goldman A.

Nature. 2017 Oct 12;550(7675):195-197. doi: 10.1038/nature24143. Epub 2017 Sep 27. No abstract available.

PMID:
28953879
7.

A Novel Small Molecule GDNF Receptor RET Agonist, BT13, Promotes Neurite Growth from Sensory Neurons in Vitro and Attenuates Experimental Neuropathy in the Rat.

Sidorova YA, Bespalov MM, Wong AW, Kambur O, Jokinen V, Lilius TO, Suleymanova I, Karelson G, Rauhala PV, Karelson M, Osborne PB, Keast JR, Kalso EA, Saarma M.

Front Pharmacol. 2017 Jun 21;8:365. doi: 10.3389/fphar.2017.00365. eCollection 2017.

8.

In vivo screening reveals interactions between Drosophila Manf and genes involved in the mitochondria and the ubiquinone synthesis pathway.

Lindström R, Lindholm P, Palgi M, Saarma M, Heino TI.

BMC Genet. 2017 Jun 2;18(1):52. doi: 10.1186/s12863-017-0509-3.

9.

Zebrafish GDNF and its co-receptor GFRα1 activate the human RET receptor and promote the survival of dopaminergic neurons in vitro.

Saarenpää T, Kogan K, Sidorova Y, Mahato AK, Tascón I, Kaljunen H, Yu L, Kallijärvi J, Jurvansuu J, Saarma M, Goldman A.

PLoS One. 2017 May 3;12(5):e0176166. doi: 10.1371/journal.pone.0176166. eCollection 2017.

10.

Evidence for an Additive Neurorestorative Effect of Simultaneously Administered CDNF and GDNF in Hemiparkinsonian Rats: Implications for Different Mechanism of Action.

Voutilainen MH, De Lorenzo F, Stepanova P, Bäck S, Yu LY, Lindholm P, Pörsti E, Saarma M, Männistö PT, Tuominen RK.

eNeuro. 2017 Mar 13;4(1). pii: ENEURO.0117-16.2017. doi: 10.1523/ENEURO.0117-16.2017. eCollection 2017 Jan-Feb.

11.

Intrastriatally Infused Exogenous CDNF Is Endocytosed and Retrogradely Transported to Substantia Nigra.

Mätlik K, Vihinen H, Bienemann A, Palgi J, Voutilainen MH, Booms S, Lindahl M, Jokitalo E, Saarma M, Huttunen HJ, Airavaara M, Arumäe U.

eNeuro. 2017 Feb 20;4(1). pii: ENEURO.0128-16.2017. doi: 10.1523/ENEURO.0128-16.2017. eCollection 2017 Jan-Feb.

12.

Dampened Amphetamine-Stimulated Behavior and Altered Dopamine Transporter Function in the Absence of Brain GDNF.

Kopra JJ, Panhelainen A, Af Bjerkén S, Porokuokka LL, Varendi K, Olfat S, Montonen H, Piepponen TP, Saarma M, Andressoo JO.

J Neurosci. 2017 Feb 8;37(6):1581-1590. doi: 10.1523/JNEUROSCI.1673-16.2016. Epub 2017 Jan 17.

13.

Editorial.

Saarma M, Castrén E, Runeberg-Roos P.

Neurobiol Dis. 2017 Jan;97(Pt B):71-72. doi: 10.1016/j.nbd.2016.11.010. No abstract available.

PMID:
27938864
14.

c-Abl Inhibitors Enable Insights into the Pathophysiology and Neuroprotection in Parkinson's Disease.

Lindholm D, Pham DD, Cascone A, Eriksson O, Wennerberg K, Saarma M.

Front Aging Neurosci. 2016 Oct 26;8:254. eCollection 2016. Review.

15.

Developing therapeutically more efficient Neurturin variants for treatment of Parkinson's disease.

Runeberg-Roos P, Piccinini E, Penttinen AM, Mätlik K, Heikkinen H, Kuure S, Bespalov MM, Peränen J, Garea-Rodríguez E, Fuchs E, Airavaara M, Kalkkinen N, Penn R, Saarma M.

Neurobiol Dis. 2016 Dec;96:335-345. doi: 10.1016/j.nbd.2016.07.008. Epub 2016 Jul 15.

PMID:
27425888
16.

[Glial cell line-derived neurotrophic factor family ligands and their therapeutic potential].

Sidorova YA, Saarma M.

Mol Biol (Mosk). 2016 Jul-Aug;50(4):589-598. Russian.

17.

Unconventional neurotrophic factors CDNF and MANF: Structure, physiological functions and therapeutic potential.

Lindahl M, Saarma M, Lindholm P.

Neurobiol Dis. 2017 Jan;97(Pt B):90-102. doi: 10.1016/j.nbd.2016.07.009. Epub 2016 Jul 15. Review.

PMID:
27425895
18.

Increased circulating concentrations of mesencephalic astrocyte-derived neurotrophic factor in children with type 1 diabetes.

Galli E, Härkönen T, Sainio MT, Ustav M, Toots U, Urtti A, Yliperttula M, Lindahl M, Knip M, Saarma M, Lindholm P.

Sci Rep. 2016 Jun 30;6:29058. doi: 10.1038/srep29058.

19.

Exploring the Conserved Role of MANF in the Unfolded Protein Response in Drosophila melanogaster.

Lindström R, Lindholm P, Kallijärvi J, Palgi M, Saarma M, Heino TI.

PLoS One. 2016 Mar 14;11(3):e0151550. doi: 10.1371/journal.pone.0151550. eCollection 2016.

20.

Comparative Analysis of the Effects of Neurotrophic Factors CDNF and GDNF in a Nonhuman Primate Model of Parkinson's Disease.

Garea-Rodríguez E, Eesmaa A, Lindholm P, Schlumbohm C, König J, Meller B, Krieglstein K, Helms G, Saarma M, Fuchs E.

PLoS One. 2016 Feb 22;11(2):e0149776. doi: 10.1371/journal.pone.0149776. eCollection 2016.

21.

Parkinson's disease: towards better preclinical models and personalized treatments.

Lindholm D, Mäkelä J, Di Liberto V, Mudò G, Belluardo N, Eriksson O, Saarma M.

Cell Mol Life Sci. 2016 Apr;73(7):1383-5. doi: 10.1007/s00018-016-2141-1. Epub 2016 Feb 3. No abstract available.

PMID:
26841827
22.

Correction: GDNF Overexpression from the Native Locus Reveals its Role in the Nigrostriatal Dopaminergic System Function.

Kumar A, Kopra J, Varendi K, Porokuokka LL, Panhelainen A, Kuure S, Marshall P, Karalija N, Härma MA, Vilenius C, Lilleväli K, Tekko T, Mijatovic J, Pulkkinen N, Jakobson M, Jakobson M, Ola R, Palm E, Lindahl M, Strömberg I, Võikar V, Piepponen TP, Saarma M, Andressoo JO.

PLoS Genet. 2016 Jan 11;12(1):e1005808. doi: 10.1371/journal.pgen.1005808. eCollection 2016 Jan.

23.

Role of two sequence motifs of mesencephalic astrocyte-derived neurotrophic factor in its survival-promoting activity.

Mätlik K, Yu LY, Eesmaa A, Hellman M, Lindholm P, Peränen J, Galli E, Anttila J, Saarma M, Permi P, Airavaara M, Arumäe U.

Cell Death Dis. 2015 Dec 31;6:e2032. doi: 10.1038/cddis.2015.371.

24.

GDNF Overexpression from the Native Locus Reveals its Role in the Nigrostriatal Dopaminergic System Function.

Kumar A, Kopra J, Varendi K, Porokuokka LL, Panhelainen A, Kuure S, Marshall P, Karalija N, Härma MA, Vilenius C, Lilleväli K, Tekko T, Mijatovic J, Pulkkinen N, Jakobson M, Jakobson M, Ola R, Palm E, Lindahl M, Strömberg I, Võikar V, Piepponen TP, Saarma M, Andressoo JO.

PLoS Genet. 2015 Dec 17;11(12):e1005710. doi: 10.1371/journal.pgen.1005710. eCollection 2015 Dec. Erratum in: PLoS Genet. 2016 Jan;12(1):e1005808.

25.

Current disease modifying approaches to treat Parkinson's disease.

Lindholm D, Mäkelä J, Di Liberto V, Mudò G, Belluardo N, Eriksson O, Saarma M.

Cell Mol Life Sci. 2016 Apr;73(7):1365-79. doi: 10.1007/s00018-015-2101-1. Epub 2015 Nov 30. Review.

PMID:
26616211
26.

Therapeutic potential of the endoplasmic reticulum located and secreted CDNF/MANF family of neurotrophic factors in Parkinson's disease.

Voutilainen MH, Arumäe U, Airavaara M, Saarma M.

FEBS Lett. 2015 Dec 21;589(24 Pt A):3739-48. doi: 10.1016/j.febslet.2015.09.031. Epub 2015 Oct 9. Review.

27.

Prospects of Neurotrophic Factors for Parkinson's Disease: Comparison of Protein and Gene Therapy.

Domanskyi A, Saarma M, Airavaara M.

Hum Gene Ther. 2015 Aug;26(8):550-9. doi: 10.1089/hum.2015.065. Review.

PMID:
26176331
28.

RNA Interference-Guided Targeting of Hepatitis C Virus Replication with Antisense Locked Nucleic Acid-Based Oligonucleotides Containing 8-oxo-dG Modifications.

Mutso M, Nikonov A, Pihlak A, Žusinaite E, Viru L, Selyutina A, Reintamm T, Kelve M, Saarma M, Karelson M, Merits A.

PLoS One. 2015 Jun 3;10(6):e0128686. doi: 10.1371/journal.pone.0128686. eCollection 2015.

29.

BDNF pro-peptide actions facilitate hippocampal LTD and are altered by the common BDNF polymorphism Val66Met.

Mizui T, Ishikawa Y, Kumanogoh H, Lume M, Matsumoto T, Hara T, Yamawaki S, Takahashi M, Shiosaka S, Itami C, Uegaki K, Saarma M, Kojima M.

Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):E3067-74. doi: 10.1073/pnas.1422336112. Epub 2015 May 26.

30.

Cerebral dopamine neurotrophic factor improves long-term memory in APP/PS1 transgenic mice modeling Alzheimer's disease as well as in wild-type mice.

Kemppainen S, Lindholm P, Galli E, Lahtinen HM, Koivisto H, Hämäläinen E, Saarma M, Tanila H.

Behav Brain Res. 2015 Sep 15;291:1-11. doi: 10.1016/j.bbr.2015.05.002. Epub 2015 May 11.

PMID:
25975173
31.

Suppression of RNAi by dsRNA-degrading RNaseIII enzymes of viruses in animals and plants.

Weinheimer I, Jiu Y, Rajamäki ML, Matilainen O, Kallijärvi J, Cuellar WJ, Lu R, Saarma M, Holmberg CI, Jäntti J, Valkonen JP.

PLoS Pathog. 2015 Mar 6;11(3):e1004711. doi: 10.1371/journal.ppat.1004711. eCollection 2015 Mar.

32.

GDNF is not required for catecholaminergic neuron survival in vivo.

Kopra J, Vilenius C, Grealish S, Härma MA, Varendi K, Lindholm J, Castrén E, Võikar V, Björklund A, Piepponen TP, Saarma M, Andressoo JO.

Nat Neurosci. 2015 Mar;18(3):319-22. doi: 10.1038/nn.3941. No abstract available.

33.

Transient transfection of human CDNF gene reduces the 6-hydroxydopamine-induced neuroinflammation in the rat substantia nigra.

Nadella R, Voutilainen MH, Saarma M, Gonzalez-Barrios JA, Leon-Chavez BA, Jiménez JM, Jiménez SH, Escobedo L, Martinez-Fong D.

J Neuroinflammation. 2014 Dec 16;11:209. doi: 10.1186/s12974-014-0209-0.

34.

MANF is indispensable for the proliferation and survival of pancreatic β cells.

Lindahl M, Danilova T, Palm E, Lindholm P, Võikar V, Hakonen E, Ustinov J, Andressoo JO, Harvey BK, Otonkoski T, Rossi J, Saarma M.

Cell Rep. 2014 Apr 24;7(2):366-75. doi: 10.1016/j.celrep.2014.03.023. Epub 2014 Apr 13.

35.

Short-term preoperative dietary restriction is neuroprotective in a rat focal stroke model.

Varendi K, Airavaara M, Anttila J, Vose S, Planken A, Saarma M, Mitchell JR, Andressoo JO.

PLoS One. 2014 Apr 4;9(4):e93911. doi: 10.1371/journal.pone.0093911. eCollection 2014.

36.

Mitogen-activated protein kinase (MAPK) pathway regulates branching by remodeling epithelial cell adhesion.

Ihermann-Hella A, Lume M, Miinalainen IJ, Pirttiniemi A, Gui Y, Peränen J, Charron J, Saarma M, Costantini F, Kuure S.

PLoS Genet. 2014 Mar 6;10(3):e1004193. doi: 10.1371/journal.pgen.1004193. eCollection 2014 Mar.

37.

Characterization of the structural and functional determinants of MANF/CDNF in Drosophila in vivo model.

Lindström R, Lindholm P, Kallijärvi J, Yu LY, Piepponen TP, Arumäe U, Saarma M, Heino TI.

PLoS One. 2013 Sep 3;8(9):e73928. doi: 10.1371/journal.pone.0073928. eCollection 2013.

38.

Echinococcus granulosus genotype G1 dominated in cattle and sheep during 2003-2006 in Buenos Aires province, an endemic area for cystic echinococcosis in Argentina.

Andresiuk MV, Gordo FP, Saarma M, Elissondo MC, Taraborelli A, Casalongue C, Denegri G, Saarma U.

Acta Trop. 2013 Aug;127(2):136-42. doi: 10.1016/j.actatropica.2013.04.008. Epub 2013 Apr 28.

PMID:
23632259
39.

Gene therapy with AAV2-CDNF provides functional benefits in a rat model of Parkinson's disease.

Bäck S, Peränen J, Galli E, Pulkkila P, Lonka-Nevalaita L, Tamminen T, Voutilainen MH, Raasmaja A, Saarma M, Männistö PT, Tuominen RK.

Brain Behav. 2013 Mar;3(2):75-88. doi: 10.1002/brb3.117. Epub 2013 Jan 14.

40.

SorLA controls neurotrophic activity by sorting of GDNF and its receptors GFRα1 and RET.

Glerup S, Lume M, Olsen D, Nyengaard JR, Vaegter CB, Gustafsen C, Christensen EI, Kjolby M, Hay-Schmidt A, Bender D, Madsen P, Saarma M, Nykjaer A, Petersen CM.

Cell Rep. 2013 Jan 31;3(1):186-99. doi: 10.1016/j.celrep.2012.12.011. Epub 2013 Jan 17.

41.

Glial cell line-derived neurotrophic factor: characterization of mammalian posttranslational modifications.

Piccinini E, Kalkkinen N, Saarma M, Runeberg-Roos P.

Ann Med. 2013 Feb;45(1):66-73. doi: 10.3109/07853890.2012.663927. Epub 2012 Mar 9.

PMID:
23305235
42.

Characterization of Drosophila GDNF receptor-like and evidence for its evolutionarily conserved interaction with neural cell adhesion molecule (NCAM)/FasII.

Kallijärvi J, Stratoulias V, Virtanen K, Hietakangas V, Heino TI, Saarma M.

PLoS One. 2012;7(12):e51997. doi: 10.1371/journal.pone.0051997. Epub 2012 Dec 20.

43.

Advanced brain dopamine transporter imaging in mice using small-animal SPECT/CT.

Pitkonen M, Hippeläinen E, Raki M, Andressoo JO, Urtti A, Männistö PT, Savolainen S, Saarma M, Bergström K.

EJNMMI Res. 2012 Sep 29;2(1):55. doi: 10.1186/2191-219X-2-55.

44.

CDNF protects the nigrostriatal dopamine system and promotes recovery after MPTP treatment in mice.

Airavaara M, Harvey BK, Voutilainen MH, Shen H, Chou J, Lindholm P, Lindahl M, Tuominen RK, Saarma M, Hoffer B, Wang Y.

Cell Transplant. 2012;21(6):1213-23. doi: 10.3727/096368911X600948. Epub 2011 Sep 22.

45.

Neurturin evokes MAPK-dependent upregulation of Egr4 and KCC2 in developing neurons.

Ludwig A, Uvarov P, Pellegrino C, Thomas-Crusells J, Schuchmann S, Saarma M, Airaksinen MS, Rivera C.

Neural Plast. 2011;2011:1-8. doi: 10.1155/2011/641248. Epub 2011 Jul 4.

46.

Vascular endothelial growth factor C acts as a neurotrophic factor for dopamine neurons in vitro and in vivo.

Piltonen M, Planken A, Leskelä O, Myöhänen TT, Hänninen AL, Auvinen P, Alitalo K, Andressoo JO, Saarma M, Männistö PT.

Neuroscience. 2011 Sep 29;192:550-63. doi: 10.1016/j.neuroscience.2011.06.084. Epub 2011 Jul 14.

PMID:
21767614
47.

Heparan sulfate proteoglycan syndecan-3 is a novel receptor for GDNF, neurturin, and artemin.

Bespalov MM, Sidorova YA, Tumova S, Ahonen-Bishopp A, Magalhães AC, Kulesskiy E, Paveliev M, Rivera C, Rauvala H, Saarma M.

J Cell Biol. 2011 Jan 10;192(1):153-69. doi: 10.1083/jcb.201009136. Epub 2011 Jan 3.

48.

Chronic infusion of CDNF prevents 6-OHDA-induced deficits in a rat model of Parkinson's disease.

Voutilainen MH, Bäck S, Peränen J, Lindholm P, Raasmaja A, Männistö PT, Saarma M, Tuominen RK.

Exp Neurol. 2011 Mar;228(1):99-108. doi: 10.1016/j.expneurol.2010.12.013. Epub 2010 Dec 24.

PMID:
21185834
49.

Mesencephalic astrocyte-derived neurotrophic factor (MANF) has a unique mechanism to rescue apoptotic neurons.

Hellman M, Arumäe U, Yu LY, Lindholm P, Peränen J, Saarma M, Permi P.

J Biol Chem. 2011 Jan 28;286(4):2675-80. doi: 10.1074/jbc.M110.146738. Epub 2010 Nov 3.

50.

Characterization of the intracellular localization, processing, and secretion of two glial cell line-derived neurotrophic factor splice isoforms.

Lonka-Nevalaita L, Lume M, Leppänen S, Jokitalo E, Peränen J, Saarma M.

J Neurosci. 2010 Aug 25;30(34):11403-13. doi: 10.1523/JNEUROSCI.5888-09.2010.

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