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Items: 43

1.

Pneumococci Can Become Virulent by Acquiring a New Capsule From Oral Streptococci.

Nahm MH, Brissac T, Kilian M, Vlach J, Orihuela CJ, Saad JS, Ganaie F.

J Infect Dis. 2019 Sep 7. pii: jiz456. doi: 10.1093/infdis/jiz456. [Epub ahead of print]

PMID:
31605125
2.

The KN-93 Molecule Inhibits Calcium/Calmodulin-Dependent Protein Kinase II (CaMKII) Activity by Binding to Ca2+/CaM.

Wong MH, Samal AB, Lee M, Vlach J, Novikov N, Niedziela-Majka A, Feng JY, Koltun DO, Brendza KM, Kwon HJ, Schultz BE, Sakowicz R, Saad JS, Papalia GA.

J Mol Biol. 2019 Mar 29;431(7):1440-1459. doi: 10.1016/j.jmb.2019.02.001. Epub 2019 Feb 10.

PMID:
30753871
3.

The tuberculosis necrotizing toxin is an NAD+ and NADP+ glycohydrolase with distinct enzymatic properties.

Tak U, Vlach J, Garza-Garcia A, William D, Danilchanka O, de Carvalho LPS, Saad JS, Niederweis M.

J Biol Chem. 2019 Mar 1;294(9):3024-3036. doi: 10.1074/jbc.RA118.005832. Epub 2018 Dec 28.

4.

Structural basis for targeting avian sarcoma virus Gag polyprotein to the plasma membrane for virus assembly.

Vlach J, Eastep GN, Ghanam RH, Watanabe SM, Carter CA, Saad JS.

J Biol Chem. 2018 Dec 7;293(49):18828-18840. doi: 10.1074/jbc.RA118.003944. Epub 2018 Oct 11.

PMID:
30309983
5.

The matrix domain of the Gag protein from avian sarcoma virus contains a PI(4,5)P2-binding site that targets Gag to the cell periphery.

Watanabe SM, Medina GN, Eastep GN, Ghanam RH, Vlach J, Saad JS, Carter CA.

J Biol Chem. 2018 Dec 7;293(49):18841-18853. doi: 10.1074/jbc.RA118.003947. Epub 2018 Oct 11.

PMID:
30309982
6.

Solution Structure and Membrane Interaction of the Cytoplasmic Tail of HIV-1 gp41 Protein.

Murphy RE, Samal AB, Vlach J, Saad JS.

Structure. 2017 Nov 7;25(11):1708-1718.e5. doi: 10.1016/j.str.2017.09.010. Epub 2017 Oct 19.

7.

Position of O-Acetylation within the Capsular Repeat Unit Impacts the Biological Properties of Pneumococcal Serotypes 33A and 33F.

Spencer BL, Saad JS, Shenoy AT, Orihuela CJ, Nahm MH.

Infect Immun. 2017 Jun 20;85(7). pii: e00132-17. doi: 10.1128/IAI.00132-17. Print 2017 Jul.

8.

Derepression of SaPIbov1 Is Independent of φNM1 Type 2 dUTPase Activity and Is Inhibited by dUTP and dUMP.

Hill RLL, Vlach J, Parker LK, Christie GE, Saad JS, Dokland T.

J Mol Biol. 2017 May 19;429(10):1570-1580. doi: 10.1016/j.jmb.2017.04.001. Epub 2017 Apr 8.

9.

Discovery of Novel Pneumococcal Serotype 35D, a Natural WciG-Deficient Variant of Serotype 35B.

Geno KA, Saad JS, Nahm MH.

J Clin Microbiol. 2017 May;55(5):1416-1425. doi: 10.1128/JCM.00054-17. Epub 2017 Feb 15.

10.

The Interplay between Calmodulin and Membrane Interactions with the Pleckstrin Homology Domain of Akt.

Agamasu C, Ghanam RH, Xu F, Sun Y, Chen Y, Saad JS.

J Biol Chem. 2017 Jan 6;292(1):251-263. doi: 10.1074/jbc.M116.752816. Epub 2016 Nov 21.

11.

Pneumococcus with the "6E" cps Locus Produces Serotype 6B Capsular Polysaccharide.

Burton RL, Geno KA, Saad JS, Nahm MH.

J Clin Microbiol. 2016 Apr;54(4):967-71. doi: 10.1128/JCM.03194-15. Epub 2016 Jan 27.

12.

Identification of the Calmodulin-Binding Domains of Fas Death Receptor.

Chang BJ, Samal AB, Vlach J, Fernandez TF, Brooke D, Prevelige PE Jr, Saad JS.

PLoS One. 2016 Jan 6;11(1):e0146493. doi: 10.1371/journal.pone.0146493. eCollection 2016.

13.

Discovery of Streptococcus pneumoniae serotype 6 variants with glycosyltransferases synthesizing two differing repeating units.

Oliver MB, van der Linden MP, Küntzel SA, Saad JS, Nahm MH.

J Biol Chem. 2015 Oct 30;290(44):26474-5. doi: 10.1074/jbc.A113.480152. No abstract available.

14.

Structural and Biophysical Characterization of the Interactions between Calmodulin and the Pleckstrin Homology Domain of Akt.

Agamasu C, Ghanam RH, Saad JS.

J Biol Chem. 2015 Nov 6;290(45):27403-13. doi: 10.1074/jbc.M115.673939. Epub 2015 Sep 21.

15.

Editorial: Role of lipids in virus assembly.

Saad JS, Muriaux DM.

Front Microbiol. 2015 May 5;6:410. doi: 10.3389/fmicb.2015.00410. eCollection 2015. No abstract available.

16.

Targeting the Early Step of Building Block Organization in Viral Capsid Assembly.

Lampel A, Bram Y, Ezer A, Shaltiel-Kario R, Saad JS, Bacharach E, Gazit E.

ACS Chem Biol. 2015 Aug 21;10(8):1785-90. doi: 10.1021/acschembio.5b00347. Epub 2015 May 29.

PMID:
25997366
17.

Structural and molecular determinants of HIV-1 Gag binding to the plasma membrane.

Vlach J, Saad JS.

Front Microbiol. 2015 Mar 20;6:232. doi: 10.3389/fmicb.2015.00232. eCollection 2015.

18.

HIV: a vicTIM.

Vlach J, Saad JS.

Trends Microbiol. 2014 Nov;22(11):603-4. doi: 10.1016/j.tim.2014.09.008. Epub 2014 Oct 16.

PMID:
25438615
19.

Solution structure of calmodulin bound to the binding domain of the HIV-1 matrix protein.

Vlach J, Samal AB, Saad JS.

J Biol Chem. 2014 Mar 21;289(12):8697-705. doi: 10.1074/jbc.M113.543694. Epub 2014 Feb 5.

20.

Spectrum of pneumococcal serotype 11A variants results from incomplete loss of capsule O-acetylation.

Calix JJ, Brady AM, Du VY, Saad JS, Nahm MH.

J Clin Microbiol. 2014 Mar;52(3):758-65. doi: 10.1128/JCM.02695-13. Epub 2013 Dec 18.

21.

Discovery of Streptococcus pneumoniae serotype 6 variants with glycosyltransferases synthesizing two differing repeating units.

Oliver MB, van der Linden MP, Küntzel SA, Saad JS, Nahm MH.

J Biol Chem. 2013 Sep 6;288(36):25976-85. doi: 10.1074/jbc.M113.480152. Epub 2013 Jul 29. Erratum in: J Biol Chem. 2015 Oct 30;290(44):26474-5.

22.

Structural and biophysical characterization of the interactions between the death domain of Fas receptor and calmodulin.

Fernandez TF, Samal AB, Bedwell GJ, Chen Y, Saad JS.

J Biol Chem. 2013 Jul 26;288(30):21898-908. doi: 10.1074/jbc.M113.471821. Epub 2013 Jun 11.

23.

Trio engagement via plasma membrane phospholipids and the myristoyl moiety governs HIV-1 matrix binding to bilayers.

Vlach J, Saad JS.

Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3525-30. doi: 10.1073/pnas.1216655110. Epub 2013 Feb 11.

24.
25.

Role of the HIV-1 Matrix Protein in Gag Intracellular Trafficking and Targeting to the Plasma Membrane for Virus Assembly.

Ghanam RH, Samal AB, Fernandez TF, Saad JS.

Front Microbiol. 2012 Feb 17;3:55. doi: 10.3389/fmicb.2012.00055. eCollection 2012.

26.

The Staphylococcus aureus pathogenicity island 1 protein gp6 functions as an internal scaffold during capsid size determination.

Dearborn AD, Spilman MS, Damle PK, Chang JR, Monroe EB, Saad JS, Christie GE, Dokland T.

J Mol Biol. 2011 Sep 30;412(4):710-22. doi: 10.1016/j.jmb.2011.07.036. Epub 2011 Jul 29.

27.

Single-stranded oligonucleotide adducts formed by Pt complexes favoring left-handed base canting: steric effect of flanking residues and relevance to DNA adducts formed by Pt anticancer drugs.

Saad JS, Marzilli PA, Intini FP, Natile G, Marzilli LG.

Inorg Chem. 2011 Sep 5;50(17):8608-20. doi: 10.1021/ic2011716. Epub 2011 Aug 5.

PMID:
21819051
28.

NMR, biophysical, and biochemical studies reveal the minimal Calmodulin binding domain of the HIV-1 matrix protein.

Samal AB, Ghanam RH, Fernandez TF, Monroe EB, Saad JS.

J Biol Chem. 2011 Sep 23;286(38):33533-43. doi: 10.1074/jbc.M111.273623. Epub 2011 Jul 28.

29.

NMR studies of models having the Pt(d(GpG)) 17-membered macrocyclic ring formed in DNA by platinum anticancer drugs: Pt complexes with bulky chiral diamine ligands.

Saad JS, Benedetti M, Natile G, Marzilli LG.

Inorg Chem. 2011 May 16;50(10):4559-71. doi: 10.1021/ic200259s. Epub 2011 Apr 21.

PMID:
21510625
30.

Binding of calmodulin to the HIV-1 matrix protein triggers myristate exposure.

Ghanam RH, Fernandez TF, Fledderman EL, Saad JS.

J Biol Chem. 2010 Dec 31;285(53):41911-20. doi: 10.1074/jbc.M110.179093. Epub 2010 Oct 18.

31.

Myristate exposure in the human immunodeficiency virus type 1 matrix protein is modulated by pH.

Fledderman EL, Fujii K, Ghanam RH, Waki K, Prevelige PE, Freed EO, Saad JS.

Biochemistry. 2010 Nov 9;49(44):9551-62. doi: 10.1021/bi101245j.

32.

Basic coordination chemistry relevant to DNA adducts formed by the cisplatin anticancer drug. NMR studies on compounds with sterically crowded chiral ligands.

Saad JS, Benedetti M, Natile G, Marzilli LG.

Inorg Chem. 2010 Jun 21;49(12):5573-83. doi: 10.1021/ic100494f.

PMID:
20496875
33.

Reverse micelle encapsulation of membrane-anchored proteins for solution NMR studies.

Valentine KG, Peterson RW, Saad JS, Summers MF, Xu X, Ames JB, Wand AJ.

Structure. 2010 Jan 13;18(1):9-16. doi: 10.1016/j.str.2009.11.010.

34.

Targeting of murine leukemia virus gag to the plasma membrane is mediated by PI(4,5)P2/PS and a polybasic region in the matrix.

Hamard-Peron E, Juillard F, Saad JS, Roy C, Roingeard P, Summers MF, Darlix JL, Picart C, Muriaux D.

J Virol. 2010 Jan;84(1):503-15. doi: 10.1128/JVI.01134-09.

36.

Structure of the myristylated human immunodeficiency virus type 2 matrix protein and the role of phosphatidylinositol-(4,5)-bisphosphate in membrane targeting.

Saad JS, Ablan SD, Ghanam RH, Kim A, Andrews K, Nagashima K, Soheilian F, Freed EO, Summers MF.

J Mol Biol. 2008 Oct 3;382(2):434-47. doi: 10.1016/j.jmb.2008.07.027. Epub 2008 Jul 16.

37.

Mutations that mimic phosphorylation of the HIV-1 matrix protein do not perturb the myristyl switch.

Saad JS, Kim A, Ghanam RH, Dalton AK, Vogt VM, Wu Z, Lu W, Summers MF.

Protein Sci. 2007 Aug;16(8):1793-7.

38.

Point mutations in the HIV-1 matrix protein turn off the myristyl switch.

Saad JS, Loeliger E, Luncsford P, Liriano M, Tai J, Kim A, Miller J, Joshi A, Freed EO, Summers MF.

J Mol Biol. 2007 Feb 16;366(2):574-85. Epub 2006 Dec 1.

39.

Structural basis for targeting HIV-1 Gag proteins to the plasma membrane for virus assembly.

Saad JS, Miller J, Tai J, Kim A, Ghanam RH, Summers MF.

Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11364-9. Epub 2006 Jul 13.

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