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Items: 44


An explorative study on deep profiling of peripheral leukocytes to identify predictors for responsiveness to anti-tumour necrosis factor alpha therapies in ankylosing spondylitis: natural killer cells in focus.

Schulte-Wrede U, Sörensen T, Grün JR, Häupl T, Hirseland H, Steinbrich-Zöllner M, Wu P, Radbruch A, Poddubnyy D, Sieper J, Syrbe U, Grützkau A.

Arthritis Res Ther. 2018 Aug 29;20(1):191. doi: 10.1186/s13075-018-1692-y.



Syrbe U, Baraliakos X.

Z Rheumatol. 2018 Nov;77(9):783-788. doi: 10.1007/s00393-018-0475-9. Review. German.


Serum levels of leptin and high molecular weight adiponectin are inversely associated with radiographic spinal progression in patients with ankylosing spondylitis: results from the ENRADAS trial.

Hartl A, Sieper J, Syrbe U, Listing J, Hermann KG, Rudwaleit M, Poddubnyy D.

Arthritis Res Ther. 2017 Jun 15;19(1):140. doi: 10.1186/s13075-017-1350-9.


Synovial cell production of IL-26 induces bone mineralization in spondyloarthritis.

Heftdal LD, Andersen T, Jæhger D, Woetmann A, Østgård R, Kenngott EE, Syrbe U, Sieper J, Hvid M, Deleuran B, Kragstrup TW.

J Mol Med (Berl). 2017 Jul;95(7):779-787. doi: 10.1007/s00109-017-1528-2. Epub 2017 Apr 2.


Gut memories do not fade: epigenetic regulation of lasting gut homing receptor expression in CD4+ memory T cells.

Szilagyi BA, Triebus J, Kressler C, de Almeida M, Tierling S, Durek P, Mardahl M, Szilagyi A, Floess S, Huehn J, Syrbe U, Walter J, Polansky JK, Hamann A.

Mucosal Immunol. 2017 Nov;10(6):1443-1454. doi: 10.1038/mi.2017.7. Epub 2017 Feb 15.


Epigenomic Profiling of Human CD4+ T Cells Supports a Linear Differentiation Model and Highlights Molecular Regulators of Memory Development.

Durek P, Nordström K, Gasparoni G, Salhab A, Kressler C, de Almeida M, Bassler K, Ulas T, Schmidt F, Xiong J, Glažar P, Klironomos F, Sinha A, Kinkley S, Yang X, Arrigoni L, Amirabad AD, Ardakani FB, Feuerbach L, Gorka O, Ebert P, Müller F, Li N, Frischbutter S, Schlickeiser S, Cendon C, Fröhler S, Felder B, Gasparoni N, Imbusch CD, Hutter B, Zipprich G, Tauchmann Y, Reinke S, Wassilew G, Hoffmann U, Richter AS, Sieverling L; DEEP Consortium, Chang HD, Syrbe U, Kalus U, Eils J, Brors B, Manke T, Ruland J, Lengauer T, Rajewsky N, Chen W, Dong J, Sawitzki B, Chung HR, Rosenstiel P, Schulz MH, Schultze JL, Radbruch A, Walter J, Hamann A, Polansky JK.

Immunity. 2016 Nov 15;45(5):1148-1161. doi: 10.1016/j.immuni.2016.10.022.


Imprinting of Skin/Inflammation Homing in CD4+ T Cells Is Controlled by DNA Methylation within the Fucosyltransferase 7 Gene.

Pink M, Ratsch BA, Mardahl M, Durek P, Polansky JK, Karl M, Baumgrass R, Wallner S, Cadenas C, Gianmoena K, Floess S, Chen W, Nordstroem K, Tierling S, Olek S, Walter J, Hamann A, Syrbe U.

J Immunol. 2016 Oct 15;197(8):3406-3414. Epub 2016 Sep 2.


Core 2 ß1,6-N-acetylglucosaminyltransferase-I, crucial for P-selectin ligand expression is controlled by a distal enhancer regulated by STAT4 and T-bet in CD4+ T helper cells 1.

Mardahl M, Schröter MF, Engelbert D, Pink M, Sperandio M, Hamann A, Syrbe U.

Mol Immunol. 2016 Sep;77:132-40. doi: 10.1016/j.molimm.2016.08.001. Epub 2016 Aug 6.


Granulation Tissue Eroding the Subchondral Bone Also Promotes New Bone Formation in Ankylosing Spondylitis.

Bleil J, Maier R, Hempfing A, Sieper J, Appel H, Syrbe U.

Arthritis Rheumatol. 2016 Oct;68(10):2456-65. doi: 10.1002/art.39715.


Anti-RANKL treatment inhibits erosive joint destruction and lowers inflammation but has no effect on bone formation in the delayed-type hypersensitivity arthritis (DTHA) model.

Atkinson SM, Bleil J, Maier R, Kühl AA, Thorn M, Serikawa K, Fox B, Kruse K, Haase C, Skov S, Nansen A, Syrbe U.

Arthritis Res Ther. 2016 Jan 23;18:28. doi: 10.1186/s13075-016-0931-3.


Effect of continuous versus on-demand treatment of ankylosing spondylitis with diclofenac over 2 years on radiographic progression of the spine: results from a randomised multicentre trial (ENRADAS).

Sieper J, Listing J, Poddubnyy D, Song IH, Hermann KG, Callhoff J, Syrbe U, Braun J, Rudwaleit M.

Ann Rheum Dis. 2016 Aug;75(8):1438-43. doi: 10.1136/annrheumdis-2015-207897. Epub 2015 Aug 4.


In vivo pre-activation of monocytes in patients with axial spondyloarthritis.

Conrad K, Wu P, Sieper J, Syrbe U.

Arthritis Res Ther. 2015 Jul 16;17:179. doi: 10.1186/s13075-015-0694-2.


Cartilage in facet joints of patients with ankylosing spondylitis (AS) shows signs of cartilage degeneration rather than chondrocyte hypertrophy: implications for joint remodeling in AS.

Bleil J, Sieper J, Maier R, Schlichting U, Hempfing A, Syrbe U, Appel H.

Arthritis Res Ther. 2015 Jul 17;17:170. doi: 10.1186/s13075-015-0675-5.


In situ analysis of interleukin-6 expression at different sites of zygapophyseal joints from patients with ankylosing spondylitis in comparison to controls.

Bleil J, Maier R, Syrbe U, Sieper J, Appel H.

Scand J Rheumatol. 2015;44(4):296-301. doi: 10.3109/03009742.2014.1000371. Epub 2015 Apr 30.


Serum adipokine levels in patients with ankylosing spondylitis and their relationship to clinical parameters and radiographic spinal progression.

Syrbe U, Callhoff J, Conrad K, Poddubnyy D, Haibel H, Junker S, Frommer KW, Müller-Ladner U, Neumann E, Sieper J.

Arthritis Rheumatol. 2015 Mar;67(3):678-85. doi: 10.1002/art.38968.


Bone marrow Th17 TNFα cells induce osteoclast differentiation and link bone destruction to IBD.

Syrbe U, Siegmund B.

Gut. 2015 Jul;64(7):1011-2. doi: 10.1136/gutjnl-2014-308436. Epub 2014 Nov 12. No abstract available.


Identification of two regulatory elements controlling Fucosyltransferase 7 transcription in murine CD4+ T cells.

Pink M, Ratsch BA, Mardahl M, Schröter MF, Engelbert D, Triebus J, Hamann A, Syrbe U.

Mol Immunol. 2014 Nov;62(1):1-9. doi: 10.1016/j.molimm.2014.05.005. Epub 2014 Jun 7.


Histomorphologic and histomorphometric characteristics of zygapophyseal joint remodeling in ankylosing spondylitis.

Bleil J, Maier R, Hempfing A, Schlichting U, Appel H, Sieper J, Syrbe U.

Arthritis Rheumatol. 2014 Jul;66(7):1745-54. doi: 10.1002/art.38404.


[Epigenetic analyses - new therapeutic approaches for rheumatic diseases?].

Polansky JK, Syrbe U, Hamann A.

Z Rheumatol. 2013 Oct;72(8):804-8. doi: 10.1007/s00393-012-1121-6. German. No abstract available.


Elevated serum level of the vascular endothelial growth factor predicts radiographic spinal progression in patients with axial spondyloarthritis.

Poddubnyy D, Conrad K, Haibel H, Syrbe U, Appel H, Braun J, Rudwaleit M, Sieper J.

Ann Rheum Dis. 2014 Dec;73(12):2137-43. doi: 10.1136/annrheumdis-2013-203824. Epub 2013 Aug 16.


Regulation and migratory role of P-selectin ligands during intestinal inflammation.

Hoffmann U, Pink M, Lauer U, Heimesaat MM, Winsauer C, Kruglov A, Schlawe K, Leichsenring C, Liesenfeld O, Hamann A, Syrbe U.

PLoS One. 2013 Apr 22;8(4):e62055. doi: 10.1371/journal.pone.0062055. Print 2013.


In situ analysis of interleukin-23- and interleukin-12-positive cells in the spine of patients with ankylosing spondylitis.

Appel H, Maier R, Bleil J, Hempfing A, Loddenkemper C, Schlichting U, Syrbe U, Sieper J.

Arthritis Rheum. 2013 Jun;65(6):1522-9. doi: 10.1002/art.37937.


TNF signaling drives myeloid-derived suppressor cell accumulation.

Zhao X, Rong L, Zhao X, Li X, Liu X, Deng J, Wu H, Xu X, Erben U, Wu P, Syrbe U, Sieper J, Qin Z.

J Clin Invest. 2012 Nov;122(11):4094-104. doi: 10.1172/JCI64115. Epub 2012 Oct 15.


Differential synovial Th1 cell reactivity towards Escherichia coli antigens in patients with ankylosing spondylitis and rheumatoid arthritis.

Syrbe U, Scheer R, Wu P, Sieper J.

Ann Rheum Dis. 2012 Sep;71(9):1573-6. doi: 10.1136/annrheumdis-2012-201404. Epub 2012 Jun 26.


Synovial and peripheral blood CD4+FoxP3+ T cells in spondyloarthritis.

Appel H, Wu P, Scheer R, Kedor C, Sawitzki B, Thiel A, Radbruch A, Sieper J, Syrbe U.

J Rheumatol. 2011 Nov;38(11):2445-51. doi: 10.3899/jrheum.110377. Epub 2011 Sep 15.


Impaired peripheral Th1 CD4+ T cell response to Escherichia coli proteins in patients with Crohn's disease and ankylosing spondylitis.

Ergin A, Syrbe U, Scheer R, Thiel A, Adam T, Büssow K, Duchmann R, Zeitz M, Sieper J.

J Clin Immunol. 2011 Dec;31(6):998-1009. doi: 10.1007/s10875-011-9575-x. Epub 2011 Sep 8.


Accumulation and local proliferation of antigen-specific CD4+ T cells in antigen-bearing tissue.

Doebis C, Menning A, Neumann K, Ghani S, Schlawe K, Lauer U, Hamann A, Huehn J, Syrbe U.

Immunol Cell Biol. 2011 May;89(4):566-72. doi: 10.1038/icb.2010.128. Epub 2010 Nov 9.


T cells as pioneers: antigen-specific T cells condition inflamed sites for high-rate antigen-non-specific effector cell recruitment.

Ghani S, Feuerer M, Doebis C, Lauer U, Loddenkemper C, Huehn J, Hamann A, Syrbe U.

Immunology. 2009 Sep;128(1 Suppl):e870-80. doi: 10.1111/j.1365-2567.2009.03096.x. Epub 2009 Mar 26.


[Tissue retention of T cells as a therapeutic target in rheumatoid arthritis].

Syrbe U, Hamann A.

Z Rheumatol. 2009 Oct;68(8):678-82. doi: 10.1007/s00393-009-0496-5. Review. German.


Cellular players and role of selectin ligands in leukocyte recruitment in a T-cell-initiated delayed-type hypersensitivity reaction.

Doebis C, Siegmund K, Loddenkemper C, Lowe JB, Issekutz AC, Hamann A, Huehn J, Syrbe U.

Am J Pathol. 2008 Oct;173(4):1067-76. doi: 10.2353/ajpath.2008.080052. Epub 2008 Aug 28.


Long-term commitment to inflammation-seeking homing in CD4+ effector cells.

Jennrich S, Ratsch BA, Hamann A, Syrbe U.

J Immunol. 2007 Jun 15;178(12):8073-80.


Migration matters: regulatory T-cell compartmentalization determines suppressive activity in vivo.

Siegmund K, Feuerer M, Siewert C, Ghani S, Haubold U, Dankof A, Krenn V, Schön MP, Scheffold A, Lowe JB, Hamann A, Syrbe U, Huehn J.

Blood. 2005 Nov 1;106(9):3097-104. Epub 2005 Jul 12.


Expression of selectin ligands on murine effector and IL-10-producing CD4+ T cells from non-infected and infected tissues.

Kretschmer U, Bonhagen K, Debes GF, Mittrücker HW, Erb KJ, Liesenfeld O, Zaiss D, Kamradt T, Syrbe U, Hamann A.

Eur J Immunol. 2004 Nov;34(11):3070-81.


Differential regulation of P-selectin ligand expression in naive versus memory CD4+ T cells: evidence for epigenetic regulation of involved glycosyltransferase genes.

Syrbe U, Jennrich S, Schottelius A, Richter A, Radbruch A, Hamann A.

Blood. 2004 Nov 15;104(10):3243-8. Epub 2004 Aug 5.


Selectin ligands on T cells.

Hamann A, Syrbe U, Kretschmer U, Jennrich S, Hühn J.

Ernst Schering Res Found Workshop. 2004;(44):1-14. Review. No abstract available.


Enhanced antitumor immunity in mice deficient in CD69.

Esplugues E, Sancho D, Vega-Ramos J, Martínez C, Syrbe U, Hamann A, Engel P, Sánchez-Madrid F, Lauzurica P.

J Exp Med. 2003 May 5;197(9):1093-106.


T-cell trafficking into sites of inflammation.

Hamann A, Syrbe U.

Rheumatology (Oxford). 2000 Jul;39(7):696-9. No abstract available.


Th1/Th2 subsets: distinct differences in homing and chemokine receptor expression?

Syrbe U, Siveke J, Hamann A.

Springer Semin Immunopathol. 1999;21(3):263-85. Review.


Monocyte deactivation in septic patients: restoration by IFN-gamma treatment.

Döcke WD, Randow F, Syrbe U, Krausch D, Asadullah K, Reinke P, Volk HD, Kox W.

Nat Med. 1997 Jun;3(6):678-81.


Mechanism of endotoxin desensitization: involvement of interleukin 10 and transforming growth factor beta.

Randow F, Syrbe U, Meisel C, Krausch D, Zuckermann H, Platzer C, Volk HD.

J Exp Med. 1995 May 1;181(5):1887-92.


Cytomegalovirus reactivation and tumour necrosis factor.

Döcke WD, Prösch S, Fietze E, Kimel V, Zuckermann H, Klug C, Syrbe U, Krüger DH, von Baehr R, Volk HD.

Lancet. 1994 Jan 29;343(8892):268-9.


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