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Items: 40


Coupling to Gq Signaling Is Required for Cardioprotection by an Alpha-1A-Adrenergic Receptor Agonist.

Myagmar BE, Ismaili T, Swigart PM, Raghunathan A, Baker AJ, Sahdeo S, Blevitt JM, Milla ME, Simpson PC.

Circ Res. 2019 Sep 13;125(7):699-706. doi: 10.1161/CIRCRESAHA.118.314416. Epub 2019 Aug 20.


Reversal of right ventricular failure by chronic α1A-subtype adrenergic agonist therapy.

Cowley PM, Wang G, Swigart PM, Raghunathan A, Reddy N, Dulam P, Lovett DH, Simpson PC, Baker AJ.

Am J Physiol Heart Circ Physiol. 2019 Jan 1;316(1):H224-H232. doi: 10.1152/ajpheart.00507.2018. Epub 2018 Nov 9.


α1A-Subtype adrenergic agonist therapy for the failing right ventricle.

Cowley PM, Wang G, Joshi S, Swigart PM, Lovett DH, Simpson PC, Baker AJ.

Am J Physiol Heart Circ Physiol. 2017 Dec 1;313(6):H1109-H1118. doi: 10.1152/ajpheart.00153.2017. Epub 2017 Aug 19.


Novel large-particle FACS purification of adult ventricular myocytes reveals accumulation of myosin and actin disproportionate to cell size and proteome in normal post-weaning development.

López JE, Sharma J, Avila J, Wood TS, VanDyke JE, McLaughlin B, Abbey CK, Wong A, Myagmar BE, Swigart PM, Simpson PC, Chiamvimonvat N.

J Mol Cell Cardiol. 2017 Oct;111:114-122. doi: 10.1016/j.yjmcc.2017.07.012. Epub 2017 Aug 2.


Adrenergic Receptors in Individual Ventricular Myocytes: The Beta-1 and Alpha-1B Are in All Cells, the Alpha-1A Is in a Subpopulation, and the Beta-2 and Beta-3 Are Mostly Absent.

Myagmar BE, Flynn JM, Cowley PM, Swigart PM, Montgomery MD, Thai K, Nair D, Gupta R, Deng DX, Hosoda C, Melov S, Baker AJ, Simpson PC.

Circ Res. 2017 Mar 31;120(7):1103-1115. doi: 10.1161/CIRCRESAHA.117.310520. Epub 2017 Feb 20.


An Alpha-1A Adrenergic Receptor Agonist Prevents Acute Doxorubicin Cardiomyopathy in Male Mice.

Montgomery MD, Chan T, Swigart PM, Myagmar BE, Dash R, Simpson PC.

PLoS One. 2017 Jan 12;12(1):e0168409. doi: 10.1371/journal.pone.0168409. eCollection 2017.


A Myocardial Slice Culture Model Reveals Alpha-1A-Adrenergic Receptor Signaling in the Human Heart.

Thomas RC, Singh A, Cowley P, Myagmar BE, Montgomery MD, Swigart PM, De Marco T, Baker AJ, Simpson PC.

JACC Basic Transl Sci. 2016 Apr;1(3):155-167.


The Alpha-1A Adrenergic Receptor in the Rabbit Heart.

Thomas RC Jr, Cowley PM, Singh A, Myagmar BE, Swigart PM, Baker AJ, Simpson PC.

PLoS One. 2016 Jun 3;11(6):e0155238. doi: 10.1371/journal.pone.0155238. eCollection 2016.


The α1A-adrenergic receptor subtype mediates increased contraction of failing right ventricular myocardium.

Cowley PM, Wang G, Chang AN, Makwana O, Swigart PM, Lovett DH, Stull JT, Simpson PC, Baker AJ.

Am J Physiol Heart Circ Physiol. 2015 Sep;309(5):H888-96. doi: 10.1152/ajpheart.00042.2015. Epub 2015 Jun 26.


β-myosin heavy chain is induced by pressure overload in a minor subpopulation of smaller mouse cardiac myocytes.

López JE, Myagmar BE, Swigart PM, Montgomery MD, Haynam S, Bigos M, Rodrigo MC, Simpson PC.

Circ Res. 2011 Sep 2;109(6):629-38. doi: 10.1161/CIRCRESAHA.111.243410. Epub 2011 Jul 21.


Functional alpha-1B adrenergic receptors on human epicardial coronary artery endothelial cells.

Jensen BC, Swigart PM, Montgomery MD, Simpson PC.

Naunyn Schmiedebergs Arch Pharmacol. 2010 Dec;382(5-6):475-82. doi: 10.1007/s00210-010-0558-x. Epub 2010 Sep 22.


Distinctive ERK and p38 signaling in remote and infarcted myocardium during post-MI remodeling in the mouse.

Yeh CC, Li H, Malhotra D, Turcato S, Nicholas S, Tu R, Zhu BQ, Cha J, Swigart PM, Myagmar BE, Baker AJ, Simpson PC, Mann MJ.

J Cell Biochem. 2010 Apr 15;109(6):1185-91. doi: 10.1002/jcb.22498.


{alpha}1-Adrenergic receptor subtypes in nonfailing and failing human myocardium.

Jensen BC, Swigart PM, De Marco T, Hoopes C, Simpson PC.

Circ Heart Fail. 2009 Nov;2(6):654-63. doi: 10.1161/CIRCHEARTFAILURE.108.846212. Epub 2009 Aug 6.


The alpha-1D Is the predominant alpha-1-adrenergic receptor subtype in human epicardial coronary arteries.

Jensen BC, Swigart PM, Laden ME, DeMarco T, Hoopes C, Simpson PC.

J Am Coll Cardiol. 2009 Sep 22;54(13):1137-45. doi: 10.1016/j.jacc.2009.05.056.


Ten commercial antibodies for alpha-1-adrenergic receptor subtypes are nonspecific.

Jensen BC, Swigart PM, Simpson PC.

Naunyn Schmiedebergs Arch Pharmacol. 2009 Apr;379(4):409-12. doi: 10.1007/s00210-008-0368-6. Epub 2008 Nov 7.


Contrasting inotropic responses to alpha1-adrenergic receptor stimulation in left versus right ventricular myocardium.

Wang GY, McCloskey DT, Turcato S, Swigart PM, Simpson PC, Baker AJ.

Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H2013-7. Epub 2006 May 26.


Alpha1-adrenergic receptors prevent a maladaptive cardiac response to pressure overload.

O'Connell TD, Swigart PM, Rodrigo MC, Ishizaka S, Joho S, Turnbull L, Tecott LH, Baker AJ, Foster E, Grossman W, Simpson PC.

J Clin Invest. 2006 Apr;116(4):1005-15.


Measurement of phospholipase C by monitoring inositol phosphates using [3H]inositol-labeling protocols in permeabilized cells.

Skippen A, Swigart P, Cockcroft S.

Methods Mol Biol. 2006;312:183-93. No abstract available.


Sustained preconditioning induced by cardiac transgenesis with the tetracycline transactivator.

Turnbull L, Zhou HZ, Swigart PM, Turcato S, Karliner JS, Conklin BR, Simpson PC, Baker AJ.

Am J Physiol Heart Circ Physiol. 2006 Mar;290(3):H1103-9. Epub 2005 Oct 21.


Cardiac transgenic matrix metalloproteinase-2 expression directly induces impaired contractility.

Wang GY, Bergman MR, Nguyen AP, Turcato S, Swigart PM, Rodrigo MC, Simpson PC, Karliner JS, Lovett DH, Baker AJ.

Cardiovasc Res. 2006 Feb 15;69(3):688-96. Epub 2005 Sep 23.


Cardiac transgenesis with the tetracycline transactivator changes myocardial function and gene expression.

McCloskey DT, Turnbull L, Swigart PM, Zambon AC, Turcato S, Joho S, Grossman W, Conklin BR, Simpson PC, Baker AJ.

Physiol Genomics. 2005 Jun 16;22(1):118-26. Epub 2005 Mar 29.


Measurement of phospholipase C by monitoring inositol phosphates using [³H]inositol-labeling protocols in permeabilized cells.

Skippen A, Swigart P, Cockcroft S.

Methods Mol Biol. 2005;312:183-93. doi: 10.1385/1-59259-949-4:183.


Structure-function analysis of human [corrected] phosphatidylinositol transfer protein alpha bound to phosphatidylinositol.

Tilley SJ, Skippen A, Murray-Rust J, Swigart PM, Stewart A, Morgan CP, Cockcroft S, McDonald NQ.

Structure. 2004 Feb;12(2):317-26. Erratum in: Structure (Camb). 2004 May;12(5):907.


Abnormal myocardial contraction in alpha(1A)- and alpha(1B)-adrenoceptor double-knockout mice.

McCloskey DT, Turnbull L, Swigart P, O'Connell TD, Simpson PC, Baker AJ.

J Mol Cell Cardiol. 2003 Oct;35(10):1207-16.


The alpha(1A/C)- and alpha(1B)-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse.

O'Connell TD, Ishizaka S, Nakamura A, Swigart PM, Rodrigo MC, Simpson GL, Cotecchia S, Rokosh DG, Grossman W, Foster E, Simpson PC.

J Clin Invest. 2003 Jun;111(11):1783-91.


Co-operation of phosphatidylinositol transfer protein with phosphoinositide 3-kinase gamma in vitro.

Kular GS, Chaudhary A, Prestwich G, Swigart P, Wetzker R, Cockcroft S.

Adv Enzyme Regul. 2002;42:53-61. No abstract available.


Yeast Sec14p deficient in phosphatidylinositol transfer activity is functional in vivo.

Phillips SE, Sha B, Topalof L, Xie Z, Alb JG, Klenchin VA, Swigart P, Cockcroft S, Martin TF, Luo M, Bankaitis VA.

Mol Cell. 1999 Aug;4(2):187-97.


Measurement of inositol (poly)phosphate formation using [3H]inositol labeling protocols in permeabilized cells.

Swigart P, Cockcroft S.

Methods Mol Biol. 1999;114:165-73. Review. No abstract available.


Phosphatidylinositol transfer proteins: an essential requirement in inositol lipid signalling.

Cockcroft S, Ball A, Fensome A, Hara S, Jones D, Prosser S, Swigart P.

Biochem Soc Trans. 1997 Nov;25(4):1125-31. Review. No abstract available.


Regulation of inositol lipid-specific phospholipase cdelta by changes in Ca2+ ion concentrations.

Allen V, Swigart P, Cheung R, Cockcroft S, Katan M.

Biochem J. 1997 Oct 15;327 ( Pt 2):545-52.


ARF and PITP restore GTP gamma S-stimulated protein secretion from cytosol-depleted HL60 cells by promoting PIP2 synthesis.

Fensome A, Cunningham E, Prosser S, Tan SK, Swigart P, Thomas G, Hsuan J, Cockcroft S.

Curr Biol. 1996 Jun 1;6(6):730-8.


Carboxyl-terminal domains in the avian beta 1-adrenergic receptor that regulate agonist-promoted endocytosis.

Parker EM, Swigart P, Nunnally MH, Perkins JP, Ross EM.

J Biol Chem. 1995 Mar 24;270(12):6482-7. Erratum in: J Biol Chem 1995 Apr 28;270(17):10358.

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