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Items: 1 to 50 of 221

1.

A key role for interferon regulatory factors in mediating early-life metabolic defects in male offspring of maternal protein restricted rats.

Silvestre MF, Kieswich J, Yaqoob MM, Holness MJ, Sugden MC, Caton PW.

Horm Metab Res. 2014 Apr;46(4):252-8. doi: 10.1055/s-0034-1370933. Epub 2014 Mar 13.

PMID:
24627105
2.

The AMPK-SIRT signaling network regulates glucose tolerance under calorie restriction conditions.

Silvestre MF, Viollet B, Caton PW, Leclerc J, Sakakibara I, Foretz M, Holness MC, Sugden MC.

Life Sci. 2014 Mar 28;100(1):55-60. doi: 10.1016/j.lfs.2014.01.080. Epub 2014 Feb 13.

PMID:
24530742
3.

Sirtuin 3 regulates mouse pancreatic beta cell function and is suppressed in pancreatic islets isolated from human type 2 diabetic patients.

Caton PW, Richardson SJ, Kieswich J, Bugliani M, Holland ML, Marchetti P, Morgan NG, Yaqoob MM, Holness MJ, Sugden MC.

Diabetologia. 2013 May;56(5):1068-77. doi: 10.1007/s00125-013-2851-y. Epub 2013 Feb 9.

PMID:
23397292
4.

Metformin, metabolic stress, and mitochondria. Focus on "A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells".

Sugden MC, Holness MJ.

Am J Physiol Cell Physiol. 2012 Jul 1;303(1):C1-3. doi: 10.1152/ajpcell.00090.2012. Epub 2012 Mar 21. No abstract available.

5.

Actions and interactions of AMPK with insulin, the peroxisomal-proliferator activated receptors and sirtuins.

Holness MJ, Sugden PH, Silvestre MF, Sugden MC.

Expert Rev Endocrinol Metab. 2012 Mar;7(2):191-208. doi: 10.1586/eem.12.9.

PMID:
30764011
6.

Damaging loss of self-control by stressed β-cells.

Holness MJ, Sugden MC.

Diabetes. 2012 Feb;61(2):267-9. doi: 10.2337/db11-1647. No abstract available.

7.

Adipocyte pyruvate dehydrogenase kinase 4 expression is associated with augmented PPARγ upregulation in early-life programming of later obesity.

Holness MJ, Zariwala G, Walker CG, Sugden MC.

FEBS Open Bio. 2012 Mar 5;2:32-6. doi: 10.1016/j.fob.2012.02.003. Print 2012.

8.

The involvement of PPARs in the causes, consequences and mechanisms for correction of cardiac lipotoxicity and oxidative stress.

Sugden MC, Warlow MP, Holness MJ.

Curr Mol Pharmacol. 2012 Jun;5(2):224-40. Review.

PMID:
22122452
9.

Endogenous epoxygenases are modulators of monocyte/macrophage activity.

Bystrom J, Wray JA, Sugden MC, Holness MJ, Swales KE, Warner TD, Edin ML, Zeldin DC, Gilroy DW, Bishop-Bailey D.

PLoS One. 2011;6(10):e26591. doi: 10.1371/journal.pone.0026591. Epub 2011 Oct 19.

10.

The pyruvate carboxylase-pyruvate dehydrogenase axis in islet pyruvate metabolism: Going round in circles?

Sugden MC, Holness MJ.

Islets. 2011 Nov-Dec;3(6):302-19. doi: 10.4161/isl.3.6.17806. Epub 2011 Nov 1. Review.

11.

Signalling satiety and starvation to β-Cell insulin secretion.

Holness MJ, Hegazy S, Sugden MC.

Curr Diabetes Rev. 2011 Sep;7(5):336-45. Review.

PMID:
21916833
12.

Nicotinamide mononucleotide protects against pro-inflammatory cytokine-mediated impairment of mouse islet function.

Caton PW, Kieswich J, Yaqoob MM, Holness MJ, Sugden MC.

Diabetologia. 2011 Dec;54(12):3083-92. doi: 10.1007/s00125-011-2288-0. Epub 2011 Sep 8.

PMID:
21901281
13.

Metformin opposes impaired AMPK and SIRT1 function and deleterious changes in core clock protein expression in white adipose tissue of genetically-obese db/db mice.

Caton PW, Kieswich J, Yaqoob MM, Holness MJ, Sugden MC.

Diabetes Obes Metab. 2011 Dec;13(12):1097-104. doi: 10.1111/j.1463-1326.2011.01466.x.

PMID:
21733059
14.

PPARα-LXR as a novel metabolostatic signalling axis in skeletal muscle that acts to optimize substrate selection in response to nutrient status.

Caton PW, Holness MJ, Bishop-Bailey D, Sugden MC.

Biochem J. 2011 Aug 1;437(3):521-30. doi: 10.1042/BJ20110702.

PMID:
21609322
15.

Pyruvate dehydrogenase kinase 1 controls mitochondrial metabolism and insulin secretion in INS-1 832/13 clonal beta-cells.

Krus U, Kotova O, Spégel P, Hallgard E, Sharoyko VV, Vedin A, Moritz T, Sugden MC, Koeck T, Mulder H.

Biochem J. 2010 Jul 1;429(1):205-13. doi: 10.1042/BJ20100142.

PMID:
20415663
16.

Acute and long-term nutrient-led modifications of gene expression: potential role of SIRT1 as a central co-ordinator of short and longer-term programming of tissue function.

Holness MJ, Caton PW, Sugden MC.

Nutrition. 2010 May;26(5):491-501. doi: 10.1016/j.nut.2009.09.012. Epub 2010 Jan 25. Review.

PMID:
20097539
17.

The epoxygenases CYP2J2 activates the nuclear receptor PPARalpha in vitro and in vivo.

Wray JA, Sugden MC, Zeldin DC, Greenwood GK, Samsuddin S, Miller-Degraff L, Bradbury JA, Holness MJ, Warner TD, Bishop-Bailey D.

PLoS One. 2009 Oct 12;4(10):e7421. doi: 10.1371/journal.pone.0007421.

18.

PPAR control: it's SIRTainly as easy as PGC.

Sugden MC, Caton PW, Holness MJ.

J Endocrinol. 2010 Feb;204(2):93-104. doi: 10.1677/JOE-09-0359. Epub 2009 Sep 21. Review.

PMID:
19770177
19.

PPARs and the orchestration of metabolic fuel selection.

Sugden MC, Zariwala MG, Holness MJ.

Pharmacol Res. 2009 Sep;60(3):141-50. doi: 10.1016/j.phrs.2009.03.014. Epub 2009 Apr 2. Review.

PMID:
19646653
20.

The role of PPARs in modulating cardiac metabolism in diabetes.

Holness MJ, Samsuddin S, Sugden MC.

Pharmacol Res. 2009 Sep;60(3):185-94. doi: 10.1016/j.phrs.2009.04.006. Epub 2009 Apr 17. Review.

PMID:
19376230
21.

PPARalpha activation and increased dietary lipid oppose thyroid hormone signaling and rescue impaired glucose-stimulated insulin secretion in hyperthyroidism.

Holness MJ, Greenwood GK, Smith ND, Sugden MC.

Am J Physiol Endocrinol Metab. 2008 Dec;295(6):E1380-9. doi: 10.1152/ajpendo.90700.2008. Epub 2008 Oct 14.

22.

Role of nuclear receptors in the modulation of insulin secretion in lipid-induced insulin resistance.

Sugden MC, Holness MJ.

Biochem Soc Trans. 2008 Oct;36(Pt 5):891-900. doi: 10.1042/BST0360891. Review.

PMID:
18793157
23.

PDC deletion: the way to a man's heart disease.

Sugden MC.

Am J Physiol Heart Circ Physiol. 2008 Sep;295(3):H917-H919. doi: 10.1152/ajpheart.00663.2008. Epub 2008 Jul 18. No abstract available.

24.

In appreciation of Sir Philip Randle: the glucose-fatty acid cycle.

Sugden MC.

Br J Nutr. 2007 May;97(5):809-13.

PMID:
17408519
25.

Peroxisome proliferator-activated receptor alpha deficiency modifies glucose handling by isolated mouse adipocytes.

Walker CG, Sugden MC, Gibbons GF, Holness MJ.

J Endocrinol. 2007 Apr;193(1):39-43.

PMID:
17400801
26.
27.

PPARalpha activation reverses adverse effects induced by high-saturated-fat feeding on pancreatic beta-cell function in late pregnancy.

Holness MJ, Smith ND, Greenwood GK, Sugden MC.

Am J Physiol Endocrinol Metab. 2007 Apr;292(4):E1087-94. Epub 2006 Dec 12.

28.

Diet, obesity and diabetes: a current update.

Walker CG, Zariwala MG, Holness MJ, Sugden MC.

Clin Sci (Lond). 2007 Jan;112(2):93-111. Review.

PMID:
17155931
29.

Mechanisms underlying regulation of the expression and activities of the mammalian pyruvate dehydrogenase kinases.

Sugden MC, Holness MJ.

Arch Physiol Biochem. 2006 Jul;112(3):139-49. Review.

PMID:
17132539
30.
31.

Epigenetic regulation of metabolism in children born small for gestational age.

Holness MJ, Sugden MC.

Curr Opin Clin Nutr Metab Care. 2006 Jul;9(4):482-8. Review.

PMID:
16778581
32.

Hyperthyroidism impairs pancreatic beta cell adaptations to late pregnancy and maternal liporegulation in the rat.

Holness MJ, Greenwood GK, Smith ND, Sugden MC.

Diabetologia. 2005 Nov;48(11):2305-12. Epub 2005 Oct 5.

PMID:
16205881
35.
36.

Regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation.

Holness MJ, Sugden MC.

Biochem Soc Trans. 2003 Dec;31(Pt 6):1143-51. Review.

PMID:
14641014
37.
38.
40.

Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs.

Sugden MC, Holness MJ.

Am J Physiol Endocrinol Metab. 2003 May;284(5):E855-62. Review.

41.

Control of cardiac pyruvate dehydrogenase activity in peroxisome proliferator-activated receptor-alpha transgenic mice.

Hopkins TA, Sugden MC, Holness MJ, Kozak R, Dyck JR, Lopaschuk GD.

Am J Physiol Heart Circ Physiol. 2003 Jul;285(1):H270-6. Epub 2003 Mar 27.

42.

PDK4: A factor in fatness?

Sugden MC.

Obes Res. 2003 Feb;11(2):167-9. Review. No abstract available.

45.

Therapeutic potential of the mammalian pyruvate dehydrogenase kinases in the prevention of hyperglycaemia.

Sugden MC, Holness MJ.

Curr Drug Targets Immune Endocr Metabol Disord. 2002 Jul;2(2):151-65. Review.

PMID:
12476789
46.

Gender-specific programming of insulin secretion and action.

Sugden MC, Holness MJ.

J Endocrinol. 2002 Dec;175(3):757-67.

PMID:
12475386

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