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Items: 1 to 50 of 91

1.

Phospholipase A2 inhibitors in the treatment of atherosclerosis: a new approach moves forward in the clinic.

Suckling KE.

Expert Opin Investig Drugs. 2009 Oct;18(10):1425-30. doi: 10.1517/13543780903184583.

PMID:
19691442
2.

Legumain and cathepsin-L expression in human unstable carotid plaque.

Mattock KL, Gough PJ, Humphries J, Burnand K, Patel L, Suckling KE, Cuello F, Watts C, Gautel M, Avkiran M, Smith A.

Atherosclerosis. 2010 Jan;208(1):83-9. doi: 10.1016/j.atherosclerosis.2009.07.022. Epub 2009 Aug 9.

PMID:
19671471
3.

Oxidation of chylomicron remnant-like particles inhibits their uptake by THP-1 macrophages by apolipoprotein E-dependent processes.

Bejta F, Moore EH, Avella M, Gough PJ, Suckling KE, Botham KM.

Biochim Biophys Acta. 2007 Jul;1771(7):901-10. Epub 2007 May 3.

4.

The return of two old targets?

Suckling KE.

Expert Opin Ther Targets. 2006 Dec;10(6):785-8. Review.

PMID:
17105365
5.

Novel candidate genes in unstable areas of human atherosclerotic plaques.

Papaspyridonos M, Smith A, Burnand KG, Taylor P, Padayachee S, Suckling KE, James CH, Greaves DR, Patel L.

Arterioscler Thromb Vasc Biol. 2006 Aug;26(8):1837-44. Epub 2006 Jun 1.

PMID:
16741146
6.

Efflux of lipid from macrophages after induction of lipid accumulation by chylomicron remnants.

Moore EH, Bejta F, Avella M, Suckling KE, Botham KM.

Biochim Biophys Acta. 2005 Jun 15;1735(1):20-9.

PMID:
15951238
7.

Characterisation of the lipoprotein structure in the St. Thomas' Mixed Hyperlipidaemic (SMHL) rabbit.

de Roos B, Caslake MJ, Milliner K, Benson GM, Suckling KE, Packard CJ.

Atherosclerosis. 2005 Jul;181(1):63-8. Epub 2005 Feb 12.

PMID:
15939055
8.

The PPARdelta agonist GW0742X reduces atherosclerosis in LDLR(-/-) mice.

Graham TL, Mookherjee C, Suckling KE, Palmer CN, Patel L.

Atherosclerosis. 2005 Jul;181(1):29-37. Erratum in: Atherosclerosis. 2005 Oct;182(2):381.

PMID:
15939051
9.

Short term arterial remodelling in the aortae of cholesterol fed New Zealand white rabbits shown in vivo by high-resolution magnetic resonance imaging - implications for human pathology.

Hegyi L, Hockings PD, Benson MG, Busza AL, Overend P, Grimsditch DC, Burton KJ, Lloyd H, Whelan GA, Skepper JN, Vidgeon-Hart MP, Carpenter AT, Reid DG, Suckling KE, Weissberg PL.

Pathol Oncol Res. 2004;10(3):159-65. Epub 2004 Sep 25.

10.
11.

Differential effects of low-density lipoprotein and chylomicron remnants on lipid accumulation in human macrophages.

Batt KV, Avella M, Moore EH, Jackson B, Suckling KE, Botham KM.

Exp Biol Med (Maywood). 2004 Jun;229(6):528-37.

PMID:
15169972
12.
13.

Incorporation of lycopene into chylomicron remnant-like particles enhances their induction of lipid accumulation in macrophages.

Moore EH, Napolitano M, Prosperi A, Avella M, Suckling KE, Bravo E, Botham KM.

Biochem Biophys Res Commun. 2003 Dec 26;312(4):1216-9.

PMID:
14652003
14.

Repeated three-dimensional magnetic resonance imaging of atherosclerosis development in innominate arteries of low-density lipoprotein receptor-knockout mice.

Hockings PD, Roberts T, Galloway GJ, Reid DG, Harris DA, Vidgeon-Hart M, Groot PH, Suckling KE, Benson GM.

Circulation. 2002 Sep 24;106(13):1716-21.

PMID:
12270868
15.

Lipoprotein-associated phospholipase A2: a target directed at the atherosclerotic plaque.

Suckling KE, Macphee CH.

Expert Opin Ther Targets. 2002 Jun;6(3):309-14. Review.

PMID:
12223071
16.

The peroxisome proliferator-activated receptor delta promotes lipid accumulation in human macrophages.

Vosper H, Patel L, Graham TL, Khoudoli GA, Hill A, Macphee CH, Pinto I, Smith SA, Suckling KE, Wolf CR, Palmer CN.

J Biol Chem. 2001 Nov 23;276(47):44258-65. Epub 2001 Sep 13.

17.

Insulin resistance in the St. Thomas' mixed hyperlipidaemic (SMHL) rabbit, a model for familial combined hyperlipidaemia.

de Roos B, Caslake MJ, Ardern HA, Martin Benson G, Suckling KE, Packard CJ.

Atherosclerosis. 2001 Jun;156(2):249-54.

PMID:
11395020
18.

Lipoprotein-associated phospholipase A2 as an independent predictor of coronary heart disease. West of Scotland Coronary Prevention Study Group.

Packard CJ, O'Reilly DS, Caslake MJ, McMahon AD, Ford I, Cooney J, Macphee CH, Suckling KE, Krishna M, Wilkinson FE, Rumley A, Lowe GD.

N Engl J Med. 2000 Oct 19;343(16):1148-55.

19.

Lipoprotein-associated phospholipase A(2), platelet-activating factor acetylhydrolase: a potential new risk factor for coronary artery disease.

Caslake MJ, Packard CJ, Suckling KE, Holmes SD, Chamberlain P, Macphee CH.

Atherosclerosis. 2000 Jun;150(2):413-9.

PMID:
10856534
20.

Hypocholesterolaemic and antiatherosclerotic effects of tetra-iso-propyl 2-(3,5-di-tert-butyl-4-hydroxyphenyl)ethyl-1,1-diphosphonate (SR-9223i).

Jackson B, Gee AN, Guyon-Gellin Y, Niesor E, Bentzen CL, Kerns WD, Suckling KE.

Arzneimittelforschung. 2000 Apr;50(4):380-6.

PMID:
10800637
21.

Apolipoprotein B overproduction by the perfused liver of the St. Thomas' mixed hyperlipidemic (SMHL) rabbit.

Ardern HA, Benson GM, Suckling KE, Caslake MJ, Shepherd J, Packard CJ.

J Lipid Res. 1999 Dec;40(12):2234-43.

22.

Lipoprotein-associated phospholipase A2, platelet-activating factor acetylhydrolase, generates two bioactive products during the oxidation of low-density lipoprotein: use of a novel inhibitor.

MacPhee CH, Moores KE, Boyd HF, Dhanak D, Ife RJ, Leach CA, Leake DS, Milliner KJ, Patterson RA, Suckling KE, Tew DG, Hickey DM.

Biochem J. 1999 Mar 1;338 ( Pt 2):479-87.

23.

Effect of probucol on serum lipids, atherosclerosis and toxicology in fat-fed LDL receptor deficient mice.

Benson GM, Schiffelers R, Nicols C, Latcham J, Vidgeon-Hart M, Toseland CD, Suckling KE, Groot PH.

Atherosclerosis. 1998 Dec;141(2):237-47.

PMID:
9862172
24.

SR-12813 lowers plasma cholesterol in beagle dogs by decreasing cholesterol biosynthesis.

Berkhout TA, Simon HM, Jackson B, Yates J, Pearce N, Groot PH, Bentzen C, Niesor E, Kerns WD, Suckling KE.

Atherosclerosis. 1997 Sep;133(2):203-12.

PMID:
9298680
25.

SK&F 97426-A: a novel bile acid sequestrant with higher affinities and slower dissociation rates for bile acids in vitro than cholestyramine.

Benson GM, Alston DR, Hickey DM, Jaxa-Chamiec AA, Whittaker CM, Haynes C, Glen A, Blanchard S, Cresswell SR, Suckling KE.

J Pharm Sci. 1997 Jan;86(1):76-81.

PMID:
9002463
26.
27.

Effects of novel synthetic sterol probes on enzymes of cholesterol metabolism in cell-free and cellular systems.

Harte RA, Yeaman SJ, McElhinney J, Suckling CJ, Jackson B, Suckling KE.

Chem Phys Lipids. 1996 Sep 16;83(1):45-59.

PMID:
8858832
28.

Cyclic AMP analogues stimulate triacylglycerol synthesis but not cholesterol esterification in J774 macrophages.

Jones AK, Jackson B, Botham KM, Suckling KE.

Biochem Soc Trans. 1996 Aug;24(3):440S. No abstract available.

PMID:
8878984
29.

The novel cholesterol-lowering drug SR-12813 inhibits cholesterol synthesis via an increased degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

Berkhout TA, Simon HM, Patel DD, Bentzen C, Niesor E, Jackson B, Suckling KE.

J Biol Chem. 1996 Jun 14;271(24):14376-82.

30.

Comparison of the effects of cyclic AMP analogues on cholesterol metabolism in cultured rat and hamster hepatocytes.

Botham KM, Hoang VQ, Jones AK, Martinez MJ, Ochoa B, Suckling KE.

Comp Biochem Physiol B Biochem Mol Biol. 1996 Jan;113(1):185-91.

PMID:
8936053
31.

Effect of membrane environment on inhibition of acyl-CoA:cholesterol acyltransferase by a range of synthetic inhibitors.

Harte RA, Yeaman SJ, Jackson B, Suckling KE.

Biochim Biophys Acta. 1995 Oct 5;1258(3):241-50.

PMID:
7548193
32.

Time-course studies by neutron solution scattering and biochemical assays of the aggregation of human low-density lipoprotein during Cu(2+)-induced oxidation.

Meyer DF, Mayans MO, Groot PH, Suckling KE, Bruckdorfer KR, Perkins SJ.

Biochem J. 1995 Sep 1;310 ( Pt 2):417-26.

33.

Evaluation of cultured hamster hepatocytes as an experimental model for the study of very low density lipoprotein secretion.

Hoang VQ, Pearce NJ, Suckling KE, Botham KM.

Biochim Biophys Acta. 1995 Jan 3;1254(1):37-44.

PMID:
7811744
34.

Atherosclerosis patents: clues to the next drug generation.

Suckling KE.

Biotechnology (N Y). 1994 Dec;12(13):1379-80. No abstract available.

PMID:
7765570
35.

Bile acid synthesis in hamster hepatocytes in primary culture: sources of cholesterol and comparison with other species.

Hoang VQ, Botham KM, Benson GM, Eldredge EE, Jackson B, Pearce N, Suckling KE.

Biochim Biophys Acta. 1993 Dec 2;1210(1):73-80.

PMID:
8257721
36.

Polydeoxycholate in human and hamster feces: a major product of cholate metabolism.

Benson GM, Haskins NJ, Eckers C, Moore PJ, Reid DG, Mitchell RC, Waghmare S, Suckling KE.

J Lipid Res. 1993 Dec;34(12):2121-34.

37.
38.

Emerging strategies for the treatment of atherosclerosis as seen from the patent literature.

Suckling KE.

Biochem Soc Trans. 1993 Aug;21 ( Pt 3)(3):660-2. Review. No abstract available.

PMID:
8224485
39.

Differences in the potency of ACAT inhibitors in two assay systems.

Harte RA, Jackson B, Suckling KE, Yeaman SJ.

Biochem Soc Trans. 1993 Aug;21 ( Pt 3)(3):325S. No abstract available.

PMID:
8224469
40.

The regulation of bile acid synthesis in cultured hamster hepatocytes.

Hoang VQ, Botham KM, Pearce NJ, Suckling KE.

Biochem Soc Trans. 1993 Aug;21 ( Pt 3)(3):284S. No abstract available.

PMID:
8224434
41.

Animal models of human lipid metabolism.

Suckling KE, Jackson B.

Prog Lipid Res. 1993;32(1):1-24. Review. No abstract available.

PMID:
8415795
42.

Lipoprotein secretion by cultured hamster hepatocytes.

Hoang VQ, Suckling KE, Botham KM.

Biochem Soc Trans. 1992 Nov;20(4):337S. No abstract available.

PMID:
1487002
43.

Cholesterol metabolism in cultured hamster hepatocytes.

Hoang VQ, Fry RP, Suckling KE, Botham KM.

Biochem Soc Trans. 1992 May;20(2):100S. No abstract available.

PMID:
1397510
44.

Effects of cholestyramine on lipoprotein levels and metabolism in Syrian hamsters.

Groot PH, Pearce NJ, Suckling KE, Eisenberg S.

Biochim Biophys Acta. 1992 Jan 3;1123(1):76-84.

PMID:
1730048
45.

Cholesterol lowering and bile acid excretion in the hamster with cholestyramine treatment.

Suckling KE, Benson GM, Bond B, Gee A, Glen A, Haynes C, Jackson B.

Atherosclerosis. 1991 Aug;89(2-3):183-90.

PMID:
1793446
46.

cDNA and deduced amino acid sequence of a novel cytochrome P-450 from female rat liver mRNA with high homology to P-450 IIC family.

Cook EA, Groenewegen WA, Gloger IS, Piggott JR, Suckling KE, Wolf CR.

Nucleic Acids Res. 1990 Dec 11;18(23):7156. No abstract available.

47.

The characterization of bile acid synthesis by cultured hamster hepatocytes.

Fry RP, Benson GM, Botham KM, Suckling KE.

Biochem Soc Trans. 1990 Dec;18(6):1211-2. No abstract available.

PMID:
2088873
48.

The effects of feeding a saturated fat-rich diet on enzymes of cholesterol metabolism in the liver, intestine and aorta of the hamster.

Jackson B, Gee AN, Martinez-Cayuela M, Suckling KE.

Biochim Biophys Acta. 1990 Jun 28;1045(1):21-8.

PMID:
2369583
49.

Regulation of cholesteryl ester metabolism in the hamster liver.

Ochoa B, Gee A, Jackson B, Suckling KE.

Biochim Biophys Acta. 1990 May 1;1044(1):133-8.

PMID:
2340303
50.

Effects of octimibate, an inhibitor of acyl coenzyme A: cholesterol acyltransferase, on cholesterol metabolism in the hamster and rat.

Jackson B, Gee A, Black S, Suckling KE.

Biochem Pharmacol. 1990 May 1;39(9):1487-9. No abstract available.

PMID:
2334447

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