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Allopurinol treatment adversely impacts left ventricular mass regression in patients with well-controlled hypertension.

Gingles CR, Symon R, Gandy SJ, Struthers AD, Houston G, MacDonald TM, Lang CC, Donnan PT, George J.

J Hypertens. 2019 Jul 1. doi: 10.1097/HJH.0000000000002189. [Epub ahead of print]


A randomized controlled trial of metformin on left ventricular hypertrophy in patients with coronary artery disease without diabetes: the MET-REMODEL trial.

Mohan M, Al-Talabany S, McKinnie A, Mordi IR, Singh JSS, Gandy SJ, Baig F, Hussain MS, Bhalraam U, Khan F, Choy AM, Matthew S, Houston JG, Struthers AD, George J, Lang CC.

Eur Heart J. 2019 Apr 17. pii: ehz203. doi: 10.1093/eurheartj/ehz203. [Epub ahead of print]


Acceptability and feasibility of magnetic femoral nerve stimulation in older, functionally impaired patients.

Beveridge LA, Price RJG, Burton LA, Witham MD, Struthers AD, Sumukadas D.

BMC Res Notes. 2018 Jun 15;11(1):394. doi: 10.1186/s13104-018-3493-4.


Disconnection of pulmonary and systemic arterial stiffness in COPD.

Weir-McCall JR, Liu-Shiu-Cheong PS, Struthers AD, Lipworth BJ, Houston JG.

Int J Chron Obstruct Pulmon Dis. 2018 May 28;13:1755-1765. doi: 10.2147/COPD.S160077. eCollection 2018.


Effect of Vitamin D Supplementation on Markers of Vascular Function: A Systematic Review and Individual Participant Meta-Analysis.

Beveridge LA, Khan F, Struthers AD, Armitage J, Barchetta I, Bressendorff I, Cavallo MG, Clarke R, Dalan R, Dreyer G, Gepner AD, Forouhi NG, Harris RA, Hitman GA, Larsen T, Khadgawat R, Marckmann P, Mose FH, Pilz S, Scholze A, Shargorodsky M, Sokol SI, Stricker H, Zoccali C, Witham MD.

J Am Heart Assoc. 2018 May 30;7(11). pii: e008273. doi: 10.1161/JAHA.117.008273. Review.


Prevalence and Distribution of Atherosclerosis in a Low- to Intermediate-Risk Population: Assessment with Whole-Body MR Angiography.

Lambert MA, Weir-McCall JR, Salsano M, Gandy SJ, Levin D, Cavin I, Littleford R, MacFarlane JA, Matthew SZ, Nicholas RS, Struthers AD, Sullivan F, Henderson SA, White RD, Belch JJF, Houston JG.

Radiology. 2018 Jun;287(3):795-804. doi: 10.1148/radiol.2018171609. Epub 2018 May 1.


Development and Validation of a Path Length Calculation for Carotid-Femoral Pulse Wave Velocity Measurement: A TASCFORCE, SUMMIT, and Caerphilly Collaborative Venture.

Weir-McCall JR, Brown L, Summersgill J, Talarczyk P, Bonnici-Mallia M, Chin SC, Khan F, Struthers AD, Sullivan F, Colhoun HM, Shore AC, Aizawa K, Groop L, Nilsson J, Cockcroft JR, McEniery CM, Wilkinson IB, Ben-Shlomo Y, Houston JG.

Hypertension. 2018 May;71(5):937-945. doi: 10.1161/HYPERTENSIONAHA.117.10620. Epub 2018 Mar 19.


Pulmonary arterial stiffening in COPD and its implications for right ventricular remodelling.

Weir-McCall JR, Liu-Shiu-Cheong PS, Struthers AD, Lipworth BJ, Houston JG.

Eur Radiol. 2018 Aug;28(8):3464-3472. doi: 10.1007/s00330-018-5346-x. Epub 2018 Feb 27.


Systemic arteriosclerosis is associated with left ventricular remodeling but not atherosclerosis: a TASCFORCE study.

Weir-McCall JR, Lambert M, Gandy SJ, Belch JJF, Cavin I, Henderson SA, Littleford R, Macfarlane JA, Matthew SZ, Stephen Nicholas R, Struthers AD, Sullivan F, White RD, Graeme Houston J.

J Cardiovasc Magn Reson. 2018 Jan 30;20(1):7. doi: 10.1186/s12968-018-0428-0.


Leucine and ACE inhibitors as therapies for sarcopenia (LACE trial): study protocol for a randomised controlled trial.

Band MM, Sumukadas D, Struthers AD, Avenell A, Donnan PT, Kemp PR, Smith KT, Hume CL, Hapca A, Witham MD.

Trials. 2018 Jan 4;19(1):6. doi: 10.1186/s13063-017-2390-9.


Effects of contrast administration on cardiac MRI volumetric, flow and pulse wave velocity quantification using manual and software-based analysis.

Fathi A, Weir-McCall JR, Struthers AD, Lipworth BJ, Houston G.

Br J Radiol. 2018 Apr;91(1084):20170717. doi: 10.1259/bjr.20170717. Epub 2018 Jan 19.


The APEX trial: Effects of allopurinol on exercise capacity, coronary and peripheral endothelial function, and natriuretic peptides in patients with cardiac syndrome X.

Lim TK, Noman A, Choy AMJ, Khan F, Struthers AD, Lang CC.

Cardiovasc Ther. 2018 Feb;36(1). doi: 10.1111/1755-5922.12311. Epub 2017 Nov 26.


Myocardial changes in incident haemodialysis patients over 6-months: an observational cardiac magnetic resonance imaging study.

Rutherford E, Mangion K, McComb C, Bell E, Cockburn S, Talle M, Roditi G, Welsh P, Woodward R, Radjenovic A, Struthers AD, Jardine AG, Berry C, Patel RK, Mark PB.

Sci Rep. 2017 Oct 25;7(1):13976. doi: 10.1038/s41598-017-14481-y.


Twenty-Year Predictors of Peripheral Arterial Disease Compared With Coronary Heart Disease in the Scottish Heart Health Extended Cohort (SHHEC).

Tunstall-Pedoe H, Peters SAE, Woodward M, Struthers AD, Belch JJF.

J Am Heart Assoc. 2017 Sep 18;6(9). pii: e005967. doi: 10.1161/JAHA.117.005967. Erratum in: J Am Heart Assoc. 2017 Dec 23;6(12):e004215.


An Open-Label Dose-Finding Study of Allopurinol to Target Defined Reduction in Urate Levels in Hemodialysis Patients.

Rutherford E, Stewart G, Houston JG, Jardine AG, Mark PB, Struthers AD.

J Clin Pharmacol. 2017 Nov;57(11):1409-1414. doi: 10.1002/jcph.939. Epub 2017 Jun 9. No abstract available.


Reply: The Enigma of Left Ventricular Non-Compaction.

Weir-McCall JR, Yeap PM, Papagiorcopulo C, Fitzgerald K, Gandy SJ, Lambert M, Belch JJF, Cavin I, Littleford R, Macfarlane JA, Matthew SZ, Nicholas RS, Struthers AD, Sullivan F, Henderson SA, White RD, Houston JG.

J Am Coll Cardiol. 2017 May 16;69(19):2470-2471. doi: 10.1016/j.jacc.2017.02.062. No abstract available.


Left Ventricular Noncompaction: Anatomical Phenotype or Distinct Cardiomyopathy?

Weir-McCall JR, Yeap PM, Papagiorcopulo C, Fitzgerald K, Gandy SJ, Lambert M, Belch JJ, Cavin I, Littleford R, Macfarlane JA, Matthew SZ, Nicholas RS, Struthers AD, Sullivan F, Waugh SA, White RD, Houston JG.

J Am Coll Cardiol. 2016 Nov 15;68(20):2157-2165. doi: 10.1016/j.jacc.2016.08.054.


Assessment of proximal pulmonary arterial stiffness using magnetic resonance imaging: effects of technique, age and exercise.

Weir-McCall JR, Kamalasanan A, Cassidy DB, Struthers AD, Lipworth BJ, Houston JG.

BMJ Open Respir Res. 2016 Oct 7;3(1):e000149. eCollection 2016.


Association between GDF-15 levels and changes in vascular and physical function in older patients with hypertension.

Barma M, Khan F, Price RJG, Donnan PT, Messow CM, Ford I, McConnachie A, Struthers AD, McMurdo MET, Witham MD.

Aging Clin Exp Res. 2017 Oct;29(5):1055-1059. doi: 10.1007/s40520-016-0636-0. Epub 2016 Oct 12.


Multicentre, prospective, randomised, open-label, blinded end point trial of the efficacy of allopurinol therapy in improving cardiovascular outcomes in patients with ischaemic heart disease: protocol of the ALL-HEART study.

Mackenzie IS, Ford I, Walker A, Hawkey C, Begg A, Avery A, Taggar J, Wei L, Struthers AD, MacDonald TM; ALL-HEART study group.

BMJ Open. 2016 Sep 8;6(9):e013774. doi: 10.1136/bmjopen-2016-013774.


Prevalence of unrecognized myocardial infarction in a low-intermediate risk asymptomatic cohort and its relation to systemic atherosclerosis.

Weir-McCall JR, Fitzgerald K, Papagiorcopulo CJ, Gandy SJ, Lambert M, Belch JJF, Cavin I, Littleford R, Macfarlane JA, Matthew SZ, Nicholas RS, Struthers AD, Sullivan FM, Waugh SA, White RD, Houston JG.

Eur Heart J Cardiovasc Imaging. 2017 Jun 1;18(6):657-662. doi: 10.1093/ehjci/jew155.


Defining myocardial tissue abnormalities in end-stage renal failure with cardiac magnetic resonance imaging using native T1 mapping.

Rutherford E, Talle MA, Mangion K, Bell E, Rauhalammi SM, Roditi G, McComb C, Radjenovic A, Welsh P, Woodward R, Struthers AD, Jardine AG, Patel RK, Berry C, Mark PB.

Kidney Int. 2016 Oct;90(4):845-52. doi: 10.1016/j.kint.2016.06.014. Epub 2016 Aug 5.


Research into the effect Of SGLT2 inhibition on left ventricular remodelling in patients with heart failure and diabetes mellitus (REFORM) trial rationale and design.

Singh JS, Fathi A, Vickneson K, Mordi I, Mohan M, Houston JG, Pearson ER, Struthers AD, Lang CC.

Cardiovasc Diabetol. 2016 Jul 15;15:97. doi: 10.1186/s12933-016-0419-0.


Whole-body cardiovascular MRI for the comparison of atherosclerotic burden and cardiac remodelling in healthy South Asian and European adults.

Weir-McCall JR, Cassidy DB, Belch JJ, Gandy SJ, Houston JG, Lambert MA, Littleford RC, Rowland J, Struthers AD, Khan F.

Br J Radiol. 2016 Sep;89(1065):20160342. doi: 10.1259/bjr.20160342. Epub 2016 Jun 28.


Research cardiac magnetic resonance imaging in end stage renal disease - incidence, significance and implications of unexpected incidental findings.

Rutherford E, Weir-McCall JR, Patel RK, Houston JG, Roditi G, Struthers AD, Jardine AG, Mark PB.

Eur Radiol. 2017 Jan;27(1):315-324. Epub 2016 Apr 7.


Letter to the editor: Comparing pace and speed in the pulmonary circulation?

Weir-McCall JR, Struthers AD, Lipworth BJ, Houston JG.

Am J Physiol Heart Circ Physiol. 2016 Apr 1;310(7):H949. doi: 10.1152/ajpheart.00065.2016. No abstract available.


Whole body cardiovascular magnetic resonance imaging to stratify symptomatic and asymptomatic atherosclerotic burden in patients with isolated cardiovascular disease.

Weir-McCall JR, Duce SL, Gandy SJ, Matthew SZ, Martin P, Cassidy DB, McCormick L, Belch JJF, Struthers AD, Colhoun HM, Houston JG.

BMC Med Imaging. 2016 Feb 29;16:18. doi: 10.1186/s12880-016-0121-4.


Effect of Vitamin K on Vascular Health and Physical Function in Older People with Vascular Disease--A Randomised Controlled Trial.

Fulton RL, McMurdo ME, Hill A, Abboud RJ, Arnold GP, Struthers AD, Khan F, Vermeer C, Knapen MH, Drummen NE, Witham MD.

J Nutr Health Aging. 2016 Mar;20(3):325-33. doi: 10.1007/s12603-015-0619-4.


MRI of the left atrium at 3T: evaluation of measurement reproducibility in healthy volunteers and patients with cardiovascular disease.

Gandy SJ, Matthew S, Rekhraj S, Szwejkowski B, Crowe E, Struthers AD, Houston JG.

Acta Radiol. 2016 Dec;57(12):1468-1475. doi: 10.1177/0284185115627386. Epub 2016 Jul 19.


Follow-up of atheroma burden with sequential whole body contrast enhanced MR angiography: a feasibility study.

Weir-McCall JR, White RD, Ramkumar PG, Gandy SJ, Khan F, Belch JJ, Struthers AD, Houston JG.

Int J Cardiovasc Imaging. 2016 May;32(5):825-32. doi: 10.1007/s10554-016-0842-z. Epub 2016 Jan 25.


Mean HbA1c and mortality in diabetic individuals with heart failure: a population cohort study.

Elder DH, Singh JS, Levin D, Donnelly LA, Choy AM, George J, Struthers AD, Doney AS, Lang CC.

Eur J Heart Fail. 2016 Jan;18(1):94-102. doi: 10.1002/ejhf.455. Epub 2015 Dec 13.


Ezetimibe plus a Statin after Acute Coronary Syndromes.

Singh JS, Struthers AD, Lang CC.

N Engl J Med. 2015 Oct 8;373(15):1476. doi: 10.1056/NEJMc1509363. No abstract available.


High B-Type Natriuretic Peptide Hypertensives at Target Blood Pressure: Potential Role of β-Blockers to Reduce Their Elevated Risk.

Struthers AD, George J.

Hypertension. 2015 Nov;66(5):927-32. doi: 10.1161/HYPERTENSIONAHA.115.06270. Epub 2015 Sep 21. Review. No abstract available.


Spironolactone for People Age 70 Years and Older With Osteoarthritic Knee Pain: A Proof-of-Concept Trial.

Mcmurdo ME, Sumukadas D, Donnan PT, Cvoro V, Rauchhaus P, Argo I, Waldie H, Littleford R, Struthers AD, Witham MD.

Arthritis Care Res (Hoboken). 2016 May;68(5):716-21. doi: 10.1002/acr.22724.


A Randomized Controlled Trial of Allopurinol in Patients With Peripheral Arterial Disease.

Robertson AJ, Struthers AD.

Can J Cardiol. 2016 Feb;32(2):190-6. doi: 10.1016/j.cjca.2015.05.010. Epub 2015 May 19.


The role of pulmonary arterial stiffness in COPD.

Weir-McCall JR, Struthers AD, Lipworth BJ, Houston JG.

Respir Med. 2015 Nov;109(11):1381-90. doi: 10.1016/j.rmed.2015.06.005. Epub 2015 Jun 12. Review.


Myocardial fibrosis in stroke survivors.

Wong K, Sze S, Wong S, McSwiggan S, Allgar V, MacWalter R, Struthers AD.

Int J Cardiol. 2015;187:138-40. doi: 10.1016/j.ijcard.2015.03.212. Epub 2015 Mar 18. No abstract available.


Impact of Left Ventricular Hypertrophy on Survival in Chronic Obstructive Pulmonary Disease.

Short PM, Anderson WJ, Elder DH, Struthers AD, Lipworth BJ.

Lung. 2015 Aug;193(4):487-95. doi: 10.1007/s00408-015-9724-8. Epub 2015 Mar 29.


Technical assessment of whole body angiography and cardiac function within a single MRI examination.

Gandy SJ, Lambert M, Belch JJ, Cavin ID, Crowe E, Littleford R, Macfarlane JA, Matthew SZ, Martin P, Nicholas RS, Struthers AD, Sullivan F, Waugh SA, White RD, Weir-McCall JR, Houston JG.

Clin Radiol. 2015 Jun;70(6):595-603. doi: 10.1016/j.crad.2015.02.003. Epub 2015 Mar 16.


Effect of Vitamin D Supplementation on Blood Pressure: A Systematic Review and Meta-analysis Incorporating Individual Patient Data.

Beveridge LA, Struthers AD, Khan F, Jorde R, Scragg R, Macdonald HM, Alvarez JA, Boxer RS, Dalbeni A, Gepner AD, Isbel NM, Larsen T, Nagpal J, Petchey WG, Stricker H, Strobel F, Tangpricha V, Toxqui L, Vaquero MP, Wamberg L, Zittermann A, Witham MD; D-PRESSURE Collaboration.

JAMA Intern Med. 2015 May;175(5):745-54. doi: 10.1001/jamainternmed.2015.0237. Review.


Both high and low HbA1c predict incident heart failure in type 2 diabetes mellitus.

Parry HM, Deshmukh H, Levin D, Van Zuydam N, Elder DH, Morris AD, Struthers AD, Palmer CN, Doney AS, Lang CC.

Circ Heart Fail. 2015 Mar;8(2):236-42. doi: 10.1161/CIRCHEARTFAILURE.113.000920. Epub 2015 Jan 5.


Aortic remodelling following the treatment and regression of hypertensive left ventricular hypertrophy: a cardiovascular magnetic resonance study.

Ripley DP, Negrou K, Oliver JJ, Worthy G, Struthers AD, Plein S, Greenwood JP.

Clin Exp Hypertens. 2015;37(4):308-16. doi: 10.3109/10641963.2014.960974. Epub 2014 Oct 1.


Common carotid intima media thickness and ankle-brachial pressure index correlate with local but not global atheroma burden: a cross sectional study using whole body magnetic resonance angiography.

Weir-McCall JR, Khan F, Lambert MA, Adamson CL, Gardner M, Gandy SJ, Ramkumar PG, Belch JJ, Struthers AD, Rauchhaus P, Morris AD, Houston JG.

PLoS One. 2014 Jun 16;9(6):e99190. doi: 10.1371/journal.pone.0099190. eCollection 2014.


Effect of vitamin D supplementation on orthostatic hypotension: data from the vitamin D in isolated systolic hypertension randomized controlled trial.

Witham MD, Price RJ, Struthers AD, Donnan PT, Messow M, McConnachie A, Ford I, McMurdo ME.

J Hypertens. 2014 Aug;32(8):1693-9; discussion 1699. doi: 10.1097/HJH.0000000000000223.


The source of BNP in rheumatoid arthritis.

George J, Khan F, Struthers AD.

Int J Cardiol. 2014 Jul 1;174(3):740. doi: 10.1016/j.ijcard.2014.04.091. Epub 2014 Apr 15. No abstract available.


Tadalafil in patients with chronic obstructive pulmonary disease: a randomised, double-blind, parallel-group, placebo-controlled trial.

Goudie AR, Lipworth BJ, Hopkinson PJ, Wei L, Struthers AD.

Lancet Respir Med. 2014 Apr;2(4):293-300. doi: 10.1016/S2213-2600(14)70013-X. Epub 2014 Mar 5.


Identifying older heart failure patients with major depression in primary care: a feasibility study.

McMurdo ME, Witham MD, Johnston D, Struthers AD, Guthrie B, Matthews K.

Int J Geriatr Psychiatry. 2014 May;29(5):547-9. doi: 10.1002/gps.4089. No abstract available.


High-potency statin and ezetimibe use and mortality in survivors of an acute myocardial infarction: a population-based study.

Pauriah M, Elder DH, Ogston S, Noman AY, Majeed A, Wyatt JC, Choy AM, Macdonald TM, Struthers AD, Lang CC.

Heart. 2014 Jun;100(11):867-72. doi: 10.1136/heartjnl-2013-304678. Epub 2014 Feb 19.


Modulation of the renin-angiotensin-aldosterone system in heart failure.

George J, Struthers AD, Lang CC.

Curr Atheroscler Rep. 2014 Apr;16(4):403. doi: 10.1007/s11883-014-0403-7. Review.


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