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Items: 1 to 50 of 405

1.

Mitochondrial Damage and Mitochondria-Targeted Antioxidant Protection in LPS-Induced Acute Kidney Injury.

Plotnikov EY, Pevzner IB, Zorova LD, Chernikov VP, Prusov AN, Kireev II, Silachev DN, Skulachev VP, Zorov DB.

Antioxidants (Basel). 2019 Jun 14;8(6). pii: E176. doi: 10.3390/antiox8060176.

2.

The single intravenous administration of mitochondria-targeted antioxidant SkQR1 after traumatic brain injury attenuates neurological deficit in rats.

Genrikhs EE, Stelmashook EV, Alexandrova OP, Novikova SV, Voronkov DN, Glibka YA, Skulachev VP, Isaev NK.

Brain Res Bull. 2019 May;148:100-108. doi: 10.1016/j.brainresbull.2019.03.011. Epub 2019 Mar 29.

PMID:
30935979
3.

Ants as Object of Gerontological Research.

Shilovsky GA, Putyatina TS, Ashapkin VV, Rozina AA, Lyubetsky VA, Minina EP, Bychkovskaia IB, Markov AV, Skulachev VP.

Biochemistry (Mosc). 2018 Dec;83(12):1489-1503. doi: 10.1134/S0006297918120076. Review.

PMID:
30878024
4.

Neuroprotective Effects of Mitochondria-Targeted Plastoquinone in a Rat Model of Neonatal Hypoxic⁻Ischemic Brain Injury.

Silachev DN, Plotnikov EY, Pevzner IB, Zorova LD, Balakireva AV, Gulyaev MV, Pirogov YA, Skulachev VP, Zorov DB.

Molecules. 2018 Jul 27;23(8). pii: E1871. doi: 10.3390/molecules23081871.

5.

Programmed Aging of Mammals: Proof of Concept and Prospects of Biochemical Approaches for Anti-aging Therapy.

Skulachev MV, Skulachev VP.

Biochemistry (Mosc). 2017 Dec;82(12):1403-1422. doi: 10.1134/S000629791712001X. Review.

6.

Induction of autophagy by depolarization of mitochondria.

Lyamzaev KG, Tokarchuk AV, Panteleeva AA, Mulkidjanian AY, Skulachev VP, Chernyak BV.

Autophagy. 2018;14(5):921-924. doi: 10.1080/15548627.2018.1436937. Epub 2018 Mar 13.

7.

Mitochondria-Targeted Antioxidants SkQ1 and MitoTEMPO Failed to Exert a Long-Term Beneficial Effect in Murine Polymicrobial Sepsis.

Rademann P, Weidinger A, Drechsler S, Meszaros A, Zipperle J, Jafarmadar M, Dumitrescu S, Hacobian A, Ungelenk L, Röstel F, Kaszaki J, Szabo A, Skulachev VP, Bauer M, Bahrami S, Weis S, Kozlov AV, Osuchowski MF.

Oxid Med Cell Longev. 2017;2017:6412682. doi: 10.1155/2017/6412682. Epub 2017 Sep 19.

8.

Mitochondria-Targeted Antioxidant SkQ1 Improves Dermal Wound Healing in Genetically Diabetic Mice.

Demyanenko IA, Zakharova VV, Ilyinskaya OP, Vasilieva TV, Fedorov AV, Manskikh VN, Zinovkin RA, Pletjushkina OY, Chernyak BV, Skulachev VP, Popova EN.

Oxid Med Cell Longev. 2017;2017:6408278. doi: 10.1155/2017/6408278. Epub 2017 Jul 6.

9.

Mitochondria-targeted antioxidants as highly effective antibiotics.

Nazarov PA, Osterman IA, Tokarchuk AV, Karakozova MV, Korshunova GA, Lyamzaev KG, Skulachev MV, Kotova EA, Skulachev VP, Antonenko YN.

Sci Rep. 2017 May 3;7(1):1394. doi: 10.1038/s41598-017-00802-8.

10.

Is It Possible to Prove the Existence of an Aging Program by Quantitative Analysis of Mortality Dynamics?

Shilovsky GA, Putyatina TS, Lysenkov SN, Ashapkin VV, Luchkina OS, Markov AV, Skulachev VP.

Biochemistry (Mosc). 2016 Dec;81(12):1461-1476. doi: 10.1134/S0006297916120075. Review.

11.

Study of Age-Dependent Structural and Functional Changes of Mitochondria in Skeletal Muscles and Heart of Naked Mole Rats (Heterocephalus glaber).

Holtze S, Eldarov CM, Vays VB, Vangeli IM, Vysokikh MY, Bakeeva LE, Skulachev VP, Hildebrandt TB.

Biochemistry (Mosc). 2016 Dec;81(12):1429-1437. doi: 10.1134/S000629791612004X.

12.

Mitochondrial Genome and Longevity.

Zinovkin RA, Skulachev MV, Skulachev VP.

Biochemistry (Mosc). 2016 Dec;81(12):1401-1405. doi: 10.1134/S0006297916120014. Review.

13.

Improved health-span and lifespan in mtDNA mutator mice treated with the mitochondrially targeted antioxidant SkQ1.

Shabalina IG, Vyssokikh MY, Gibanova N, Csikasz RI, Edgar D, Hallden-Waldemarson A, Rozhdestvenskaya Z, Bakeeva LE, Vays VB, Pustovidko AV, Skulachev MV, Cannon B, Skulachev VP, Nedergaard J.

Aging (Albany NY). 2017 Feb 15;9(2):315-339. doi: 10.18632/aging.101174.

14.

Neoteny, Prolongation of Youth: From Naked Mole Rats to "Naked Apes" (Humans).

Skulachev VP, Holtze S, Vyssokikh MY, Bakeeva LE, Skulachev MV, Markov AV, Hildebrandt TB, Sadovnichii VA.

Physiol Rev. 2017 Apr;97(2):699-720. doi: 10.1152/physrev.00040.2015. Review.

15.

Low concentration of uncouplers of oxidative phosphorylation decreases the TNF-induced endothelial permeability and lethality in mice.

Zakharova VV, Pletjushkina OY, Galkin II, Zinovkin RA, Chernyak BV, Krysko DV, Bachert C, Krysko O, Skulachev VP, Popova EN.

Biochim Biophys Acta Mol Basis Dis. 2017 Apr;1863(4):968-977. doi: 10.1016/j.bbadis.2017.01.024. Epub 2017 Jan 26.

16.

Cellular and Molecular Mechanisms of Action of Mitochondria-Targeted Antioxidants.

Feniouk BA, Skulachev VP.

Curr Aging Sci. 2017;10(1):41-48. Review.

PMID:
27659264
17.

Neuroprotective properties of mitochondria-targeted antioxidants of the SkQ-type.

Isaev NK, Stelmashook EV, Genrikhs EE, Korshunova GA, Sumbatyan NV, Kapkaeva MR, Skulachev VP.

Rev Neurosci. 2016 Dec 1;27(8):849-855. doi: 10.1515/revneuro-2016-0036. Review.

PMID:
27559690
18.

Mitochondria-targeted dodecyltriphenylphosphonium (C12TPP) combats high-fat-diet-induced obesity in mice.

Kalinovich AV, Mattsson CL, Youssef MR, Petrovic N, Ost M, Skulachev VP, Shabalina IG.

Int J Obes (Lond). 2016 Dec;40(12):1864-1874. doi: 10.1038/ijo.2016.146. Epub 2016 Aug 18.

19.

A mitochondria-targeted antioxidant can inhibit peroxidase activity of cytochrome c by detachment of the protein from liposomes.

Firsov AM, Kotova EA, Orlov VN, Antonenko YN, Skulachev VP.

FEBS Lett. 2016 Sep;590(17):2836-43. doi: 10.1002/1873-3468.12319. Epub 2016 Aug 4.

20.

Impact of Antioxidants on Cardiolipin Oxidation in Liposomes: Why Mitochondrial Cardiolipin Serves as an Apoptotic Signal?

Lokhmatikov AV, Voskoboynikova N, Cherepanov DA, Skulachev MV, Steinhoff HJ, Skulachev VP, Mulkidjanian AY.

Oxid Med Cell Longev. 2016;2016:8679469. doi: 10.1155/2016/8679469. Epub 2016 May 26.

21.

Ubiquinol and plastoquinol triphenylphosphonium conjugates can carry electrons through phospholipid membranes.

Rokitskaya TI, Murphy MP, Skulachev VP, Antonenko YN.

Bioelectrochemistry. 2016 Oct;111:23-30. doi: 10.1016/j.bioelechem.2016.04.009. Epub 2016 Apr 28.

PMID:
27182824
22.

Real-time kinetics of electrogenic Na(+) transport by rhodopsin from the marine flavobacterium Dokdonia sp. PRO95.

Bogachev AV, Bertsova YV, Verkhovskaya ML, Mamedov MD, Skulachev VP.

Sci Rep. 2016 Feb 11;6:21397. doi: 10.1038/srep21397.

23.

Results of a Multicenter, Randomized, Double-Masked, Placebo-Controlled Clinical Study of the Efficacy and Safety of Visomitin Eye Drops in Patients with Dry Eye Syndrome.

Brzheskiy VV, Efimova EL, Vorontsova TN, Alekseev VN, Gusarevich OG, Shaidurova KN, Ryabtseva AA, Andryukhina OM, Kamenskikh TG, Sumarokova ES, Miljudin ES, Egorov EA, Lebedev OI, Surov AV, Korol AR, Nasinnyk IO, Bezditko PA, Muzhychuk OP, Vygodin VA, Yani EV, Savchenko AY, Karger EM, Fedorkin ON, Mironov AN, Ostapenko V, Popeko NA, Skulachev VP, Skulachev MV.

Adv Ther. 2015 Dec;32(12):1263-79. doi: 10.1007/s12325-015-0273-6. Epub 2015 Dec 11.

24.

Thymic Involution in Ontogenesis: Role in Aging Program.

Shilovsky GA, Feniouk BA, Skulachev VP.

Biochemistry (Mosc). 2015 Dec;80(12):1629-31. doi: 10.1134/S0006297915120135.

25.

Uncoupling and Toxic Action of Alkyltriphenylphosphonium Cations on Mitochondria and the Bacterium Bacillus subtilis as a Function of Alkyl Chain Length.

Khailova LS, Nazarov PA, Sumbatyan NV, Korshunova GA, Rokitskaya TI, Dedukhova VI, Antonenko YN, Skulachev VP.

Biochemistry (Mosc). 2015 Dec;80(12):1589-97. doi: 10.1134/S000629791512007X.

26.

Alzheimer's Disease: An Exacerbation of Senile Phenoptosis.

Isaev NK, Stelmashook EV, Genrikhs EE, Oborina MV, Kapkaeva MR, Skulachev VP.

Biochemistry (Mosc). 2015 Dec;80(12):1578-81. doi: 10.1134/S0006297915120056. Review.

27.

Contribution of Quantitative Methods of Estimating Mortality Dynamics to Explaining Mechanisms of Aging.

Shilovsky GA, Putyatina TS, Markov AV, Skulachev VP.

Biochemistry (Mosc). 2015 Dec;80(12):1547-59. doi: 10.1134/S0006297915120020.

28.

[SPECTRUM OF SPONTANEOUS PATHOLOGICAL CHANGES IN MOLE-VOLES AND THE EFFECT OF MITOCHONDRIA-TARGETED ANTIOXIDANT SkQ1 ON IT].

Manskikh VN, Gancharova OS, Novikov EA, Kondratiuk EIu, Skulachev VP, Moshkin MP.

Adv Gerontol. 2015;28(1):53-61. Russian.

PMID:
26390611
29.

Neuroprotective Effects of Mitochondria-Targeted Plastoquinone and Thymoquinone in a Rat Model of Brain Ischemia/Reperfusion Injury.

Silachev DN, Plotnikov EY, Zorova LD, Pevzner IB, Sumbatyan NV, Korshunova GA, Gulyaev MV, Pirogov YA, Skulachev VP, Zorov DB.

Molecules. 2015 Aug 11;20(8):14487-503. doi: 10.3390/molecules200814487.

30.

Mitochondria-targeted antioxidant SkQ1 improves impaired dermal wound healing in old mice.

Demyanenko IA, Popova EN, Zakharova VV, Ilyinskaya OP, Vasilieva TV, Romashchenko VP, Fedorov AV, Manskikh VN, Skulachev MV, Zinovkin RA, Pletjushkina OY, Skulachev VP, Chernyak BV.

Aging (Albany NY). 2015 Jul;7(7):475-85.

31.

Cytochrome cbb3 of Thioalkalivibrio is a Na+-pumping cytochrome oxidase.

Muntyan MS, Cherepanov DA, Malinen AM, Bloch DA, Sorokin DY, Severina II, Ivashina TV, Lahti R, Muyzer G, Skulachev VP.

Proc Natl Acad Sci U S A. 2015 Jun 23;112(25):7695-700. doi: 10.1073/pnas.1417071112. Epub 2015 Jun 8.

32.

Aging as an evolvability-increasing program which can be switched off by organism to mobilize additional resources for survival.

Skulachev MV, Severin FF, Skulachev VP.

Curr Aging Sci. 2015;8(1):95-109. Review.

PMID:
26054352
33.

Aging As An Evolvability-Increasing Program Which Can Be Switched Off By Organism To Mobilize Additional Resources For Survival.

Skulachev MV, Severin FF, Skulachev VP.

Curr Aging Sci. 2015 Apr 22. [Epub ahead of print]

PMID:
25902450
34.

Proteorhodopsin from Dokdonia sp. PRO95 is a light-driven Na+-pump.

Bertsova YV, Bogachev AV, Skulachev VP.

Biochemistry (Mosc). 2015 Apr;80(4):449-54. doi: 10.1134/S0006297915040082.

35.

Mouse lymphomyeloid cells can function with significantly decreased expression levels of cytochrome C.

Shilov ES, Kislyakov IV, Gorshkova EA, Zvartsev RV, Drutskaya MS, Mufazalov IA, Skulachev VP, Nedospasov SA.

Biochemistry (Mosc). 2014 Dec;79(12):1412-22. doi: 10.1134/S0006297914120177.

36.

Methodology for use of mitochondria-targeted cations in the field of oxidative stress-related research.

Vyssokikh MY, Antonenko YN, Lyamzaev KG, Rokitskaya TI, Skulachev VP.

Methods Mol Biol. 2015;1265:149-59. doi: 10.1007/978-1-4939-2288-8_12.

PMID:
25634274
37.

Mitochondria-targeted antioxidant SkQT1 decreases trauma-induced neurological deficit in rat and prevents amyloid-β-induced impairment of long-term potentiation in rat hippocampal slices.

Genrikhs EE, Stelmashook EV, Popova OV, Kapay NA, Korshunova GA, Sumbatyan NV, Skrebitsky VG, Skulachev VP, Isaev NK.

J Drug Target. 2015 May;23(4):347-52. doi: 10.3109/1061186X.2014.997736. Epub 2015 Jan 14.

PMID:
25585580
38.

Mitochondria-targeted antioxidant SkQ1 reverses glaucomatous lesions in rabbits.

Iomdina EN, Khoroshilova-Maslova IP, Robustova OV, Averina OA, Kovaleva NA, Aliev G, Reddy VP, Zamyatnin AA Jr, Skulachev MV, Senin II, Skulachev VP.

Front Biosci (Landmark Ed). 2015 Jan 1;20:892-901.

PMID:
25553485
39.

Prevention of peroxidation of cardiolipin liposomes by quinol-based antioxidants.

Lokhmatikov AV, Voskoboynikova NE, Cherepanov DA, Sumbatyan NV, Korshunova GA, Skulachev MV, Steinhoff HJ, Skulachev VP, Mulkidjanian AY.

Biochemistry (Mosc). 2014 Oct;79(10):1081-100. doi: 10.1134/S0006297914100101.

40.

Receptor regulation of senile phenoptosis.

Skulachev MV, Severin FF, Skulachev VP.

Biochemistry (Mosc). 2014 Oct;79(10):994-1003. doi: 10.1134/S0006297914100022.

41.

New data on programmed aging - slow phenoptosis.

Skulachev MV, Skulachev VP.

Biochemistry (Mosc). 2014 Oct;79(10):977-93. doi: 10.1134/S0006297914100010. Review.

42.

Radioprotective effects of mitochondria-targeted antioxidant SkQR1.

Fetisova EK, Antoschina MM, Cherepanynets VD, Izumov DS, Kireev II, Kireev RI, Lyamzaev KG, Riabchenko NI, Chernyak BV, Skulachev VP.

Radiat Res. 2015 Jan;183(1):64-71. doi: 10.1667/RR13708.1. Epub 2014 Dec 12.

PMID:
25496313
43.

Vicious inducible nitric oxide synthase-mitochondrial reactive oxygen species cycle accelerates inflammatory response and causes liver injury in rats.

Weidinger A, Müllebner A, Paier-Pourani J, Banerjee A, Miller I, Lauterböck L, Duvigneau JC, Skulachev VP, Redl H, Kozlov AV.

Antioxid Redox Signal. 2015 Mar 1;22(7):572-86. doi: 10.1089/ars.2014.5996. Epub 2014 Dec 22.

PMID:
25365698
44.

Age-associated murine cardiac lesions are attenuated by the mitochondria-targeted antioxidant SkQ1.

Manskikh VN, Gancharova OS, Nikiforova AI, Krasilshchikova MS, Shabalina IG, Egorov MV, Karger EM, Milanovsky GE, Galkin II, Skulachev VP, Zinovkin RA.

Histol Histopathol. 2015 Mar;30(3):353-60. doi: 10.14670/HH-30.353. Epub 2014 Oct 17.

PMID:
25323729
45.

Advances in development of rechargeable mitochondrial antioxidants.

Lukashev AN, Skulachev MV, Ostapenko V, Savchenko AY, Pavshintsev VV, Skulachev VP.

Prog Mol Biol Transl Sci. 2014;127:251-65. doi: 10.1016/B978-0-12-394625-6.00010-6. Review.

PMID:
25149221
46.

A short-chain alkyl derivative of Rhodamine 19 acts as a mild uncoupler of mitochondria and a neuroprotector.

Khailova LS, Silachev DN, Rokitskaya TI, Avetisyan AV, Lyamsaev KG, Severina II, Il'yasova TM, Gulyaev MV, Dedukhova VI, Trendeleva TA, Plotnikov EY, Zvyagilskaya RA, Chernyak BV, Zorov DB, Antonenko YN, Skulachev VP.

Biochim Biophys Acta. 2014 Oct;1837(10):1739-47. doi: 10.1016/j.bbabio.2014.07.006. Epub 2014 Jul 16.

47.

Antioxidant SkQ1 delays sarcopenia-associated damage of mitochondrial ultrastructure.

Vays VB, Eldarov CM, Vangely IM, Kolosova NG, Bakeeva LE, Skulachev VP.

Aging (Albany NY). 2014 Feb;6(2):140-8.

48.

SkBQ - prooxidant addressed to mitochondria.

Vyssokikh MY, Chernyak BV, Domnina LV, Esipov DS, Ivanova OY, Korshunova GA, Symonyan RA, Skulachev MV, Zinevich TV, Skulachev VP.

Biochemistry (Mosc). 2013 Dec;78(12):1366-70. doi: 10.1134/S0006297913120079.

49.

[Mitochondria-targeted antioxidant SkQR1 selectively protects MDR-negative cells against ionizing radiation].

Fetisova EK, Antoshina MM, Cherepanynets VD, Izumov DS, Kireev II, Kireev RI, Lyamzaev KG, Riabchenko NI, Chernyak BV, Skulachev VP.

Tsitologiia. 2014;56(12):890-8. Russian.

PMID:
25929130
50.

Advanced glycation of cellular proteins as a possible basic component of the "master biological clock".

Severin FF, Feniouk BA, Skulachev VP.

Biochemistry (Mosc). 2013 Sep;78(9):1043-7. doi: 10.1134/S0006297913090101.

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