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Items: 1 to 50 of 237


Self-association and subcellular localization of Puumala hantavirus envelope proteins.

Sperber HS, Welke RW, Petazzi RA, Bergmann R, Schade M, Shai Y, Chiantia S, Herrmann A, Schwarzer R.

Sci Rep. 2019 Jan 24;9(1):707. doi: 10.1038/s41598-018-36879-y.


The HIV gp41 Fusion Protein Inhibits T-Cell Activation through the Lentiviral Lytic Peptide 2 Motif.

Klug YA, Schwarzer R, Rotem E, Charni M, Nudelman A, Gramatica A, Zarmi B, Rotter V, Shai Y.

Biochemistry. 2019 Feb 12;58(6):818-832. doi: 10.1021/acs.biochem.8b01175. Epub 2019 Jan 15.


The HTLV-1 gp21 fusion peptide inhibits antigen specific T-cell activation in-vitro and in mice.

Rotem E, Faingold O, Charni M, Klug YA, Harari D, Shmuel-Galia L, Nudelman A, Rotter V, Shai Y.

PLoS Pathog. 2018 May 4;14(5):e1007044. doi: 10.1371/journal.ppat.1007044. eCollection 2018 May.


Deficient Lipid A Remodeling by the arnB Gene Promotes Biofilm Formation in Antimicrobial Peptide Susceptible Pseudomonas aeruginosa.

Segev-Zarko LA, Kapach G, Josten M, Klug YA, Sahl HG, Shai Y.

Biochemistry. 2018 Apr 3;57(13):2024-2034. doi: 10.1021/acs.biochem.8b00149. Epub 2018 Mar 19.


Fractal properties of cell surface structures: A view from AFM.

Bitler A, Dover RS, Shai Y.

Semin Cell Dev Biol. 2018 Jan;73:64-70. doi: 10.1016/j.semcdb.2017.07.034. Epub 2017 Jul 29. Review.


Intramembrane attenuation of the TLR4-TLR6 dimer impairs receptor assembly and reduces microglia-mediated neurodegeneration.

Shmuel-Galia L, Klug Y, Porat Z, Charni M, Zarmi B, Shai Y.

J Biol Chem. 2017 Aug 11;292(32):13415-13427. doi: 10.1074/jbc.M117.784983. Epub 2017 Jun 27.


Methods for Investigating Biofilm Inhibition and Degradation by Antimicrobial Peptides.

Segev-Zarko LA, Shai Y.

Methods Mol Biol. 2017;1548:309-322. doi: 10.1007/978-1-4939-6737-7_22.


Heat Shock Protein 90 Facilitates Latent HIV Reactivation through Maintaining the Function of Positive Transcriptional Elongation Factor b (p-TEFb) under Proteasome Inhibition.

Pan XY, Zhao W, Wang CY, Lin J, Zeng XY, Ren RX, Wang K, Xun TR, Shai Y, Liu SW.

J Biol Chem. 2016 Dec 9;291(50):26177-26187. Epub 2016 Oct 31.


Mapping out the intricate relationship of the HIV envelope protein and the membrane environment.

Klug YA, Rotem E, Schwarzer R, Shai Y.

Biochim Biophys Acta Biomembr. 2017 Apr;1859(4):550-560. doi: 10.1016/j.bbamem.2016.10.012. Epub 2016 Oct 25. Review.


Esculentin-1a-Derived Peptides Promote Clearance of Pseudomonas aeruginosa Internalized in Bronchial Cells of Cystic Fibrosis Patients and Lung Cell Migration: Biochemical Properties and a Plausible Mode of Action.

Cappiello F, Di Grazia A, Segev-Zarko LA, Scali S, Ferrera L, Galietta L, Pini A, Shai Y, Di YP, Mangoni ML.

Antimicrob Agents Chemother. 2016 Nov 21;60(12):7252-7262. Print 2016 Dec.


Sustained Release of Antibacterial Lipopeptides from Biodegradable Polymers against Oral Pathogens.

Eckhard LH, Houri-Haddad Y, Sol A, Zeharia R, Shai Y, Beyth S, Domb AJ, Bachrach G, Beyth N.

PLoS One. 2016 Sep 8;11(9):e0162537. doi: 10.1371/journal.pone.0162537. eCollection 2016.


Interfering with the Dimerization of the ErbB Receptors by Transmembrane Domain-Derived Peptides Inhibits Tumorigenic Growth in Vitro and in Vivo.

Bublil EM, Cohen T, Arnusch CJ, Peleg A, Pines G, Lavi S, Yarden Y, Shai Y.

Biochemistry. 2016 Oct 4;55(39):5520-5530. Epub 2016 Sep 19.


Neutralization of pro-inflammatory monocytes by targeting TLR2 dimerization ameliorates colitis.

Shmuel-Galia L, Aychek T, Fink A, Porat Z, Zarmi B, Bernshtein B, Brenner O, Jung S, Shai Y.

EMBO J. 2016 Mar 15;35(6):685-98. doi: 10.15252/embj.201592649. Epub 2016 Feb 15.


The Transmembrane Domain of HIV-1 gp41 Inhibits T-Cell Activation by Targeting Multiple T-Cell Receptor Complex Components through Its GxxxG Motif.

Rotem E, Reuven EM, Klug YA, Shai Y.

Biochemistry. 2016 Feb 23;55(7):1049-57. doi: 10.1021/acs.biochem.5b01307. Epub 2016 Feb 11.


The HIV gp41 pocket binding domain enables C-terminal heptad repeat transition from mediating membrane fusion to immune modulation.

Klug YA, Kapach G, Rotem E, Dubreuil B, Shai Y.

Biochem J. 2016 Apr 1;473(7):911-8. doi: 10.1042/BJ20151252. Epub 2016 Jan 28.


NMR structure and binding of esculentin-1a (1-21)NH2 and its diastereomer to lipopolysaccharide: Correlation with biological functions.

Ghosh A, Bera S, Shai Y, Mangoni ML, Bhunia A.

Biochim Biophys Acta. 2016 Apr;1858(4):800-12. doi: 10.1016/j.bbamem.2015.12.027. Epub 2015 Dec 23.


Bacterial resistance to antimicrobial peptides.

Sahl HG, Shai Y.

Biochim Biophys Acta. 2015 Nov;1848(11 Pt B):3019-20. doi: 10.1016/j.bbamem.2015.08.009. Epub 2015 Sep 3. No abstract available.


D-Amino acids incorporation in the frog skin-derived peptide esculentin-1a(1-21)NH2 is beneficial for its multiple functions.

Di Grazia A, Cappiello F, Cohen H, Casciaro B, Luca V, Pini A, Di YP, Shai Y, Mangoni ML.

Amino Acids. 2015 Dec;47(12):2505-19. doi: 10.1007/s00726-015-2041-y. Epub 2015 Jul 11.


Defensive remodeling: How bacterial surface properties and biofilm formation promote resistance to antimicrobial peptides.

Nuri R, Shprung T, Shai Y.

Biochim Biophys Acta. 2015 Nov;1848(11 Pt B):3089-100. doi: 10.1016/j.bbamem.2015.05.022. Epub 2015 Jun 4. Review.


Multiparametric AFM reveals turgor-responsive net-like peptidoglycan architecture in live streptococci.

Dover RS, Bitler A, Shimoni E, Trieu-Cuot P, Shai Y.

Nat Commun. 2015 May 28;6:7193. doi: 10.1038/ncomms8193.


Mechanisms of biofilm inhibition and degradation by antimicrobial peptides.

Segev-Zarko L, Saar-Dover R, Brumfeld V, Mangoni ML, Shai Y.

Biochem J. 2015 Jun 1;468(2):259-70. doi: 10.1042/BJ20141251.


Biohybrid polymer-antimicrobial peptide medium against Enterococcus faecalis.

Eckhard LH, Sol A, Abtew E, Shai Y, Domb AJ, Bachrach G, Beyth N.

PLoS One. 2014 Oct 3;9(10):e109413. doi: 10.1371/journal.pone.0109413. eCollection 2014.


The HIV-1 envelope transmembrane domain binds TLR2 through a distinct dimerization motif and inhibits TLR2-mediated responses.

Reuven EM, Ali M, Rotem E, Schwarzer R, Gramatica A, Futerman AH, Shai Y.

PLoS Pathog. 2014 Aug 14;10(8):e1004248. doi: 10.1371/journal.ppat.1004248. eCollection 2014 Aug. Erratum in: PLoS Pathog. 2014 Sep;10(9):e1004408. Schwarzter, Roland [corrected to Schwarzer, Roland].


Proline localized to the interaction interface can mediate self-association of transmembrane domains.

Sal-Man N, Gerber D, Shai Y.

Biochim Biophys Acta. 2014 Sep;1838(9):2313-8. doi: 10.1016/j.bbamem.2014.05.006. Epub 2014 May 17.


Early and late HIV-1 membrane fusion events are impaired by sphinganine lipidated peptides that target the fusion site.

Klug YA, Ashkenazi A, Viard M, Porat Z, Blumenthal R, Shai Y.

Biochem J. 2014 Jul 15;461(2):213-22. doi: 10.1042/BJ20140189.


Temporins A and B stimulate migration of HaCaT keratinocytes and kill intracellular Staphylococcus aureus.

Di Grazia A, Luca V, Segev-Zarko LA, Shai Y, Mangoni ML.

Antimicrob Agents Chemother. 2014 May;58(5):2520-7. doi: 10.1128/AAC.02801-13. Epub 2014 Feb 10.


Regulation of innate immune responses by transmembrane interactions: lessons from the TLR family.

Reuven EM, Fink A, Shai Y.

Biochim Biophys Acta. 2014 Jun;1838(6):1586-93. doi: 10.1016/j.bbamem.2014.01.020. Epub 2014 Jan 27. Review.


An immunomodulating motif of the HIV-1 fusion protein is chirality-independent: implications for its mode of action.

Faingold O, Ashkenazi A, Kaushansky N, Ben-Nun A, Shai Y.

J Biol Chem. 2013 Nov 15;288(46):32852-60. doi: 10.1074/jbc.M113.512038. Epub 2013 Sep 27.


Peptide interaction with and insertion into membranes.

Saar-Dover R, Ashkenazi A, Shai Y.

Methods Mol Biol. 2013;1033:173-83. doi: 10.1007/978-1-62703-487-6_12.


Structural and functional properties of the membranotropic HIV-1 glycoprotein gp41 loop region are modulated by its intrinsic hydrophobic core.

Qiu J, Ashkenazi A, Liu S, Shai Y.

J Biol Chem. 2013 Oct 4;288(40):29143-50. doi: 10.1074/jbc.M113.496646. Epub 2013 Aug 19.


Single-particle tracking reveals switching of the HIV fusion peptide between two diffusive modes in membranes.

Ott M, Shai Y, Haran G.

J Phys Chem B. 2013 Oct 24;117(42):13308-21. doi: 10.1021/jp4039418. Epub 2013 Aug 26.


The topology, in model membranes, of the core peptide derived from the T-cell receptor transmembrane domain.

Matalon E, Faingold O, Eisenstein M, Shai Y, Goldfarb D.

Chembiochem. 2013 Sep 23;14(14):1867-75. doi: 10.1002/cbic.201300191. Epub 2013 Jul 24.


HIV-1 fusion protein exerts complex immunosuppressive effects.

Ashkenazi A, Faingold O, Shai Y.

Trends Biochem Sci. 2013 Jul;38(7):345-9. doi: 10.1016/j.tibs.2013.04.003. Epub 2013 May 17. Review.


Assembly of the TLR2/6 transmembrane domains is essential for activation and is a target for prevention of sepsis.

Fink A, Reuven EM, Arnusch CJ, Shmuel-Galia L, Antonovsky N, Shai Y.

J Immunol. 2013 Jun 15;190(12):6410-22. doi: 10.4049/jimmunol.1202033. Epub 2013 May 15.


A highly conserved sequence associated with the HIV gp41 loop region is an immunomodulator of antigen-specific T cells in mice.

Ashkenazi A, Faingold O, Kaushansky N, Ben-Nun A, Shai Y.

Blood. 2013 Mar 21;121(12):2244-52. doi: 10.1182/blood-2012-11-468900. Epub 2013 Jan 16.


Topology of the trans-membrane peptide WALP23 in model membranes under negative mismatch conditions.

Matalon E, Kaminker I, Zimmermann H, Eisenstein M, Shai Y, Goldfarb D.

J Phys Chem B. 2013 Feb 28;117(8):2280-93. doi: 10.1021/jp310056h. Epub 2013 Feb 14.


ATR-FTIR studies in pore forming and membrane induced fusion peptides.

Shai Y.

Biochim Biophys Acta. 2013 Oct;1828(10):2306-13. doi: 10.1016/j.bbamem.2012.11.027. Epub 2012 Nov 29. Review.


D-alanylation of lipoteichoic acids confers resistance to cationic peptides in group B streptococcus by increasing the cell wall density.

Saar-Dover R, Bitler A, Nezer R, Shmuel-Galia L, Firon A, Shimoni E, Trieu-Cuot P, Shai Y.

PLoS Pathog. 2012 Sep;8(9):e1002891. doi: 10.1371/journal.ppat.1002891. Epub 2012 Sep 6. Erratum in: PLoS Pathog. 2012 Nov;8(11):10.1371/annotation/05894f00-6d95-4b7a-aff1-2e008d2a864f.


Antimicrobial host defensins - specific antibiotic activities and innate defense modulation.

Ulm H, Wilmes M, Shai Y, Sahl HG.

Front Immunol. 2012 Aug 14;3:249. doi: 10.3389/fimmu.2012.00249. eCollection 2012. No abstract available.


Intramolecular interactions within the human immunodeficiency virus-1 gp41 loop region and their involvement in lipid merging.

Ashkenazi A, Merklinger E, Shai Y.

Biochemistry. 2012 Sep 4;51(35):6981-9. doi: 10.1021/bi300868f. Epub 2012 Aug 23.


Sphingopeptides: dihydrosphingosine-based fusion inhibitors against wild-type and enfuvirtide-resistant HIV-1.

Ashkenazi A, Viard M, Unger L, Blumenthal R, Shai Y.

FASEB J. 2012 Nov;26(11):4628-36. doi: 10.1096/fj.12-215111. Epub 2012 Aug 7.


Fractal properties of macrophage membrane studied by AFM.

Bitler A, Dover R, Shai Y.

Micron. 2012 Dec;43(12):1239-45. doi: 10.1016/j.micron.2012.04.009. Epub 2012 May 7.


HIV-1 gp41 transmembrane domain interacts with the fusion peptide: implication in lipid mixing and inhibition of virus-cell fusion.

Reuven EM, Dadon Y, Viard M, Manukovsky N, Blumenthal R, Shai Y.

Biochemistry. 2012 Apr 3;51(13):2867-78. doi: 10.1021/bi201721r. Epub 2012 Mar 23.


Trivalent ultrashort lipopeptides are potent pH dependent antifungal agents.

Arnusch CJ, Albada HB, van Vaardegem M, Liskamp RM, Sahl HG, Shadkchan Y, Osherov N, Shai Y.

J Med Chem. 2012 Feb 9;55(3):1296-302. doi: 10.1021/jm2014474. Epub 2012 Feb 1.


Oncolytic activities of host defense peptides.

Al-Benna S, Shai Y, Jacobsen F, Steinstraesser L.

Int J Mol Sci. 2011;12(11):8027-51. doi: 10.3390/ijms12118027. Epub 2011 Nov 16. Review.


Effect of PhoP-PhoQ activation by broad repertoire of antimicrobial peptides on bacterial resistance.

Shprung T, Peleg A, Rosenfeld Y, Trieu-Cuot P, Shai Y.

J Biol Chem. 2012 Feb 10;287(7):4544-51. doi: 10.1074/jbc.M111.278523. Epub 2011 Dec 12.


Transmembrane domains interactions within the membrane milieu: principles, advances and challenges.

Fink A, Sal-Man N, Gerber D, Shai Y.

Biochim Biophys Acta. 2012 Apr;1818(4):974-83. doi: 10.1016/j.bbamem.2011.11.029. Epub 2011 Dec 3. Review.


Membrane integration of a mitochondrial signal-anchored protein does not require additional proteinaceous factors.

Merklinger E, Gofman Y, Kedrov A, Driessen AJ, Ben-Tal N, Shai Y, Rapaport D.

Biochem J. 2012 Mar 1;442(2):381-9. doi: 10.1042/BJ20111363.


Investigation of model membrane disruption mechanism by melittin using pulse electron paramagnetic resonance spectroscopy and cryogenic transmission electron microscopy.

Gordon-Grossman M, Zimmermann H, Wolf SG, Shai Y, Goldfarb D.

J Phys Chem B. 2012 Jan 12;116(1):179-88. doi: 10.1021/jp207159z. Epub 2011 Dec 12.


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