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Environmental DNA size sorting and degradation experiment indicates the state of Daphnia magna mitochondrial and nuclear eDNA is subcellular.

Moushomi R, Wilgar G, Carvalho G, Creer S, Seymour M.

Sci Rep. 2019 Aug 29;9(1):12500. doi: 10.1038/s41598-019-48984-7.


Drift versus selection as drivers of phenotypic divergence at small spatial scales: The case of Belgjarskógur threespine stickleback.

Seymour M, Räsänen K, Kristjánsson BK.

Ecol Evol. 2019 Jun 27;9(14):8133-8145. doi: 10.1002/ece3.5381. eCollection 2019 Jul.


Safety and Efficacy of the Addition of Lapatinib to Perioperative Chemotherapy for Resectable HER2-Positive Gastroesophageal Adenocarcinoma: A Randomized Phase 2 Clinical Trial.

Smyth EC, Rowley S, Cafferty FH, Allum W, Grabsch HI, Stenning S, Wotherspoon A, Alderson D, Crosby T, Mansoor W, Waters JS, Neville-Webbe H, Darby S, Dent J, Seymour M, Thompson J, Sothi S, Blazeby J, Langley RE, Cunningham D.

JAMA Oncol. 2019 Jun 20. doi: 10.1001/jamaoncol.2019.1179. [Epub ahead of print]


Improving outcomes for older people with cancer - A workshop of the UK National Cancer Research Institute.

Alexander S, Bridges J, Kalsi T, Meltzer D, Lewis I, Seymour M.

J Geriatr Oncol. 2019 May;10(3):378-381. doi: 10.1016/j.jgo.2019.01.025. Epub 2019 Mar 4. No abstract available.


Rapid progression and future of environmental DNA research.

Seymour M.

Commun Biol. 2019 Feb 27;2:80. doi: 10.1038/s42003-019-0330-9. eCollection 2019.


Spontaneous Pneumothorax in a Young Woman.

Van Hook CJ, Sullivan PR, Seymour M.

Am J Med. 2019 Jun;132(6):706-707. doi: 10.1016/j.amjmed.2019.01.013. Epub 2019 Jan 31. No abstract available.


Combining Volumetric Capnography And Barometric Plethysmography To Measure The Lung Structure-function Relationship.

Seymour M, Pritchard E, Sajjad H, Tomasson EP, Blodgett CM, Winnike H, Paun OV, Eberlein M, Bates ML.

J Vis Exp. 2019 Jan 8;(143). doi: 10.3791/58238.


Choosing the right strategy based on individualized treatment effect predictions: combination versus sequential chemotherapy in patients with metastatic colorectal cancer.

Kwakman JJM, van Kruijsdijk RCM, Elias SG, Seymour MT, Meade AM, Visseren FLJ, Punt CJA, Koopman M.

Acta Oncol. 2019 Mar;58(3):326-333. doi: 10.1080/0284186X.2018.1564840. Epub 2019 Jan 18.


Biodiversity increases and decreases ecosystem stability.

Pennekamp F, Pontarp M, Tabi A, Altermatt F, Alther R, Choffat Y, Fronhofer EA, Ganesanandamoorthy P, Garnier A, Griffiths JI, Greene S, Horgan K, Massie TM, Mächler E, Palamara GM, Seymour M, Petchey OL.

Nature. 2018 Nov;563(7729):109-112. doi: 10.1038/s41586-018-0627-8. Epub 2018 Oct 17.


Acidity promotes degradation of multi-species environmental DNA in lotic mesocosms.

Seymour M, Durance I, Cosby BJ, Ransom-Jones E, Deiner K, Ormerod SJ, Colbourne JK, Wilgar G, Carvalho GR, de Bruyn M, Edwards F, Emmett BA, Bik HM, Creer S.

Commun Biol. 2018 Jan 22;1:4. doi: 10.1038/s42003-017-0005-3. eCollection 2018.


Clinicopathological differences and survival outcomes with first-line therapy in patients with left-sided colon cancer and rectal cancer: Pooled analysis of 2879 patients from AGITG (MAX), COIN, FOCUS2, OPUS, CRYSTAL and COIN-B trials in the ARCAD database.

Salem ME, Yin J, Weinberg BA, Renfro LA, Pederson LD, Maughan TS, Adams RA, Van Cutsem E, Falcone A, Tebbutt NC, Seymour MT, Díaz-Rubio E, Aranda E, Bokemeyer C, Heinemann V, Wasan H, de Gramont A, Grothey A, Shi Q, Sargent DJ, Marshall JL.

Eur J Cancer. 2018 Nov;103:205-213. doi: 10.1016/j.ejca.2018.08.020. Epub 2018 Sep 27.


Inspiratory and expiratory resistance cause right-to-left bubble passage through the foramen ovale.

Moses KL, Seymour M, Beshish A, Baker KR, Pegelow DF, Lamers LJ, Eldridge MW, Bates ML.

Physiol Rep. 2018 Jun;6(12):e13719. doi: 10.14814/phy2.13719.


Trehalose reduces retinal degeneration, neuroinflammation and storage burden caused by a lysosomal hydrolase deficiency.

Lotfi P, Tse DY, Di Ronza A, Seymour ML, Martano G, Cooper JD, Pereira FA, Passafaro M, Wu SM, Sardiello M.

Autophagy. 2018;14(8):1419-1434. doi: 10.1080/15548627.2018.1474313. Epub 2018 Jul 23.


In situ chemically specific mapping of agrochemical seed coatings using stimulated Raman scattering microscopy.

Wang CC, Moorhouse S, Stain C, Seymour M, Green E, Penfield S, Moger J.

J Biophotonics. 2018 Nov;11(11):e201800108. doi: 10.1002/jbio.201800108. Epub 2018 Jul 18.


Performance of amplicon and shotgun sequencing for accurate biomass estimation in invertebrate community samples.

Bista I, Carvalho GR, Tang M, Walsh K, Zhou X, Hajibabaei M, Shokralla S, Seymour M, Bradley D, Liu S, Christmas M, Creer S.

Mol Ecol Resour. 2018 Apr 18. doi: 10.1111/1755-0998.12888. [Epub ahead of print]


Profiling of dalcetrapib metabolites in human plasma by accelerator mass spectrometry and investigation of the free phenothiol by derivatisation with methylacrylate.

Husser C, Pähler A, Seymour M, Kuhlmann O, Schadt S, Zell M.

J Pharm Biomed Anal. 2018 Apr 15;152:143-154. doi: 10.1016/j.jpba.2018.01.022. Epub 2018 Jan 12.


Two-component structural phase-field crystal models for graphene symmetries.

Elder KLM, Seymour M, Lee M, Hilke M, Provatas N.

Philos Trans A Math Phys Eng Sci. 2018 Feb 28;376(2113). pii: 20170211. doi: 10.1098/rsta.2017.0211.


The prevalence and correlates of self-harm ideation trajectories in Australian women from pregnancy to 4-years postpartum.

Giallo R, Pilkington P, Borschmann R, Seymour M, Dunning M, Brown S.

J Affect Disord. 2018 Mar 15;229:152-158. doi: 10.1016/j.jad.2017.12.064. Epub 2018 Jan 2.


Personalizing Survival Predictions in Advanced Colorectal Cancer: The ARCAD Nomogram Project.

Sjoquist KM, Renfro LA, Simes RJ, Tebbutt NC, Clarke S, Seymour MT, Adams R, Maughan TS, Saltz L, Goldberg RM, Schmoll HJ, Van Cutsem E, Douillard JY, Hoff PM, Hecht JR, Tournigand C, Punt CJA, Koopman M, Hurwitz H, Heinemann V, Falcone A, Porschen R, Fuchs C, Diaz-Rubio E, Aranda E, Bokemeyer C, Souglakos I, Kabbinavar FF, Chibaudel B, Meyers JP, Sargent DJ, de Gramont A, Zalcberg JR; Fondation Aide et Recherche en Cancerologie Digestive Group (ARCAD).

J Natl Cancer Inst. 2018 Jun 1;110(6):638-648. doi: 10.1093/jnci/djx253.


Inhibition of EGFR, HER2, and HER3 signalling in patients with colorectal cancer wild-type for BRAF, PIK3CA, KRAS, and NRAS (FOCUS4-D): a phase 2-3 randomised trial.

Adams R, Brown E, Brown L, Butler R, Falk S, Fisher D, Kaplan R, Quirke P, Richman S, Samuel L, Seligmann J, Seymour M, Shiu KK, Wasan H, Wilson R, Maughan T; FOCUS4 Trial Investigators.

Lancet Gastroenterol Hepatol. 2018 Mar;3(3):162-171. doi: 10.1016/S2468-1253(17)30394-1. Epub 2017 Dec 16.


Association of Tumor HER3 Messenger RNA Expression With Panitumumab Efficacy in Advanced Colorectal Cancer.

Seligmann JF, Hatch AJ, Richman SD, Elliott F, Jacobs B, Brown S, Hurwitz H, Barrett JH, Quirke P, Nixon AB, Seymour MT.

JAMA Oncol. 2018 Apr 1;4(4):564-568. doi: 10.1001/jamaoncol.2017.3168.


Decoy receptor 1 (DCR1) promoter hypermethylation and response to irinotecan in metastatic colorectal cancer.

Bosch LJW, Trooskens G, Snaebjornsson P, Coupé VMH, Mongera S, Haan JC, Richman SD, Koopman M, Tol J, de Meyer T, Louwagie J, Dehaspe L, van Grieken NCT, Ylstra B, Verheul HMW, van Engeland M, Nagtegaal ID, Herman JG, Quirke P, Seymour MT, Punt CJA, van Criekinge W, Carvalho B, Meijer GA.

Oncotarget. 2017 Jun 27;8(38):63140-63154. doi: 10.18632/oncotarget.18702. eCollection 2017 Sep 8.


Environmental DNA metabarcoding: Transforming how we survey animal and plant communities.

Deiner K, Bik HM, Mächler E, Seymour M, Lacoursière-Roussel A, Altermatt F, Creer S, Bista I, Lodge DM, de Vere N, Pfrender ME, Bernatchez L.

Mol Ecol. 2017 Nov;26(21):5872-5895. doi: 10.1111/mec.14350. Epub 2017 Oct 26. Review.


Impact of tumour histological subtype on chemotherapy outcome in advanced oesophageal cancer.

Davidson M, Chau I, Cunningham D, Khabra K, Iveson T, Hickish T, Seymour M, Starling N.

World J Gastrointest Oncol. 2017 Aug 15;9(8):333-340. doi: 10.4251/wjgo.v9.i8.333.


PDA PAC iAM 2017 Survey on Post Approval Change: Is the Regulatory Environment Hindering Much-Needed Innovation in the Pharma Industry?

Authors: Members of the PDA Task Force Post Approval Changes for Innovation in Availability of Medicines (PAC iAM), Ramnarine E, Busse U, Colao M, Edwards J, Follman K, Gale K, Good K, Kiani S, Jornitz M, Munk M, O'Donnel K, Seymour M, Simianu M, Skeens L, Vinther A, Baker D, Levy R.

PDA J Pharm Sci Technol. 2017 Sep-Oct;71(5):421-427. doi: 10.5731/pdajpst.2017.008219. Epub 2017 Aug 17. No abstract available.


Marine ecology: Genetics from a drop in the ocean.

Creer S, Seymour M.

Nat Ecol Evol. 2017 Jan 4;1(1):37. doi: 10.1038/s41559-016-0037. No abstract available.


Bio-ecological factors associated with the psychological distress of fathers of children with autism spectrum disorder: A population-based study of Australian families.

Seymour M, Giallo R, Wood CE.

Autism. 2018 Oct;22(7):825-836. doi: 10.1177/1362361317709971. Epub 2017 Jul 28.


Intratumoral stromal morphometry predicts disease recurrence but not response to 5-fluorouracil-results from the QUASAR trial of colorectal cancer.

Hutchins GGA, Treanor D, Wright A, Handley K, Magill L, Tinkler-Hundal E, Southward K, Seymour M, Kerr D, Gray R, Quirke P; QUASAR trial collaborators and the UK National Cancer Research Institute Colorectal Cancer Clinical Studies Group.

Histopathology. 2018 Feb;72(3):391-404. doi: 10.1111/his.13326. Epub 2017 Nov 27.


An Atoh1-S193A Phospho-Mutant Allele Causes Hearing Deficits and Motor Impairment.

Xie WR, Jen HI, Seymour ML, Yeh SY, Pereira FA, Groves AK, Klisch TJ, Zoghbi HY.

J Neurosci. 2017 Sep 6;37(36):8583-8594. doi: 10.1523/JNEUROSCI.0295-17.2017. Epub 2017 Jul 20.


Corrigendum: mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases.

Palmieri M, Pal R, Nelvagal HR, Lotfi P, Stinnett GR, Seymour ML, Chaudhury A, Bajaj L, Bondar VV, Bremner L, Saleem U, Tse DY, Sanagasetti D, Wu SM, Neilson JR, Pereira FA, Pautler RG, Rodney GG, Cooper JD, Sardiello M.

Nat Commun. 2017 Jun 13;8:15793. doi: 10.1038/ncomms15793.


Dynamic species classification of microorganisms across time, abiotic and biotic environments-A sliding window approach.

Pennekamp F, Griffiths JI, Fronhofer EA, Garnier A, Seymour M, Altermatt F, Petchey OL.

PLoS One. 2017 May 4;12(5):e0176682. doi: 10.1371/journal.pone.0176682. eCollection 2017.


Clinical Calculator for Early Mortality in Metastatic Colorectal Cancer: An Analysis of Patients From 28 Clinical Trials in the Aide et Recherche en Cancérologie Digestive Database.

Renfro LA, Goldberg RM, Grothey A, Sobrero A, Adams R, Seymour MT, Heinemann V, Schmoll HJ, Douillard JY, Hurwitz H, Fuchs CS, Diaz-Rubio E, Porschen R, Tournigand C, Chibaudel B, Hoff PM, Kabbinavar FF, Falcone A, Tebbutt NC, Punt CJA, Hecht JR, Souglakos J, Bokemeyer C, Van Cutsem E, Saltz L, de Gramont A, Sargent DJ; ARCAD Clinical Trials Program.

J Clin Oncol. 2017 Jun 10;35(17):1929-1937. doi: 10.1200/JCO.2016.71.5771. Epub 2017 Apr 17.


Use of Gene Expression Profiles to Distinguish Molecular Subtypes in Colorectal Cancer: Progression Toward Primetime.

Seligmann JF, Seymour MT.

J Natl Cancer Inst. 2017 Jul 1;109(7). doi: 10.1093/jnci/djx019. No abstract available.


Single-crystal X-ray diffraction and NMR crystallography of a 1:1 cocrystal of dithianon and pyrimethanil.

Pöppler AC, Corlett EK, Pearce H, Seymour MP, Reid M, Montgomery MG, Brown SP.

Acta Crystallogr C Struct Chem. 2017 Mar 1;73(Pt 3):149-156. doi: 10.1107/S2053229617000870. Epub 2017 Feb 6.


PDA Points to Consider: Technical Product Lifecycle Management. Pharmaceutical Quality System Effectiveness for Managing Post-approval Changes.

Authors: Members of the PDA Task Force on Post-approval Changes for Innovation in Availability of Medicines (PAC iAMsm), Ramnarine E, Busse U, Colao M, Edwards J, O'Donnell K, Jornitz M, Munk M, Seymour M, Simianu M, Skeens L, Vinther A.

PDA J Pharm Sci Technol. 2017 May-Jun;71(3):252-258. doi: 10.5731/pdajpst.2017.007575. Epub 2017 Feb 14. Review. No abstract available.


Unilateral facial swelling in a thyrotoxic patient.

Seymour M, Morton A.

BMJ. 2017 Feb 9;356:j534. doi: 10.1136/bmj.j534. No abstract available.


mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases.

Palmieri M, Pal R, Nelvagal HR, Lotfi P, Stinnett GR, Seymour ML, Chaudhury A, Bajaj L, Bondar VV, Bremner L, Saleem U, Tse DY, Sanagasetti D, Wu SM, Neilson JR, Pereira FA, Pautler RG, Rodney GG, Cooper JD, Sardiello M.

Nat Commun. 2017 Feb 6;8:14338. doi: 10.1038/ncomms14338. Erratum in: Nat Commun. 2017 Jun 13;8:15793.


Annual time-series analysis of aqueous eDNA reveals ecologically relevant dynamics of lake ecosystem biodiversity.

Bista I, Carvalho GR, Walsh K, Seymour M, Hajibabaei M, Lallias D, Christmas M, Creer S.

Nat Commun. 2017 Jan 18;8:14087. doi: 10.1038/ncomms14087.


A randomised phase II trial and feasibility study of palliative chemotherapy in frail or elderly patients with advanced gastroesophageal cancer (321GO).

Hall PS, Lord SR, Collinson M, Marshall H, Jones M, Lowe C, Howard H, Swinson D, Velikova G, Anthoney A, Roy R, Dent J, Cheeseman S, Last K, Seymour MT.

Br J Cancer. 2017 Feb 14;116(4):472-478. doi: 10.1038/bjc.2016.442. Epub 2017 Jan 17.


PDA Points To Consider: Technical Product Lifecycle Management: Communication and Knowledge Exchange between Marketing Authorization Holders and Health Authorities.

Authors: Members of the PDA Task Force Post Approval Changes for Innovation in Availability of Medicines (PAC iAM), Ramnarine E, Busse U, Colao M, Edwards J, Jornitz M, Munk M, Seymour M, Simianu M, Skeens L, Vinther A.

PDA J Pharm Sci Technol. 2017 Mar-Apr;71(2):163-169. doi: 10.5731/pdajpst.2016.007492. Epub 2017 Jan 15. Review. No abstract available.


Investigating the poor outcomes of BRAF-mutant advanced colorectal cancer: analysis from 2530 patients in randomised clinical trials.

Seligmann JF, Fisher D, Smith CG, Richman SD, Elliott F, Brown S, Adams R, Maughan T, Quirke P, Cheadle J, Seymour M, Middleton G.

Ann Oncol. 2017 Mar 1;28(3):562-568. doi: 10.1093/annonc/mdw645.


High hospital research participation and improved colorectal cancer survival outcomes: a population-based study.

Downing A, Morris EJ, Corrigan N, Sebag-Montefiore D, Finan PJ, Thomas JD, Chapman M, Hamilton R, Campbell H, Cameron D, Kaplan R, Parmar M, Stephens R, Seymour M, Gregory W, Selby P.

Gut. 2017 Jan;66(1):89-96. doi: 10.1136/gutjnl-2015-311308. Epub 2016 Oct 19.


Prognosis of patients with peritoneal metastatic colorectal cancer given systemic therapy: an analysis of individual patient data from prospective randomised trials from the Analysis and Research in Cancers of the Digestive System (ARCAD) database.

Franko J, Shi Q, Meyers JP, Maughan TS, Adams RA, Seymour MT, Saltz L, Punt CJA, Koopman M, Tournigand C, Tebbutt NC, Diaz-Rubio E, Souglakos J, Falcone A, Chibaudel B, Heinemann V, Moen J, De Gramont A, Sargent DJ, Grothey A; Analysis and Research in Cancers of the Digestive System (ARCAD) Group.

Lancet Oncol. 2016 Dec;17(12):1709-1719. doi: 10.1016/S1470-2045(16)30500-9. Epub 2016 Oct 12.


Dinuclear uranium complexation and manipulation using robust tetraaryloxides.

Wells JA, Seymour ML, Suvova M, Arnold PL.

Dalton Trans. 2016 Oct 12;45(40):16026-16032.


Depression and anger in fathers of unsettled infants: A community cohort study.

Cook F, Giallo R, Petrovic Z, Coe A, Seymour M, Cann W, Hiscock H.

J Paediatr Child Health. 2017 Feb;53(2):131-135. doi: 10.1111/jpc.13311. Epub 2016 Sep 19.


A Phase I Study to Investigate the Absorption, Pharmacokinetics, and Excretion of [(14)C]Prucalopride After a Single Oral Dose in Healthy Volunteers.

Flach S, Scarfe G, Dragone J, Ding J, Seymour M, Pennick M, Pankratz T, Troy S, Getsy J.

Clin Ther. 2016 Sep;38(9):2106-15. doi: 10.1016/j.clinthera.2016.08.003. Epub 2016 Sep 7.


Adding value through accelerator mass spectrometry-enabled first in human studies.

Seymour MA.

J Labelled Comp Radiopharm. 2016 Dec;59(14):640-647. doi: 10.1002/jlcr.3420. Epub 2016 Jul 22.


Manipulations of MeCP2 in glutamatergic neurons highlight their contributions to Rett and other neurological disorders.

Meng X, Wang W, Lu H, He LJ, Chen W, Chao ES, Fiorotto ML, Tang B, Herrera JA, Seymour ML, Neul JL, Pereira FA, Tang J, Xue M, Zoghbi HY.

Elife. 2016 Jun 21;5. pii: e14199. doi: 10.7554/eLife.14199.


Ordering Multiple Soft Gluon Emissions.

Ángeles Martínez R, Forshaw JR, Seymour MH.

Phys Rev Lett. 2016 May 27;116(21):212003. doi: 10.1103/PhysRevLett.116.212003. Epub 2016 May 26.


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