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[Use HbA1cas a diagnostic test for type 2 diabetes mellitus].

Smulders Y, Serné E.

Ned Tijdschr Geneeskd. 2019 Sep 9;163. pii: D4225. Dutch.


Contrast-enhanced ultrasound for quantification of tissue perfusion in humans.

Emanuel AL, Meijer RI, van Poelgeest E, Spoor P, Serné EH, Eringa EC.

Microcirculation. 2019 Aug 29:e12588. doi: 10.1111/micc.12588. [Epub ahead of print] Review.


Assessment of real-time and quantitative changes in renal hemodynamics in healthy overweight males: Contrast-enhanced ultrasonography vs para-aminohippuric acid clearance.

Muskiet MHA, Emanuel AL, Smits MM, Tonneijck L, Meijer RI, Joles JA, Serné EH, van Raalte DH.

Microcirculation. 2019 Oct;26(7):e12580. doi: 10.1111/micc.12580. Epub 2019 Aug 26.


JNK2 in myeloid cells impairs insulin's vasodilator effects in muscle during early obesity development through perivascular adipose tissue dysfunction.

Meijer RI, Hoevenaars FPM, Serné EH, Yudkin JS, Kokhuis TJA, Weijers EM, van Hinsbergh VWM, Smulders YM, Eringa EC.

Am J Physiol Heart Circ Physiol. 2019 Aug 1;317(2):H364-H374. doi: 10.1152/ajpheart.00663.2018. Epub 2019 May 31.


Prescription patterns of lipid lowering agents among older patients in general practice: an analysis from a national database in the Netherlands.

Kleipool EEF, Nielen MMJ, Korevaar JC, Harskamp RE, Smulders YM, Serné E, Thijs A, Peters MJL, Muller M.

Age Ageing. 2019 Jul 1;48(4):577-582. doi: 10.1093/ageing/afz034.


[Towards personalized treatment of type 2 diabetes].

Serné E.

Ned Tijdschr Geneeskd. 2019 Jan 14;163. pii: D3494. Dutch.


The presence of cerebral white matter lesions and lower skin microvascular perfusion predicts lower cognitive performance in type 1 diabetes patients with retinopathy but not in healthy controls-A longitudinal study.

Emanuel AL, van Duinkerken E, Wattjes MP, Klein M, Barkhof F, Snoek FJ, Diamant M, Eringa EC, IJzerman RG, Serné EH.

Microcirculation. 2019 Apr;26(3):e12530. doi: 10.1111/micc.12530. Epub 2019 Feb 22.


Standing is not enough: A randomized crossover study on the acute cardiometabolic effects of variations in sitting in healthy young men.

Altenburg TM, Rotteveel J, Serné EH, Chinapaw MJM.

J Sci Med Sport. 2019 Jul;22(7):790-796. doi: 10.1016/j.jsams.2018.12.016. Epub 2019 Jan 4.


Peripheral Insulin Extraction in Non-Diabetic Subjects and Type 2 Diabetes Mellitus Patients.

van Raalte DH, van der Palen E, Idema P, Wong L, Keet SWM, Vlot M, Tukkie R, van Vlies B, Serné EH, Ten Kate RW.

Exp Clin Endocrinol Diabetes. 2018 Dec 17. doi: 10.1055/a-0808-4029. [Epub ahead of print]


Resilience to cognitive impairment in the oldest-old: design of the EMIF-AD 90+ study.

Legdeur N, Badissi M, Carter SF, de Crom S, van de Kreeke A, Vreeswijk R, Trappenburg MC, Oudega ML, Koek HL, van Campen JP, Keijsers CJPW, Amadi C, Hinz R, Gordon MF, Novak G, Podhorna J, Serné E, Verbraak F, Yaqub M, Hillebrand A, Griffa A, Pendleton N, Kramer SE, Teunissen CE, Lammertsma A, Barkhof F, van Berckel BNM, Scheltens P, Muller M, Maier AB, Herholz K, Visser PJ.

BMC Geriatr. 2018 Nov 26;18(1):289. doi: 10.1186/s12877-018-0984-z.


Individually shortened duration versus standard duration of elastic compression therapy for prevention of post-thrombotic syndrome: a cost-effectiveness analysis.

Amin EE, Ten Cate-Hoek AJ, Bouman AC, Meijer K, Tick L, Middeldorp S, Mostard G, Ten Wolde M, van den Heiligenberg S, van Wissen S, van de Poel M, Villalta S, Serné E, Otten HM, Klappe E, Prandoni P, Prins MH, Ten Cate H, Joore MA.

Lancet Haematol. 2018 Nov;5(11):e512-e519. doi: 10.1016/S2352-3026(18)30151-0. Epub 2018 Oct 9.


Reduced incidence of vein occlusion and postthrombotic syndrome after immediate compression for deep vein thrombosis.

Amin EE, Bistervels IM, Meijer K, Tick LW, Middeldorp S, Mostard G, van de Poel M, Serné EH, Otten HM, Klappe EM, Joore MA, Ten Cate H, Ten Wolde M, Ten Cate-Hoek AJ.

Blood. 2018 Nov 22;132(21):2298-2304. doi: 10.1182/blood-2018-03-836783. Epub 2018 Sep 20.


Rationale and design of a cohort study on primary ovarian insufficiency in female survivors of Hodgkin's lymphoma: influence on long-term adverse effects (SOPHIA).

Krul IM, Opstal-van Winden AWJ, Zijlstra JM, Appelman Y, Schagen SB, Meijboom LJ, Serné E, Lambalk CB, Lips P, van Dulmen-den Broeder E, Hauptmann M, Daniëls LA, Aleman BMP, van Leeuwen FE.

BMJ Open. 2018 Sep 11;8(9):e018120. doi: 10.1136/bmjopen-2017-018120.


The EMIF-AD PreclinAD study: study design and baseline cohort overview.

Konijnenberg E, Carter SF, Ten Kate M, den Braber A, Tomassen J, Amadi C, Wesselman L, Nguyen HT, van de Kreeke JA, Yaqub M, Demuru M, Mulder SD, Hillebrand A, Bouwman FH, Teunissen CE, Serné EH, Moll AC, Verbraak FD, Hinz R, Pendleton N, Lammertsma AA, van Berckel BNM, Barkhof F, Boomsma DI, Scheltens P, Herholz K, Visser PJ.

Alzheimers Res Ther. 2018 Aug 4;10(1):75. doi: 10.1186/s13195-018-0406-7.


Iloprost infusion prevents the insulin-induced reduction in skeletal muscle microvascular blood volume but does not enhance peripheral glucose uptake in type 2 diabetic patients.

Emanuel AL, de Clercq NC, Koopen AM, van Poelgeest E, Serlie MJM, van Raalte DH, Kramer MHH, Nieuwdorp M, Eringa EC, Serné EH.

Diabetes Obes Metab. 2018 Nov;20(11):2523-2531. doi: 10.1111/dom.13410. Epub 2018 Jul 27.


Clinical and economic impact of compression in the acute phase of deep vein thrombosis.

Amin EE, Joore MA, Ten Cate H, Meijer K, Tick LW, Middeldorp S, Mostard GJM, Ten Wolde M, van den Heiligenberg SM, van Wissen S, van de Poel MHW, Villalta S, Serné EH, Otten HM, Klappe EH, Prandoni P, Ten Cate-Hoek AJ.

J Thromb Haemost. 2018 Jun 1. doi: 10.1111/jth.14163. [Epub ahead of print]


Insulin Receptor Substrate 2 Controls Insulin-Mediated Vasoreactivity and Perivascular Adipose Tissue Function in Muscle.

Turaihi AH, Bakker W, van Hinsbergh VWM, Serné EH, Smulders YM, Niessen HWM, Eringa EC.

Front Physiol. 2018 Mar 23;9:245. doi: 10.3389/fphys.2018.00245. eCollection 2018.


Is HbA1c a good diagnostic test for (pre)diabetes in cardiac rehabilitation patients?

Smulders Y, Serné E.

Eur J Prev Cardiol. 2018 Mar;25(5):462-463. doi: 10.1177/2047487318757553. Epub 2018 Feb 7. No abstract available.


Individualised versus standard duration of elastic compression therapy for prevention of post-thrombotic syndrome (IDEAL DVT): a multicentre, randomised, single-blind, allocation-concealed, non-inferiority trial.

Ten Cate-Hoek AJ, Amin EE, Bouman AC, Meijer K, Tick LW, Middeldorp S, Mostard GJM, Ten Wolde M, van den Heiligenberg SM, van Wissen S, van de Poel MH, Villalta S, Serné EH, Otten HM, Klappe EH, Bistervels IM, Lauw MN, Piersma-Wichers M, Prandoni P, Joore MA, Prins MH, Ten Cate H; IDEAL DVT investigators.

Lancet Haematol. 2018 Jan;5(1):e25-e33. doi: 10.1016/S2352-3026(17)30227-2. Epub 2017 Dec 5.


The relation between HbA1c and hypoglycemia revisited; a secondary analysis from an intervention trial in patients with type 1 diabetes and impaired awareness of hypoglycemia.

van Beers CAJ, Caris MG, DeVries JH, Serné EH.

J Diabetes Complications. 2018 Jan;32(1):100-103. doi: 10.1016/j.jdiacomp.2017.09.005. Epub 2017 Sep 18.


Continuous Glucose Monitoring in Patients with Type 1 Diabetes and Impaired Awareness of Hypoglycemia: Also Effective in Patients with Psychological Distress?

van Beers CAJ, de Wit M, Kleijer SJ, Geelhoed-Duijvestijn PH, DeVries JH, Kramer MHH, Diamant M, Serné EH, Snoek FJ.

Diabetes Technol Ther. 2017 Oct;19(10):595-599. doi: 10.1089/dia.2017.0141. Epub 2017 Aug 24.


Keeping safe. Continuous glucose monitoring (CGM) in persons with Type 1 diabetes and impaired awareness of hypoglycaemia: a qualitative study.

Vloemans AF, van Beers CAJ, de Wit M, Cleijne W, Rondags SM, Geelhoed-Duijvestijn PH, Kramer MHH, Serné EH, Snoek FJ.

Diabet Med. 2017 Oct;34(10):1470-1476. doi: 10.1111/dme.13429. Epub 2017 Aug 14.


Red wine polyphenols do not improve obesity-associated insulin resistance: A randomized controlled trial.

Woerdeman J, Del Rio D, Calani L, Eringa EC, Smulders YM, Serné EH.

Diabetes Obes Metab. 2018 Jan;20(1):206-210. doi: 10.1111/dom.13044. Epub 2017 Aug 14.


Combined Intravital Microscopy and Contrast-enhanced Ultrasonography of the Mouse Hindlimb to Study Insulin-induced Vasodilation and Muscle Perfusion.

Turaihi AH, van Poelgeest EM, van Hinsbergh VW, Serné EH, Smulders YM, Eringa EC.

J Vis Exp. 2017 Mar 20;(121). doi: 10.3791/54912.


Relationships Between Type 2 Diabetes, Neuropathy, and Microvascular Dysfunction: Evidence From Patients With Cryptogenic Axonal Polyneuropathy.

Emanuel AL, Nieuwenhoff MD, Klaassen ES, Verma A, Kramer MH, Strijers R, Vrancken AF, Eringa E, Groeneveld GJ, Serné EH.

Diabetes Care. 2017 Apr;40(4):583-590. doi: 10.2337/dc16-1690. Epub 2017 Feb 15.


Do grape polyphenols improve metabolic syndrome components? A systematic review.

Woerdeman J, van Poelgeest E, Ket JCF, Eringa EC, Serné EH, Smulders YM.

Eur J Clin Nutr. 2017 Dec;71(12):1381-1392. doi: 10.1038/ejcn.2016.227. Epub 2017 Feb 1. Review.


Role of Insulin-Stimulated Adipose Tissue Perfusion in the Development of Whole-Body Insulin Resistance.

Emanuel AL, Meijer RI, Muskiet MH, van Raalte DH, Eringa EC, Serné EH.

Arterioscler Thromb Vasc Biol. 2017 Mar;37(3):411-418. doi: 10.1161/ATVBAHA.116.308670. Epub 2017 Jan 26. Review.


Effects of Multiple Sedentary Days on Metabolic Risk Factors in Free-Living Conditions: Lessons Learned and Future Recommendations.

Altenburg TM, Rotteveel J, Serné EH, Chinapaw MJ.

Front Physiol. 2016 Dec 9;7:616. doi: 10.3389/fphys.2016.00616. eCollection 2016.


Continuous glucose monitoring for patients with type 1 diabetes and impaired awareness of hypoglycaemia (IN CONTROL): a randomised, open-label, crossover trial.

van Beers CA, DeVries JH, Kleijer SJ, Smits MM, Geelhoed-Duijvestijn PH, Kramer MH, Diamant M, Snoek FJ, Serné EH.

Lancet Diabetes Endocrinol. 2016 Nov;4(11):893-902. doi: 10.1016/S2213-8587(16)30193-0. Epub 2016 Sep 15.


Perivascular fat in human muscle.

Meijer RI, Serne EH, Yudkin JS, van Hinsbergh VW, Smulders YM, Eringa EC.

Lancet Diabetes Endocrinol. 2016 Nov;4(11):958. doi: 10.1016/S2213-8587(15)00520-3. Epub 2016 Feb 24. No abstract available.


GLP-1-Based Therapies Have No Microvascular Effects in Type 2 Diabetes Mellitus: An Acute and 12-Week Randomized, Double-Blind, Placebo-Controlled Trial.

Smits MM, Tonneijck L, Muskiet MH, Hoekstra T, Kramer MH, Diamant M, Serné EH, van Raalte DH.

Arterioscler Thromb Vasc Biol. 2016 Oct;36(10):2125-32. doi: 10.1161/ATVBAHA.116.307930. Epub 2016 Aug 25.


Exercise intensity modulates capillary perfusion in correspondence with ACE I/D modulated serum angiotensin II levels.

van Ginkel S, de Haan A, Woerdeman J, Vanhees L, Serné E, de Koning J, Flück M.

Appl Transl Genom. 2015 Mar 27;4:33-7. doi: 10.1016/j.atg.2015.03.002. eCollection 2015 Mar.


Insulin Sensitivity Determines Effects of Insulin and Meal Ingestion on Systemic Vascular Resistance in Healthy Subjects.

Woerdeman J, Meijer RI, Eringa EC, Hoekstra T, Smulders YM, Serné EH.

Microcirculation. 2016 Jan;23(1):62-8. doi: 10.1111/micc.12258.


Globular adiponectin controls insulin-mediated vasoreactivity in muscle through AMPKα2.

de Boer MP, Meijer RI, Richter EA, van Nieuw Amerongen GP, Sipkema P, van Poelgeest EM, Aman J, Kokhuis TJ, Koolwijk P, van Hinsbergh VW, Smulders YM, Serné EH, Eringa EC.

Vascul Pharmacol. 2016 Mar;78:24-35. doi: 10.1016/j.vph.2015.09.002. Epub 2015 Sep 10.


Design and rationale of the IN CONTROL trial: the effects of real-time continuous glucose monitoring on glycemia and quality of life in patients with type 1 diabetes mellitus and impaired awareness of hypoglycemia.

van Beers CA, Kleijer SJ, Serné EH, Geelhoed-Duijvestijn PH, Snoek FJ, Kramer MH, Diamant M.

BMC Endocr Disord. 2015 Aug 21;15:42. doi: 10.1186/s12902-015-0040-3.


Palmitic acid increases pro-oxidant adaptor protein p66Shc expression and affects vascularization factors in angiogenic mononuclear cells: Action of resveratrol.

Favre J, Yildirim C, Leyen TA, Chen WJ, van Genugten RE, van Golen LW, Garcia-Vallejo JJ, Musters R, Baggen J, Fontijn R, van der Pouw Kraan T, Serné E, Koolwijk P, Diamant M, Horrevoets AJ.

Vascul Pharmacol. 2015 Dec;75:7-18. doi: 10.1016/j.vph.2015.08.003. Epub 2015 Aug 5.


Pre-awakening diastolic hypotension in treated hypertensive patients: prevalence and predictors.

Zheng KH, Serné EH, Kooter AJ, Smulders YM.

J Hum Hypertens. 2016 May;30(5):322-7. doi: 10.1038/jhh.2015.80. Epub 2015 Jul 23.


Insulin-induced changes in skeletal muscle microvascular perfusion are dependent upon perivascular adipose tissue in women.

Meijer RI, Serné EH, Korkmaz HI, van der Peet DL, de Boer MP, Niessen HW, van Hinsbergh VW, Yudkin JS, Smulders YM, Eringa EC.

Diabetologia. 2015 Aug;58(8):1907-15. doi: 10.1007/s00125-015-3606-8. Epub 2015 May 24.


Metabolic changes in type 2 diabetes are reflected in peripheral blood cells, revealing aberrant cytotoxicity, a viral signature, and hypoxia inducible factor activity.

van der Pouw Kraan TC, Chen WJ, Bunck MC, van Raalte DH, van der Zijl NJ, van Genugten RE, van Bloemendaal L, Baggen JM, Serné EH, Diamant M, Horrevoets AJ.

BMC Med Genomics. 2015 May 9;8:20. doi: 10.1186/s12920-015-0096-y.


GLP-1 Receptor Agonist Exenatide Increases Capillary Perfusion Independent of Nitric Oxide in Healthy Overweight Men.

Smits MM, Muskiet MH, Tonneijck L, Kramer MH, Diamant M, van Raalte DH, Serné EH.

Arterioscler Thromb Vasc Biol. 2015 Jun;35(6):1538-43. doi: 10.1161/ATVBAHA.115.305447. Epub 2015 Apr 23.


Sleep quality and duration are related to microvascular function: the Amsterdam Growth and Health Longitudinal Study.

Bonsen T, Wijnstok NJ, Hoekstra T, Eringa EC, Serné EH, Smulders YM, Twisk JW.

J Sleep Res. 2015 Apr;24(2):140-7. doi: 10.1111/jsr.12256. Epub 2014 Nov 17.


Divergent paradigm shifts in national, European and American cardiovascular prevention guidelines.

Smulders YM, Serne EH, Stehouwer CD.

Neth J Med. 2014 Jun;72(5):289-93. No abstract available.


Body mass index is related to microvascular vasomotion, this is partly explained by adiponectin.

de Boer MP, Wijnstok NJ, Serné EH, Eringa EC, Stehouwer CD, Flyvbjerg A, Hoekstra T, Heymans MW, Meijer RI, Twisk JW, Smulders YM.

Eur J Clin Invest. 2014 Jul;44(7):660-7. doi: 10.1111/eci.12284.


Insulin-induced changes in microvascular vasomotion and capillary recruitment are associated in humans.

de Boer MP, Meijer RI, Newman J, Stehouwer CD, Eringa EC, Smulders YM, Serné EH.

Microcirculation. 2014 Jul;21(5):380-7. doi: 10.1111/micc.12114.


Homocysteine levels are inversely associated with capillary density in men, not in premenopausal women.

Hornstra JM, Hoekstra T, Serné EH, Eringa EC, Wijnstok NJ, Blom HJ, Twisk JW, Smulders YM.

Eur J Clin Invest. 2014;44(3):333-40. doi: 10.1111/eci.12240.


Metabolic syndrome components are associated with DNA hypomethylation.

Luttmer R, Spijkerman AM, Kok RM, Jakobs C, Blom HJ, Serne EH, Dekker JM, Smulders YM.

Obes Res Clin Pract. 2013 Mar-Apr;7(2):e106-e115. doi: 10.1016/j.orcp.2012.06.001.


Proliferative retinopathy in type 1 diabetes is associated with cerebral microbleeds, which is part of generalized microangiopathy.

Woerdeman J, van Duinkerken E, Wattjes MP, Barkhof F, Snoek FJ, Moll AC, Klein M, de Boer MP, Ijzerman RG, Serné EH, Diamant M.

Diabetes Care. 2014 Apr;37(4):1165-8. doi: 10.2337/dc13-1586. Epub 2013 Dec 6.


Tumour necrosis factor blocking agents and progression of subclinical atherosclerosis in patients with ankylosing spondylitis.

van Sijl AM, van Eijk IC, Peters MJ, Serné EH, van der Horst-Bruinsma IE, Smulders YM, Nurmohamed MT.

Ann Rheum Dis. 2015 Jan;74(1):119-23. doi: 10.1136/annrheumdis-2013-203934. Epub 2013 Oct 3.


Recurrent dyspnea following a swollen leg in a 46-year-old man.

Post JP, Westgeest HM, Blankensteijn JD, van der Meijs B, Klaassen RJL, Nossent E, Grünberg K, Buter J, Serné EH.

Chest. 2013 Oct;144(4):1402-1405. doi: 10.1378/chest.13-0390. No abstract available.


The relationship between 30-year developmental patterns of body fat and body fat distribution and its vascular properties: the Amsterdam Growth and Health Longitudinal Study.

Wijnstok NJ, Serné EH, Hoekstra T, Schouten F, Smulders YM, Twisk JW.

Nutr Diabetes. 2013 Sep 30;3:e90. doi: 10.1038/nutd.2013.31.

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