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Items: 1 to 50 of 601

1.

A novel cell-based sensor detecting the activity of individual basic proprotein convertases.

Löw K, Hardes K, Fedeli C, Seidah NG, Constam DB, Pasquato A, Steinmetzer T, Roulin A, Kunz S.

FEBS J. 2019 Jul 5. doi: 10.1111/febs.14979. [Epub ahead of print]

PMID:
31276291
2.

Site-specific O-glycosylation of members of the low-density lipoprotein receptor superfamily enhances ligand interactions.

Wang S, Mao Y, Narimatsu Y, Ye Z, Tian W, Goth CK, Lira-Navarrete E, Pedersen NB, Benito-Vicente A, Martin C, Uribe KB, Hurtado-Guerrero R, Christoffersen C, Seidah NG, Nielsen R, Christensen EI, Hansen L, Bennett EP, Vakhrushev SY, Schjoldager KT, Clausen H.

J Biol Chem. 2019 May 24;294(21):8349. doi: 10.1074/jbc.AAC119.009121. No abstract available.

3.

Diet-induced hepatic steatosis abrogates cell-surface LDLR by inducing de novo PCSK9 expression in mice.

Lebeau PF, Byun JH, Platko K, MacDonald ME, Poon SV, Faiyaz M, Seidah NG, Austin RC.

J Biol Chem. 2019 Jun 7;294(23):9037-9047. doi: 10.1074/jbc.RA119.008094. Epub 2019 Apr 19.

PMID:
31004037
4.

HIV-induced neuroinflammation: impact of PAR1 and PAR2 processing by Furin.

Sachan V, Lodge R, Mihara K, Hamelin J, Power C, Gelman BB, Hollenberg MD, Cohen ÉA, Seidah NG.

Cell Death Differ. 2019 Jan 25. doi: 10.1038/s41418-018-0264-7. [Epub ahead of print]

PMID:
30683917
5.

The Elusive Inhibitory Function of the Acidic N-Terminal Segment of the Prodomain of PCSK9: The Plot Thickens.

Seidah NG.

J Mol Biol. 2019 Mar 1;431(5):904-907. doi: 10.1016/j.jmb.2019.01.015. Epub 2019 Jan 15. No abstract available.

PMID:
30658056
6.

Variation in Serum PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9), Cardiovascular Disease Risk, and an Investigation of Potential Unanticipated Effects of PCSK9 Inhibition.

Brumpton BM, Fritsche LG, Zheng J, Nielsen JB, Mannila M, Surakka I, Rasheed H, Vie GÅ, Graham SE, Gabrielsen ME, Laugsand LE, Aukrust P, Vatten LJ, Damås JK, Ueland T, Janszky I, Zwart JA, Van't Hooft FM, Seidah NG, Hveem K, Willer C, Smith GD, Åsvold BO; INVENT Consortium.

Circ Genom Precis Med. 2019 Jan;12(1):e002335. doi: 10.1161/CIRCGEN.118.002335. No abstract available.

PMID:
30645169
7.

Novel strategies to target proprotein convertase subtilisin kexin 9: beyond monoclonal antibodies.

Seidah NG, Prat A, Pirillo A, Catapano AL, Norata GD.

Cardiovasc Res. 2019 Mar 1;115(3):510-518. doi: 10.1093/cvr/cvz003.

PMID:
30629143
8.

Transcriptome Analysis Reveals Nonfoamy Rather Than Foamy Plaque Macrophages Are Proinflammatory in Atherosclerotic Murine Models.

Kim K, Shim D, Lee JS, Zaitsev K, Williams JW, Kim KW, Jang MY, Seok Jang H, Yun TJ, Lee SH, Yoon WK, Prat A, Seidah NG, Choi J, Lee SP, Yoon SH, Nam JW, Seong JK, Oh GT, Randolph GJ, Artyomov MN, Cheong C, Choi JH.

Circ Res. 2018 Oct 26;123(10):1127-1142. doi: 10.1161/CIRCRESAHA.118.312804.

PMID:
30359200
9.

A single domain antibody against the Cys- and His-rich domain of PCSK9 and evolocumab exhibit different inhibition mechanisms in humanized PCSK9 mice.

Essalmani R, Weider E, Marcinkiewicz J, Chamberland A, Susan-Resiga D, Roubtsova A, Seidah NG, Prat A.

Biol Chem. 2018 Nov 27;399(12):1363-1374. doi: 10.1515/hsz-2018-0194.

PMID:
30044755
10.

Low-density lipoprotein (LDL)-dependent uptake of Gram-positive lipoteichoic acid and Gram-negative lipopolysaccharide occurs through LDL receptor.

Grin PM, Dwivedi DJ, Chathely KM, Trigatti BL, Prat A, Seidah NG, Liaw PC, Fox-Robichaud AE.

Sci Rep. 2018 Jul 12;8(1):10496. doi: 10.1038/s41598-018-28777-0.

11.

Posttranslational modification of proprotein convertase subtilisin/kexin type 9 is differentially regulated in response to distinct cardiometabolic treatments as revealed by targeted proteomics.

Gauthier MS, Awan Z, Bouchard A, Champagne J, Tessier S, Faubert D, Chabot K, Garneau PY, Rabasa-Lhoret R, Seidah NG, Ridker PM, Genest J, Coulombe B.

J Clin Lipidol. 2018 Jul - Aug;12(4):1027-1038. doi: 10.1016/j.jacl.2018.03.092. Epub 2018 Apr 3.

PMID:
29699916
12.

Loss-of-function PCSK9 mutants evade the unfolded protein response sensor GRP78 and fail to induce endoplasmic reticulum stress when retained.

Lebeau P, Platko K, Al-Hashimi AA, Byun JH, Lhoták Š, Holzapfel N, Gyulay G, Igdoura SA, Cool DR, Trigatti B, Seidah NG, Austin RC.

J Biol Chem. 2018 May 11;293(19):7329-7343. doi: 10.1074/jbc.RA117.001049. Epub 2018 Mar 28.

13.

Site-specific O-glycosylation of members of the low-density lipoprotein receptor superfamily enhances ligand interactions.

Wang S, Mao Y, Narimatsu Y, Ye Z, Tian W, Goth CK, Lira-Navarrete E, Pedersen NB, Benito-Vicente A, Martin C, Uribe KB, Hurtado-Guerrero R, Christoffersen C, Seidah NG, Nielsen R, Christensen EI, Hansen L, Bennett EP, Vakhrushev SY, Schjoldager KT, Clausen H.

J Biol Chem. 2018 May 11;293(19):7408-7422. doi: 10.1074/jbc.M117.817981. Epub 2018 Mar 20. Erratum in: J Biol Chem. 2019 May 24;294(21):8349.

14.

New Sequencing technologies help revealing unexpected mutations in Autosomal Dominant Hypercholesterolemia.

Elbitar S, Susan-Resiga D, Ghaleb Y, El Khoury P, Peloso G, Stitziel N, Rabès JP, Carreau V, Hamelin J, Ben-Djoudi-Ouadda A, Bruckert E, Boileau C, Seidah NG, Varret M, Abifadel M.

Sci Rep. 2018 Jan 31;8(1):1943. doi: 10.1038/s41598-018-20281-9.

15.

The ever-expanding saga of the proprotein convertases and their roles in body homeostasis: emphasis on novel proprotein convertase subtilisin kexin number 9 functions and regulation.

Seidah NG, Chrétien M, Mbikay M.

Curr Opin Lipidol. 2018 Apr;29(2):144-150. doi: 10.1097/MOL.0000000000000484. Review.

PMID:
29342010
16.

Post-transcriptional Regulation of PCSK9 by miR-191, miR-222, and miR-224.

Naeli P, Mirzadeh Azad F, Malakootian M, Seidah NG, Mowla SJ.

Front Genet. 2017 Nov 27;8:189. doi: 10.3389/fgene.2017.00189. eCollection 2017.

17.

Osteopontin as a novel substrate for the proprotein convertase 5/6 (PCSK5) in bone.

Hoac B, Susan-Resiga D, Essalmani R, Marcinkiweicz E, Seidah NG, McKee MD.

Bone. 2018 Feb;107:45-55. doi: 10.1016/j.bone.2017.11.002. Epub 2017 Nov 7.

PMID:
29126984
18.

Insights into a PCSK9 structural groove: a harbinger of new drugs to reduce LDL-cholesterol.

Seidah NG.

Nat Struct Mol Biol. 2017 Oct 5;24(10):785-786. doi: 10.1038/nsmb.3471. No abstract available.

PMID:
28981076
19.

Proprotein convertase furin regulates osteocalcin and bone endocrine function.

Al Rifai O, Chow J, Lacombe J, Julien C, Faubert D, Susan-Resiga D, Essalmani R, Creemers JW, Seidah NG, Ferron M.

J Clin Invest. 2017 Nov 1;127(11):4104-4117. doi: 10.1172/JCI93437. Epub 2017 Oct 3.

20.

The PCSK9 revolution and the potential of PCSK9-based therapies to reduce LDL-cholesterol.

Seidah NG.

Glob Cardiol Sci Pract. 2017 Mar 31;2017(1):e201702. doi: 10.21542/gcsp.2017.2. Review. No abstract available.

21.

Thrombin activation of protein C requires prior processing by a liver proprotein convertase.

Essalmani R, Susan-Resiga D, Guillemot J, Kim W, Sachan V, Awan Z, Chamberland A, Asselin MC, Ly K, Desjardins R, Day R, Prat A, Seidah NG.

J Biol Chem. 2017 Aug 18;292(33):13565. doi: 10.1074/jbc.A116.77040. No abstract available.

22.

Roles of the low density lipoprotein receptor and related receptors in inhibition of lipoprotein(a) internalization by proprotein convertase subtilisin/kexin type 9.

Romagnuolo R, Scipione CA, Marcovina SM, Gemin M, Seidah NG, Boffa MB, Koschinsky ML.

PLoS One. 2017 Jul 27;12(7):e0180869. doi: 10.1371/journal.pone.0180869. eCollection 2017.

23.

Association Between Plasma Proprotein Convertase Subtilisin/Kexin Type 9 and the Presence of Metabolic Syndrome in a Predominantly Rural-Based Sub-Saharan African Population.

Paquette M, Luna Saavedra YG, Chamberland A, Prat A, Christensen DL, Lajeunesse-Trempe F, Kaduka L, Seidah NG, Dufour R, Baass A.

Metab Syndr Relat Disord. 2017 Oct;15(8):423-429. doi: 10.1089/met.2017.0027. Epub 2017 Jul 27.

PMID:
28749722
24.

A case of hypocholesterolemia and steatosis in a carrier of a PCSK9 loss-of-function mutation and polymorphisms predisposing to nonalcoholic fatty liver disease.

Di Filippo M, Vokaer B, Seidah NG.

J Clin Lipidol. 2017 Jul - Aug;11(4):1101-1105. doi: 10.1016/j.jacl.2017.06.005. Epub 2017 Jun 13.

PMID:
28711549
25.

Can iPCSK9-induced hypocholesterolemia starve cancer cells?

Gangloff A, Calon F, Seidah NG.

J Clin Lipidol. 2017 May - Jun;11(3):600-601. doi: 10.1016/j.jacl.2017.04.001. Epub 2017 Apr 21. No abstract available.

PMID:
28506383
26.

Thrombin activation of protein C requires prior processing by a liver proprotein convertase.

Essalmani R, Susan-Resiga D, Guillemot J, Kim W, Sachan V, Awan Z, Chamberland A, Asselin MC, Ly K, Desjardins R, Day R, Prat A, Seidah NG.

J Biol Chem. 2017 Jun 23;292(25):10564-10573. doi: 10.1074/jbc.M116.770040. Epub 2017 May 3. Erratum in: J Biol Chem. 2017 Aug 18;292(33):13565.

27.

Proprotein Convertase Subtilisin/Kexin type 9 affects insulin but not lipid metabolism in cystic fibrosis.

Coriati A, Arslanian E, Bouvet GF, Prat A, Seidah NG, Rabasa-Lhoret R, Berthiaume Y.

Clin Invest Med. 2017 Apr 26;40(2):E59-E65. doi: 10.25011/cim.v40i2.28196.

PMID:
28447578
28.

Pcsk5 is required in the early cranio-cardiac mesoderm for heart development.

Szumska D, Cioroch M, Keeling A, Prat A, Seidah NG, Bhattacharya S.

BMC Dev Biol. 2017 Apr 26;17(1):6. doi: 10.1186/s12861-017-0148-y.

29.

New insights of altered lipid profile in Fragile X Syndrome.

Çaku A, Seidah NG, Lortie A, Gagné N, Perron P, Dubé J, Corbin F.

PLoS One. 2017 Mar 23;12(3):e0174301. doi: 10.1371/journal.pone.0174301. eCollection 2017.

30.

The Proprotein Convertase Subtilisin/Kexin Type 9-resistant R410S Low Density Lipoprotein Receptor Mutation: A NOVEL MECHANISM CAUSING FAMILIAL HYPERCHOLESTEROLEMIA.

Susan-Resiga D, Girard E, Kiss RS, Essalmani R, Hamelin J, Asselin MC, Awan Z, Butkinaree C, Fleury A, Soldera A, Dory YL, Baass A, Seidah NG.

J Biol Chem. 2017 Feb 3;292(5):1573-1590. doi: 10.1074/jbc.M116.769430. Epub 2016 Dec 20.

31.

Proprotein convertase subtilisin/Kexin type 9 (PCSK9) single domain antibodies are potent inhibitors of low density lipoprotein receptor degradation.

Weider E, Susan-Resiga D, Essalmani R, Hamelin J, Asselin MC, Nimesh S, Ashraf Y, Wycoff KL, Zhang J, Prat A, Seidah NG.

J Biol Chem. 2016 Dec 16;291(51):26586. No abstract available.

32.

Prohormone convertase 7 is necessary for the normal processing of cholecystokinin in mouse brain.

Anyetei-Anum EN, Blum A, Seidah NG, Beinfeld MC.

Biochem Biophys Res Commun. 2017 Jan 22;482(4):1190-1193. doi: 10.1016/j.bbrc.2016.12.010. Epub 2016 Dec 5.

PMID:
27923657
33.

The Proprotein Convertases in Hypercholesterolemia and Cardiovascular Diseases: Emphasis on Proprotein Convertase Subtilisin/Kexin 9.

Seidah NG, Abifadel M, Prost S, Boileau C, Prat A.

Pharmacol Rev. 2017 Jan;69(1):33-52. Review.

PMID:
27920219
34.

Endoplasmic Reticulum Stress and Ca2+ Depletion Differentially Modulate the Sterol Regulatory Protein PCSK9 to Control Lipid Metabolism.

Lebeau P, Al-Hashimi A, Sood S, Lhoták Š, Yu P, Gyulay G, Paré G, Chen SR, Trigatti B, Prat A, Seidah NG, Austin RC.

J Biol Chem. 2017 Jan 27;292(4):1510-1523. doi: 10.1074/jbc.M116.744235. Epub 2016 Dec 1.

36.

Differential Expression of PCSK9 Modulates Infection, Inflammation, and Coagulation in a Murine Model of Sepsis.

Dwivedi DJ, Grin PM, Khan M, Prat A, Zhou J, Fox-Robichaud AE, Seidah NG, Liaw PC.

Shock. 2016 Dec;46(6):672-680.

PMID:
27405064
37.

Proprotein convertase subtilisin / kexin 9 (PCSK9) inhibitors and the future of dyslipidemia therapy: an updated patent review (2011-2015).

Elbitar S, Khoury PE, Ghaleb Y, Rabès JP, Varret M, Seidah NG, Boileau C, Abifadel M.

Expert Opin Ther Pat. 2016 Dec;26(12):1377-1392. Epub 2016 Jul 12. Review.

PMID:
27359211
38.

Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Single Domain Antibodies Are Potent Inhibitors of Low Density Lipoprotein Receptor Degradation.

Weider E, Susan-Resiga D, Essalmani R, Hamelin J, Asselin MC, Nimesh S, Ashraf Y, Wycoff KL, Zhang J, Prat A, Seidah NG.

J Biol Chem. 2016 Aug 5;291(32):16659-71. doi: 10.1074/jbc.M116.717736. Epub 2016 Jun 8. Erratum in: J Biol Chem. 2016 Dec 16;291(51):26586.

39.

PCSK9 inhibition-mediated reduction in Lp(a) with evolocumab: an analysis of 10 clinical trials and the LDL receptor's role.

Raal FJ, Giugliano RP, Sabatine MS, Koren MJ, Blom D, Seidah NG, Honarpour N, Lira A, Xue A, Chiruvolu P, Jackson S, Di M, Peach M, Somaratne R, Wasserman SM, Scott R, Stein EA.

J Lipid Res. 2016 Jun;57(6):1086-96. doi: 10.1194/jlr.P065334. Epub 2016 Apr 21.

40.

New developments in proprotein convertase subtilisin-kexin 9's biology and clinical implications.

Seidah NG.

Curr Opin Lipidol. 2016 Jun;27(3):274-81. doi: 10.1097/MOL.0000000000000295. Review.

PMID:
27031271
41.

Statins can exert dual, concentration dependent effects on HCV entry in vitro.

Blanchet M, Le QT, Seidah NG, Labonté P.

Antiviral Res. 2016 Apr;128:43-8. doi: 10.1016/j.antiviral.2016.02.006. Epub 2016 Feb 8.

PMID:
26868875
42.

Deletion of Mbtps1 (Pcsk8, S1p, Ski-1) Gene in Osteocytes Stimulates Soleus Muscle Regeneration and Increased Size and Contractile Force with Age.

Gorski JP, Huffman NT, Vallejo J, Brotto L, Chittur SV, Breggia A, Stern A, Huang J, Mo C, Seidah NG, Bonewald L, Brotto M.

J Biol Chem. 2016 Feb 26;291(9):4308-22. doi: 10.1074/jbc.M115.686626. Epub 2015 Dec 30.

43.

Decreased PCSK9 expression in human hepatocellular carcinoma.

Bhat M, Skill N, Marcus V, Deschenes M, Tan X, Bouteaud J, Negi S, Awan Z, Aikin R, Kwan J, Amre R, Tabaries S, Hassanain M, Seidah NG, Maluccio M, Siegel P, Metrakos P.

BMC Gastroenterol. 2015 Dec 16;15:176. doi: 10.1186/s12876-015-0371-6.

44.

Mechanism of Folding and Activation of Subtilisin Kexin Isozyme-1 (SKI-1)/Site-1 Protease (S1P).

da Palma JR, Cendron L, Seidah NG, Pasquato A, Kunz S.

J Biol Chem. 2016 Jan 29;291(5):2055-66. doi: 10.1074/jbc.M115.677757. Epub 2015 Dec 8.

45.

Role of Ostm1 Cytosolic Complex with Kinesin 5B in Intracellular Dispersion and Trafficking.

Pandruvada SN, Beauregard J, Benjannet S, Pata M, Lazure C, Seidah NG, Vacher J.

Mol Cell Biol. 2015 Nov 23;36(3):507-21. doi: 10.1128/MCB.00656-15. Print 2016 Feb 1.

46.

Deferoxamine stimulates LDLR expression and LDL uptake in HepG2 cells.

Guillemot J, Asselin MC, Susan-Resiga D, Essalmani R, Seidah NG.

Mol Nutr Food Res. 2016 Mar;60(3):600-8. doi: 10.1002/mnfr.201500467. Epub 2015 Dec 9.

PMID:
26577249
47.

Cleavage of a Neuroinvasive Human Respiratory Virus Spike Glycoprotein by Proprotein Convertases Modulates Neurovirulence and Virus Spread within the Central Nervous System.

Le Coupanec A, Desforges M, Meessen-Pinard M, Dubé M, Day R, Seidah NG, Talbot PJ.

PLoS Pathog. 2015 Nov 6;11(11):e1005261. doi: 10.1371/journal.ppat.1005261. eCollection 2015.

48.

PACE4 (PCSK6): another proprotein convertase link to iron homeostasis?

Guillemot J, Seidah NG.

Haematologica. 2015 Sep;100(9):e377. doi: 10.3324/haematol.2015.127175. No abstract available.

49.

A novel assay uncovers an unexpected role for SR-BI in LDL transcytosis.

Armstrong SM, Sugiyama MG, Fung KY, Gao Y, Wang C, Levy AS, Azizi P, Roufaiel M, Zhu SN, Neculai D, Yin C, Bolz SS, Seidah NG, Cybulsky MI, Heit B, Lee WL.

Cardiovasc Res. 2015 Nov 1;108(2):268-77. doi: 10.1093/cvr/cvv218. Epub 2015 Sep 2.

50.

PCSK9 deficiency unmasks a sex- and tissue-specific subcellular distribution of the LDL and VLDL receptors in mice.

Roubtsova A, Chamberland A, Marcinkiewicz J, Essalmani R, Fazel A, Bergeron JJ, Seidah NG, Prat A.

J Lipid Res. 2015 Nov;56(11):2133-42. doi: 10.1194/jlr.M061952. Epub 2015 Aug 31.

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