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Items: 1 to 50 of 107

1.

Lipophilic 2'-O-Acetal Ester RNAs: Synthesis, Thermal Duplex Stability, Nuclease Resistance, Cellular Uptake, and siRNA Activity after Spontaneous Naked Delivery.

Biscans A, Bertrand JR, Dubois J, Rüger J, Vasseur JJ, Sczakiel G, Dupouy C, Debart F.

Chembiochem. 2016 Nov 3;17(21):2054-2062. doi: 10.1002/cbic.201600317. Epub 2016 Sep 29.

PMID:
27569765
2.

RNAi revised--target mRNA-dependent enhancement of gene silencing.

Dornseifer S, Willkomm S, Far RK, Liebschwager J, Beltsiou F, Frank K, Laufer SD, Martinetz T, Sczakiel G, Claussen JC, Restle T.

Nucleic Acids Res. 2015 Dec 15;43(22):10623-32. doi: 10.1093/nar/gkv1200. Epub 2015 Nov 17.

3.

Direct synthesis of partially modified 2'-O-pivaloyloxymethyl RNAs by a base-labile protecting group strategy and their potential for prodrug-based gene-silencing applications.

Biscans A, Bos M, Martin AR, Ader N, Sczakiel G, Vasseur JJ, Dupouy C, Debart F.

Chembiochem. 2014 Dec 15;15(18):2674-9. doi: 10.1002/cbic.201402382. Epub 2014 Oct 24.

PMID:
25346406
4.

Coronary heart disease-associated variation in TCF21 disrupts a miR-224 binding site and miRNA-mediated regulation.

Miller CL, Haas U, Diaz R, Leeper NJ, Kundu RK, Patlolla B, Assimes TL, Kaiser FJ, Perisic L, Hedin U, Maegdefessel L, Schunkert H, Erdmann J, Quertermous T, Sczakiel G.

PLoS Genet. 2014 Mar 27;10(3):e1004263. doi: 10.1371/journal.pgen.1004263. eCollection 2014 Mar.

5.

Computational identification of biologically functional non-hairpin GC-helices in human Argonaute mRNA.

Dornseifer S, Sczakiel G.

BMC Bioinformatics. 2013 Apr 10;14:122. doi: 10.1186/1471-2105-14-122.

6.

MicroRNA-mediated regulation of gene expression is affected by disease-associated SNPs within the 3'-UTR via altered RNA structure.

Haas U, Sczakiel G, Laufer SD.

RNA Biol. 2012 Jun;9(6):924-37. doi: 10.4161/rna.20497. Epub 2012 Jun 1.

7.

Nonstructural proteins 7 and 8 of feline coronavirus form a 2:1 heterotrimer that exhibits primer-independent RNA polymerase activity.

Xiao Y, Ma Q, Restle T, Shang W, Svergun DI, Ponnusamy R, Sczakiel G, Hilgenfeld R.

J Virol. 2012 Apr;86(8):4444-54. doi: 10.1128/JVI.06635-11. Epub 2012 Feb 8.

8.

Functional binding of hexanucleotides to 3C protease of hepatitis A virus.

Blaum BS, Wünsche W, Benie AJ, Kusov Y, Peters H, Gauss-Müller V, Peters T, Sczakiel G.

Nucleic Acids Res. 2012 Apr;40(7):3042-55. doi: 10.1093/nar/gkr1152. Epub 2011 Dec 10.

9.

Synthesis and preliminary evaluation of pro-RNA 2'-O-masked with biolabile pivaloyloxymethyl groups in an RNA interference assay.

Lavergne T, Baraguey C, Dupouy C, Parey N, Wuensche W, Sczakiel G, Vasseur JJ, Debart F.

J Org Chem. 2011 Jul 15;76(14):5719-31. doi: 10.1021/jo200826h. Epub 2011 Jun 16.

PMID:
21619027
10.

Specific recognition of proteins by array-bound hexanucleotides.

Mescalchin A, Wünsche W, Sczakiel G.

Angew Chem Int Ed Engl. 2011 Feb 1;50(5):1052-4. doi: 10.1002/anie.201003462. Epub 2010 Dec 22. No abstract available.

PMID:
21268192
11.

Cell stress is related to re-localization of Argonaute 2 and to decreased RNA interference in human cells.

Detzer A, Engel C, Wünsche W, Sczakiel G.

Nucleic Acids Res. 2011 Apr;39(7):2727-41. doi: 10.1093/nar/gkq1216. Epub 2010 Dec 8.

12.

Antisense tools for functional studies of human Argonaute proteins.

Mescalchin A, Detzer A, Weirauch U, Hahnel MJ, Engel C, Sczakiel G.

RNA. 2010 Dec;16(12):2529-36. doi: 10.1261/rna.2204610. Epub 2010 Oct 8.

13.

Phosphorothioate-stimulated uptake of siRNA by mammalian cells: a novel route for delivery.

Detzer A, Sczakiel G.

Curr Top Med Chem. 2009;9(12):1109-16. Review.

PMID:
19860711
14.

RNAi2009--fourth international conference and exhibition.

Sczakiel G.

IDrugs. 2009 May;12(5):278-81. No abstract available.

PMID:
19431088
15.

A robust methodology to study urine microRNA as tumor marker: microRNA-126 and microRNA-182 are related to urinary bladder cancer.

Hanke M, Hoefig K, Merz H, Feller AC, Kausch I, Jocham D, Warnecke JM, Sczakiel G.

Urol Oncol. 2010 Nov-Dec;28(6):655-61. doi: 10.1016/j.urolonc.2009.01.027. Epub 2009 Apr 17.

PMID:
19375957
16.

Increased RNAi is related to intracellular release of siRNA via a covalently attached signal peptide.

Detzer A, Overhoff M, Wünsche W, Rompf M, Turner JJ, Ivanova GD, Gait MJ, Sczakiel G.

RNA. 2009 Apr;15(4):627-36. doi: 10.1261/rna.1305209. Epub 2009 Feb 18.

17.

Phosphorothioate-stimulated cellular uptake of siRNA: a cell culture model for mechanistic studies.

Detzer A, Overhoff M, Mescalchin A, Rompf M, Sczakiel G.

Curr Pharm Des. 2008;14(34):3666-73. Review.

PMID:
19075742
18.

Delivery, intracellular trafficking, and biological effectiveness of oligonucleotide-based therapeutics.

Mescalchin A, Sczakiel G.

Curr Pharm Des. 2008;14(34):3601-2. No abstract available.

PMID:
19075736
19.

[Breast cancer diagnostics based on extracellular DNA and RNA circulating in blood].

Rykova EIu, Skvortsova TE, Hoffmann AL, Tamkovich SN, Starikov AV, Bryzgunova OE, Permiakova VI, Warnecke JM, Sczakiel G, Vlasov VV, Laktionov PP.

Biomed Khim. 2008 Jan-Feb;54(1):94-103. Russian.

PMID:
18421914
20.

Cellular uptake and intracellular release are major obstacles to the therapeutic application of siRNA: novel options by phosphorothioate-stimulated delivery.

Mescalchin A, Detzer A, Wecke M, Overhoff M, Wünsche W, Sczakiel G.

Expert Opin Biol Ther. 2007 Oct;7(10):1531-8. Review.

PMID:
17916045
21.

Activity and stability of hammerhead ribozymes containing 2'-C-methyluridine: a new RNA mimic.

Gallo M, Kretschmer-Kazemi Far R, Sczakiel G, Iribarren AM.

Chem Biodivers. 2005 Feb;2(2):198-204.

PMID:
17191972
22.

A hexanucleotide selected for increased cellular uptake in cis contains a highly active CpG-motif in human B cells and primary peripheral blood mononuclear cells.

Mende M, Hopert A, Wünsche W, Overhoff M, Detzer A, Börngen K, Schlenke P, Kirchner H, Sczakiel G.

Immunology. 2007 Feb;120(2):261-72. Epub 2006 Nov 27.

23.

Concentrations of circulating RNA from healthy donors and cancer patients estimated by different methods.

Rykova EY, Wunsche W, Brizgunova OE, Skvortsova TE, Tamkovich SN, Senin IS, Laktionov PP, Sczakiel G, Vlassov VV.

Ann N Y Acad Sci. 2006 Sep;1075:328-33.

PMID:
17108228
24.

Specific binding of a hexanucleotide to HIV-1 reverse transcriptase: a novel class of bioactive molecules.

Mescalchin A, Wünsche W, Laufer SD, Grohmann D, Restle T, Sczakiel G.

Nucleic Acids Res. 2006;34(19):5631-7. Epub 2006 Oct 12.

25.

Molecular alterations after Polo-like kinase 1 mRNA suppression versus pharmacologic inhibition in cancer cells.

Schmidt M, Hofmann HP, Sanders K, Sczakiel G, Beckers TL, Gekeler V.

Mol Cancer Ther. 2006 Apr;5(4):809-17.

26.

Technical improvements in the computational target search for antisense oligonucleotides.

Far RK, Leppert J, Frank K, Sczakiel G.

Oligonucleotides. 2005 Fall;15(3):223-33.

PMID:
16201910
27.

Phosphorothioate-stimulated uptake of short interfering RNA by human cells.

Overhoff M, Sczakiel G.

EMBO Rep. 2005 Dec;6(12):1176-81.

28.

[Ki-67 antisense therapy in murine renal cell carcinoma models].

Kausch I, Jiang H, Brocks C, Albers A, Krüger S, Sczakiel G, Jocham D.

Aktuelle Urol. 2005 Apr;36(2):142-8. German.

PMID:
15902575
29.

Local RNA target structure influences siRNA efficacy: a systematic global analysis.

Overhoff M, Alken M, Far RK, Lemaitre M, Lebleu B, Sczakiel G, Robbins I.

J Mol Biol. 2005 May 13;348(4):871-81.

PMID:
15843019
30.
31.
32.
33.
34.

Ki-67 protein concentrations in urothelial bladder carcinomas are related to Ki-67-specific RNA concentrations in urine.

Menke TB, Boettcher K, Krüger S, Kausch I, Boehle A, Sczakiel G, Warnecke JM.

Clin Chem. 2004 Aug;50(8):1461-3. No abstract available.

35.

Ki-67-directed antisense therapy in an orthotopic renal cell carcinoma model.

Kausch I, Jiang H, Brocks C, Bruderek K, Krüger S, Sczakiel G, Jocham D, Böhle A.

Eur Urol. 2004 Jul;46(1):118-24; discussion 124-5.

PMID:
15183557
36.
37.

Antisense treatment against Ki-67 mRNA inhibits proliferation and tumor growth in vitro and in vivo.

Kausch I, Lingnau A, Endl E, Sellmann K, Deinert I, Ratliff TL, Jocham D, Sczakiel G, Gerdes J, Böhle A.

Int J Cancer. 2003 Jul 10;105(5):710-6.

38.
39.

Endogenous expression of a high-affinity pseudoknot RNA aptamer suppresses replication of HIV-1.

Chaloin L, Lehmann MJ, Sczakiel G, Restle T.

Nucleic Acids Res. 2002 Sep 15;30(18):4001-8.

40.

Antisense-mediated inhibition of ICAM-1 expression: a therapeutic strategy against inflammation of human periodontal tissue.

Nedbal W, Tomakidi P, Lehmann MJ, Dörfer C, Kohl A, Sczakiel G.

Antisense Nucleic Acid Drug Dev. 2002 Apr;12(2):71-8.

PMID:
12074367
41.

Selecting karyophilic DNA cis elements in Xenopus laevis oocytes; a new approach.

Marcello M, Fischer R, Tröster H, Trendelenburg MF, Sczakiel G.

Int J Dev Biol. 2002 May;46(3):309-16.

42.

The role of target accessibility for antisense inhibition.

Sczakiel G, Far RK.

Curr Opin Mol Ther. 2002 Apr;4(2):149-53. Review.

PMID:
12044036
43.

Concepts to automate the theoretical design of effective antisense oligonucleotides.

Far RK, Nedbal W, Sczakiel G.

Bioinformatics. 2001 Nov;17(11):1058-61.

PMID:
11724735
44.

Theoretical design of antisense genes with statistically increased efficacy.

Lehmann MJ, Patzel V, Sczakiel G.

Nucleic Acids Res. 2000 Jul 1;28(13):2597-604. doi: 10.1093/nar/28.13.2597.

45.

In vitro selection supports the view of a kinetic control of antisense RNA-mediated inhibition of gene expression in mammalian cells.

Patzel V, Sczakiel G.

Nucleic Acids Res. 2000 Jul 1;28(13):2462-6. doi: 10.1093/nar/28.13.2462.

46.

RNA accessibility prediction: a theoretical approach is consistent with experimental studies in cell extracts.

Scherr M, Rossi JJ, Sczakiel G, Patzel V.

Nucleic Acids Res. 2000 Jul 1;28(13):2455-61. doi: 10.1093/nar/28.13.2455.

47.
48.

Length dependence of RNA-RNA annealing.

Patzel V, Sczakiel G.

J Mol Biol. 1999 Dec 17;294(5):1127-34.

PMID:
10600371
49.

A theoretical approach to select effective antisense oligodeoxyribonucleotides at high statistical probability.

Patzel V, Steidl U, Kronenwett R, Haas R, Sczakiel G.

Nucleic Acids Res. 1999 Nov 15;27(22):4328-34.

50.

Recombinant AAV-2 harboring gfp-antisense/ribozyme fusion sequences monitor transduction, gene expression, and show anti-HIV-1 efficacy.

Hörster A, Teichmann B, Hormes R, Grimm D, Kleinschmidt J, Sczakiel G.

Gene Ther. 1999 Jul;6(7):1231-8.

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