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Items: 1 to 50 of 112

1.

A synthetic epoxyeicosatrienoic acid analogue prevents the initiation of ischemic acute kidney injury.

Hoff U, Bubalo G, Fechner M, Blum M, Zhu Y, Pohlmann A, Hentschel J, Arakelyan K, Seeliger E, Flemming B, Gürgen D, Rothe M, Niendorf T, Manthati VL, Falck JR, Haase M, Schunck WH, Dragun D.

Acta Physiol (Oxf). 2019 May 11:e13297. doi: 10.1111/apha.13297. [Epub ahead of print]

PMID:
31077555
2.

Linoleic Acid Metabolite DiHOME Decreases Post-ischemic Cardiac Recovery in Murine Hearts.

Bannehr M, Löhr L, Gelep J, Haverkamp W, Schunck WH, Gollasch M, Wutzler A.

Cardiovasc Toxicol. 2019 Feb 6. doi: 10.1007/s12012-019-09508-x. [Epub ahead of print]

PMID:
30725262
3.

Chiral lipidomics of monoepoxy and monohydroxy metabolites derived from long-chain polyunsaturated fatty acids.

Blum M, Dogan I, Karber M, Rothe M, Schunck WH.

J Lipid Res. 2019 Jan;60(1):135-148. doi: 10.1194/jlr.M089755. Epub 2018 Nov 8.

PMID:
30409844
4.

Possible Role of CYP450 Generated Omega-3/Omega-6 PUFA Metabolites in the Modulation of Blood Pressure and Vascular Function in Obese Children.

Bonafini S, Giontella A, Tagetti A, Marcon D, Montagnana M, Benati M, Gaudino R, Cavarzere P, Karber M, Rothe M, Minuz P, Antonazzi F, Maffeis C, Schunck WH, Fava C.

Nutrients. 2018 Nov 5;10(11). pii: E1689. doi: 10.3390/nu10111689.

5.

Therapeutic potential of omega-3 fatty acid-derived epoxyeicosanoids in cardiovascular and inflammatory diseases.

Schunck WH, Konkel A, Fischer R, Weylandt KH.

Pharmacol Ther. 2018 Mar;183:177-204. doi: 10.1016/j.pharmthera.2017.10.016. Epub 2017 Nov 7. Review.

PMID:
29080699
6.

Hypoxia-reoxygenation enhances murine afferent arteriolar vasoconstriction by angiotensin II.

Pahlitzsch T, Liu ZZ, Al-Masri A, Braun D, Dietze S, Persson PB, Schunck WH, Blum M, Kupsch E, Ludwig M, Patzak A.

Am J Physiol Renal Physiol. 2018 Mar 1;314(3):F430-F438. doi: 10.1152/ajprenal.00252.2017. Epub 2017 Oct 25.

7.

Cytochrome P450 monooxygenase lipid metabolites are significant second messengers in the resolution of choroidal neovascularization.

Hasegawa E, Inafuku S, Mulki L, Okunuki Y, Yanai R, Smith KE, Kim CB, Klokman G, Bielenberg DR, Puli N, Falck JR, Husain D, Miller JW, Edin ML, Zeldin DC, Lee KSS, Hammock BD, Schunck WH, Connor KM.

Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):E7545-E7553. doi: 10.1073/pnas.1620898114. Epub 2017 Aug 21.

8.

Role of Müller cell cytochrome P450 2c44 in murine retinal angiogenesis.

Hu J, Geyer A, Dziumbla S, Awwad K, Zeldin DC, Schunck WH, Popp R, Frömel T, Fleming I.

Prostaglandins Other Lipid Mediat. 2017 Nov;133:93-102. doi: 10.1016/j.prostaglandins.2017.04.002. Epub 2017 Apr 23.

PMID:
28442442
9.

Dietary Omega-3 Polyunsaturated Fatty Acids Prevent Vascular Dysfunction and Attenuate Cytochrome P4501A1 Expression by 2,3,7,8-Tetrachlorodibenzo-P-Dioxin.

Wiest EF, Walsh-Wilcox MT, Rothe M, Schunck WH, Walker MK.

Toxicol Sci. 2016 Nov;154(1):43-54. Epub 2016 Aug 4.

10.

Vasopressin lowers renal epoxyeicosatrienoic acid levels by activating soluble epoxide hydrolase.

Boldt C, Röschel T, Himmerkus N, Plain A, Bleich M, Labes R, Blum M, Krause H, Magheli A, Giesecke T, Mutig K, Rothe M, Weldon SM, Dragun D, Schunck WH, Bachmann S, Paliege A.

Am J Physiol Renal Physiol. 2016 Dec 1;311(6):F1198-F1210. doi: 10.1152/ajprenal.00062.2016. Epub 2016 Sep 28.

11.

EPA and/or DHA? A test question on the principles and opportunities in utilizing the therapeutic potential of omega-3 fatty acids.

Schunck WH.

J Lipid Res. 2016 Sep;57(9):1608-11. doi: 10.1194/jlr.C071084. Epub 2016 Jul 19. No abstract available.

12.

Activation of Peroxisome Proliferator-Activated Receptor-δ as Novel Therapeutic Strategy to Prevent In-Stent Restenosis and Stent Thrombosis.

Hytönen J, Leppänen O, Braesen JH, Schunck WH, Mueller D, Jung F, Mrowietz C, Jastroch M, von Bergwelt-Baildon M, Kappert K, Heuser A, Drenckhahn JD, Pieske B, Thierfelder L, Ylä-Herttuala S, Blaschke F.

Arterioscler Thromb Vasc Biol. 2016 Aug;36(8):1534-48. doi: 10.1161/ATVBAHA.115.306962. Epub 2016 Jun 9.

PMID:
27283742
13.

Renal Ischemia/Reperfusion Injury in Soluble Epoxide Hydrolase-Deficient Mice.

Zhu Y, Blum M, Hoff U, Wesser T, Fechner M, Westphal C, Gürgen D, Catar RA, Philippe A, Wu K, Bubalo G, Rothe M, Weldon SM, Dragun D, Schunck WH.

PLoS One. 2016 Jan 4;11(1):e0145645. doi: 10.1371/journal.pone.0145645. eCollection 2016.

14.

Epoxides Derived from Dietary Dihomo-Gamma-Linolenic Acid Induce Germ Cell Death in C. elegans.

Deline M, Keller J, Rothe M, Schunck WH, Menzel R, Watts JL.

Sci Rep. 2015 Oct 21;5:15417. doi: 10.1038/srep15417.

15.

Role of CYP eicosanoids in the regulation of pharyngeal pumping and food uptake in Caenorhabditis elegans.

Zhou Y, Falck JR, Rothe M, Schunck WH, Menzel R.

J Lipid Res. 2015 Nov;56(11):2110-23. doi: 10.1194/jlr.M061887. Epub 2015 Sep 23.

16.

Cytochrome p450 enzymes in the bioactivation of polyunsaturated Fatty acids and their role in cardiovascular disease.

Westphal C, Konkel A, Schunck WH.

Adv Exp Med Biol. 2015;851:151-87. doi: 10.1007/978-3-319-16009-2_6. Review.

PMID:
26002735
17.

Interaction of epoxyeicosatrienoic acids and adipocyte fatty acid-binding protein in the modulation of cardiomyocyte contractility.

Lamounier-Zepter V, Look C, Schunck WH, Schlottmann I, Woischwill C, Bornstein SR, Xu A, Morano I.

Int J Obes (Lond). 2015 May;39(5):755-61. doi: 10.1038/ijo.2014.193. Epub 2014 Nov 5.

PMID:
25370574
18.

Role of CYP1A1 in modulating the vascular and blood pressure benefits of omega-3 polyunsaturated fatty acids.

Agbor LN, Wiest EF, Rothe M, Schunck WH, Walker MK.

J Pharmacol Exp Ther. 2014 Dec;351(3):688-98. doi: 10.1124/jpet.114.219535. Epub 2014 Oct 14.

19.

CYP-13A12 of the nematode Caenorhabditis elegans is a PUFA-epoxygenase involved in behavioural response to reoxygenation.

Keller J, Ellieva A, Ma DK, Ju J, Nehk E, Konkel A, Falck JR, Schunck WH, Menzel R.

Biochem J. 2014 Nov 15;464(1):61-71. doi: 10.1042/BJ20140848.

PMID:
25138176
20.

Cytochrome P450-generated metabolites derived from ω-3 fatty acids attenuate neovascularization.

Yanai R, Mulki L, Hasegawa E, Takeuchi K, Sweigard H, Suzuki J, Gaissert P, Vavvas DG, Sonoda KH, Rothe M, Schunck WH, Miller JW, Connor KM.

Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9603-8. doi: 10.1073/pnas.1401191111. Epub 2014 Jun 16.

21.

The biological actions of 11,12-epoxyeicosatrienoic acid in endothelial cells are specific to the R/S-enantiomer and require the G(s) protein.

Ding Y, Frömel T, Popp R, Falck JR, Schunck WH, Fleming I.

J Pharmacol Exp Ther. 2014 Jul;350(1):14-21. doi: 10.1124/jpet.114.214254. Epub 2014 Apr 24.

22.

Dietary omega-3 fatty acids modulate the eicosanoid profile in man primarily via the CYP-epoxygenase pathway.

Fischer R, Konkel A, Mehling H, Blossey K, Gapelyuk A, Wessel N, von Schacky C, Dechend R, Muller DN, Rothe M, Luft FC, Weylandt K, Schunck WH.

J Lipid Res. 2014 Jun;55(6):1150-64. doi: 10.1194/jlr.M047357. Epub 2014 Mar 16.

23.

CYP2J2 overexpression protects against arrhythmia susceptibility in cardiac hypertrophy.

Westphal C, Spallek B, Konkel A, Marko L, Qadri F, DeGraff LM, Schubert C, Bradbury JA, Regitz-Zagrosek V, Falck JR, Zeldin DC, Müller DN, Schunck WH, Fischer R.

PLoS One. 2013 Aug 30;8(8):e73490. doi: 10.1371/journal.pone.0073490. eCollection 2013.

24.

Variations in the human soluble epoxide hydrolase gene and recurrence of atrial fibrillation after catheter ablation.

Wutzler A, Kestler C, Perrot A, Loehr L, Huemer M, Parwani AS, Attanasio P, Özcelik C, Schunck WH, Gollasch M, Haverkamp W, Boldt LH.

Int J Cardiol. 2013 Oct 9;168(4):3647-51. doi: 10.1016/j.ijcard.2013.05.010. Epub 2013 May 25.

PMID:
23711456
25.

Contribution of iNOS/sGC/PKG pathway, COX-2, CYP4A1, and gp91(phox) to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against vasodilation, hypotension, tachycardia, and inflammation in a rat model of septic shock.

Tunctan B, Korkmaz B, Sari AN, Kacan M, Unsal D, Serin MS, Buharalioglu CK, Sahan-Firat S, Cuez T, Schunck WH, Manthati VL, Falck JR, Malik KU.

Nitric Oxide. 2013 Sep 1;33:18-41. doi: 10.1016/j.niox.2013.05.001. Epub 2013 May 14.

26.

High temporal resolution parametric MRI monitoring of the initial ischemia/reperfusion phase in experimental acute kidney injury.

Pohlmann A, Hentschel J, Fechner M, Hoff U, Bubalo G, Arakelyan K, Cantow K, Seeliger E, Flemming B, Waiczies H, Waiczies S, Schunck WH, Dragun D, Niendorf T.

PLoS One. 2013;8(2):e57411. doi: 10.1371/journal.pone.0057411. Epub 2013 Feb 28.

27.

5,14-HEDGE, a 20-HETE mimetic, reverses hypotension and improves survival in a rodent model of septic shock: contribution of soluble epoxide hydrolase, CYP2C23, MEK1/ERK1/2/IKKβ/IκB-α/NF-κB pathway, and proinflammatory cytokine formation.

Tunctan B, Korkmaz B, Sari AN, Kacan M, Unsal D, Serin MS, Buharalioglu CK, Sahan-Firat S, Cuez T, Schunck WH, Falck JR, Malik KU.

Prostaglandins Other Lipid Mediat. 2013 Apr-May;102-103:31-41. doi: 10.1016/j.prostaglandins.2013.01.005. Epub 2013 Feb 27.

28.

Novel signalling mechanisms and targets in renal ischaemia and reperfusion injury.

Kusch A, Hoff U, Bubalo G, Zhu Y, Fechner M, Schmidt-Ullrich R, Marko L, Müller DN, Schmidt-Ott KM, Gürgen D, Blum M, Schunck WH, Dragun D.

Acta Physiol (Oxf). 2013 May;208(1):25-40. doi: 10.1111/apha.12089. Epub 2013 Mar 22. Review.

PMID:
23432924
29.

Cytochrome P450 subfamily 2J polypeptide 2 expression and circulating epoxyeicosatrienoic metabolites in preeclampsia.

Herse F, Lamarca B, Hubel CA, Kaartokallio T, Lokki AI, Ekholm E, Laivuori H, Gauster M, Huppertz B, Sugulle M, Ryan MJ, Novotny S, Brewer J, Park JK, Kacik M, Hoyer J, Verlohren S, Wallukat G, Rothe M, Luft FC, Muller DN, Schunck WH, Staff AC, Dechend R.

Circulation. 2012 Dec 18;126(25):2990-9. doi: 10.1161/CIRCULATIONAHA.112.127340. Epub 2012 Nov 15.

30.

A novel treatment strategy for sepsis and septic shock based on the interactions between prostanoids, nitric oxide, and 20-hydroxyeicosatetraenoic acid.

Tunctan B, Korkmaz B, Sari AN, Kacan M, Unsal D, Serin MS, Buharalioglu CK, Sahan-Firat S, Schunck WH, Falck JR, Malik KU.

Antiinflamm Antiallergy Agents Med Chem. 2012;11(2):121-50. Review.

PMID:
23013331
31.

Effect of cytochrome P450-dependent epoxyeicosanoids on Ristocetin-induced thrombocyte aggregation.

Jung F, Schulz C, Blaschke F, Muller DN, Mrowietz C, Franke RP, Lendlein A, Schunck WH.

Clin Hemorheol Microcirc. 2012;52(2-4):403-16. doi: 10.3233/CH-2012-1614.

PMID:
22975950
32.

OS066. Intrauterine CYP2J2 expression and circulatingepoxyeicosatrienoic acid levels in preeclampsia.

Herse F, LaMarca BB, Hubel CA, Laivuori H, Huppertz B, Verlohren S, Muller DN, Schunck WH, Staff AC, Dechend R.

Pregnancy Hypertens. 2012 Jul;2(3):212-3. doi: 10.1016/j.preghy.2012.04.067. Epub 2012 Jun 13.

PMID:
26105280
33.

CYP-eicosanoids--a new link between omega-3 fatty acids and cardiac disease?

Westphal C, Konkel A, Schunck WH.

Prostaglandins Other Lipid Mediat. 2011 Nov;96(1-4):99-108. doi: 10.1016/j.prostaglandins.2011.09.001. Epub 2011 Sep 16. Review.

PMID:
21945326
34.

17(R),18(S)-epoxyeicosatetraenoic acid, a potent eicosapentaenoic acid (EPA) derived regulator of cardiomyocyte contraction: structure-activity relationships and stable analogues.

Falck JR, Wallukat G, Puli N, Goli M, Arnold C, Konkel A, Rothe M, Fischer R, Müller DN, Schunck WH.

J Med Chem. 2011 Jun 23;54(12):4109-18. doi: 10.1021/jm200132q. Epub 2011 Jun 1.

35.

Eicosanoid formation by a cytochrome P450 isoform expressed in the pharynx of Caenorhabditis elegans.

Kosel M, Wild W, Bell A, Rothe M, Lindschau C, Steinberg CE, Schunck WH, Menzel R.

Biochem J. 2011 May 1;435(3):689-700. doi: 10.1042/BJ20101942.

PMID:
21309752
36.

Analysis of omega-3 and omega-6 fatty acid-derived lipid metabolite formation in human and mouse blood samples.

Gomolka B, Siegert E, Blossey K, Schunck WH, Rothe M, Weylandt KH.

Prostaglandins Other Lipid Mediat. 2011 Apr;94(3-4):81-7. doi: 10.1016/j.prostaglandins.2010.12.006. Epub 2011 Jan 12.

PMID:
21236358
37.

Inhibition of 20-HETE synthesis and action protects the kidney from ischemia/reperfusion injury.

Hoff U, Lukitsch I, Chaykovska L, Ladwig M, Arnold C, Manthati VL, Fuller TF, Schneider W, Gollasch M, Muller DN, Flemming B, Seeliger E, Luft FC, Falck JR, Dragun D, Schunck WH.

Kidney Int. 2011 Jan;79(1):57-65. doi: 10.1038/ki.2010.377. Epub 2010 Oct 20.

38.

Inhibition of 17β-estradiol activation by CYP1A1: genotype- and regioselective inhibition by St. John's Wort and several natural polyphenols.

Schwarz D, Kisselev P, Schunck WH, Roots I.

Biochim Biophys Acta. 2011 Jan;1814(1):168-74. doi: 10.1016/j.bbapap.2010.09.014. Epub 2010 Sep 29.

PMID:
20883830
39.

Role of cytochrome P450 enzymes in the bioactivation of polyunsaturated fatty acids.

Konkel A, Schunck WH.

Biochim Biophys Acta. 2011 Jan;1814(1):210-22. doi: 10.1016/j.bbapap.2010.09.009. Epub 2010 Sep 30.

PMID:
20869469
40.

Arachidonic acid-metabolizing cytochrome P450 enzymes are targets of {omega}-3 fatty acids.

Arnold C, Markovic M, Blossey K, Wallukat G, Fischer R, Dechend R, Konkel A, von Schacky C, Luft FC, Muller DN, Rothe M, Schunck WH.

J Biol Chem. 2010 Oct 22;285(43):32720-33. doi: 10.1074/jbc.M110.118406. Epub 2010 Aug 23.

41.

Cytochrome P450-dependent metabolism of omega-6 and omega-3 long-chain polyunsaturated fatty acids.

Arnold C, Konkel A, Fischer R, Schunck WH.

Pharmacol Rep. 2010 May-Jun;62(3):536-47. Review.

42.

Direct angiotensin II type 2 receptor stimulation acts anti-inflammatory through epoxyeicosatrienoic acid and inhibition of nuclear factor kappaB.

Rompe F, Artuc M, Hallberg A, Alterman M, Ströder K, Thöne-Reineke C, Reichenbach A, Schacherl J, Dahlöf B, Bader M, Alenina N, Schwaninger M, Zuberbier T, Funke-Kaiser H, Schmidt C, Schunck WH, Unger T, Steckelings UM.

Hypertension. 2010 Apr;55(4):924-31. doi: 10.1161/HYPERTENSIONAHA.109.147843. Epub 2010 Feb 15.

PMID:
20157051
43.

Adipocyte fatty acid-binding protein suppresses cardiomyocyte contraction: a new link between obesity and heart disease.

Lamounier-Zepter V, Look C, Alvarez J, Christ T, Ravens U, Schunck WH, Ehrhart-Bornstein M, Bornstein SR, Morano I.

Circ Res. 2009 Aug 14;105(4):326-34. doi: 10.1161/CIRCRESAHA.109.200501. Epub 2009 Jul 16.

PMID:
19608978
44.

Decreased catecholamine degradation associates with shock and kidney injury after cardiac surgery.

Haase-Fielitz A, Haase M, Bellomo R, Lambert G, Matalanis G, Story D, Doolan L, Buxton B, Gutteridge G, Luft FC, Schunck WH, Dragun D.

J Am Soc Nephrol. 2009 Jun;20(6):1393-403. doi: 10.1681/ASN.2008080915. Epub 2009 Apr 30.

45.

Prostaglandin receptors mediate effects of substances released from ischaemic rat hearts on non-ischaemic cardiomyocytes.

Birkenmeier K, Janke I, Schunck WH, Trimpert C, Krieg T, Landsberger M, Völker U, Felix SB, Staudt A.

Eur J Clin Invest. 2008 Dec;38(12):902-9. doi: 10.1111/j.1365-2362.2008.02052.x.

PMID:
19021714
46.

Interaction between P450 eicosanoids and nitric oxide in the control of arterial tone in mice.

Hercule HC, Schunck WH, Gross V, Seringer J, Leung FP, Weldon SM, da Costa Goncalves ACh, Huang Y, Luft FC, Gollasch M.

Arterioscler Thromb Vasc Biol. 2009 Jan;29(1):54-60. doi: 10.1161/ATVBAHA.108.171298. Epub 2008 Oct 16.

PMID:
18927469
47.

Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease.

Monti J, Fischer J, Paskas S, Heinig M, Schulz H, Gösele C, Heuser A, Fischer R, Schmidt C, Schirdewan A, Gross V, Hummel O, Maatz H, Patone G, Saar K, Vingron M, Weldon SM, Lindpaintner K, Hammock BD, Rohde K, Dietz R, Cook SA, Schunck WH, Luft FC, Hubner N.

Nat Genet. 2008 May;40(5):529-37. doi: 10.1038/ng.129.

PMID:
18443590
48.

Cytochrome P450-dependent metabolism of eicosapentaenoic acid in the nematode Caenorhabditis elegans.

Kulas J, Schmidt C, Rothe M, Schunck WH, Menzel R.

Arch Biochem Biophys. 2008 Apr 1;472(1):65-75. doi: 10.1016/j.abb.2008.02.002. Epub 2008 Feb 8.

PMID:
18282462
49.

Dietary n-3 polyunsaturated fatty acids and direct renin inhibition improve electrical remodeling in a model of high human renin hypertension.

Fischer R, Dechend R, Qadri F, Markovic M, Feldt S, Herse F, Park JK, Gapelyuk A, Schwarz I, Zacharzowsky UB, Plehm R, Safak E, Heuser A, Schirdewan A, Luft FC, Schunck WH, Muller DN.

Hypertension. 2008 Feb;51(2):540-6. Epub 2007 Dec 24.

PMID:
18158339
50.

The vasodilator 17,18-epoxyeicosatetraenoic acid targets the pore-forming BK alpha channel subunit in rodents.

Hercule HC, Salanova B, Essin K, Honeck H, Falck JR, Sausbier M, Ruth P, Schunck WH, Luft FC, Gollasch M.

Exp Physiol. 2007 Nov;92(6):1067-76. Epub 2007 Aug 3.

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