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Items: 1 to 50 of 131

1.

Coupling of Ligands to the Liposome Surface by Click Chemistry.

Spanedda MV, De Giorgi M, Hassane FS, Schuber F, Bourel-Bonnet L, Frisch B.

Methods Mol Biol. 2017;1522:93-106.

PMID:
27837533
2.

Discovery of Potent Inhibitors of Schistosoma mansoni NAD⁺ Catabolizing Enzyme.

Jacques SA, Kuhn I, Koniev O, Schuber F, Lund FE, Wagner A, Muller-Steffner H, Kellenberger E.

J Med Chem. 2015 Apr 23;58(8):3582-92. doi: 10.1021/acs.jmedchem.5b00203. Epub 2015 Apr 1.

PMID:
25803425
3.

Probing the catalytic mechanism of bovine CD38/NAD+ glycohydrolase by site directed mutagenesis of key active site residues.

Kuhn I, Kellenberger E, Cakir-Kiefer C, Muller-Steffner H, Schuber F.

Biochim Biophys Acta. 2014 Jul;1844(7):1317-31. doi: 10.1016/j.bbapap.2014.03.014. Epub 2014 Apr 8.

PMID:
24721563
4.

Schistosoma mansoni NAD(+) catabolizing enzyme: identification of key residues in catalysis.

Kuhn I, Kellenberger E, Schuber F, Muller-Steffner H.

Biochim Biophys Acta. 2013 Dec;1834(12):2520-7. doi: 10.1016/j.bbapap.2013.09.002. Epub 2013 Sep 12.

PMID:
24035885
5.

Insights into the mechanism of bovine CD38/NAD+glycohydrolase from the X-ray structures of its Michaelis complex and covalently-trapped intermediates.

Egea PF, Muller-Steffner H, Kuhn I, Cakir-Kiefer C, Oppenheimer NJ, Stroud RM, Kellenberger E, Schuber F.

PLoS One. 2012;7(4):e34918. doi: 10.1371/journal.pone.0034918. Epub 2012 Apr 18.

6.

Novel glycolipid TLR2 ligands of the type Pam2Cys-α-Gal: synthesis and biological properties.

Thomann JS, Monneaux F, Creusat G, Spanedda MV, Heurtault B, Habermacher C, Schuber F, Bourel-Bonnet L, Frisch B.

Eur J Med Chem. 2012 May;51:174-83. doi: 10.1016/j.ejmech.2012.02.039. Epub 2012 Mar 21.

PMID:
22483966
7.

Flavonoids as inhibitors of human CD38.

Kellenberger E, Kuhn I, Schuber F, Muller-Steffner H.

Bioorg Med Chem Lett. 2011 Jul 1;21(13):3939-42. doi: 10.1016/j.bmcl.2011.05.022. Epub 2011 May 14.

PMID:
21641214
8.

Antitumor activity of liposomal ErbB2/HER2 epitope peptide-based vaccine constructs incorporating TLR agonists and mannose receptor targeting.

Thomann JS, Heurtault B, Weidner S, Brayé M, Beyrath J, Fournel S, Schuber F, Frisch B.

Biomaterials. 2011 Jul;32(20):4574-83. doi: 10.1016/j.biomaterials.2011.03.015. Epub 2011 Apr 7.

PMID:
21474175
9.

Identification by high-throughput screening of inhibitors of Schistosoma mansoni NAD(+) catabolizing enzyme.

Kuhn I, Kellenberger E, Said-Hassane F, Villa P, Rognan D, Lobstein A, Haiech J, Hibert M, Schuber F, Muller-Steffner H.

Bioorg Med Chem. 2010 Nov 15;18(22):7900-10. doi: 10.1016/j.bmc.2010.09.041. Epub 2010 Sep 25.

PMID:
20951593
10.

A single residue in a novel ADP-ribosyl cyclase controls production of the calcium-mobilizing messengers cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate.

Ramakrishnan L, Muller-Steffner H, Bosc C, Vacquier VD, Schuber F, Moutin MJ, Dale L, Patel S.

J Biol Chem. 2010 Jun 25;285(26):19900-9. doi: 10.1074/jbc.M110.105312. Epub 2010 Apr 12.

11.

Conjugation of ligands to the surface of preformed liposomes by click chemistry.

Frisch B, Hassane FS, Schuber F.

Methods Mol Biol. 2010;605:267-77. doi: 10.1007/978-1-60327-360-2_18.

PMID:
20072887
12.

Identification of the N-glycosylation sites on recombinant bovine CD38 expressed in Pichia pastoris: their impact on enzyme stability and catalytic activity.

Muller-Steffner H, Kuhn I, Argentini M, Schuber F.

Protein Expr Purif. 2010 Apr;70(2):151-7. doi: 10.1016/j.pep.2009.10.003. Epub 2009 Oct 7.

PMID:
19818407
13.

Rational design and immunogenicity of liposome-based diepitope constructs: application to synthetic oligosaccharides mimicking the Shigella flexneri 2a O-antigen.

Said Hassane F, Phalipon A, Tanguy M, Guerreiro C, Bélot F, Frisch B, Mulard LA, Schuber F.

Vaccine. 2009 Aug 27;27(39):5419-26. doi: 10.1016/j.vaccine.2009.06.031. Epub 2009 Jun 24.

PMID:
19559116
14.

Influence of ligand valency on the targeting of immature human dendritic cells by mannosylated liposomes.

Espuelas S, Thumann C, Heurtault B, Schuber F, Frisch B.

Bioconjug Chem. 2008 Dec;19(12):2385-93. doi: 10.1021/bc8002524.

PMID:
19053315
15.

Nicotinamide 2-fluoroadenine dinucleotide unmasks the NAD+ glycohydrolase activity of Aplysia californica adenosine 5'-diphosphate ribosyl cyclase.

Zhang B, Muller-Steffner H, Schuber F, Potter BV.

Biochemistry. 2007 Apr 3;46(13):4100-9. Epub 2007 Mar 7.

PMID:
17341094
16.

Redesign of Schistosoma mansoni NAD+ catabolizing enzyme: active site H103W mutation restores ADP-ribosyl cyclase activity.

Kuhn I, Kellenberger E, Rognan D, Lund FE, Muller-Steffner H, Schuber F.

Biochemistry. 2006 Oct 3;45(39):11867-78.

17.

The 'co-delivery' approach to liposomal vaccines: application to the development of influenza-A and hepatitis-B vaccine candidates.

Laing P, Bacon A, McCormack B, Gregoriadis G, Frisch B, Schuber F.

J Liposome Res. 2006;16(3):229-35.

PMID:
16952877
18.

Liposome-based systems for anti-tumor vaccination: influence of lipopeptide adjuvants.

Heurtault B, Thomann JS, Jedrzejewska J, Wels WS, Schuber F, Frisch B.

J Liposome Res. 2006;16(3):205-13.

PMID:
16952875
19.

CD38 induces apoptosis of a murine pro-B leukemic cell line by a tyrosine kinase-dependent but ADP-ribosyl cyclase- and NAD glycohydrolase-independent mechanism.

Lund FE, Muller-Steffner H, Romero-Ramirez H, Moreno-García ME, Partida-Sánchez S, Makris M, Oppenheimer NJ, Santos-Argumedo L, Schuber F.

Int Immunol. 2006 Jul;18(7):1029-42. Epub 2006 May 23.

PMID:
16720618
20.

Targeted liposomes: convenient coupling of ligands to preformed vesicles using "click chemistry".

Said Hassane F, Frisch B, Schuber F.

Bioconjug Chem. 2006 May-Jun;17(3):849-54.

PMID:
16704226
21.

The CD38-independent ADP-ribosyl cyclase from mouse brain synaptosomes: a comparative study of neonate and adult brain.

Ceni C, Pochon N, Villaz M, Muller-Steffner H, Schuber F, Baratier J, De Waard M, Ronjat M, Moutin MJ.

Biochem J. 2006 Apr 15;395(2):417-26.

22.

ADP-ribosyl cyclase and GDP-ribosyl cyclase activities are not always equivalent: impact on the study of the physiological role of cyclic ADP-ribose.

Lund FE, Moutin MJ, Muller-Steffner H, Schuber F.

Anal Biochem. 2005 Nov 15;346(2):336-8. Epub 2005 Sep 1. No abstract available.

PMID:
16212930
23.

Production of calcium-mobilizing metabolites by a novel member of the ADP-ribosyl cyclase family expressed in Schistosoma mansoni.

Goodrich SP, Muller-Steffner H, Osman A, Moutin MJ, Kusser K, Roberts A, Woodland DL, Randall TD, Kellenberger E, LoVerde PT, Schuber F, Lund FE.

Biochemistry. 2005 Aug 23;44(33):11082-97.

PMID:
16101292
24.

Induction of effective and antigen-specific antitumour immunity by a liposomal ErbB2/HER2 peptide-based vaccination construct.

Roth A, Rohrbach F, Weth R, Frisch B, Schuber F, Wels WS.

Br J Cancer. 2005 Apr 25;92(8):1421-9.

25.

Effect of synthetic lipopeptides formulated in liposomes on the maturation of human dendritic cells.

Espuelas S, Roth A, Thumann C, Frisch B, Schuber F.

Mol Immunol. 2005 Apr;42(6):721-9.

PMID:
15781116
26.

Soybean epoxide hydrolase: identification of the catalytic residues and probing of the reaction mechanism with secondary kinetic isotope effects.

Blée E, Summerer S, Flenet M, Rogniaux H, Van Dorsselaer A, Schuber F.

J Biol Chem. 2005 Feb 25;280(8):6479-87. Epub 2004 Dec 13.

27.

A new triantennary galactose-targeted PEGylated gene carrier, characterization of its complex with DNA, and transfection of hepatoma cells.

Frisch B, Carrière M, Largeau C, Mathey F, Masson C, Schuber F, Scherman D, Escriou V.

Bioconjug Chem. 2004 Jul-Aug;15(4):754-64.

PMID:
15264862
28.

Synthesis of thiol-reactive lipopeptide adjuvants. Incorporation into liposomes and study of their mitogenic effect on mouse splenocytes.

Roth A, Espuelas S, Thumann C, Frisch B, Schuber F.

Bioconjug Chem. 2004 May-Jun;15(3):541-53. Erratum in: Bioconjug Chem. 2005 Jul-Aug;16(4):1049.

PMID:
15149182
29.
30.

CD38 is expressed as noncovalently associated homodimers on the surface of murine B lymphocytes.

Moreno-García ME, Partida-Sánchez S, Primack J, Sumoza-Toledo A, Muller-Steffner H, Schuber F, Oppenheimer N, Lund FE, Santos-Argumedo L.

Eur J Biochem. 2004 Mar;271(5):1025-34.

31.

Synthetic peptide-based highly immunogenic liposomal constructs.

Frisch B, Roth A, Schuber F.

Methods Enzymol. 2003;373:51-73. No abstract available.

PMID:
14714396
32.

Fluorometric studies of ligand-induced conformational changes of CD38.

Lacapère JJ, Boulla G, Lund FE, Primack J, Oppenheimer N, Schuber F, Deterre P.

Biochim Biophys Acta. 2003 Nov 3;1652(1):17-26.

PMID:
14580993
33.

Evidence for an intracellular ADP-ribosyl cyclase/NAD+-glycohydrolase in brain from CD38-deficient mice.

Ceni C, Muller-Steffner H, Lund F, Pochon N, Schweitzer A, De Waard M, Schuber F, Villaz M, Moutin MJ.

J Biol Chem. 2003 Oct 17;278(42):40670-8. Epub 2003 Aug 8.

34.

Synthesis of an amphiphilic tetraantennary mannosyl conjugate and incorporation into liposome carriers.

Espuelas S, Haller P, Schuber F, Frisch B.

Bioorg Med Chem Lett. 2003 Aug 4;13(15):2557-60.

PMID:
12852965
35.

CD38-dependent ADP-ribosyl cyclase activity in developing and adult mouse brain.

Ceni C, Pochon N, Brun V, Muller-Steffner H, Andrieux A, Grunwald D, Schuber F, De Waard M, Lund F, Villaz M, Moutin MJ.

Biochem J. 2003 Feb 15;370(Pt 1):175-83.

36.

Novel hydrolysis-resistant analogues of cyclic ADP-ribose: modification of the "northern" ribose and calcium release activity.

Guse AH, Cakir-Kiefer C, Fukuoka M, Shuto S, Weber K, Bailey VC, Matsuda A, Mayr GW, Oppenheimer N, Schuber F, Potter BV.

Biochemistry. 2002 May 28;41(21):6744-51.

PMID:
12022878
37.

Stereochemical features of the hydrolysis of 9,10-epoxystearic acid catalysed by plant and mammalian epoxide hydrolases.

Summerer S, Hanano A, Utsumi S, Arand M, Schuber F, Blée E.

Biochem J. 2002 Sep 1;366(Pt 2):471-80.

38.

Membrane-active properties of alpha-MSH analogs: aggregation and fusion of liposomes triggered by surface-conjugated peptides.

de Souza DL, Frisch B, Duportail G, Schuber F.

Biochim Biophys Acta. 2002 Feb 1;1558(2):222-37.

39.
40.

Enhancement of gene delivery by an analogue of alpha-MSH in a receptor-independent fashion.

Chluba J, Lima de Souza D, Frisch B, Schuber F.

Biochim Biophys Acta. 2001 Feb 9;1510(1-2):198-208.

42.

Unifying mechanism for Aplysia ADP-ribosyl cyclase and CD38/NAD(+) glycohydrolases.

Cakir-Kiefer C, Muller-Steffner H, Schuber F.

Biochem J. 2000 Jul 1;349(Pt 1):203-10.

43.

CD38 in T- and B-cell functions.

Deterre P, Berthelier V, Bauvois B, Dalloul A, Schuber F, Lund F.

Chem Immunol. 2000;75:146-68. Review. No abstract available.

PMID:
10851783
44.

Probing ligand-induced conformational changes of human CD38.

Berthelier V, Laboureau J, Boulla G, Schuber F, Deterre P.

Eur J Biochem. 2000 May;267(10):3056-64.

45.
46.
47.

Design of highly immunogenic liposomal constructs combining structurally independent B cell and T helper cell peptide epitopes.

Boeckler C, Dautel D, Schelté P, Frisch B, Wachsmann D, Klein JP, Schuber F.

Eur J Immunol. 1999 Jul;29(7):2297-308.

48.

CD38 signaling in B lymphocytes is controlled by its ectodomain but occurs independently of enzymatically generated ADP-ribose or cyclic ADP-ribose.

Lund FE, Muller-Steffner HM, Yu N, Stout CD, Schuber F, Howard MC.

J Immunol. 1999 Mar 1;162(5):2693-702.

50.

Design and synthesis of thiol-reactive lipopeptides.

Boeckler C, Frisch B, Schuber F.

Bioorg Med Chem Lett. 1998 Aug 4;8(15):2055-8.

PMID:
9873485

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