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Items: 1 to 50 of 744

1.

19F-NMR Monitoring of Reversible Protein Post-Translational Modifications: Class D β-Lactamase Carbamylation and Inhibition.

van Groesen E, Lohans CT, Brem J, Aertker KM, Claridge TD, Schofield C.

Chemistry. 2019 Jul 16. doi: 10.1002/chem.201902529. [Epub ahead of print]

PMID:
31310409
2.

The Clinically Used Iron Chelator Deferasirox is an Inhibitor of Epigenetic JumonjiC Domain-Containing Histone Demethylases.

Roatsch M, Hoffmann I, Abboud MI, Hancock RL, Tarhonskaya H, Hsu KF, Wilkins SE, Yeh TL, Lippl K, Serrer K, Moneke I, Ahrens TD, Robaa D, Wenzler S, Barthes NPF, Franz H, Sippl W, Lassmann S, Diederichs S, Schleicher E, Schofield CJ, Kawamura A, Schüle R, Jung M.

ACS Chem Biol. 2019 Jul 9. doi: 10.1021/acschembio.9b00289. [Epub ahead of print]

PMID:
31287655
3.

Requirements for improving health and well-being of children with Prader-Willi syndrome and their families.

Mackay J, McCallum Z, Ambler GR, Vora K, Nixon G, Bergman P, Shields N, Milner K, Kapur N, Crock P, Caudri D, Curran J, Verge C, Seton C, Tai A, Tham E, Musthaffa Y, Lafferty AR, Blecher G, Harper J, Schofield C, Nielsen A, Wilson A, Leonard H, Choong CS, Downs J.

J Paediatr Child Health. 2019 Jun 30. doi: 10.1111/jpc.14546. [Epub ahead of print] Review.

PMID:
31257692
4.

Rapid Identification of Novel Psychoactive and Other Controlled Substances Using Low-Field 1H NMR Spectroscopy.

Antonides LH, Brignall RM, Costello A, Ellison J, Firth SE, Gilbert N, Groom BJ, Hudson SJ, Hulme MC, Marron J, Pullen ZA, Robertson TBR, Schofield CJ, Williamson DC, Kemsley EK, Sutcliffe OB, Mewis RE.

ACS Omega. 2019 Apr 30;4(4):7103-7112. doi: 10.1021/acsomega.9b00302. Epub 2019 Apr 19.

5.

Profiling interactions of vaborbactam with metallo-β-lactamases.

Langley GW, Cain R, Tyrrell JM, Hinchliffe P, Calvopiña K, Tooke CL, Widlake E, Dowson CG, Spencer J, Walsh TR, Schofield CJ, Brem J.

Bioorg Med Chem Lett. 2019 Aug 1;29(15):1981-1984. doi: 10.1016/j.bmcl.2019.05.031. Epub 2019 May 17.

6.

Biocatalytic production of bicyclic β-lactams with three contiguous chiral centres using engineered crotonases.

Hamed RB, Gomez-Castellanos JR, Henry L, Warhaut S, Claridge TDW, Schofield CJ.

Commun Chem. 2019 May 17;2. doi: 10.1038/s42004-018-0106-z. Epub 2019 Jan 24.

7.

Biochemical and structural investigations clarify the substrate selectivity of the 2-oxoglutarate oxygenase JMJD6.

Islam MS, McDonough MA, Chowdhury R, Gault J, Khan A, Pires E, Schofield CJ.

J Biol Chem. 2019 May 30. pii: jbc.RA119.008693. doi: 10.1074/jbc.RA119.008693. [Epub ahead of print]

8.

Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors.

Holt-Martyn JP, Tumber A, Rahman MZ, Lippl K, Figg W Jr, McDonough MA, Chowdhury R, Schofield CJ.

Medchemcomm. 2019 Mar 1;10(4):500-504. doi: 10.1039/c8md00548f. eCollection 2019 Apr 1. Review.

9.

Will morphing boron-based inhibitors beat the β-lactamases?

Krajnc A, Lang PA, Panduwawala TD, Brem J, Schofield CJ.

Curr Opin Chem Biol. 2019 Jun;50:101-110. doi: 10.1016/j.cbpa.2019.03.001. Epub 2019 Apr 18. Review.

10.

Does Motivation Impact OCD Symptom Severity? An Exploration of Longitudinal Effects.

Ponzini G, Van Kirk N, Schreck M, Nota JA, Schofield CA, Gironda C, Elias J.

Behav Ther. 2019 Mar;50(2):300-313. doi: 10.1016/j.beth.2018.06.001. Epub 2018 Jun 19.

PMID:
30824247
11.

Conformational Dynamics Underlies Different Functions of Human KDM7 Histone Demethylases.

Chaturvedi SS, Ramanan R, Waheed SO, Ainsley J, Evison M, Ames JM, Schofield CJ, Karabencheva-Christova TG, Christov CZ.

Chemistry. 2019 Apr 11;25(21):5422-5426. doi: 10.1002/chem.201900492. Epub 2019 Mar 26.

PMID:
30817054
12.

A Noninvasive Comparison Study between Human Gliomas with IDH1 and IDH2 Mutations by MR Spectroscopy.

Shen X, Voets NL, Larkin SJ, de Pennington N, Plaha P, Stacey R, McCullagh JSO, Schofield CJ, Clare S, Jezzard P, Cadoux-Hudson T, Ansorge O, Emir UE.

Metabolites. 2019 Feb 20;9(2). pii: E35. doi: 10.3390/metabo9020035.

13.

Structure-Based in Silico Screening Identifies a Potent Ebolavirus Inhibitor from a Traditional Chinese Medicine Library.

Shaikh F, Zhao Y, Alvarez L, Iliopoulou M, Lohans C, Schofield CJ, Padilla-Parra S, Siu SWI, Fry EE, Ren J, Stuart DI.

J Med Chem. 2019 Mar 28;62(6):2928-2937. doi: 10.1021/acs.jmedchem.8b01328. Epub 2019 Mar 6.

14.

Persistent Low-Level Viremia while on Antiretroviral Therapy is an Independent Risk Factor for Virologic Failure.

Joya C, Won SH, Schofield C, Lalani T, Maves RC, Kronmann K, Deiss R, Okulicz J, Agan BK, Ganesan A.

Clin Infect Dis. 2019 Feb 16. pii: ciz129. doi: 10.1093/cid/ciz129. [Epub ahead of print]

PMID:
30785191
15.

Impact of causal explanations for social anxiety disorder on stigma and treatment perceptions.

Schofield CA, Abdul-Chani M, Gaudiano BA.

J Ment Health. 2019 Feb 9:1-8. doi: 10.1080/09638237.2018.1487543. [Epub ahead of print]

PMID:
30741047
16.

Studies on the inhibition of AmpC and other β-lactamases by cyclic boronates.

Cahill ST, Tyrrell JM, Navratilova IH, Calvopiña K, Robinson SW, Lohans CT, McDonough MA, Cain R, Fishwick CWG, Avison MB, Walsh TR, Schofield CJ, Brem J.

Biochim Biophys Acta Gen Subj. 2019 Apr;1863(4):742-748. doi: 10.1016/j.bbagen.2019.02.004. Epub 2019 Feb 7.

17.

Inhibition of a viral prolyl hydroxylase.

Langley GW, Abboud MI, Lohans CT, Schofield CJ.

Bioorg Med Chem. 2019 Jun 15;27(12):2405-2412. doi: 10.1016/j.bmc.2019.01.018. Epub 2019 Jan 23.

PMID:
30737136
18.

Conformational flexibility influences structure-function relationships in nucleic acid N-methyl demethylases.

Waheed SO, Ramanan R, Chaturvedi SS, Ainsley J, Evison M, Ames JM, Schofield CJ, Christov CZ, Karabencheva-Christova TG.

Org Biomol Chem. 2019 Feb 20;17(8):2223-2231. doi: 10.1039/c9ob00162j.

PMID:
30720838
19.

Age, Race, and At-Risk Drinking in an HIV-infected U.S. Military Cohort.

Byrne M, Deiss R, Mesner O, Glancey M, Ganesan A, Okulicz J, Kronmann K, Maves R, Schofield C, Agan B, Macalino G.

Mil Med. 2019 May 1;184(5-6):e263-e267. doi: 10.1093/milmed/usy318.

PMID:
30690493
20.

An essential role for dNTP homeostasis following CDK-induced replication stress.

Pai CC, Hsu KF, Durley SC, Keszthelyi A, Kearsey SE, Rallis C, Folkes LK, Deegan R, Wilkins SE, Pfister SX, De León N, Schofield CJ, Bähler J, Carr AM, Humphrey TC.

J Cell Sci. 2019 Mar 25;132(6). pii: jcs226969. doi: 10.1242/jcs.226969.

21.

New developments for prevention of type 1 diabetes: a paradigm shift?

Schofield CJ, Sutherland C.

Br J Hosp Med (Lond). 2019 Jan 2;80(1):4-5. doi: 10.12968/hmed.2019.80.1.4. No abstract available.

PMID:
30592679
22.

Non-Hydrolytic β-Lactam Antibiotic Fragmentation by l,d-Transpeptidases and Serine β-Lactamase Cysteine Variants.

Lohans CT, Chan HTH, Malla TR, Kumar K, Kamps JJAG, McArdle DJB, van Groesen E, de Munnik M, Tooke CL, Spencer J, Paton RS, Brem J, Schofield CJ.

Angew Chem Int Ed Engl. 2019 Feb 11;58(7):1990-1994. doi: 10.1002/anie.201809424. Epub 2019 Jan 21.

23.

Herpes Zoster Rates Continue to Decline in People Living With Human Immunodeficiency Virus but Remain Higher Than Rates Reported in the General US Population.

Gilbert L, Wang X, Deiss R, Okulicz J, Maves R, Schofield C, Ferguson T, Whitman T, Kronmann K, Agan B, Ganesan A.

Clin Infect Dis. 2019 Jun 18;69(1):155-158. doi: 10.1093/cid/ciy1041.

PMID:
30561578
24.

Born to sense: biophysical analyses of the oxygen sensing prolyl hydroxylase from the simplest animal Trichoplax adhaerens.

Lippl K, Boleininger A, McDonough MA, Abboud MI, Tarhonskaya H, Chowdhury R, Loenarz C, Schofield CJ.

Hypoxia (Auckl). 2018 Nov 9;6:57-71. doi: 10.2147/HP.S174655. eCollection 2018.

25.

Biosynthesis of histone messenger RNA employs a specific 3' end endonuclease.

Pettinati I, Grzechnik P, Ribeiro de Almeida C, Brem J, McDonough MA, Dhir S, Proudfoot NJ, Schofield CJ.

Elife. 2018 Dec 3;7. pii: e39865. doi: 10.7554/eLife.39865.

26.
27.

Small-molecules that covalently react with a human prolyl hydroxylase - towards activity modulation and substrate capture.

Bush JT, Leśniak RK, Yeh TL, Belle R, Kramer H, Tumber A, Chowdhury R, Flashman E, Mecinović J, Schofield CJ.

Chem Commun (Camb). 2019 Jan 22;55(8):1020-1023. doi: 10.1039/c8cc07706a.

28.

Crystal structures of VIM-1 complexes explain active site heterogeneity in VIM-class metallo-β-lactamases.

Salimraj R, Hinchliffe P, Kosmopoulou M, Tyrrell JM, Brem J, van Berkel SS, Verma A, Owens RJ, McDonough MA, Walsh TR, Schofield CJ, Spencer J.

FEBS J. 2019 Jan;286(1):169-183. doi: 10.1111/febs.14695. Epub 2018 Nov 23.

29.

Selective Inhibitors of a Human Prolyl Hydroxylase (OGFOD1) Involved in Ribosomal Decoding.

Thinnes CC, Lohans CT, Abboud MI, Yeh TL, Tumber A, Nowak RP, Attwood M, Cockman ME, Oppermann U, Loenarz C, Schofield CJ.

Chemistry. 2019 Feb 6;25(8):2019-2024. doi: 10.1002/chem.201804790. Epub 2019 Jan 8.

30.

A Fluorescent Benzo[g]isoquinoline-Based HIF Prolyl Hydroxylase Inhibitor for Cellular Imaging.

Mayer M, Fey K, Heinze E, Wick CR, Abboud MI, Yeh TL, Tumber A, Orth N, Schley G, Buchholz B, Clark T, Schofield CJ, Willam C, Burzlaff N.

ChemMedChem. 2019 Jan 8;14(1):94-99. doi: 10.1002/cmdc.201800483. Epub 2018 Dec 21.

PMID:
30380199
31.

Histone H2A monoubiquitylation and p38-MAPKs regulate immediate-early gene-like reactivation of latent retrovirus HTLV-1.

Kulkarni A, Taylor GP, Klose RJ, Schofield CJ, Bangham CR.

JCI Insight. 2018 Oct 18;3(20). pii: 123196. doi: 10.1172/jci.insight.123196.

32.

Nuclear entry and export of FIH are mediated by HIF1α and exportin1, respectively.

Wang Y, Zhong S, Schofield CJ, Ratcliffe PJ, Lu X.

J Cell Sci. 2018 Nov 19;131(22). pii: jcs219782. doi: 10.1242/jcs.219782.

33.

Mechanistic and structural studies of KDM-catalysed demethylation of histone 1 isotype 4 at lysine 26.

Walport LJ, Hopkinson RJ, Chowdhury R, Zhang Y, Bonnici J, Schiller R, Kawamura A, Schofield CJ.

FEBS Lett. 2018 Oct;592(19):3264-3273. doi: 10.1002/1873-3468.13231. Epub 2018 Sep 14.

34.

Adventures in Defining Roles of Oxygenases in the Regulation of Protein Biosynthesis.

Walport LJ, Schofield CJ.

Chem Rec. 2018 Dec;18(12):1760-1781. doi: 10.1002/tcr.201800056. Epub 2018 Aug 27. Review.

PMID:
30151867
35.

Studies on the Substrate Selectivity of the Hypoxia-Inducible Factor Prolyl Hydroxylase 2 Catalytic Domain.

Abboud MI, Chowdhury R, Leung IKH, Lippl K, Loenarz C, Claridge TDW, Schofield CJ.

Chembiochem. 2018 Nov 2;19(21):2262-2267. doi: 10.1002/cbic.201800246. Epub 2018 Sep 26.

PMID:
30144273
36.

A comparison of Indigenous and non-Indigenous users of MindSpot: an Australian digital mental health service.

Titov N, Schofield C, Staples L, Dear BF, Nielssen O.

Australas Psychiatry. 2018 Jul 30:1039856218789784. doi: 10.1177/1039856218789784. [Epub ahead of print]

PMID:
30058351
37.

Synthesis and Biological Evaluation of Tripartin, a Putative KDM4 Natural Product Inhibitor, and 1-Dichloromethylinden-1-ol Analogues.

Guillade L, Sarno F, Tarhonskaya H, Nebbioso A, Alvarez S, Kawamura A, Schofield CJ, Altucci L, de Lera ÁR.

ChemMedChem. 2018 Sep 19;13(18):1949-1956. doi: 10.1002/cmdc.201800377. Epub 2018 Aug 21.

PMID:
30047603
38.

In Vitro Enzyme Assays for JmjC-Domain-Containing Lysine Histone Demethylases (JmjC-KDMs).

Tarhonskaya H, Tumber A, Kawamura A, Schofield CJ.

Curr Protoc Pharmacol. 2018 Mar;80(1):3.15.1-3.15.12. doi: 10.1002/cpph.34.

PMID:
30040204
39.

Preclinical Evaluation of Discorhabdins in Antiangiogenic and Antitumor Models.

Harris EM, Strope JD, Beedie SL, Huang PA, Goey AKL, Cook KM, Schofield CJ, Chau CH, Cadelis MM, Copp BR, Gustafson KR, Figg WD.

Mar Drugs. 2018 Jul 19;16(7). pii: E241. doi: 10.3390/md16070241.

40.

Symmetry breaking by enzyme-catalyzed epoxide hydrolysis.

Schofield CJ.

IUCrJ. 2018 May 18;5(Pt 4):373-374. doi: 10.1107/S2052252518007005. eCollection 2018 Jul 1.

41.

Human histone demethylase KDM6B can catalyse sequential oxidations.

Hopkinson RJ, Langley GW, Belle R, Walport LJ, Dunne K, Münzel M, Salah E, Kawamura A, Claridge TDW, Schofield CJ.

Chem Commun (Camb). 2018 Jul 12;54(57):7975-7978. doi: 10.1039/c8cc04057e.

42.

Publisher Correction: The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases.

Markolovic S, Zhuang Q, Wilkins SE, Eaton CD, Abboud MI, Katz MJ, McNeil HE, Leśniak RK, Hall C, Struwe WB, Konietzny R, Davis S, Yang M, Ge W, Benesch JLP, Kessler BM, Ratcliffe PJ, Cockman ME, Fischer R, Wappner P, Chowdhury R, Coleman ML, Schofield CJ.

Nat Chem Biol. 2018 Oct;14(10):988. doi: 10.1038/s41589-018-0104-6.

PMID:
29950663
43.

The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases.

Markolovic S, Zhuang Q, Wilkins SE, Eaton CD, Abboud MI, Katz MJ, McNeil HE, Leśniak RK, Hall C, Struwe WB, Konietzny R, Davis S, Yang M, Ge W, Benesch JLP, Kessler BM, Ratcliffe PJ, Cockman ME, Fischer R, Wappner P, Chowdhury R, Coleman ML, Schofield CJ.

Nat Chem Biol. 2018 Jul;14(7):688-695. doi: 10.1038/s41589-018-0071-y. Epub 2018 Jun 18. Erratum in: Nat Chem Biol. 2018 Jun 27;:.

44.

Non-competitive cyclic peptides for targeting enzyme-substrate complexes.

McAllister TE, Yeh TL, Abboud MI, Leung IKH, Hookway ES, King ONF, Bhushan B, Williams ST, Hopkinson RJ, Münzel M, Loik ND, Chowdhury R, Oppermann U, Claridge TDW, Goto Y, Suga H, Schofield CJ, Kawamura A.

Chem Sci. 2018 Apr 23;9(20):4569-4578. doi: 10.1039/c8sc00286j. eCollection 2018 May 28.

45.

Antibiotics as food for bacteria.

Schofield CJ.

Nat Microbiol. 2018 Jul;3(7):752-753. doi: 10.1038/s41564-018-0181-z. No abstract available.

PMID:
29891863
46.

Roles of 2-oxoglutarate oxygenases and isopenicillin N synthase in β-lactam biosynthesis.

Rabe P, Kamps JJAG, Schofield CJ, Lohans CT.

Nat Prod Rep. 2018 Aug 15;35(8):735-756. doi: 10.1039/c8np00002f. Review.

47.

NMR analyses on N-hydroxymethylated nucleobases - implications for formaldehyde toxicity and nucleic acid demethylases.

Shishodia S, Zhang D, El-Sagheer AH, Brown T, Claridge TDW, Schofield CJ, Hopkinson RJ.

Org Biomol Chem. 2018 May 30;16(21):4021-4032. doi: 10.1039/c8ob00734a.

48.

Investigations on small molecule inhibitors targeting the histone H3K4 tri-methyllysine binding PHD-finger of JmjC histone demethylases.

Bhushan B, Erdmann A, Zhang Y, Belle R, Johannson C, Oppermann U, Hopkinson RJ, Schofield CJ, Kawamura A.

Bioorg Med Chem. 2018 Jul 15;26(11):2984-2991. doi: 10.1016/j.bmc.2018.03.030. Epub 2018 Mar 19. Review.

49.

In response to: 'Thyroid hormone replacement - a counterblast to guidelines'.

Leese GP, Flynn RV, MacDonald TM, Schofield C, Mackie AD.

J R Coll Physicians Edinb. 2018 Mar;48(1):93. doi: 10.4997/JRCPE.2018.120. No abstract available.

PMID:
29741539
50.

Attentional Bias Modification for Social Anxiety Disorder: What do Patients Think and Why does it Matter?

Kuckertz JM, Schofield CA, Clerkin EM, Primack J, Boettcher H, Weisberg RB, Amir N, Beard C.

Behav Cogn Psychother. 2019 Jan;47(1):16-38. doi: 10.1017/S1352465818000231. Epub 2018 May 6.

PMID:
29729676

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