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Items: 24

1.

2,6-Bis(2-Benzimidazolyl)Pyridine (BBP) Is a Potent and Selective Inhibitor of Small Conductance Calcium-Activated Potassium (SK) Channels.

Simó-Vicens R, Bomholtz SH, Sørensen US, Bentzen BH.

Front Pharmacol. 2018 Dec 3;9:1409. doi: 10.3389/fphar.2018.01409. eCollection 2018.

2.

Termination of Vernakalant-Resistant Atrial Fibrillation by Inhibition of Small-Conductance Ca2+-Activated K+ Channels in Pigs.

Diness JG, Skibsbye L, Simó-Vicens R, Santos JL, Lundegaard P, Citerni C, Sauter DRP, Bomholtz SH, Svendsen JH, Olesen SP, Sørensen US, Jespersen T, Grunnet M, Bentzen BH.

Circ Arrhythm Electrophysiol. 2017 Oct;10(10). pii: e005125. doi: 10.1161/CIRCEP.117.005125.

3.

A new negative allosteric modulator, AP14145, for the study of small conductance calcium-activated potassium (KCa 2) channels.

Simó-Vicens R, Kirchhoff JE, Dolce B, Abildgaard L, Speerschneider T, Sørensen US, Grunnet M, Diness JG, Bentzen BH.

Br J Pharmacol. 2017 Dec;174(23):4396-4408. doi: 10.1111/bph.14043. Epub 2017 Oct 22.

4.

pH-dependent inhibition of K₂P3.1 prolongs atrial refractoriness in whole hearts.

Skarsfeldt MA, Jepps TA, Bomholtz SH, Abildgaard L, Sørensen US, Gregers E, Svendsen JH, Diness JG, Grunnet M, Schmitt N, Olesen SP, Bentzen BH.

Pflugers Arch. 2016 Apr;468(4):643-54. doi: 10.1007/s00424-015-1779-0. Epub 2016 Jan 5.

PMID:
26729267
5.

Role of Calcium-activated Potassium Channels in Atrial Fibrillation Pathophysiology and Therapy.

Diness JG, Bentzen BH, Sørensen US, Grunnet M.

J Cardiovasc Pharmacol. 2015 Nov;66(5):441-8. doi: 10.1097/FJC.0000000000000249. Review.

6.

Pharmacologic inhibition of small-conductance calcium-activated potassium (SK) channels by NS8593 reveals atrial antiarrhythmic potential in horses.

Haugaard MM, Hesselkilde EZ, Pehrson S, Carstensen H, Flethøj M, Præstegaard KF, Sørensen US, Diness JG, Grunnet M, Buhl R, Jespersen T.

Heart Rhythm. 2015 Apr;12(4):825-35. doi: 10.1016/j.hrthm.2014.12.028. Epub 2014 Dec 24.

PMID:
25542425
7.

IgG subclass profiles in normal human sera of antibodies specific to five kinds of microbial antigens.

Hjelholt A, Christiansen G, Sørensen US, Birkelund S.

Pathog Dis. 2013 Apr;67(3):206-13. doi: 10.1111/2049-632X.12034. Epub 2013 Mar 25.

PMID:
23620184
8.

Proteolytic activation of proteose peptone component 3 by release of a C-terminal peptide with antibacterial properties.

Pedersen LR, Hansted JG, Nielsen SB, Petersen TE, Sørensen US, Otzen D, Sørensen ES.

J Dairy Sci. 2012 Jun;95(6):2819-29. doi: 10.3168/jds.2011-4837.

9.

Evidence for a common pharmacological interaction site on K(Ca)2 channels providing both selective activation and selective inhibition of the human K(Ca)2.1 subtype.

Hougaard C, Hammami S, Eriksen BL, Sørensen US, Jensen ML, Strøbæk D, Christophersen P.

Mol Pharmacol. 2012 Feb;81(2):210-9. doi: 10.1124/mol.111.074252. Epub 2011 Nov 1.

PMID:
22046005
10.

Cardiac ion channels and mechanisms for protection against atrial fibrillation.

Grunnet M, Bentzen BH, Sørensen US, Diness JG.

Rev Physiol Biochem Pharmacol. 2012;162:1-58. doi: 10.1007/112_2011_3. Review.

PMID:
21987061
11.

Effects on atrial fibrillation in aged hypertensive rats by Ca(2+)-activated K(+) channel inhibition.

Diness JG, Skibsbye L, Jespersen T, Bartels ED, Sørensen US, Hansen RS, Grunnet M.

Hypertension. 2011 Jun;57(6):1129-35. doi: 10.1161/HYPERTENSIONAHA.111.170613. Epub 2011 Apr 18.

PMID:
21502564
12.

The duration of pacing-induced atrial fibrillation is reduced in vivo by inhibition of small conductance Ca(2+)-activated K(+) channels.

Skibsbye L, Diness JG, Sørensen US, Hansen RS, Grunnet M.

J Cardiovasc Pharmacol. 2011 Jun;57(6):672-81. doi: 10.1097/FJC.0b013e318217943d.

PMID:
21394037
13.

Negative gating modulation by (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine (NS8593) depends on residues in the inner pore vestibule: pharmacological evidence of deep-pore gating of K(Ca)2 channels.

Jenkins DP, Strøbæk D, Hougaard C, Jensen ML, Hummel R, Sørensen US, Christophersen P, Wulff H.

Mol Pharmacol. 2011 Jun;79(6):899-909. doi: 10.1124/mol.110.069807. Epub 2011 Mar 1.

14.

Inhibition of small-conductance Ca2+-activated K+ channels terminates and protects against atrial fibrillation.

Diness JG, Sørensen US, Nissen JD, Al-Shahib B, Jespersen T, Grunnet M, Hansen RS.

Circ Arrhythm Electrophysiol. 2010 Aug;3(4):380-90. doi: 10.1161/CIRCEP.110.957407. Epub 2010 Jun 19.

PMID:
20562443
15.

Curvature of synthetic and natural surfaces is an important target feature in classical pathway complement activation.

Pedersen MB, Zhou X, Larsen EK, Sørensen US, Kjems J, Nygaard JV, Nyengaard JR, Meyer RL, Boesen T, Vorup-Jensen T.

J Immunol. 2010 Feb 15;184(4):1931-45. doi: 10.4049/jimmunol.0902214. Epub 2010 Jan 6.

16.

Synthesis and structure-activity relationship studies of 2-(N-substituted)-aminobenzimidazoles as potent negative gating modulators ofsmall conductance Ca2+-activated K+ channels.

Sørensen US, Strøbaek D, Christophersen P, Hougaard C, Jensen ML, Nielsen EØ, Peters D, Teuber L.

J Med Chem. 2008 Dec 11;51(23):7625-34. doi: 10.1021/jm800809f.

PMID:
18998663
17.

Inhibitory gating modulation of small conductance Ca2+-activated K+ channels by the synthetic compound (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphtylamine (NS8593) reduces afterhyperpolarizing current in hippocampal CA1 neurons.

Strøbaek D, Hougaard C, Johansen TH, Sørensen US, Nielsen EØ, Nielsen KS, Taylor RD, Pedarzani P, Christophersen P.

Mol Pharmacol. 2006 Nov;70(5):1771-82. Epub 2006 Aug 22.

PMID:
16926279
18.

Synthesis and structure-activity relationship studies of novel 2-diarylethyl substituted (2-carboxycycloprop-1-yl)glycines as high-affinity group II metabotropic glutamate receptor ligands.

Sørensen US, Bleisch TJ, Kingston AE, Wright RA, Johnson BG, Schoepp DD, Ornstein PL.

Bioorg Med Chem. 2003 Jan 17;11(2):197-205.

PMID:
12470714
19.

Structural determinants for AMPA agonist activity of aryl or heteroaryl substituted AMPA analogues. Synthesis and pharmacology.

Sørensen US, Falch E, Stensbøl TB, Jaroszewski JW, Madsen U, Krogsgaard-Larsen P.

Arch Pharm (Weinheim). 2001 Feb;334(2):62-8.

PMID:
11268776
20.
21.
22.

Prevention of invasive bacterial diseases by immunization with polysaccharide-protein conjugates.

Robbins JB, Schneerson R, Szu SC, Fattom A, Yang Y, Lagergard T, Chu C, Sørensen US.

Curr Top Microbiol Immunol. 1989;146:169-80. Review.

PMID:
2659266
23.

Anti-C-carbohydrate antibodies after pneumococcal vaccination.

Pedersen FK, Henrichsen J, Sørensen US, Nielsen JL.

Acta Pathol Microbiol Immunol Scand C. 1982 Dec;90(6):353-5.

PMID:
7170960
24.

[Preliminary serological investigations on Aeromonas and Vibrio strains associated with the ulcussyndrome in cod (author's transl)].

Sørensen US.

Nord Vet Med. 1977 Dec;29(12 Suppl 1):10-2. Danish. No abstract available.

PMID:
600698

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