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Best matches for Sørensen CS[au]:

Hereditary breast and ovarian cancer: new genes in confined pathways. Nielsen FC et al. Nat Rev Cancer. (2016)

Whole genome sequencing of breast cancer. Rossing M et al. APMIS. (2019)

The caspase-activated DNase: apoptosis and beyond. Larsen BD et al. FEBS J. (2017)

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Items: 1 to 50 of 61


Effective concentrations enforced by intrinsically disordered linkers are governed by polymer physics.

Sørensen CS, Kjaergaard M.

Proc Natl Acad Sci U S A. 2019 Nov 12;116(46):23124-23131. doi: 10.1073/pnas.1904813116. Epub 2019 Oct 28.


E2F transcription regulation: an orphan cyclin enters the stage.

Rösner HI, Sørensen CS.

EMBO J. 2019 Oct 15;38(20):e103421. doi: 10.15252/embj.2019103421. Epub 2019 Sep 30.


Linker Dependence of Avidity in Multivalent Interactions Between Disordered Proteins.

Sørensen CS, Jendroszek A, Kjaergaard M.

J Mol Biol. 2019 Dec 6;431(24):4784-4795. doi: 10.1016/j.jmb.2019.09.001. Epub 2019 Sep 10.


Acute hydroxyurea-induced replication blockade results in replisome components disengagement from nascent DNA without causing fork collapse.

Ercilla A, Feu S, Aranda S, Llopis A, Brynjólfsdóttir SH, Sørensen CS, Toledo LI, Agell N.

Cell Mol Life Sci. 2019 Jul 11. doi: 10.1007/s00018-019-03206-1. [Epub ahead of print]


Overcoming Treatment Toxicity through Sequential Therapy.

Benada J, Ejlertsen B, Sørensen CS.

Cancer Cell. 2019 Jun 10;35(6):821-822. doi: 10.1016/j.ccell.2019.05.006.


Whole genome sequencing of breast cancer.

Rossing M, Sørensen CS, Ejlertsen B, Nielsen FC.

APMIS. 2019 May;127(5):303-315. doi: 10.1111/apm.12920. Epub 2019 Jan 28. Review.


PALB2 connects BRCA1 and BRCA2 in the G2/M checkpoint response.

Simhadri S, Vincelli G, Huo Y, Misenko S, Foo TK, Ahlskog J, Sørensen CS, Oakley GG, Ganesan S, Bunting SF, Xia B.

Oncogene. 2019 Mar;38(10):1585-1596. doi: 10.1038/s41388-018-0535-2. Epub 2018 Oct 18.


Topokaryotyping demonstrates single cell variability and stress dependent variations in nuclear envelope associated domains.

Jurisic A, Robin C, Tarlykov P, Siggens L, Schoell B, Jauch A, Ekwall K, Sørensen CS, Lipinski M, Shoaib M, Ogryzko V.

Nucleic Acids Res. 2018 Dec 14;46(22):e135. doi: 10.1093/nar/gky818.


Histone H4K20 methylation mediated chromatin compaction threshold ensures genome integrity by limiting DNA replication licensing.

Shoaib M, Walter D, Gillespie PJ, Izard F, Fahrenkrog B, Lleres D, Lerdrup M, Johansen JV, Hansen K, Julien E, Blow JJ, Sørensen CS.

Nat Commun. 2018 Sep 12;9(1):3704. doi: 10.1038/s41467-018-06066-8.


Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability.

Galanos P, Pappas G, Polyzos A, Kotsinas A, Svolaki I, Giakoumakis NN, Glytsou C, Pateras IS, Swain U, Souliotis VL, Georgakilas AG, Geacintov N, Scorrano L, Lukas C, Lukas J, Livneh Z, Lygerou Z, Chowdhury D, Sørensen CS, Bartek J, Gorgoulis VG.

Genome Biol. 2018 Mar 16;19(1):37. doi: 10.1186/s13059-018-1401-9.


Chromatin Dynamics in Genome Stability: Roles in Suppressing Endogenous DNA Damage and Facilitating DNA Repair.

Nair N, Shoaib M, Sørensen CS.

Int J Mol Sci. 2017 Jul 10;18(7). pii: E1486. doi: 10.3390/ijms18071486. Review.


The caspase-activated DNase: apoptosis and beyond.

Larsen BD, Sørensen CS.

FEBS J. 2017 Apr;284(8):1160-1170. doi: 10.1111/febs.13970. Epub 2016 Dec 15. Review.


Hereditary breast and ovarian cancer: new genes in confined pathways.

Nielsen FC, van Overeem Hansen T, Sørensen CS.

Nat Rev Cancer. 2016 Sep;16(9):599-612. doi: 10.1038/nrc.2016.72. Epub 2016 Aug 12. Review.


Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing.

Galanos P, Vougas K, Walter D, Polyzos A, Maya-Mendoza A, Haagensen EJ, Kokkalis A, Roumelioti FM, Gagos S, Tzetis M, Canovas B, Igea A, Ahuja AK, Zellweger R, Havaki S, Kanavakis E, Kletsas D, Roninson IB, Garbis SD, Lopes M, Nebreda A, Thanos D, Blow JJ, Townsend P, Sørensen CS, Bartek J, Gorgoulis VG.

Nat Cell Biol. 2016 Jul;18(7):777-89. doi: 10.1038/ncb3378. Epub 2016 Jun 20.


ATM/ATR-mediated phosphorylation of PALB2 promotes RAD51 function.

Ahlskog JK, Larsen BD, Achanta K, Sørensen CS.

EMBO Rep. 2016 May;17(5):671-81. doi: 10.15252/embr.201541455. Epub 2016 Apr 4.


SCF(Cyclin F)-dependent degradation of CDC6 suppresses DNA re-replication.

Walter D, Hoffmann S, Komseli ES, Rappsilber J, Gorgoulis V, Sørensen CS.

Nat Commun. 2016 Jan 28;7:10530. doi: 10.1038/ncomms10530.


DNA replication and cancer: From dysfunctional replication origin activities to therapeutic opportunities.

Boyer AS, Walter D, Sørensen CS.

Semin Cancer Biol. 2016 Jun;37-38:16-25. doi: 10.1016/j.semcancer.2016.01.001. Epub 2016 Jan 12. Review.


The PCNA-associated protein PARI negatively regulates homologous recombination via the inhibition of DNA repair synthesis.

Burkovics P, Dome L, Juhasz S, Altmannova V, Sebesta M, Pacesa M, Fugger K, Sorensen CS, Lee MY, Haracska L, Krejci L.

Nucleic Acids Res. 2016 Apr 20;44(7):3176-89. doi: 10.1093/nar/gkw024. Epub 2016 Jan 20.


Epigenetic Deficiencies and Replicative Stress: Driving Cancer Cells to an Early Grave.

Shoaib M, Sørensen CS.

Cancer Cell. 2015 Nov 9;28(5):545-547. doi: 10.1016/j.ccell.2015.10.009.


FBH1: a new checkpoint factor.

Boyer AS, Sørensen CS.

Oncotarget. 2015 Aug 14;6(23):19354-5. No abstract available.


Early Events in the Amyloid Formation of the A546T Mutant of Transforming Growth Factor β-Induced Protein in Corneal Dystrophies Compared to the Nonfibrillating R555W and R555Q Mutants.

Koldsø H, Andersen OJ, Nikolajsen CL, Scavenius C, Sørensen CS, Underhaug J, Runager K, Nielsen NC, Enghild JJ, Schiøtt B.

Biochemistry. 2015 Sep 15;54(36):5546-56. doi: 10.1021/acs.biochem.5b00473. Epub 2015 Sep 2.


Near-complete 1H, 13C, 15N resonance assignments of dimethylsulfoxide-denatured TGFBIp FAS1-4 A546T.

Kulminskaya NV, Yoshimura Y, Runager K, Sørensen CS, Bjerring M, Andreasen M, Otzen DE, Enghild JJ, Nielsen NC, Mulder FA.

Biomol NMR Assign. 2016 Apr;10(1):25-9. doi: 10.1007/s12104-015-9630-2. Epub 2015 Aug 15.


Exploiting replicative stress to treat cancer.

Dobbelstein M, Sørensen CS.

Nat Rev Drug Discov. 2015 Jun;14(6):405-23. doi: 10.1038/nrd4553. Epub 2015 May 8. Review.


Fibril Core of Transforming Growth Factor Beta-Induced Protein (TGFBIp) Facilitates Aggregation of Corneal TGFBIp.

Sørensen CS, Runager K, Scavenius C, Jensen MM, Nielsen NS, Christiansen G, Petersen SV, Karring H, Sanggaard KW, Enghild JJ.

Biochemistry. 2015 May 19;54(19):2943-56. doi: 10.1021/acs.biochem.5b00292. Epub 2015 May 6.


FBH1 Catalyzes Regression of Stalled Replication Forks.

Fugger K, Mistrik M, Neelsen KJ, Yao Q, Zellweger R, Kousholt AN, Haahr P, Chu WK, Bartek J, Lopes M, Hickson ID, Sørensen CS.

Cell Rep. 2015 Mar 17;10(10):1749-1757. doi: 10.1016/j.celrep.2015.02.028. Epub 2015 Mar 12.


Cyclin F suppresses B-Myb activity to promote cell cycle checkpoint control.

Klein DK, Hoffmann S, Ahlskog JK, O'Hanlon K, Quaas M, Larsen BD, Rolland B, Rösner HI, Walter D, Kousholt AN, Menzel T, Lees M, Johansen JV, Rappsilber J, Engeland K, Sørensen CS.

Nat Commun. 2015 Jan 5;6:5800. doi: 10.1038/ncomms6800.


miR-19, a component of the oncogenic miR-17∼92 cluster, targets the DNA-end resection factor CtIP.

Hühn D, Kousholt AN, Sørensen CS, Sartori AA.

Oncogene. 2015 Jul 23;34(30):3977-84. doi: 10.1038/onc.2014.329. Epub 2014 Oct 13.


Mutation in transforming growth factor beta induced protein associated with granular corneal dystrophy type 1 reduces the proteolytic susceptibility through local structural stabilization.

Underhaug J, Koldsø H, Runager K, Nielsen JT, Sørensen CS, Kristensen T, Otzen DE, Karring H, Malmendal A, Schiøtt B, Enghild JJ, Nielsen NC.

Biochim Biophys Acta. 2013 Dec;1834(12):2812-22. doi: 10.1016/j.bbapap.2013.10.008. Epub 2013 Oct 12.


Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity.

Köpper F, Bierwirth C, Schön M, Kunze M, Elvers I, Kranz D, Saini P, Menon MB, Walter D, Sørensen CS, Gaestel M, Helleday T, Schön MP, Dobbelstein M.

Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):16856-61. doi: 10.1073/pnas.1304355110. Epub 2013 Sep 30.


FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress.

Fugger K, Chu WK, Haahr P, Kousholt AN, Beck H, Payne MJ, Hanada K, Hickson ID, Sørensen CS.

Nat Commun. 2013;4:1423. doi: 10.1038/ncomms2395.


Histone H4 lysine 20 methylation: key player in epigenetic regulation of genomic integrity.

Jørgensen S, Schotta G, Sørensen CS.

Nucleic Acids Res. 2013 Mar 1;41(5):2797-806. doi: 10.1093/nar/gkt012. Epub 2013 Jan 23. Review.


Correction: Kousholt, A.N. et al. Pathways for Genome Integrity in G2 Phase of the Cell Cycle. Biomolecules 2012, 2, 579-607.

Kousholt AN, Menzel T, Sørensen CS.

Biomolecules. 2013 Jan 15;3(1):72-4. doi: 10.3390/biom3010072.


Cyclin-dependent kinase suppression by WEE1 kinase protects the genome through control of replication initiation and nucleotide consumption.

Beck H, Nähse-Kumpf V, Larsen MS, O'Hanlon KA, Patzke S, Holmberg C, Mejlvang J, Groth A, Nielsen O, Syljuåsen RG, Sørensen CS.

Mol Cell Biol. 2012 Oct;32(20):4226-36. Epub 2012 Aug 20.


LEDGF (p75) promotes DNA-end resection and homologous recombination.

Daugaard M, Baude A, Fugger K, Povlsen LK, Beck H, Sørensen CS, Petersen NH, Sorensen PH, Lukas C, Bartek J, Lukas J, Rohde M, Jäättelä M.

Nat Struct Mol Biol. 2012 Aug;19(8):803-10. doi: 10.1038/nsmb.2314. Epub 2012 Jul 8.


CtIP-dependent DNA resection is required for DNA damage checkpoint maintenance but not initiation.

Kousholt AN, Fugger K, Hoffmann S, Larsen BD, Menzel T, Sartori AA, Sørensen CS.

J Cell Biol. 2012 Jun 25;197(7):869-76. doi: 10.1083/jcb.201111065.


Pathways for genome integrity in G2 phase of the cell cycle.

Kousholt AN, Menzel T, Sørensen CS.

Biomolecules. 2012 Nov 30;2(4):579-607. doi: 10.3390/biom2040579. Erratum in: Biomolecules. 2013;3(1):72-4.


Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication.

Sørensen CS, Syljuåsen RG.

Nucleic Acids Res. 2012 Jan;40(2):477-86. doi: 10.1093/nar/gkr697. Epub 2011 Sep 21. Review.


A genetic screen identifies BRCA2 and PALB2 as key regulators of G2 checkpoint maintenance.

Menzel T, Nähse-Kumpf V, Kousholt AN, Klein DK, Lund-Andersen C, Lees M, Johansen JV, Syljuåsen RG, Sørensen CS.

EMBO Rep. 2011 Jul 1;12(7):705-12. doi: 10.1038/embor.2011.99.


SAXS models of TGFBIp reveal a trimeric structure and show that the overall shape is not affected by the Arg124His mutation.

Basaiawmoit RV, Oliveira CL, Runager K, Sørensen CS, Behrens MA, Jonsson BH, Kristensen T, Klintworth GK, Enghild JJ, Pedersen JS, Otzen DE.

J Mol Biol. 2011 May 6;408(3):503-13. doi: 10.1016/j.jmb.2011.02.052. Epub 2011 Mar 1.


SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation.

Jørgensen S, Eskildsen M, Fugger K, Hansen L, Larsen MS, Kousholt AN, Syljuåsen RG, Trelle MB, Jensen ON, Helin K, Sørensen CS.

J Cell Biol. 2011 Jan 10;192(1):43-54. doi: 10.1083/jcb.201009076.


Human phenotypically distinct TGFBI corneal dystrophies are linked to the stability of the fourth FAS1 domain of TGFBIp.

Runager K, Basaiawmoit RV, Deva T, Andreasen M, Valnickova Z, Sørensen CS, Karring H, Thøgersen IB, Christiansen G, Underhaug J, Kristensen T, Nielsen NC, Klintworth GK, Otzen DE, Enghild JJ.

J Biol Chem. 2011 Feb 18;286(7):4951-8. doi: 10.1074/jbc.M110.181099. Epub 2010 Dec 6.


High-throughput siRNA screens using γH2AX as marker uncover key regulators of genome integrity in mammalian cells.

Beck H, Menzel T, Syljuåsen RG, Sørensen CS.

Cell Cycle. 2010 Jun 15;9(12):2257-8. Epub 2010 Jun 15. No abstract available.


Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase.

Beck H, Nähse V, Larsen MS, Groth P, Clancy T, Lees M, Jørgensen M, Helleday T, Syljuåsen RG, Sørensen CS.

J Cell Biol. 2010 Mar 8;188(5):629-38. doi: 10.1083/jcb.200905059. Epub 2010 Mar 1.


NEK11: linking CHK1 and CDC25A in DNA damage checkpoint signaling.

Sørensen CS, Melixetian M, Klein DK, Helin K.

Cell Cycle. 2010 Feb 1;9(3):450-5. Epub 2010 Feb 3.


NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint.

Melixetian M, Klein DK, Sørensen CS, Helin K.

Nat Cell Biol. 2009 Oct;11(10):1247-53. doi: 10.1038/ncb1969. Epub 2009 Sep 6.


The histone methyltransferase SET8 is required for S-phase progression.

Jørgensen S, Elvers I, Trelle MB, Menzel T, Eskildsen M, Jensen ON, Helleday T, Helin K, Sørensen CS.

J Cell Biol. 2007 Dec 31;179(7):1337-45. doi: 10.1083/jcb.200706150.


RPA mediates recombination repair during replication stress and is displaced from DNA by checkpoint signalling in human cells.

Sleeth KM, Sørensen CS, Issaeva N, Dziegielewski J, Bartek J, Helleday T.

J Mol Biol. 2007 Oct 12;373(1):38-47. Epub 2007 Aug 15.


Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage.

Syljuåsen RG, Sørensen CS, Hansen LT, Fugger K, Lundin C, Johansson F, Helleday T, Sehested M, Lukas J, Bartek J.

Mol Cell Biol. 2005 May;25(9):3553-62.


The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair.

Sørensen CS, Hansen LT, Dziegielewski J, Syljuåsen RG, Lundin C, Bartek J, Helleday T.

Nat Cell Biol. 2005 Feb;7(2):195-201. Epub 2005 Jan 23.


Inhibition of Chk1 by CEP-3891 accelerates mitotic nuclear fragmentation in response to ionizing Radiation.

Syljuåsen RG, Sørensen CS, Nylandsted J, Lukas C, Lukas J, Bartek J.

Cancer Res. 2004 Dec 15;64(24):9035-40.

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