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Items: 1 to 50 of 96

1.

Enhanced E. coli LF82 translocation through follicle-associated epithelium in Crohn's disease is dependent on long polar fimbriae and CEACAM6-expression, and increases paracellular permeability.

Keita ÅV, Alkaissi LY, Holm EB, Heil SDS, Chassaing B, Darfeuille-Michaud A, McKay DM, Söderholm JD.

J Crohns Colitis. 2019 Aug 9. pii: jjz144. doi: 10.1093/ecco-jcc/jjz144. [Epub ahead of print]

PMID:
31393983
2.

Anorectal Function After Ileo-Rectal Anastomosis Is Better than Pelvic Pouch in Selected Ulcerative Colitis Patients.

Abdalla M, Norblad R, Olsson M, Landerholm K, Andersson P, Söderholm JD, Andersson R, Myrelid P.

Dig Dis Sci. 2019 Aug 1. doi: 10.1007/s10620-019-05757-6. [Epub ahead of print]

3.
4.

Fecal microbiota profiles in treatment-naïve pediatric inflammatory bowel disease - associations with disease phenotype, treatment, and outcome.

Olbjørn C, Cvancarova Småstuen M, Thiis-Evensen E, Nakstad B, Vatn MH, Jahnsen J, Ricanek P, Vatn S, Moen AEF, Tannæs TM, Lindstrøm JC, Söderholm JD, Halfvarson J, Gomollón F, Casén C, Karlsson MK, Kalla R, Adams AT, Satsangi J, Perminow G.

Clin Exp Gastroenterol. 2019 Jan 31;12:37-49. doi: 10.2147/CEG.S186235. eCollection 2019.

5.

Interactions between gut permeability and brain structure and function in health and irritable bowel syndrome.

Witt ST, Bednarska O, Keita ÅV, Icenhour A, Jones MP, Elsenbruch S, Söderholm JD, Engström M, Mayer EA, Walter S.

Neuroimage Clin. 2019;21:101602. doi: 10.1016/j.nicl.2018.11.012. Epub 2018 Nov 17.

6.

Upregulation of intestinal mucosal mast cells expressing VPAC1 in close proximity to vasoactive intestinal polypeptide in inflammatory bowel disease and murine colitis.

Casado-Bedmar M, Heil SDS, Myrelid P, Söderholm JD, Keita ÅV.

Neurogastroenterol Motil. 2019 Mar;31(3):e13503. doi: 10.1111/nmo.13503. Epub 2018 Nov 8.

PMID:
30407703
7.

Mucosal permeability and mast cells as targets for functional gastrointestinal disorders.

Keita ÅV, Söderholm JD.

Curr Opin Pharmacol. 2018 Dec;43:66-71. doi: 10.1016/j.coph.2018.08.011. Epub 2018 Sep 11. Review.

PMID:
30216901
8.

Infliximab restores colonic barrier to adherent-invasive E. coli in Crohn's disease via effects on epithelial lipid rafts.

Yakymenko O, Schoultz I, Gullberg E, Ström M, Almer S, Wallon C, Wang A, Keita ÅV, Campbell BJ, McKay DM, Söderholm JD.

Scand J Gastroenterol. 2018 Jun;53(6):677-684. doi: 10.1080/00365521.2018.1458146. Epub 2018 Apr 24.

PMID:
29688802
9.

A Novel Topical PPARγ Agonist Induces PPARγ Activity in Ulcerative Colitis Mucosa and Prevents and Reverses Inflammation in Induced Colitis Models.

Da Silva S, Keita ÅV, Mohlin S, Påhlman S, Theodorou V, Påhlman I, Mattson JP, Söderholm JD.

Inflamm Bowel Dis. 2018 Mar 19;24(4):792-805. doi: 10.1093/ibd/izx079.

PMID:
29529198
10.

ER-stress mobilization of death-associated protein kinase-1-dependent xenophagy counteracts mitochondria stress-induced epithelial barrier dysfunction.

Lopes F, Keita ÅV, Saxena A, Reyes JL, Mancini NL, Al Rajabi A, Wang A, Baggio CH, Dicay M, van Dalen R, Ahn Y, Carneiro MBH, Peters NC, Rho JM, MacNaughton WK, Girardin SE, Jijon H, Philpott DJ, Söderholm JD, McKay DM.

J Biol Chem. 2018 Mar 2;293(9):3073-3087. doi: 10.1074/jbc.RA117.000809. Epub 2018 Jan 9.

11.

The Swedish Crohn Trial: A Prematurely Terminated Randomized Controlled Trial of Thiopurines or Open Surgery for Primary Treatment of Ileocaecal Crohn's Disease.

Gerdin L, Eriksson AS, Olaison G, Sjödahl R, Ström M, Söderholm JD, Myrelid P.

J Crohns Colitis. 2016 Jan;10(1):50-4. doi: 10.1093/ecco-jcc/jjv184. Epub 2015 Oct 27.

12.

Effects of anti-inflammatory therapy on bursting pressure of colonic anastomosis in murine dextran sulfate sodium induced colitis.

Myrelid P, Salim SY, Darby T, Almer S, Melgar S, Andersson P, Söderholm JD.

Scand J Gastroenterol. 2015 Aug;50(8):991-1001. doi: 10.3109/00365521.2014.964760. Epub 2015 Apr 10.

PMID:
25861827
13.

Gut immunology: Nanoparticles ferry gut antigens.

Söderholm JD.

Nat Nanotechnol. 2015 Apr;10(4):298-9. doi: 10.1038/nnano.2015.58. No abstract available.

PMID:
25855255
14.

Increased humoral immunity in the jejunum of diarrhoea-predominant irritable bowel syndrome associated with clinical manifestations.

Vicario M, González-Castro AM, Martínez C, Lobo B, Pigrau M, Guilarte M, de Torres I, Mosquera JL, Fortea M, Sevillano-Aguilera C, Salvo-Romero E, Alonso C, Rodiño-Janeiro BK, Söderholm JD, Azpiroz F, Santos J.

Gut. 2015 Sep;64(9):1379-88. doi: 10.1136/gutjnl-2013-306236. Epub 2014 Sep 10.

PMID:
25209656
15.

Targeting mitochondria-derived reactive oxygen species to reduce epithelial barrier dysfunction and colitis.

Wang A, Keita ÅV, Phan V, McKay CM, Schoultz I, Lee J, Murphy MP, Fernando M, Ronaghan N, Balce D, Yates R, Dicay M, Beck PL, MacNaughton WK, Söderholm JD, McKay DM.

Am J Pathol. 2014 Sep;184(9):2516-27. doi: 10.1016/j.ajpath.2014.05.019. Epub 2014 Jul 14.

16.

Dietary supplementation with soluble plantain non-starch polysaccharides inhibits intestinal invasion of Salmonella Typhimurium in the chicken.

Parsons BN, Wigley P, Simpson HL, Williams JM, Humphrey S, Salisbury AM, Watson AJ, Fry SC, O'Brien D, Roberts CL, O'Kennedy N, Keita AV, Söderholm JD, Rhodes JM, Campbell BJ.

PLoS One. 2014 Feb 3;9(2):e87658. doi: 10.1371/journal.pone.0087658. eCollection 2014.

17.

Ileorectal anastomosis in comparison with ileal pouch anal anastomosis in reconstructive surgery for ulcerative colitis--a single institution experience.

Andersson P, Norblad R, Söderholm JD, Myrelid P.

J Crohns Colitis. 2014 Jul;8(7):582-9. doi: 10.1016/j.crohns.2013.11.014. Epub 2013 Dec 5.

PMID:
24315777
18.
19.

Faecalibacterium prausnitzii supernatant improves intestinal barrier function in mice DSS colitis.

Carlsson AH, Yakymenko O, Olivier I, Håkansson F, Postma E, Keita AV, Söderholm JD.

Scand J Gastroenterol. 2013 Oct;48(10):1136-44. doi: 10.3109/00365521.2013.828773. Epub 2013 Aug 26.

PMID:
23971882
20.

The effects of probiotics on barrier function and mucosal pouch microbiota during maintenance treatment for severe pouchitis in patients with ulcerative colitis.

Persborn M, Gerritsen J, Wallon C, Carlsson A, Akkermans LM, Söderholm JD.

Aliment Pharmacol Ther. 2013 Oct;38(7):772-83. doi: 10.1111/apt.12451. Epub 2013 Aug 19.

21.

Vasoactive intestinal polypeptide regulates barrier function via mast cells in human intestinal follicle-associated epithelium and during stress in rats.

Keita AV, Carlsson AH, Cigéhn M, Ericson AC, McKay DM, Söderholm JD.

Neurogastroenterol Motil. 2013 Jun;25(6):e406-17. doi: 10.1111/nmo.12127. Epub 2013 Apr 18.

PMID:
23600853
22.

Impaired duodenal mucosal integrity and low-grade inflammation in functional dyspepsia.

Vanheel H, Vicario M, Vanuytsel T, Van Oudenhove L, Martinez C, Keita ÅV, Pardon N, Santos J, Söderholm JD, Tack J, Farré R.

Gut. 2014 Feb;63(2):262-71. doi: 10.1136/gutjnl-2012-303857. Epub 2013 Mar 8.

PMID:
23474421
23.

TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal degradation.

Zurek B, Schoultz I, Neerincx A, Napolitano LM, Birkner K, Bennek E, Sellge G, Lerm M, Meroni G, Söderholm JD, Kufer TA.

PLoS One. 2012;7(7):e41255. doi: 10.1371/journal.pone.0041255. Epub 2012 Jul 19.

24.

Soluble plantain fibre blocks adhesion and M-cell translocation of intestinal pathogens.

Roberts CL, Keita AV, Parsons BN, Prorok-Hamon M, Knight P, Winstanley C, O' Kennedy N, Söderholm JD, Rhodes JM, Campbell BJ.

J Nutr Biochem. 2013 Jan;24(1):97-103. doi: 10.1016/j.jnutbio.2012.02.013. Epub 2012 Jul 19.

25.

Barrier dysfunction and bacterial uptake in the follicle-associated epithelium of ileal Crohn's disease.

Keita AV, Söderholm JD.

Ann N Y Acad Sci. 2012 Jul;1258:125-34. doi: 10.1111/j.1749-6632.2012.06502.x. Review.

PMID:
22731725
26.

Is metabolic stress a common denominator in inflammatory bowel disease?

Schoultz I, Söderholm JD, McKay DM.

Inflamm Bowel Dis. 2011 Sep;17(9):2008-18. doi: 10.1002/ibd.21556. Epub 2010 Dec 3. Review.

PMID:
21830276
27.

Split stoma in resectional surgery of high-risk patients with ileocolonic Crohn's disease.

Myrelid P, Söderholm JD, Olaison G, Sjödahl R, Andersson P.

Colorectal Dis. 2012 Feb;14(2):188-93. doi: 10.1111/j.1463-1318.2011.02578.x.

PMID:
21689286
28.

Low levels of bile acids increase bacterial uptake in colonic biopsies from patients with collagenous colitis in remission.

Münch A, Söderholm JD, Ost A, Carlsson AH, Magnusson KE, Ström M.

Aliment Pharmacol Ther. 2011 Apr;33(8):954-60. doi: 10.1111/j.1365-2036.2011.04611.x. Epub 2011 Mar 1.

29.

Crohn disease--associated adherent-invasive E. coli bacteria target mouse and human Peyer's patches via long polar fimbriae.

Chassaing B, Rolhion N, de Vallée A, Salim SY, Prorok-Hamon M, Neut C, Campbell BJ, Söderholm JD, Hugot JP, Colombel JF, Darfeuille-Michaud A.

J Clin Invest. 2011 Mar;121(3):966-75. doi: 10.1172/JCI44632. Epub 2011 Feb 21.

30.

Eosinophils express muscarinic receptors and corticotropin-releasing factor to disrupt the mucosal barrier in ulcerative colitis.

Wallon C, Persborn M, Jönsson M, Wang A, Phan V, Lampinen M, Vicario M, Santos J, Sherman PM, Carlson M, Ericson AC, McKay DM, Söderholm JD.

Gastroenterology. 2011 May;140(5):1597-607. doi: 10.1053/j.gastro.2011.01.042. Epub 2011 Jan 26.

PMID:
21277851
31.

Translocation of Crohn's disease Escherichia coli across M-cells: contrasting effects of soluble plant fibres and emulsifiers.

Roberts CL, Keita AV, Duncan SH, O'Kennedy N, Söderholm JD, Rhodes JM, Campbell BJ.

Gut. 2010 Oct;59(10):1331-9. doi: 10.1136/gut.2009.195370. Epub 2010 Sep 2.

32.

Importance of disrupted intestinal barrier in inflammatory bowel diseases.

Salim SY, Söderholm JD.

Inflamm Bowel Dis. 2011 Jan;17(1):362-81. doi: 10.1002/ibd.21403. Epub 2010 Aug 19. Review.

PMID:
20725949
33.

Release of satiety hormones in response to specific dietary proteins is different between human and murine small intestinal mucosa.

Geraedts MC, Troost FJ, Tinnemans R, Söderholm JD, Brummer RJ, Saris WH.

Ann Nutr Metab. 2010;56(4):308-13. doi: 10.1159/000312664. Epub 2010 Jun 8.

PMID:
20530962
34.

The intestinal barrier and its regulation by neuroimmune factors.

Keita AV, Söderholm JD.

Neurogastroenterol Motil. 2010 Jul;22(7):718-33. doi: 10.1111/j.1365-2982.2010.01498.x. Epub 2010 Apr 9. Review.

PMID:
20377785
35.

Stress-induced barrier disruption of rat follicle-associated epithelium involves corticotropin-releasing hormone, acetylcholine, substance P, and mast cells.

Keita AV, Söderholm JD, Ericson AC.

Neurogastroenterol Motil. 2010 Jul;22(7):770-8, e221-2. doi: 10.1111/j.1365-2982.2010.01471.x. Epub 2010 Feb 10.

PMID:
20149111
36.

Enhanced translocation of bacteria across metabolically stressed epithelia is reduced by butyrate.

Lewis K, Lutgendorff F, Phan V, Söderholm JD, Sherman PM, McKay DM.

Inflamm Bowel Dis. 2010 Jul;16(7):1138-48. doi: 10.1002/ibd.21177.

PMID:
20024905
37.

[Surgery--indispensable complement ot drug therapy].

Andersson MV, Andersson P, Bohe M, Börjesson L, Graf W, Jeppsson B, Törkvist L, Akerlund JE, Söderholm JD.

Lakartidningen. 2009 Nov 4-12;106(45):3003-9. Review. Swedish. No abstract available.

PMID:
19998827
38.

[Polygenetic disturbance in the front line mucosa defense].

Söderholm JD, Pettersson S.

Lakartidningen. 2009 Nov 4-12;106(45):2974, 2976-8. Review. Swedish. No abstract available.

PMID:
19998821
39.

Surgery in ulcerative colitis: indication and timing.

Andersson P, Söderholm JD.

Dig Dis. 2009;27(3):335-40. doi: 10.1159/000228570. Epub 2009 Sep 24. Review.

PMID:
19786761
40.

Regulation of mucosal structure and barrier function in rat colon exposed to tumor necrosis factor alpha and interferon gamma in vitro: a novel model for studying the pathomechanisms of inflammatory bowel disease cytokines.

Amasheh M, Grotjohann I, Amasheh S, Fromm A, Söderholm JD, Zeitz M, Fromm M, Schulzke JD.

Scand J Gastroenterol. 2009;44(10):1226-35. doi: 10.1080/00365520903131973.

PMID:
19658020
41.

Corticotropin-releasing hormone and mast cells in the regulation of mucosal barrier function in the human colon.

Wallon C, Söderholm JD.

Ann N Y Acad Sci. 2009 May;1165:206-10. doi: 10.1111/j.1749-6632.2009.04030.x.

PMID:
19538308
42.

Increased expression of protease-activated receptor-2 in mucosal mast cells in Crohn's ileitis.

Christerson U, Keita AV, Söderholm JD, Gustafson-Svärd C.

J Crohns Colitis. 2009 Jun;3(2):100-8. doi: 10.1016/j.crohns.2008.11.003. Epub 2009 Mar 5.

PMID:
21172252
43.

Combined polymorphisms in genes encoding the inflammasome components NALP3 and CARD8 confer susceptibility to Crohn's disease in Swedish men.

Schoultz I, Verma D, Halfvarsson J, Törkvist L, Fredrikson M, Sjöqvist U, Lördal M, Tysk C, Lerm M, Söderkvist P, Söderholm JD.

Am J Gastroenterol. 2009 May;104(5):1180-8. doi: 10.1038/ajg.2009.29. Epub 2009 Mar 24.

PMID:
19319132
44.

Probiotics prevent intestinal barrier dysfunction in acute pancreatitis in rats via induction of ileal mucosal glutathione biosynthesis.

Lutgendorff F, Nijmeijer RM, Sandström PA, Trulsson LM, Magnusson KE, Timmerman HM, van Minnen LP, Rijkers GT, Gooszen HG, Akkermans LM, Söderholm JD.

PLoS One. 2009;4(2):e4512. doi: 10.1371/journal.pone.0004512. Epub 2009 Feb 18.

45.

Increased transmucosal uptake of E. coli K12 in collagenous colitis persists after budesonide treatment.

Münch A, Söderholm JD, Ost A, Ström M.

Am J Gastroenterol. 2009 Mar;104(3):679-85. doi: 10.1038/ajg.2008.95. Epub 2009 Feb 10.

PMID:
19209166
46.

Potential role of protease-activated receptor-2-stimulated activation of cytosolic phospholipase A(2) in intestinal myofibroblast proliferation: Implications for stricture formation in Crohn's disease.

Christerson U, Keita AV, Söderholm JD, Gustafson-Svärd C.

J Crohns Colitis. 2009 Feb;3(1):15-24. doi: 10.1016/j.crohns.2008.10.002. Epub 2008 Dec 6.

PMID:
21172243
47.

Mast cells and mastocytosis.

Söderholm JD.

Dig Dis. 2009;27 Suppl 1:129-36. doi: 10.1159/000268133. Epub 2010 Mar 4. Review.

PMID:
20203509
48.

CD83+CCR7- dendritic cells accumulate in the subepithelial dome and internalize translocated Escherichia coli HB101 in the Peyer's patches of ileal Crohn's disease.

Salim SY, Silva MA, Keita AV, Larsson M, Andersson P, Magnusson KE, Perdue MH, Söderholm JD.

Am J Pathol. 2009 Jan;174(1):82-90. doi: 10.2353/ajpath.2009.080273. Epub 2008 Dec 18.

49.

Probiotics enhance pancreatic glutathione biosynthesis and reduce oxidative stress in experimental acute pancreatitis.

Lutgendorff F, Trulsson LM, van Minnen LP, Rijkers GT, Timmerman HM, Franzén LE, Gooszen HG, Akkermans LM, Söderholm JD, Sandström PA.

Am J Physiol Gastrointest Liver Physiol. 2008 Nov;295(5):G1111-21. doi: 10.1152/ajpgi.00603.2007. Epub 2008 Oct 2.

50.

Yersinia pseudotuberculosis induces transcytosis of nanoparticles across human intestinal villus epithelium via invasin-dependent macropinocytosis.

Ragnarsson EG, Schoultz I, Gullberg E, Carlsson AH, Tafazoli F, Lerm M, Magnusson KE, Söderholm JD, Artursson P.

Lab Invest. 2008 Nov;88(11):1215-26. doi: 10.1038/labinvest.2008.86.

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