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Items: 1 to 50 of 240

1.

Exacerbated intestinal inflammation in P2Y6 deficient mice is associated with Th17 activation.

Salem M, El Azreq MA, Pelletier J, Robaye B, Aoudjit F, Sévigny J.

Biochim Biophys Acta Mol Basis Dis. 2019 Jul 2;1865(10):2595-2605. doi: 10.1016/j.bbadis.2019.06.019. [Epub ahead of print]

PMID:
31271845
2.

Highly potent and selective ectonucleoside triphosphate diphosphohydrolases (ENTPDase1, 2, 3 and 8) inhibitors having 2-substituted-7-trifluoromethyl-thiadiazolopyrimidones scaffold.

Afzal S, Zaib S, Jafari B, Langer P, Lecka J, Sévigny J, Iqbal J.

Med Chem. 2019 Jun 13. doi: 10.2174/1573406415666190614095821. [Epub ahead of print]

PMID:
31203806
3.

NTPDase1 and -2 are expressed by distinct cellular compartments in the mouse colon and differentially impact colonic physiology and function after DSS-colitis.

Grubišić V, Perez-Medina AL, Fried DE, Sevigny J, Robson SC, Galligan JJ, Gulbransen BD.

Am J Physiol Gastrointest Liver Physiol. 2019 Jun 12. doi: 10.1152/ajpgi.00104.2019. [Epub ahead of print]

PMID:
31188623
4.

Elucidating the ecological networks in stone-dwelling microbiomes.

Louati M, Ennis NJ, Ghodhbane-Gtari F, Hezbri K, Sevigny JL, Fahnestock MF, Cherif-Silini H, Bryce JG, Tisa LS, Gtari M.

Environ Microbiol. 2019 Jun 3. doi: 10.1111/1462-2920.14700. [Epub ahead of print]

PMID:
31158316
5.

The ectonucleoside triphosphate diphosphohydrolase-2 (NTPDase2) in human endometrium: a novel marker of basal stroma and mesenchymal stem cells.

Trapero C, Vidal A, Rodríguez-Martínez A, Sévigny J, Ponce J, Coroleu B, Matias-Guiu X, Martín-Satué M.

Purinergic Signal. 2019 May 23. doi: 10.1007/s11302-019-09656-3. [Epub ahead of print]

PMID:
31123897
6.

Induction of NTPDase1/CD39 by Reactive Microglia and Macrophages Is Associated With the Functional State During EAE.

Jakovljevic M, Lavrnja I, Bozic I, Milosevic A, Bjelobaba I, Savic D, Sévigny J, Pekovic S, Nedeljkovic N, Laketa D.

Front Neurosci. 2019 Apr 26;13:410. doi: 10.3389/fnins.2019.00410. eCollection 2019.

7.

Synthesis, biological evaluation, and molecular docking study of sulfonate derivatives as nucleotide pyrophosphatase/phosphodiesterase (NPP) inhibitors.

Semreen MH, El-Gamal MI, Ullah S, Jalil S, Zaib S, Anbar HS, Lecka J, Sévigny J, Iqbal J.

Bioorg Med Chem. 2019 Jul 1;27(13):2741-2752. doi: 10.1016/j.bmc.2019.04.031. Epub 2019 Apr 26.

PMID:
31088715
8.

Characterization of soluble CD39 (SolCD39/NTPDase1) from PiggyBac nonviral system as a tool to control the nucleotides level.

Beckenkamp LR, Iser IC, Onzi GR, Fontoura DMSD, Bertoni APS, Sévigny J, Lenz G, Wink MR.

Biochem J. 2019 Jun 11;476(11):1637-1651. doi: 10.1042/BCJ20190040.

PMID:
31085558
9.

A phase 2 clinical trial of a vasopressin V1a receptor antagonist shows improved adaptive behaviors in men with autism spectrum disorder.

Bolognani F, Del Valle Rubido M, Squassante L, Wandel C, Derks M, Murtagh L, Sevigny J, Khwaja O, Umbricht D, Fontoura P.

Sci Transl Med. 2019 May 8;11(491). pii: eaat7838. doi: 10.1126/scitranslmed.aat7838. Epub 2019 May 1.

PMID:
31043521
10.

Identification of adenine-N9-(methoxy)ethyl-β-bisphosphonate as NPP1 inhibitor attenuates NPPase activity in human osteoarthritic chondrocytes.

Nassir M, Arad U, Lee SY, Journo S, Mirza S, Renn C, Zimmermann H, Pelletier J, Sévigny J, Müller CE, Fischer B.

Purinergic Signal. 2019 Apr 25. doi: 10.1007/s11302-019-09649-2. [Epub ahead of print]

PMID:
31025169
11.

Probing the high potency of pyrazolyl pyrimidinetriones and thioxopyrimidinediones as selective and efficient non-nucleotide inhibitors of recombinant human ectonucleotidases.

Andleeb H, Hameed S, Ejaz SA, Khan I, Zaib S, Lecka J, Sévigny J, Iqbal J.

Bioorg Chem. 2019 Jul;88:102893. doi: 10.1016/j.bioorg.2019.03.067. Epub 2019 Apr 2.

PMID:
30986550
12.

Marker genes as predictors of shared genomic function.

Sevigny JL, Rothenheber D, Diaz KS, Zhang Y, Agustsson K, Bergeron RD, Thomas WK.

BMC Genomics. 2019 Apr 4;20(1):268. doi: 10.1186/s12864-019-5641-1.

13.

Investigation of new quinoline derivatives as promising inhibitors of NTPDases: Synthesis, SAR analysis and molecular docking studies.

Hayat K, Afzal S, Saeed A, Murtaza A, Ur Rahman S, Khan KM, Saeed A, Zaib S, Lecka J, Sévigny J, Iqbal J, Hassan A.

Bioorg Chem. 2019 Jun;87:218-226. doi: 10.1016/j.bioorg.2019.03.019. Epub 2019 Mar 12.

PMID:
30903944
14.

Synthesis of novel (E)-1-(2-(2-(4(dimethylamino) benzylidene) hydrazinyl)-4-methylthiazol-5-yl)ethanone derivatives as ecto-5'-nucleotidase inhibitors.

Hassan S, Channar PA, Larik FA, Saeed A, Shah HS, Lecka J, Sévigny J, Iqbal J.

R Soc Open Sci. 2018 Sep 12;5(9):180837. doi: 10.1098/rsos.180837. eCollection 2018 Sep.

15.

Patients with autism spectrum disorders display reproducible functional connectivity alterations.

Holiga Š, Hipp JF, Chatham CH, Garces P, Spooren W, D'Ardhuy XL, Bertolino A, Bouquet C, Buitelaar JK, Bours C, Rausch A, Oldehinkel M, Bouvard M, Amestoy A, Caralp M, Gueguen S, Ly-Le Moal M, Houenou J, Beckmann CF, Loth E, Murphy D, Charman T, Tillmann J, Laidi C, Delorme R, Beggiato A, Gaman A, Scheid I, Leboyer M, d'Albis MA, Sevigny J, Czech C, Bolognani F, Honey GD, Dukart J.

Sci Transl Med. 2019 Feb 27;11(481). pii: eaat9223. doi: 10.1126/scitranslmed.aat9223.

PMID:
30814340
16.

Erratum: Author Correction: Biodiversity estimates and ecological interpretations of meiofaunal communities are biased by the taxonomic approach.

Leasi F, Sevigny JL, Laflamme EM, Artois T, Curini-Galletti M, de Jesus Navarrete A, Di Domenico M, Goetz F, Hall JA, Hochberg R, Jörger KM, Jondelius U, Todaro MA, Wirshing HH, Norenburg JL, Thomas WK.

Commun Biol. 2018 Dec 20;1:237. doi: 10.1038/s42003-018-0249-6. eCollection 2018.

17.

Whole-Genome Sequences of Two Pseudomonas fluorescens Strains Isolated from Roots of Tomato and Cucumber Plants.

Sevigny JL, LaJoie J, Shehata S, Christensen E, Cornfield S, Koziol L.

Microbiol Resour Announc. 2018 Sep 6;7(9). pii: e00974-18. doi: 10.1128/MRA.00974-18. eCollection 2018 Sep.

18.

Physical exercise prevents memory impairment in an animal model of hypertension through modulation of CD39 and CD73 activities and A2A receptor expression.

Cardoso AM, Manfredi LH, Zanini D, Bagatini MD, Gutierres JM, Carvalho F, Tremblay A, Belló-Klein A, Rubin MA, Morsch VM, Sévigny J, Schetinger MRC.

J Hypertens. 2019 Jan;37(1):135-143. doi: 10.1097/HJH.0000000000001845.

PMID:
30507864
19.

Current state of Alzheimer's fluid biomarkers.

Molinuevo JL, Ayton S, Batrla R, Bednar MM, Bittner T, Cummings J, Fagan AM, Hampel H, Mielke MM, Mikulskis A, O'Bryant S, Scheltens P, Sevigny J, Shaw LM, Soares HD, Tong G, Trojanowski JQ, Zetterberg H, Blennow K.

Acta Neuropathol. 2018 Dec;136(6):821-853. doi: 10.1007/s00401-018-1932-x. Epub 2018 Nov 28. Review.

20.

Ectonucleoside Triphosphate Diphosphohydrolase-3 Antibody Targets Adult Human Pancreatic β Cells for In Vitro and In Vivo Analysis.

Saunders DC, Brissova M, Phillips N, Shrestha S, Walker JT, Aramandla R, Poffenberger G, Flaherty DK, Weller KP, Pelletier J, Cooper T, Goff MT, Virostko J, Shostak A, Dean ED, Greiner DL, Shultz LD, Prasad N, Levy SE, Carnahan RH, Dai C, Sévigny J, Powers AC.

Cell Metab. 2019 Mar 5;29(3):745-754.e4. doi: 10.1016/j.cmet.2018.10.007. Epub 2018 Nov 15.

PMID:
30449685
21.

Schiff bases of tryptamine as potent inhibitors of nucleoside triphosphate diphosphohydrolases (NTPDases): Structure-activity relationship.

Kanwal, Mohammed Khan K, Salar U, Afzal S, Wadood A, Taha M, Perveen S, Khan H, Lecka J, Sévigny J, Iqbal J.

Bioorg Chem. 2019 Feb;82:253-266. doi: 10.1016/j.bioorg.2018.10.046. Epub 2018 Oct 30.

PMID:
30391856
22.

Development of a selective and highly sensitive fluorescence assay for nucleoside triphosphate diphosphohydrolase1 (NTPDase1, CD39).

Lee SY, Luo X, Namasivayam V, Geiss J, Mirza S, Pelletier J, Stephan H, Sévigny J, Müller CE.

Analyst. 2018 Nov 5;143(22):5417-5430. doi: 10.1039/c8an01108g.

PMID:
30303204
23.

Hybrid compounds from chalcone and 1,2-benzothiazine pharmacophores as selective inhibitors of alkaline phosphatase isozymes.

Ashraf A, Ejaz SA, Rahman SU, Siddiqui WA, Arshad MN, Lecka J, Sévigny J, Zayed MEM, Asiri AM, Iqbal J, Hartinger CG, Hanif M.

Eur J Med Chem. 2018 Nov 5;159:282-291. doi: 10.1016/j.ejmech.2018.09.063. Epub 2018 Sep 26.

PMID:
30296687
24.

Biodiversity estimates and ecological interpretations of meiofaunal communities are biased by the taxonomic approach.

Leasi F, Sevigny JL, Laflamme EM, Artois T, Curini-Galletti M, de Jesus Navarrete A, Di Domenico M, Goetz F, Hall JA, Hochberg R, Jörger KM, Jondelius U, Todaro MA, Wirshing HH, Norenburg JL, Thomas WK.

Commun Biol. 2018 Aug 14;1:112. doi: 10.1038/s42003-018-0119-2. eCollection 2018. Erratum in: Commun Biol. 2018 Dec 20;1:237.

25.

Physical exercise prevents alterations in purinergic system and oxidative status in lipopolysaccharide-induced sepsis in rats.

Miron VV, Bottari NB, Assmann CE, Stefanello N, da Costa P, Pelinson LP, Reichert KP, da Silva AD, Lopes TF, da Cruz IBM, Sévigny J, Morsch VM, Schetinger MRC, Cardoso AM.

J Cell Biochem. 2019 Mar;120(3):3232-3242. doi: 10.1002/jcb.27590. Epub 2018 Sep 19.

PMID:
30230598
26.

Ectonucleotidase Inhibitory and Redox Activity of Imidazole-Based Organic Salts and Ionic Liquids.

Boldescu V, Sucman N, Hassan S, Iqbal J, Neamtu M, Lecka J, Sévigny J, Prodius D, Macaev F.

ChemMedChem. 2018 Nov 6;13(21):2297-2304. doi: 10.1002/cmdc.201800520. Epub 2018 Oct 23.

PMID:
30192439
27.

CD73 Downregulation Decreases In Vitro and In Vivo Glioblastoma Growth.

Azambuja JH, Gelsleichter NE, Beckenkamp LR, Iser IC, Fernandes MC, Figueiró F, Battastini AMO, Scholl JN, de Oliveira FH, Spanevello RM, Sévigny J, Wink MR, Stefani MA, Teixeira HF, Braganhol E.

Mol Neurobiol. 2019 May;56(5):3260-3279. doi: 10.1007/s12035-018-1240-4. Epub 2018 Aug 16.

PMID:
30117104
28.

Exploration of carboxy pyrazole derivatives: Synthesis, alkaline phosphatase, nucleotide pyrophosphatase/phosphodiesterase and nucleoside triphosphate diphosphohydrolase inhibition studies with potential anticancer profile.

Channar PA, Afzal S, Ejaz SA, Saeed A, Larik FA, Mahesar PA, Lecka J, Sévigny J, Erben MF, Iqbal J.

Eur J Med Chem. 2018 Aug 5;156:461-478. doi: 10.1016/j.ejmech.2018.07.002. Epub 2018 Jul 7.

PMID:
30015078
29.

Characterization of 3 Novel Tau Radiopharmaceuticals, 11C-RO-963, 11C-RO-643, and 18F-RO-948, in Healthy Controls and in Alzheimer Subjects.

Wong DF, Comley RA, Kuwabara H, Rosenberg PB, Resnick SM, Ostrowitzki S, Vozzi C, Boess F, Oh E, Lyketsos CG, Honer M, Gobbi L, Klein G, George N, Gapasin L, Kitzmiller K, Roberts J, Sevigny J, Nandi A, Brasic J, Mishra C, Thambisetty M, Mogekar A, Mathur A, Albert M, Dannals RF, Borroni E.

J Nucl Med. 2018 Dec;59(12):1869-1876. doi: 10.2967/jnumed.118.209916. Epub 2018 May 4. Erratum in: J Nucl Med. 2019 Jan;60(1):141.

30.

Highly Selective and Potent Ectonucleotide Pyrophosphatase-1 (NPP1) Inhibitors Based on Uridine 5'-Pα,α-Dithiophosphate Analogues.

Zelikman V, Pelletier J, Simhaev L, Sela A, Gendron FP, Arguin G, Senderowitz H, Sévigny J, Fischer B.

J Med Chem. 2018 May 10;61(9):3939-3951. doi: 10.1021/acs.jmedchem.7b01906. Epub 2018 May 2.

PMID:
29681152
31.

P2Y6 Receptors Regulate CXCL10 Expression and Secretion in Mouse Intestinal Epithelial Cells.

Salem M, Tremblay A, Pelletier J, Robaye B, Sévigny J.

Front Pharmacol. 2018 Feb 28;9:149. doi: 10.3389/fphar.2018.00149. eCollection 2018.

32.

Tricyclic coumarin sulphonate derivatives with alkaline phosphatase inhibitory effects: in vitro and docking studies.

Iqbal J, El-Gamal MI, Ejaz SA, Lecka J, Sévigny J, Oh CH.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):479-484. doi: 10.1080/14756366.2018.1428193.

33.

Distinctive inhibition of alkaline phosphatase isozymes by thiazol-2-ylidene-benzamide derivatives: Functional insights into their anticancer role.

Ejaz SA, Saeed A, Shah SJA, Hameed A, Lecka J, Sévigny J, Iqbal J.

J Cell Biochem. 2018 Aug;119(8):6501-6513. doi: 10.1002/jcb.26692. Epub 2018 Apr 18.

PMID:
29363794
34.

Ecto-5'-nucleotidase/CD73 contributes to the radiosensitivity of T24 human bladder cancer cell line.

Dietrich F, Figueiró F, Filippi-Chiela EC, Cappellari AR, Rockenbach L, Tremblay A, de Paula PB, Roesler R, Filho AB, Sévigny J, Morrone FB, Battastini AMO.

J Cancer Res Clin Oncol. 2018 Mar;144(3):469-482. doi: 10.1007/s00432-017-2567-3. Epub 2018 Jan 5.

PMID:
29305710
35.

A domino reaction of 3-chlorochromones with aminoheterocycles. Synthesis of pyrazolopyridines and benzofuropyridines and their optical and ecto-5'-nucleotidase inhibitory effects.

Miliutina M, Janke J, Hassan S, Zaib S, Iqbal J, Lecka J, Sévigny J, Villinger A, Friedrich A, Lochbrunner S, Langer P.

Org Biomol Chem. 2018 Jan 31;16(5):717-732. doi: 10.1039/c7ob02729j.

PMID:
29303198
36.

Characterization of ecto-nucleotidases in human oviducts with an improved approach simultaneously identifying protein expression and in situ enzyme activity.

Villamonte ML, Torrejón-Escribano B, Rodríguez-Martínez A, Trapero C, Vidal A, Gómez de Aranda I, Sévigny J, Matías-Guiu X, Martín-Satué M.

Histochem Cell Biol. 2018 Mar;149(3):269-276. doi: 10.1007/s00418-017-1627-8. Epub 2017 Dec 22.

PMID:
29273916
37.

2-Substituted 7-trifluoromethyl-thiadiazolopyrimidones as alkaline phosphatase inhibitors. Synthesis, structure activity relationship and molecular docking study.

Jafari B, Ospanov M, Ejaz SA, Yelibayeva N, Khan SU, Amjad ST, Safarov S, Abilov ZA, Turmukhanova MZ, Kalugin SN, Ehlers P, Lecka J, Sévigny J, Iqbal J, Langer P.

Eur J Med Chem. 2018 Jan 20;144:116-127. doi: 10.1016/j.ejmech.2017.11.068. Epub 2017 Dec 6.

PMID:
29268128
38.

Loss of vascular expression of nucleoside triphosphate diphosphohydrolase-1/CD39 in hypertension.

Roy C, Tabiasco J, Caillon A, Delneste Y, Merot J, Favre J, Guihot AL, Martin L, Nascimento DC, Ryffel B, Robson SC, Sévigny J, Henrion D, Kauffenstein G.

Purinergic Signal. 2018 Mar;14(1):73-82. doi: 10.1007/s11302-017-9597-9. Epub 2017 Dec 13.

39.

4-Aminopyridine based amide derivatives as dual inhibitors of tissue non-specific alkaline phosphatase and ecto-5'-nucleotidase with potential anticancer activity.

Hassan S, Ejaz SA, Saeed A, Shehzad M, Ullah Khan S, Lecka J, Sévigny J, Shabir G, Iqbal J.

Bioorg Chem. 2018 Feb;76:237-248. doi: 10.1016/j.bioorg.2017.11.013. Epub 2017 Nov 21.

PMID:
29197225
40.

Down-regulation of NTPDase2 and ADP-sensitive P2 Purinoceptors Correlate with Severity of Symptoms during Experimental Autoimmune Encephalomyelitis.

Jakovljevic M, Lavrnja I, Bozic I, Savic D, Bjelobaba I, Pekovic S, Sévigny J, Nedeljkovic N, Laketa D.

Front Cell Neurosci. 2017 Oct 30;11:333. doi: 10.3389/fncel.2017.00333. eCollection 2017.

41.

Motor, cognitive, and functional declines contribute to a single progressive factor in early HD.

Schobel SA, Palermo G, Auinger P, Long JD, Ma S, Khwaja OS, Trundell D, Cudkowicz M, Hersch S, Sampaio C, Dorsey ER, Leavitt BR, Kieburtz KD, Sevigny JJ, Langbehn DR, Tabrizi SJ; TRACK-HD, COHORT, CARE-HD, and 2CARE Huntington Study Group Investigators.

Neurology. 2017 Dec 12;89(24):2495-2502. doi: 10.1212/WNL.0000000000004743. Epub 2017 Nov 15.

42.

Distinct roles of ecto-nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) in liver regeneration and fibrosis.

Feldbrügge L, Jiang ZG, Csizmadia E, Mitsuhashi S, Tran S, Yee EU, Rothweiler S, Vaid KA, Sévigny J, Schmelzle M, Popov YV, Robson SC.

Purinergic Signal. 2018 Mar;14(1):37-46. doi: 10.1007/s11302-017-9590-3. Epub 2017 Nov 13.

43.

Adaptive behavior in autism: Minimal clinically important differences on the Vineland-II.

Chatham CH, Taylor KI, Charman T, Liogier D'ardhuy X, Eule E, Fedele A, Hardan AY, Loth E, Murtagh L, Del Valle Rubido M, San Jose Caceres A, Sevigny J, Sikich L, Snyder L, Tillmann JE, Ventola PE, Walton-Bowen KL, Wang PP, Willgoss T, Bolognani F.

Autism Res. 2018 Feb;11(2):270-283. doi: 10.1002/aur.1874. Epub 2017 Sep 21.

44.

Chemoselective synthesis and biological evaluation of arylated 2-(Trifluoromethyl) quinolines as nucleotide pyrophosphatase (NPPs) inhibitors.

Kuhrt D, Ejaz SA, Afzal S, Khan SU, Lecka J, Sévigny J, Ehlers P, Spannenberg A, Iqbal J, Langer P.

Eur J Med Chem. 2017 Sep 29;138:816-829. doi: 10.1016/j.ejmech.2017.07.017. Epub 2017 Jul 13.

PMID:
28735213
45.

Addendum: The antibody aducanumab reduces Aβ plaques in Alzheimer's disease.

Sevigny J, Chiao P, Bussière T, Weinreb PH, Williams L, Maier M, Dunstan R, Salloway S, Chen T, Ling Y, O'Gorman J, Qian F, Arastu M, Li M, Chollate S, Brennan MS, Quintero-Monzon O, Scannevin RH, Arnold HM, Engber T, Rhodes K, Ferrero J, Hang Y, Mikulskis A, Grimm J, Hock C, Nitsch RM, Sandrock A.

Nature. 2017 Jun 21;546(7659):564. doi: 10.1038/nature22809.

PMID:
28640269
46.

Expression of Ecto-nucleoside Triphosphate Diphosphohydrolases-2 and -3 in the Enteric Nervous System Affects Inflammation in Experimental Colitis and Crohn's Disease.

Feldbrügge L, Moss AC, Yee EU, Csizmadia E, Mitsuhashi S, Longhi MS, Sandhu B, Stephan H, Wu Y, Cheifetz AS, Müller CE, Sévigny J, Robson SC, Jiang ZG.

J Crohns Colitis. 2017 Sep 1;11(9):1113-1123. doi: 10.1093/ecco-jcc/jjx058.

47.

Generation and characterization of polyclonal and monoclonal antibodies to human NTPDase2 including a blocking antibody.

Pelletier J, Agonsanou H, Delvalle N, Fausther M, Salem M, Gulbransen B, Sévigny J.

Purinergic Signal. 2017 Sep;13(3):293-304. doi: 10.1007/s11302-017-9561-8. Epub 2017 Apr 13.

48.

Generation and Characterization of Specific Antibodies to the Murine and Human Ectonucleotidase NTPDase8.

Pelletier J, Salem M, Lecka J, Fausther M, Bigonnesse F, Sévigny J.

Front Pharmacol. 2017 Mar 8;8:115. doi: 10.3389/fphar.2017.00115. eCollection 2017.

49.

Synthesis, characterization and biological evaluation of novel chalcone sulfonamide hybrids as potent intestinal alkaline phosphatase inhibitors.

Ejaz SA, Saeed A, Siddique MN, Nisa ZU, Khan S, Lecka J, Sévigny J, Iqbal J.

Bioorg Chem. 2017 Feb;70:229-236. doi: 10.1016/j.bioorg.2017.01.003. Epub 2017 Jan 5.

PMID:
28110961
50.

Erratum to: 17β-Estradiol-Induced Synaptic Rearrangements Are Accompanied by Altered Ectonucleotidase Activities in Male Rat Hippocampal Synaptosomes.

Mitrović N, Zarić M, Drakulić D, Martinović J, Sévigny J, Stanojlović M, Nedeljković N, Grković I.

J Mol Neurosci. 2017 Mar;61(3):423-424. doi: 10.1007/s12031-016-0879-4. No abstract available.

PMID:
28035555

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