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Items: 31

1.

Genome-Wide Interaction Analysis of Air Pollution Exposure and Childhood Asthma with Functional Follow-up.

Gref A, Merid SK, Gruzieva O, Ballereau S, Becker A, Bellander T, Bergström A, Bossé Y, Bottai M, Chan-Yeung M, Fuertes E, Ierodiakonou D, Jiang R, Joly S, Jones M, Kobor MS, Korek M, Kozyrskyj AL, Kumar A, Lemonnier N, MacIntyre E, Ménard C, Nickle D, Obeidat M, Pellet J, Standl M, Sääf A, Söderhäll C, Tiesler CMT, van den Berge M, Vonk JM, Vora H, Xu CJ, Antó JM, Auffray C, Brauer M, Bousquet J, Brunekreef B, Gauderman WJ, Heinrich J, Kere J, Koppelman GH, Postma D, Carlsten C, Pershagen G, Melén E.

Am J Respir Crit Care Med. 2017 May 15;195(10):1373-1383. doi: 10.1164/rccm.201605-1026OC.

2.

Meta-analysis identifies seven susceptibility loci involved in the atopic march.

Marenholz I, Esparza-Gordillo J, Rüschendorf F, Bauerfeind A, Strachan DP, Spycher BD, Baurecht H, Margaritte-Jeannin P, Sääf A, Kerkhof M, Ege M, Baltic S, Matheson MC, Li J, Michel S, Ang WQ, McArdle W, Arnold A, Homuth G, Demenais F, Bouzigon E, Söderhäll C, Pershagen G, de Jongste JC, Postma DS, Braun-Fahrländer C, Horak E, Ogorodova LM, Puzyrev VP, Bragina EY, Hudson TJ, Morin C, Duffy DL, Marks GB, Robertson CF, Montgomery GW, Musk B, Thompson PJ, Martin NG, James A, Sleiman P, Toskala E, Rodriguez E, Fölster-Holst R, Franke A, Lieb W, Gieger C, Heinzmann A, Rietschel E, Keil T, Cichon S, Nöthen MM, Pennell CE, Sly PD, Schmidt CO, Matanovic A, Schneider V, Heinig M, Hübner N, Holt PG, Lau S, Kabesch M, Weidinger S, Hakonarson H, Ferreira MAR, Laprise C, Freidin MB, Genuneit J, Koppelman GH, Melén E, Dizier MH, Henderson AJ, Lee YA.

Nat Commun. 2015 Nov 6;6:8804. doi: 10.1038/ncomms9804.

3.

A High Through-put Platform for Recombinant Antibodies to Folded Proteins.

Hornsby M, Paduch M, Miersch S, Sääf A, Matsuguchi T, Lee B, Wypisniak K, Doak A, King D, Usatyuk S, Perry K, Lu V, Thomas W, Luke J, Goodman J, Hoey RJ, Lai D, Griffin C, Li Z, Vizeacoumar FJ, Dong D, Campbell E, Anderson S, Zhong N, Gräslund S, Koide S, Moffat J, Sidhu S, Kossiakoff A, Wells J.

Mol Cell Proteomics. 2015 Oct;14(10):2833-47. doi: 10.1074/mcp.O115.052209. Epub 2015 Aug 19.

4.

BMP2 response pattern in human lung fibroblasts predicts outcome in lung adenocarcinomas.

Rajski M, Saaf A, Buess M.

BMC Med Genomics. 2015 Apr 29;8:16. doi: 10.1186/s12920-015-0090-4.

5.

Scalable high throughput selection from phage-displayed synthetic antibody libraries.

Miersch S, Li Z, Hanna R, McLaughlin ME, Hornsby M, Matsuguchi T, Paduch M, Sääf A, Wells J, Koide S, Kossiakoff A, Sidhu SS.

J Vis Exp. 2015 Jan 17;(95):51492. doi: 10.3791/51492.

6.

A novel common variant in DCST2 is associated with length in early life and height in adulthood.

van der Valk RJ, Kreiner-Møller E, Kooijman MN, Guxens M, Stergiakouli E, Sääf A, Bradfield JP, Geller F, Hayes MG, Cousminer DL, Körner A, Thiering E, Curtin JA, Myhre R, Huikari V, Joro R, Kerkhof M, Warrington NM, Pitkänen N, Ntalla I, Horikoshi M, Veijola R, Freathy RM, Teo YY, Barton SJ, Evans DM, Kemp JP, St Pourcain B, Ring SM, Davey Smith G, Bergström A, Kull I, Hakonarson H, Mentch FD, Bisgaard H, Chawes B, Stokholm J, Waage J, Eriksen P, Sevelsted A, Melbye M; Early Genetics and Lifecourse Epidemiology (EAGLE) Consortium, van Duijn CM, Medina-Gomez C, Hofman A, de Jongste JC, Taal HR, Uitterlinden AG; Genetic Investigation of ANthropometric Traits (GIANT) Consortium, Armstrong LL, Eriksson J, Palotie A, Bustamante M, Estivill X, Gonzalez JR, Llop S, Kiess W, Mahajan A, Flexeder C, Tiesler CM, Murray CS, Simpson A, Magnus P, Sengpiel V, Hartikainen AL, Keinanen-Kiukaanniemi S, Lewin A, Da Silva Couto Alves A, Blakemore AI, Buxton JL, Kaakinen M, Rodriguez A, Sebert S, Vaarasmaki M, Lakka T, Lindi V, Gehring U, Postma DS, Ang W, Newnham JP, Lyytikäinen LP, Pahkala K, Raitakari OT, Panoutsopoulou K, Zeggini E, Boomsma DI, Groen-Blokhuis M, Ilonen J, Franke L, Hirschhorn JN, Pers TH, Liang L, Huang J, Hocher B, Knip M, Saw SM, Holloway JW, Melén E, Grant SF, Feenstra B, Lowe WL, Widén E, Sergeyev E, Grallert H, Custovic A, Jacobsson B, Jarvelin MR, Atalay M, Koppelman GH, Pennell CE, Niinikoski H, Dedoussis GV, Mccarthy MI, Frayling TM, Sunyer J, Timpson NJ, Rivadeneira F, Bønnelykke K, Jaddoe VW; Early Growth Genetics (EGG) Consortium.

Hum Mol Genet. 2015 Feb 15;24(4):1155-68. doi: 10.1093/hmg/ddu510. Epub 2014 Oct 3.

7.

IgA measurements in over 12 000 Swedish twins reveal sex differential heritability and regulatory locus near CD30L.

Viktorin A, Frankowiack M, Padyukov L, Chang Z, Melén E, Sääf A, Kull I, Klareskog L, Hammarström L, Magnusson PK.

Hum Mol Genet. 2014 Aug 1;23(15):4177-84. doi: 10.1093/hmg/ddu135. Epub 2014 Mar 27.

8.

Rule-based models of the interplay between genetic and environmental factors in childhood allergy.

Bornelöv S, Sääf A, Melén E, Bergström A, Torabi Moghadam B, Pulkkinen V, Acevedo N, Orsmark Pietras C, Ege M, Braun-Fahrländer C, Riedler J, Doekes G, Kabesch M, van Hage M, Kere J, Scheynius A, Söderhäll C, Pershagen G, Komorowski J.

PLoS One. 2013 Nov 19;8(11):e80080. doi: 10.1371/journal.pone.0080080. eCollection 2013.

9.

Interaction between retinoid acid receptor-related orphan receptor alpha (RORA) and neuropeptide S receptor 1 (NPSR1) in asthma.

Acevedo N, Sääf A, Söderhäll C, Melén E, Mandelin J, Pietras CO, Ezer S, Karisola P, Vendelin J, Gennäs GB, Yli-Kauhaluoma J, Alenius H, von Mutius E, Doekes G, Braun-Fahrländer C, Riedler J, van Hage M, D'Amato M, Scheynius A, Pershagen G, Kere J, Pulkkinen V.

PLoS One. 2013;8(4):e60111. doi: 10.1371/journal.pone.0060111. Epub 2013 Apr 2.

10.

DNA methylation in the Neuropeptide S Receptor 1 (NPSR1) promoter in relation to asthma and environmental factors.

Reinius LE, Gref A, Sääf A, Acevedo N, Joerink M, Kupczyk M, D'Amato M, Bergström A, Melén E, Scheynius A, Dahlén SE; BIOAIR Study Group, Pershagen G, Söderhäll C, Kere J.

PLoS One. 2013;8(1):e53877. doi: 10.1371/journal.pone.0053877. Epub 2013 Jan 23.

11.

Genetic variation in the epidermal transglutaminase genes is not associated with atopic dermatitis.

Liedén A, Winge MC, Sääf A, Kockum I, Ekelund E, Rodriguez E, Fölster-Holst R, Franke A, Illig T, Tengvall-Linder M, Baurecht H, Weidinger S, Wahlgren CF, Nordenskjöld M, Bradley M.

PLoS One. 2012;7(11):e49694. doi: 10.1371/journal.pone.0049694. Epub 2012 Nov 26.

12.

Are BIC (miR-155) polymorphisms associated with eczema susceptibility?

Sääf A, Kockum I, Wahlgren CF, Xu N, Sonkoly E, Ståhle M, Nordenskjöld M, Bradley M, Pivarcsi A.

Acta Derm Venereol. 2013 May;93(3):366-7. doi: 10.2340/00015555-1466. No abstract available.

13.

Characterization of EGFR and ErbB2 expression in atopic dermatitis patients.

Sääf A, Pivarcsi A, Winge MC, Wahlgren CF, Homey B, Nordenskjöld M, Tengvall-Linder M, Bradley M.

Arch Dermatol Res. 2012 Dec;304(10):773-80. doi: 10.1007/s00403-012-1242-4. Epub 2012 May 3.

PMID:
22552355
14.

Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis.

Paternoster L, Standl M, Chen CM, Ramasamy A, Bønnelykke K, Duijts L, Ferreira MA, Alves AC, Thyssen JP, Albrecht E, Baurecht H, Feenstra B, Sleiman PM, Hysi P, Warrington NM, Curjuric I, Myhre R, Curtin JA, Groen-Blokhuis MM, Kerkhof M, Sääf A, Franke A, Ellinghaus D, Fölster-Holst R, Dermitzakis E, Montgomery SB, Prokisch H, Heim K, Hartikainen AL, Pouta A, Pekkanen J, Blakemore AI, Buxton JL, Kaakinen M, Duffy DL, Madden PA, Heath AC, Montgomery GW, Thompson PJ, Matheson MC, Le Souëf P; Australian Asthma Genetics Consortium (AAGC), St Pourcain B, Smith GD, Henderson J, Kemp JP, Timpson NJ, Deloukas P, Ring SM, Wichmann HE, Müller-Nurasyid M, Novak N, Klopp N, Rodríguez E, McArdle W, Linneberg A, Menné T, Nohr EA, Hofman A, Uitterlinden AG, van Duijn CM, Rivadeneira F, de Jongste JC, van der Valk RJ, Wjst M, Jogi R, Geller F, Boyd HA, Murray JC, Kim C, Mentch F, March M, Mangino M, Spector TD, Bataille V, Pennell CE, Holt PG, Sly P, Tiesler CM, Thiering E, Illig T, Imboden M, Nystad W, Simpson A, Hottenga JJ, Postma D, Koppelman GH, Smit HA, Söderhäll C, Chawes B, Kreiner-Møller E, Bisgaard H, Melén E, Boomsma DI, Custovic A, Jacobsson B, Probst-Hensch NM, Palmer LJ, Glass D, Hakonarson H, Melbye M, Jarvis DL, Jaddoe VW, Gieger C; Genetics of Overweight Young Adults (GOYA) Consortium, Strachan DP, Martin NG, Jarvelin MR, Heinrich J, Evans DM, Weidinger S; EArly Genetics & Lifecourse Epidemiology (EAGLE) Consortium.

Nat Genet. 2011 Dec 25;44(2):187-92. doi: 10.1038/ng.1017.

15.

Birt-Hogg-Dubé renal tumors are genetically distinct from other renal neoplasias and are associated with up-regulation of mitochondrial gene expression.

Klomp JA, Petillo D, Niemi NM, Dykema KJ, Chen J, Yang XJ, Sääf A, Zickert P, Aly M, Bergerheim U, Nordenskjöld M, Gad S, Giraud S, Denoux Y, Yonneau L, Méjean A, Vasiliu V, Richard S, MacKeigan JP, Teh BT, Furge KA.

BMC Med Genomics. 2010 Dec 16;3:59. doi: 10.1186/1755-8794-3-59.

16.

Characterisation of hairy cell leukaemia by tiling resolution array-based comparative genome hybridisation: a series of 13 cases and review of the literature.

Nordgren A, Corcoran M, Sääf A, Bremer A, Kluin-Nelemans HC, Schoumans J, Grandér D.

Eur J Haematol. 2010 Jan 1;84(1):17-25. doi: 10.1111/j.1600-0609.2009.01334.x. Review.

PMID:
19682064
17.

Global expression profiling in atopic eczema reveals reciprocal expression of inflammatory and lipid genes.

Sääf AM, Tengvall-Linder M, Chang HY, Adler AS, Wahlgren CF, Scheynius A, Nordenskjöld M, Bradley M.

PLoS One. 2008;3(12):e4017. doi: 10.1371/journal.pone.0004017. Epub 2008 Dec 24.

18.
19.

Parallels between global transcriptional programs of polarizing Caco-2 intestinal epithelial cells in vitro and gene expression programs in normal colon and colon cancer.

Sääf AM, Halbleib JM, Chen X, Yuen ST, Leung SY, Nelson WJ, Brown PO.

Mol Biol Cell. 2007 Nov;18(11):4245-60. Epub 2007 Aug 15.

20.

MicroRNAs: novel regulators involved in the pathogenesis of psoriasis?

Sonkoly E, Wei T, Janson PC, Sääf A, Lundeberg L, Tengvall-Linder M, Norstedt G, Alenius H, Homey B, Scheynius A, Ståhle M, Pivarcsi A.

PLoS One. 2007 Jul 11;2(7):e610.

21.

Elevated expression and genetic association links the SOCS3 gene to atopic dermatitis.

Ekelund E, Saaf A, Tengvall-Linder M, Melen E, Link J, Barker J, Reynolds NJ, Meggitt SJ, Kere J, Wahlgren CF, Pershagen G, Wickman M, Nordenskjold M, Kockum I, Bradley M.

Am J Hum Genet. 2006 Jun;78(6):1060-5. Epub 2006 Apr 14.

22.

Sec-dependent membrane protein insertion: sequential interaction of nascent FtsQ with SecY and YidC.

Urbanus ML, Scotti PA, Froderberg L, Saaf A, de Gier JW, Brunner J, Samuelson JC, Dalbey RE, Oudega B, Luirink J.

EMBO Rep. 2001 Jun;2(6):524-9.

23.

The internal repeats in the Na+/Ca2+ exchanger-related Escherichia coli protein YrbG have opposite membrane topologies.

Sääf A, Baars L, von Heijne G.

J Biol Chem. 2001 Jun 1;276(22):18905-7. Epub 2001 Mar 19.

24.
25.

Divergent evolution of membrane protein topology: the Escherichia coli RnfA and RnfE homologues.

Sääf A, Johansson M, Wallin E, von Heijne G.

Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8540-4.

26.

Differential use of the signal recognition particle translocase targeting pathway for inner membrane protein assembly in Escherichia coli.

de Gier JW, Scotti PA, Sääf A, Valent QA, Kuhn A, Luirink J, von Heijne G.

Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14646-51.

27.

Proline-induced disruption of a transmembrane alpha-helix in its natural environment.

Nilsson I, Sääf A, Whitley P, Gafvelin G, Waller C, von Heijne G.

J Mol Biol. 1998 Dec 11;284(4):1165-75.

PMID:
9837734
28.

Membrane topology of the 60-kDa Oxa1p homologue from Escherichia coli.

Sääf A, Monné M, de Gier JW, von Heijne G.

J Biol Chem. 1998 Nov 13;273(46):30415-8.

29.
30.

Membrane protein anchors and polytopic determinants.

Whitley P, Sääf A, Gafvelin G, Johansson M, Wallin E, von Heijne G.

Biochem Soc Trans. 1995 Nov;23(4):965-7. No abstract available.

PMID:
8654875
31.

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