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Items: 26


ZEB1-induced tumourigenesis requires senescence inhibition via activation of DKK1/mutant p53/Mdm2/CtBP and repression of macroH2A1.

de Barrios O, Győrffy B, Fernández-Aceñero MJ, Sánchez-Tilló E, Sánchez-Moral L, Siles L, Esteve-Arenys A, Roué G, Casal JI, Darling DS, Castells A, Postigo A.

Gut. 2017 Apr;66(4):666-682. doi: 10.1136/gutjnl-2015-310838. Epub 2016 Dec 13.


ZEB1 and TCF4 reciprocally modulate their transcriptional activities to regulate Wnt target gene expression.

Sánchez-Tilló E, de Barrios O, Valls E, Darling DS, Castells A, Postigo A.

Oncogene. 2015 Nov 12;34(46):5760-70. doi: 10.1038/onc.2015.352. Epub 2015 Sep 21.


The ZEB1 transcription factor acts in a negative feedback loop with miR200 downstream of Ras and Rb1 to regulate Bmi1 expression.

Liu Y, Sánchez-Tilló E, Lu X, Huang L, Clem B, Telang S, Jenson AB, Cuatrecasas M, Chesney J, Postigo A, Dean DC.

J Biol Chem. 2014 Feb 14;289(7):4116-25. doi: 10.1074/jbc.M113.533505. Epub 2013 Dec 26.


Rb1 family mutation is sufficient for sarcoma initiation.

Liu Y, Sánchez-Tilló E, Lu X, Clem B, Telang S, Jenson AB, Cuatrecasas M, Chesney J, Postigo A, Dean DC.

Nat Commun. 2013;4:2650. doi: 10.1038/ncomms3650.


The EMT activator ZEB1 promotes tumor growth and determines differential response to chemotherapy in mantle cell lymphoma.

Sánchez-Tilló E, Fanlo L, Siles L, Montes-Moreno S, Moros A, Chiva-Blanch G, Estruch R, Martinez A, Colomer D, Győrffy B, Roué G, Postigo A.

Cell Death Differ. 2014 Feb;21(2):247-57. doi: 10.1038/cdd.2013.123. Epub 2013 Sep 6.


Sequential inductions of the ZEB1 transcription factor caused by mutation of Rb and then Ras proteins are required for tumor initiation and progression.

Liu Y, Sánchez-Tilló E, Lu X, Huang L, Clem B, Telang S, Jenson AB, Cuatrecasas M, Chesney J, Postigo A, Dean DC.

J Biol Chem. 2013 Apr 19;288(16):11572-80. doi: 10.1074/jbc.M112.434951. Epub 2013 Feb 26.


ZEB1 Promotes invasiveness of colorectal carcinoma cells through the opposing regulation of uPA and PAI-1.

Sánchez-Tilló E, de Barrios O, Siles L, Amendola PG, Darling DS, Cuatrecasas M, Castells A, Postigo A.

Clin Cancer Res. 2013 Mar 1;19(5):1071-82. doi: 10.1158/1078-0432.CCR-12-2675. Epub 2013 Jan 22.


ZEB1 imposes a temporary stage-dependent inhibition of muscle gene expression and differentiation via CtBP-mediated transcriptional repression.

Siles L, Sánchez-Tilló E, Lim JW, Darling DS, Kroll KL, Postigo A.

Mol Cell Biol. 2013 Apr;33(7):1368-82. doi: 10.1128/MCB.01259-12. Epub 2013 Jan 22.


EMT-activating transcription factors in cancer: beyond EMT and tumor invasiveness.

Sánchez-Tilló E, Liu Y, de Barrios O, Siles L, Fanlo L, Cuatrecasas M, Darling DS, Dean DC, Castells A, Postigo A.

Cell Mol Life Sci. 2012 Oct;69(20):3429-56. doi: 10.1007/s00018-012-1122-2. Epub 2012 Sep 4. Review.


β-catenin/TCF4 complex induces the epithelial-to-mesenchymal transition (EMT)-activator ZEB1 to regulate tumor invasiveness.

Sánchez-Tilló E, de Barrios O, Siles L, Cuatrecasas M, Castells A, Postigo A.

Proc Natl Acad Sci U S A. 2011 Nov 29;108(48):19204-9. doi: 10.1073/pnas.1108977108. Epub 2011 Nov 11.


Expanding roles of ZEB factors in tumorigenesis and tumor progression.

Sánchez-Tilló E, Siles L, de Barrios O, Cuatrecasas M, Vaquero EC, Castells A, Postigo A.

Am J Cancer Res. 2011;1(7):897-912. Epub 2011 Aug 20.


Accelerated DNA replication in E2F1- and E2F2-deficient macrophages leads to induction of the DNA damage response and p21(CIP1)-dependent senescence.

Iglesias-Ara A, Zenarruzabeitia O, Fernandez-Rueda J, Sánchez-Tilló E, Field SJ, Celada A, Zubiaga AM.

Oncogene. 2010 Oct 14;29(41):5579-90. doi: 10.1038/onc.2010.296. Epub 2010 Aug 2.


ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/SNF chromatin-remodeling protein BRG1.

Sánchez-Tilló E, Lázaro A, Torrent R, Cuatrecasas M, Vaquero EC, Castells A, Engel P, Postigo A.

Oncogene. 2010 Jun 17;29(24):3490-500. doi: 10.1038/onc.2010.102. Epub 2010 Apr 26.


ZEB1 and CtBP form a repressive complex at a distal promoter element of the BCL6 locus.

Papadopoulou V, Postigo A, Sánchez-Tilló E, Porter AC, Wagner SD.

Biochem J. 2010 Apr 14;427(3):541-50. doi: 10.1042/BJ20091578.


CREB and AP-1 activation regulates MKP-1 induction by LPS or M-CSF and their kinetics correlate with macrophage activation versus proliferation.

Casals-Casas C, Alvarez E, Serra M, de la Torre C, Farrera C, Sánchez-Tilló E, Caelles C, Lloberas J, Celada A.

Eur J Immunol. 2009 Jul;39(7):1902-13. doi: 10.1002/eji.200839037.


Homogeneous conjugation of peptides onto gold nanoparticles enhances macrophage response.

Bastús NG, Sánchez-Tilló E, Pujals S, Farrera C, López C, Giralt E, Celada A, Lloberas J, Puntes V.

ACS Nano. 2009 Jun 23;3(6):1335-44. doi: 10.1021/nn8008273.


Peptides conjugated to gold nanoparticles induce macrophage activation.

Bastús NG, Sánchez-Tilló E, Pujals S, Farrera C, Kogan MJ, Giralt E, Celada A, Lloberas J, Puntes V.

Mol Immunol. 2009 Feb;46(4):743-8. doi: 10.1016/j.molimm.2008.08.277. Epub 2008 Nov 8.


IFN-{gamma}-mediated inhibition of MAPK phosphatase expression results in prolonged MAPK activity in response to M-CSF and inhibition of proliferation.

Valledor AF, Arpa L, Sánchez-Tilló E, Comalada M, Casals C, Xaus J, Caelles C, Lloberas J, Celada A.

Blood. 2008 Oct 15;112(8):3274-82. doi: 10.1182/blood-2007-11-123604. Epub 2008 Aug 5.


Selective roles of MAPKs during the macrophage response to IFN-gamma.

Valledor AF, Sánchez-Tilló E, Arpa L, Park JM, Caelles C, Lloberas J, Celada A.

J Immunol. 2008 Apr 1;180(7):4523-9.


NMR structural studies of the ItchWW3 domain reveal that phosphorylation at T30 inhibits the interaction with PPxY-containing ligands.

Morales B, Ramirez-Espain X, Shaw AZ, Martin-Malpartida P, Yraola F, Sánchez-Tilló E, Farrera C, Celada A, Royo M, Macias MJ.

Structure. 2007 Apr;15(4):473-83.


JNK1 Is required for the induction of Mkp1 expression in macrophages during proliferation and lipopolysaccharide-dependent activation.

Sánchez-Tilló E, Comalada M, Xaus J, Farrera C, Valledor AF, Caelles C, Lloberas J, Celada A.

J Biol Chem. 2007 Apr 27;282(17):12566-73. Epub 2007 Mar 2.


Kv1.3/Kv1.5 heteromeric channels compromise pharmacological responses in macrophages.

Villalonga N, Escalada A, Vicente R, Sánchez-Tilló E, Celada A, Solsona C, Felipe A.

Biochem Biophys Res Commun. 2007 Jan 26;352(4):913-8. Epub 2006 Dec 4.


Cyclophilin A is required for M-CSF-dependent macrophage proliferation.

Sànchez-Tilló E, Wojciechowska M, Comalada M, Farrera C, Lloberas J, Celada A.

Eur J Immunol. 2006 Sep;36(9):2515-24.


Differential voltage-dependent K+ channel responses during proliferation and activation in macrophages.

Vicente R, Escalada A, Coma M, Fuster G, Sánchez-Tilló E, López-Iglesias C, Soler C, Solsona C, Celada A, Felipe A.

J Biol Chem. 2003 Nov 21;278(47):46307-20. Epub 2003 Aug 15. Erratum in: J Biol Chem. 2005 Apr 1;280(13):13204.

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