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Items: 15


The role of PIGF blockade in the treatment of colorectal cancer: overcoming the pitfalls.

Macarulla T, Montagut C, Sánchez-Martin FJ, Granja M, Verdaguer H, Sastre J, Tabernero J.

Expert Opin Biol Ther. 2019 Oct 16:1-8. doi: 10.1080/14712598.2020.1677603. [Epub ahead of print]


HER-family ligands promote acquired resistance to trastuzumab in gastric cancer.

Sampera A, Sánchez-Martín FJ, Arpí O, Visa L, Iglesias M, Menéndez S, Gaye É, Dalmases A, Clavé S, Gelabert-Baldrich M, Poulsen TT, Kragh M, Bellosillo B, Albanell J, Rovira A, Montagut C.

Mol Cancer Ther. 2019 Sep 4. pii: molcanther.0455.2019. doi: 10.1158/1535-7163.MCT-19-0455. [Epub ahead of print]


Chromium disrupts chromatin organization and CTCF access to its cognate sites in promoters of differentially expressed genes.

VonHandorf A, Sánchez-Martín FJ, Biesiada J, Zhang H, Zhang X, Medvedovic M, Puga A.

Epigenetics. 2018;13(4):363-375. doi: 10.1080/15592294.2018.1454243. Epub 2018 May 3.


Efficacy of Sym004 in Patients With Metastatic Colorectal Cancer With Acquired Resistance to Anti-EGFR Therapy and Molecularly Selected by Circulating Tumor DNA Analyses: A Phase 2 Randomized Clinical Trial.

Montagut C, Argilés G, Ciardiello F, Poulsen TT, Dienstmann R, Kragh M, Kopetz S, Lindsted T, Ding C, Vidal J, Clausell-Tormos J, Siravegna G, Sánchez-Martín FJ, Koefoed K, Pedersen MW, Grandal MM, Dvorkin M, Wyrwicz L, Rovira A, Cubillo A, Salazar R, Desseigne F, Nadal C, Albanell J, Zagonel V, Siena S, Fumi G, Rospo G, Nadler P, Horak ID, Bardelli A, Tabernero J.

JAMA Oncol. 2018 Apr 12;4(4):e175245. doi: 10.1001/jamaoncol.2017.5245. Epub 2018 Apr 12. Erratum in: JAMA Oncol. 2019 May 1;5(5):745.


AhR-dependent 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity in human neuronal cell line SHSY5Y.

Morales-Hernández A, Corrales-Redondo M, Marcos-Merino JM, González-Rico FJ, Sánchez-Martín FJ, Merino JM.

Neurotoxicology. 2016 Sep;56:55-63. doi: 10.1016/j.neuro.2016.07.001. Epub 2016 Jul 5.


The First-in-class Anti-EGFR Antibody Mixture Sym004 Overcomes Cetuximab Resistance Mediated by EGFR Extracellular Domain Mutations in Colorectal Cancer.

Sánchez-Martín FJ, Bellosillo B, Gelabert-Baldrich M, Dalmases A, Cañadas I, Vidal J, Martinez A, Argilés G, Siravegna G, Arena S, Koefoed K, Visa L, Arpí O, Horak ID, Iglesias M, Stroh C, Kragh M, Rovira A, Albanell J, Tabernero J, Bardelli A, Montagut C.

Clin Cancer Res. 2016 Jul 1;22(13):3260-7. doi: 10.1158/1078-0432.CCR-15-2400. Epub 2016 Feb 17.


Prenatal and early postnatal lead exposure in mice: neuroimaging findings.

Lindquist DM, Beckwith T, Cecil KM, Sánchez-Martín FJ, Landero-Figueroa J, Puga A.

Quant Imaging Med Surg. 2015 Aug;5(4):511-8. doi: 10.3978/j.issn.2223-4292.2015.07.01.


Long-term Coexposure to Hexavalent Chromium and B[a]P Causes Tissue-Specific Differential Biological Effects in Liver and Gastrointestinal Tract of Mice.

Sánchez-Martín FJ, Fan Y, Carreira V, Ovesen JL, Vonhandorf A, Xia Y, Puga A.

Toxicol Sci. 2015 Jul;146(1):52-64. doi: 10.1093/toxsci/kfv070. Epub 2015 Mar 29.


Sex- and tissue-specific methylome changes in brains of mice perinatally exposed to lead.

Sánchez-Martín FJ, Lindquist DM, Landero-Figueroa J, Zhang X, Chen J, Cecil KM, Medvedovic M, Puga A.

Neurotoxicology. 2015 Jan;46:92-100. doi: 10.1016/j.neuro.2014.12.004. Epub 2014 Dec 18.


Lead induces similar gene expression changes in brains of gestationally exposed adult mice and in neurons differentiated from mouse embryonic stem cells.

Sánchez-Martín FJ, Fan Y, Lindquist DM, Xia Y, Puga A.

PLoS One. 2013 Nov 19;8(11):e80558. doi: 10.1371/journal.pone.0080558. eCollection 2013.


2,3,7,8-Tetrachlorodibenzo-p-dioxin induces apoptosis by disruption of intracellular calcium homeostasis in human neuronal cell line SHSY5Y.

Morales-Hernández A, Sánchez-Martín FJ, Hortigón-Vinagre MP, Henao F, Merino JM.

Apoptosis. 2012 Nov;17(11):1170-81. doi: 10.1007/s10495-012-0760-z.


Aryl hydrocarbon receptor-dependent induction of apoptosis by 2,3,7,8-tetrachlorodibenzo-p-dioxin in cerebellar granule cells from mouse.

Sánchez-Martín FJ, Fernández-Salguero PM, Merino JM.

J Neurochem. 2011 Jul;118(1):153-62. doi: 10.1111/j.1471-4159.2011.07291.x. Epub 2011 May 19.


2,3,7,8-Tetrachlorodibenzo-p-dioxin induces apoptosis in neural growth factor (NGF)-differentiated pheochromocytoma PC12 cells.

Sánchez-Martín FJ, Fernández-Salguero PM, Merino JM.

Neurotoxicology. 2010 Jun;31(3):267-76. doi: 10.1016/j.neuro.2010.03.005. Epub 2010 Mar 17.


Nerve growth factor increases the sensitivity to zinc toxicity and induces cell cycle arrest in PC12 cells.

Sánchez-Martín FJ, Valera E, Casimiro I, Merino JM.

Brain Res Bull. 2010 Mar 16;81(4-5):458-66. doi: 10.1016/j.brainresbull.2009.11.008. Epub 2009 Dec 1.


NMDA-induced neuroprotection in hippocampal neurons is mediated through the protein kinase A and CREB (cAMP-response element-binding protein) pathway.

Valera E, Sánchez-Martín FJ, Ferrer-Montiel AV, Messeguer A, Merino JM.

Neurochem Int. 2008 Nov;53(5):148-54. doi: 10.1016/j.neuint.2008.07.007. Epub 2008 Jul 25.


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