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Items: 1 to 50 of 55

1.

Sphingosine 1-phosphate receptor 2/adenylyl cyclase/protein kinase A pathway is involved in taurolithocholate-induced internalization of Abcc2 in rats.

Andermatten RB, Ciriaci N, Schuck VS, Di Siervi N, Razori MV, Miszczuk GS, Medeot AC, Davio CA, Crocenzi FA, Roma MG, Barosso IR, Sánchez Pozzi EJ.

Arch Toxicol. 2019 Jul 12. doi: 10.1007/s00204-019-02514-6. [Epub ahead of print]

PMID:
31300867
2.

Anticholestatic mechanisms of ursodeoxycholic acid in lipopolysaccharide-induced cholestasis.

Razori MV, Maidagan PM, Ciriaci N, Andermatten RB, Barosso IR, Martín PL, Basiglio CL, Sánchez Pozzi EJ, Ruiz ML, Roma MG.

Biochem Pharmacol. 2019 Jun 13;168:48-56. doi: 10.1016/j.bcp.2019.06.009. [Epub ahead of print]

PMID:
31202734
3.

Role of ERK1/2 in TNFα-induced internalization of Abcc2 in rat hepatocyte couplets.

Ciriaci N, Andermatten RB, Razori MV, Schuck VS, Miszczuk GS, Medeot AC, Crocenzi FA, Roma MG, Barosso IR, Ruiz ML, Sánchez Pozzi EJ.

Biochem Pharmacol. 2019 Jun;164:311-320. doi: 10.1016/j.bcp.2019.04.024. Epub 2019 Apr 23.

PMID:
31026445
4.

Heme oxygenase-1 induction by hemin prevents oxidative stress-induced acute cholestasis in the rat.

Martín PL, Ceccatto P, Razori MV, Francés DEA, Arriaga SMM, Pisani GB, Martínez AI, Sánchez Pozzi EJ, Roma MG, Basiglio CL.

Clin Sci (Lond). 2019 Jan 11;133(1):117-134. doi: 10.1042/CS20180675. Print 2019 Jan 15.

PMID:
30538149
5.

Mechanisms of canalicular transporter endocytosis in the cholestatic rat liver.

Miszczuk GS, Barosso IR, Larocca MC, Marrone J, Marinelli RA, Boaglio AC, Sánchez Pozzi EJ, Roma MG, Crocenzi FA.

Biochim Biophys Acta Mol Basis Dis. 2018 Apr;1864(4 Pt A):1072-1085. doi: 10.1016/j.bbadis.2018.01.015. Epub 2018 Jan 31.

6.

Activation of insulin-like growth factor 1 receptor participates downstream of GPR30 in estradiol-17β-D-glucuronide-induced cholestasis in rats.

Barosso IR, Miszczuk GS, Ciriaci N, Andermatten RB, Maidagan PM, Razori V, Taborda DR, Roma MG, Crocenzi FA, Sánchez Pozzi EJ.

Arch Toxicol. 2018 Feb;92(2):729-744. doi: 10.1007/s00204-017-2098-3. Epub 2017 Oct 31.

PMID:
29090346
7.

Mitogen-activated protein kinases are involved in hepatocanalicular dysfunction and cholestasis induced by oxidative stress.

Toledo FD, Basiglio CL, Barosso IR, Boaglio AC, Zucchetti AE, Sánchez Pozzi EJ, Roma MG.

Arch Toxicol. 2017 Jun;91(6):2391-2403. doi: 10.1007/s00204-016-1898-1. Epub 2016 Dec 2.

PMID:
27913845
8.

EGFR participates downstream of ERα in estradiol-17β-D-glucuronide-induced impairment of Abcc2 function in isolated rat hepatocyte couplets.

Barosso IR, Zucchetti AE, Miszczuk GS, Boaglio AC, Taborda DR, Roma MG, Crocenzi FA, Sánchez Pozzi EJ.

Arch Toxicol. 2016 Apr;90(4):891-903. doi: 10.1007/s00204-015-1507-8. Epub 2015 Mar 27.

PMID:
25813982
9.

Sandwich-cultured rat hepatocytes as an in vitro model to study canalicular transport alterations in cholestasis.

Miszczuk GS, Barosso IR, Zucchetti AE, Boaglio AC, Pellegrino JM, Sánchez Pozzi EJ, Roma MG, Crocenzi FA.

Arch Toxicol. 2015 Jun;89(6):979-90. doi: 10.1007/s00204-014-1283-x. Epub 2014 Jun 10.

PMID:
24912783
10.

The Ca²⁺-calmodulin-Ca²⁺/calmodulin-dependent protein kinase II signaling pathway is involved in oxidative stress-induced mitochondrial permeability transition and apoptosis in isolated rat hepatocytes.

Toledo FD, Pérez LM, Basiglio CL, Ochoa JE, Sanchez Pozzi EJ, Roma MG.

Arch Toxicol. 2014 Sep;88(9):1695-709. doi: 10.1007/s00204-014-1219-5. Epub 2014 Mar 11.

PMID:
24614978
11.

Physiological concentrations of unconjugated bilirubin prevent oxidative stress-induced hepatocanalicular dysfunction and cholestasis.

Basiglio CL, Toledo FD, Boaglio AC, Arriaga SM, Ochoa JE, Sánchez Pozzi EJ, Mottino AD, Roma MG.

Arch Toxicol. 2014 Feb;88(2):501-14. doi: 10.1007/s00204-013-1143-0. Epub 2013 Dec 4.

PMID:
24306262
12.

Hormonal modulation of hepatic cAMP prevents estradiol 17β-D-glucuronide-induced cholestasis in perfused rat liver.

Zucchetti AE, Barosso IR, Boaglio AC, Luquita MG, Roma MG, Crocenzi FA, Sánchez Pozzi EJ.

Dig Dis Sci. 2013 Jun;58(6):1602-14. doi: 10.1007/s10620-013-2558-4. Epub 2013 Jan 31.

PMID:
23371010
13.

Sequential activation of classic PKC and estrogen receptor α is involved in estradiol 17ß-D-glucuronide-induced cholestasis.

Barosso IR, Zucchetti AE, Boaglio AC, Larocca MC, Taborda DR, Luquita MG, Roma MG, Crocenzi FA, Sánchez Pozzi EJ.

PLoS One. 2012;7(11):e50711. doi: 10.1371/journal.pone.0050711. Epub 2012 Nov 27.

14.

ERK1/2 and p38 MAPKs are complementarily involved in estradiol 17ß-D-glucuronide-induced cholestasis: crosstalk with cPKC and PI3K.

Boaglio AC, Zucchetti AE, Toledo FD, Barosso IR, Sánchez Pozzi EJ, Crocenzi FA, Roma MG.

PLoS One. 2012;7(11):e49255. doi: 10.1371/journal.pone.0049255. Epub 2012 Nov 14.

15.

Localization status of hepatocellular transporters in cholestasis.

Crocenzi FA, Zucchetti AE, Boaglio AC, Barosso IR, Sanchez Pozzi EJ, Mottino AD, Roma MG.

Front Biosci (Landmark Ed). 2012 Jan 1;17:1201-18. Review.

PMID:
22201798
16.

Prevention of estradiol 17beta-D-glucuronide-induced canalicular transporter internalization by hormonal modulation of cAMP in rat hepatocytes.

Zucchetti AE, Barosso IR, Boaglio A, Pellegrino JM, Ochoa EJ, Roma MG, Crocenzi FA, Sánchez Pozzi EJ.

Mol Biol Cell. 2011 Oct;22(20):3902-15. doi: 10.1091/mbc.E11-01-0047. Epub 2011 Aug 24.

17.

Ursodeoxycholic acid in cholestasis: linking action mechanisms to therapeutic applications.

Roma MG, Toledo FD, Boaglio AC, Basiglio CL, Crocenzi FA, Sánchez Pozzi EJ.

Clin Sci (Lond). 2011 Dec;121(12):523-44. doi: 10.1042/CS20110184. Review.

PMID:
21854363
18.

Phosphoinositide 3-kinase/protein kinase B signaling pathway is involved in estradiol 17β-D-glucuronide-induced cholestasis: complementarity with classical protein kinase C.

Boaglio AC, Zucchetti AE, Sánchez Pozzi EJ, Pellegrino JM, Ochoa JE, Mottino AD, Vore M, Crocenzi FA, Roma MG.

Hepatology. 2010 Oct;52(4):1465-76. doi: 10.1002/hep.23846.

PMID:
20815017
19.

Induction of intestinal multidrug resistance-associated protein 2 (Mrp2) by spironolactone in rats.

Ruiz ML, Villanueva SS, Luquita MG, Pellegrino JM, Rigalli JP, Arias A, Sánchez Pozzi EJ, Mottino AD, Catania VA.

Eur J Pharmacol. 2009 Nov 25;623(1-3):103-6. doi: 10.1016/j.ejphar.2009.09.014. Epub 2009 Sep 17.

PMID:
19766108
20.

Putative role for actin organization status in the dynamic localization of canalicular carriers under oxidative stress conditions.

Sánchez Pozzi EJ, Roma MG.

Am J Physiol Gastrointest Liver Physiol. 2009 Apr;296(4):G969. doi: 10.1152/ajpgi.00019.2009. No abstract available.

21.

Differential effects of silymarin and its active component silibinin on plasma membrane stability and hepatocellular lysis.

Basiglio CL, Sánchez Pozzi EJ, Mottino AD, Roma MG.

Chem Biol Interact. 2009 May 15;179(2-3):297-303. doi: 10.1016/j.cbi.2008.12.008. Epub 2008 Dec 24.

PMID:
19135039
22.

Ca(2+)-dependent protein kinase C isoforms are critical to estradiol 17beta-D-glucuronide-induced cholestasis in the rat.

Crocenzi FA, Sánchez Pozzi EJ, Ruiz ML, Zucchetti AE, Roma MG, Mottino AD, Vore M.

Hepatology. 2008 Dec;48(6):1885-95. doi: 10.1002/hep.22532.

23.

Dapsone induces oxidative stress and impairs antioxidant defenses in rat liver.

Veggi LM, Pretto L, Ochoa EJ, Catania VA, Luquita MG, Taborda DR, Sánchez Pozzi EJ, Ikushiro S, Coleman MD, Roma MG, Mottino AD.

Life Sci. 2008 Aug 1;83(5-6):155-63. doi: 10.1016/j.lfs.2008.05.016. Epub 2008 Jun 18.

PMID:
18602405
24.

Oxidative stress: a radical way to stop making bile.

Roma MG, Sanchez Pozzi EJ.

Ann Hepatol. 2008 Jan-Mar;7(1):16-33. Review.

25.

Disruption of function and localization of tight junctional structures and Mrp2 in sustained estradiol-17beta-D-glucuronide-induced cholestasis.

Mottino AD, Hoffman T, Crocenzi FA, Sánchez Pozzi EJ, Roma MG, Vore M.

Am J Physiol Gastrointest Liver Physiol. 2007 Jul;293(1):G391-402. Epub 2007 Apr 26.

26.

Oxidative stress induces actin-cytoskeletal and tight-junctional alterations in hepatocytes by a Ca2+ -dependent, PKC-mediated mechanism: protective effect of PKA.

Pérez LM, Milkiewicz P, Ahmed-Choudhury J, Elias E, Ochoa JE, Sánchez Pozzi EJ, Coleman R, Roma MG.

Free Radic Biol Med. 2006 Jun 1;40(11):2005-17. Epub 2006 Feb 23.

PMID:
16716901
27.

Hepatic and extrahepatic synthesis and disposition of dinitrophenyl-S-glutathione in bile duct-ligated rats.

Villanueva SS, Ruiz ML, Soroka CJ, Cai SY, Luquita MG, Torres AM, Sánchez Pozzi EJ, Pellegrino JM, Boyer JL, Catania VA, Mottino AD.

Drug Metab Dispos. 2006 Aug;34(8):1301-9. Epub 2006 May 5.

PMID:
16679389
28.
29.

Inhibition of rat liver UDP-glucuronosyltransferase by silymarin and the metabolite silibinin-glucuronide.

D'Andrea V, Pérez LM, Sánchez Pozzi EJ.

Life Sci. 2005 Jun 24;77(6):683-92. Epub 2005 Feb 25.

PMID:
15921999
30.

Prevention of Mrp2 activity impairment in ethinylestradiol-induced cholestasis by ursodeoxycholate in the rat.

Crocenzi FA, D'Andrea V, Catania VA, Luquita MG, Pellegrino JM, Ochoa JE, Mottino AD, Sánchez Pozzi EJ.

Drug Metab Dispos. 2005 Jul;33(7):888-91. Epub 2005 Apr 20.

PMID:
15843489
31.

Mechanisms involved in spironolactone-induced choleresis in the rat. Role of multidrug resistance-associated protein 2.

Ruiz ML, Villanueva SS, Luquita MG, Sánchez-Pozzi EJ, Crocenzi FA, Pellegrino JM, Ochoa JE, Vore M, Mottino AD, Catania VA.

Biochem Pharmacol. 2005 Feb 1;69(3):531-9. Epub 2004 Dec 15.

PMID:
15652244
32.

Involvement of Mrp2 in hepatic and intestinal disposition of dinitrophenyl-S-glutathione in partially hepatectomized rats.

Villanueva SS, Ruiz ML, Luquita MG, Sánchez Pozzi EJ, Catania VA, Mottino AD.

Toxicol Sci. 2005 Mar;84(1):4-11. Epub 2004 Dec 8.

PMID:
15590889
33.

Co-regulation of expression of phase II metabolizing enzymes and multidrug resistance-associated protein 2.

Catania VA, Sánchez Pozzi EJ, Luquita MG, Ruiz ML, Villanueva SS, Jones B, Mottino AD.

Ann Hepatol. 2004 Jan-Mar;3(1):11-7. Review.

34.

Impaired localisation and transport function of canalicular Bsep in taurolithocholate induced cholestasis in the rat.

Crocenzi FA, Mottino AD, Sánchez Pozzi EJ, Pellegrino JM, Rodríguez Garay EA, Milkiewicz P, Vore M, Coleman R, Roma MG.

Gut. 2003 Aug;52(8):1170-7.

35.

Preventive effect of silymarin against taurolithocholate-induced cholestasis in the rat.

Crocenzi FA, Sánchez Pozzi EJ, Pellegrino JM, Rodríguez Garay EA, Mottino AD, Roma MG.

Biochem Pharmacol. 2003 Jul 15;66(2):355-64.

PMID:
12826278
36.

Effect of spironolactone on the expression of rat hepatic UDP-glucuronosyltransferase.

Catania VA, Luquita MG, Sánchez Pozzi EJ, Ikushiro S, Emi Y, Iyanagi T, Mottino AD.

Biochem Pharmacol. 2003 Jul 1;66(1):171-7.

PMID:
12818378
37.

Ursodeoxycholate reduces ethinylestradiol glucuronidation in the rat: role in prevention of estrogen-induced cholestasis.

Sánchez Pozzi EJ, Crocenzi FA, Pellegrino JM, Catania VA, Luquita MG, Roma MG, Rodríguez Garay EA, Mottino AD.

J Pharmacol Exp Ther. 2003 Jul;306(1):279-86. Epub 2003 Mar 27.

PMID:
12663690
38.

Dapsone-induced cholestasis and impairment of bile salt output in the rat.

Veggi LM, Crocenzi FA, Roma MG, Dawson PA, Pellegrino JM, Sánchez Pozzi EJ, Mottino AD.

Biochem Pharmacol. 2002 Apr 15;63(8):1553-63.

PMID:
11996898
39.

Increased expression of ileal apical sodium-dependent bile acid transporter in postpartum rats.

Mottino AD, Hoffman T, Dawson PA, Luquita MG, Monti JA, Sánchez Pozzi EJ, Catania VA, Cao J, Vore M.

Am J Physiol Gastrointest Liver Physiol. 2002 Jan;282(1):G41-50.

40.

Beneficial effects of silymarin on estrogen-induced cholestasis in the rat: a study in vivo and in isolated hepatocyte couplets.

Crocenzi FA, Sánchez Pozzi EJ, Pellegrino JM, Favre CO, Rodríguez Garay EA, Mottino AD, Coleman R, Roma MG.

Hepatology. 2001 Aug;34(2):329-39.

PMID:
11481618
41.
42.

Effect of silymarin on biliary bile salt secretion in the rat.

Crocenzi FA, Pellegrino JM, Sánchez Pozzi EJ, Mottino AD, Garay EA, Roma MG.

Biochem Pharmacol. 2000 Apr 15;59(8):1015-22.

PMID:
10692567
43.

Induction of phase II biotransformation reactions in rat jejunum during lactation. Possible involvement of prolactin.

Luquita MG, Catania VA, Sánchez Pozzi EJ, Vore M, Veggi LM, Pellegrino JM, Mottino AD.

Biochim Biophys Acta. 1999 Oct 18;1472(1-2):82-92.

PMID:
10572928
44.

Prolactin increases the hepatic content of mu-class subunits of glutathione S-transferase in the rat.

Luquita MG, Catania VA, Sánchez-Pozzi EJ, Vore M, Mottino AD.

Drug Metab Dispos. 1999 Jan;27(1):122-4.

PMID:
9884320
45.

Differential induction of glutathione S-transferase subunits by spironolactone in rat liver, jejunum and colon.

Catania VA, Luquita MG, Sánchez Pozzi EJ, Mottino AD.

Life Sci. 1998;63(26):2285-93.

PMID:
9877218
46.

Enhancement of intestinal UDP-glucuronosyltranferase activity in partially hepatectomized rats.

Catania VA, Luquita MG, Sánchez Pozzi EJ, Mottino AD.

Biochim Biophys Acta. 1998 May 8;1380(3):345-53.

PMID:
9555089
47.

Ovine prolactin increases hepatic UDP-glucuronosyltransferase activity in ovariectomized rats.

Luquita MG, Catania VA, Sánchez-Pozzi EJ, Mottino AD.

J Pharmacol Exp Ther. 1996 Aug;278(2):921-5.

PMID:
8768748
48.

Enhancement of intestinal bilirubin UDP-glucuronosyltransferase activity by modification of microsomal lipid composition.

Sánchez-Pozzi EJ, Catania VA, Rodríguez-Garay EA, Mottino AD.

Biochim Biophys Acta. 1995 Dec 14;1245(3):293-8.

PMID:
8541303
49.

Gender-related differences in the amount and functional state of rat liver UDP-glucuronosyltransferase.

Catania VA, Dannenberg AJ, Luquita MG, Sánchez Pozzi EJ, Tucker JK, Yang EK, Mottino AD.

Biochem Pharmacol. 1995 Aug 8;50(4):509-14.

PMID:
7646557
50.

Enhancement of cytosolic and microsomal glutathione S-transferase activities in liver and small intestine from female rats during lactation.

Luquita MG, Catania VA, Sánchez Pozzi EJ, Mottino AD.

Pharmacol Toxicol. 1995 Jan;76(1):72-5.

PMID:
7753762

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