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Items: 46

1.

Selective depletion of metastatic stem cells as therapy for human colorectal cancer.

Céspedes MV, Unzueta U, Aviñó A, Gallardo A, Álamo P, Sala R, Sánchez-Chardi A, Casanova I, Mangues MA, Lopez-Pousa A, Eritja R, Villaverde A, Vázquez E, Mangues R.

EMBO Mol Med. 2018 Oct;10(10). pii: e8772. doi: 10.15252/emmm.201708772.

2.

Conformational Conversion during Controlled Oligomerization into Nonamylogenic Protein Nanoparticles.

Sánchez JM, Sánchez-García L, Pesarrodona M, Serna N, Sánchez-Chardi A, Unzueta U, Mangues R, Vázquez E, Villaverde A.

Biomacromolecules. 2018 Sep 10;19(9):3788-3797. doi: 10.1021/acs.biomac.8b00924. Epub 2018 Aug 13.

PMID:
30052033
3.

Selective CXCR4+ Cancer Cell Targeting and Potent Antineoplastic Effect by a Nanostructured Version of Recombinant Ricin.

Díaz R, Pallarès V, Cano-Garrido O, Serna N, Sánchez-García L, Falgàs A, Pesarrodona M, Unzueta U, Sánchez-Chardi A, Sánchez JM, Casanova I, Vázquez E, Mangues R, Villaverde A.

Small. 2018 Jun;14(26):e1800665. doi: 10.1002/smll.201800665. Epub 2018 May 29.

PMID:
29845742
4.

Switching cell penetrating and CXCR4-binding activities of nanoscale-organized arginine-rich peptides.

Favaro MTP, Serna N, Sánchez-García L, Cubarsi R, Roldán M, Sánchez-Chardi A, Unzueta U, Mangues R, Ferrer-Miralles N, Azzoni AR, Vázquez E, Villaverde A.

Nanomedicine. 2018 Aug;14(6):1777-1786. doi: 10.1016/j.nano.2018.05.002. Epub 2018 May 16.

PMID:
29777875
5.

Release of targeted protein nanoparticles from functional bacterial amyloids: A death star-like approach.

Unzueta U, Cespedes MV, Sala R, Alamo P, Sánchez-Chardi A, Pesarrodona M, Sánchez-García L, Cano-Garrido O, Villaverde A, Vázquez E, Mangues R, Seras-Franzoso J.

J Control Release. 2018 Jun 10;279:29-39. doi: 10.1016/j.jconrel.2018.04.004. Epub 2018 Apr 8.

PMID:
29641987
6.

Self-assembling toxin-based nanoparticles as self-delivered antitumoral drugs.

Sánchez-García L, Serna N, Álamo P, Sala R, Céspedes MV, Roldan M, Sánchez-Chardi A, Unzueta U, Casanova I, Mangues R, Vázquez E, Villaverde A.

J Control Release. 2018 Mar 28;274:81-92. doi: 10.1016/j.jconrel.2018.01.031. Epub 2018 Jan 31.

PMID:
29408658
7.

Protein nanoparticles are nontoxic, tuneable cell stressors.

de Pinho Favaro MT, Sánchez-García L, Sánchez-Chardi A, Roldán M, Unzueta U, Serna N, Cano-Garrido O, Azzoni AR, Ferrer-Miralles N, Villaverde A, Vázquez E.

Nanomedicine (Lond). 2018 Feb;13(3):255-268. doi: 10.2217/nnm-2017-0294. Epub 2018 Jan 17.

PMID:
29338574
8.

Improving Biomaterials Imaging for Nanotechnology: Rapid Methods for Protein Localization at Ultrastructural Level.

Cano-Garrido O, Garcia-Fruitós E, Villaverde A, Sánchez-Chardi A.

Biotechnol J. 2018 Apr;13(4):e1700388. doi: 10.1002/biot.201700388. Epub 2018 Jan 24.

PMID:
29271611
9.

Engineering multifunctional protein nanoparticles by in vitro disassembling and reassembling of heterologous building blocks.

Unzueta U, Serna N, Sánchez-García L, Roldán M, Sánchez-Chardi A, Mangues R, Villaverde A, Vázquez E.

Nanotechnology. 2017 Dec 15;28(50):505102. doi: 10.1088/1361-6528/aa963e.

PMID:
29072576
10.

Protein-only, antimicrobial peptide-containing recombinant nanoparticles with inherent built-in antibacterial activity.

Serna N, Sánchez-García L, Sánchez-Chardi A, Unzueta U, Roldán M, Mangues R, Vázquez E, Villaverde A.

Acta Biomater. 2017 Sep 15;60:256-263. doi: 10.1016/j.actbio.2017.07.027. Epub 2017 Jul 19.

PMID:
28735028
11.

Intrinsic functional and architectonic heterogeneity of tumor-targeted protein nanoparticles.

Pesarrodona M, Crosas E, Cubarsi R, Sánchez-Chardi A, Saccardo P, Unzueta U, Rueda F, Sanchez-García L, Serna N, Mangues R, Ferrer-Miralles N, Vázquez E, Villaverde A.

Nanoscale. 2017 May 18;9(19):6427-6435. doi: 10.1039/c6nr09182b.

PMID:
28463351
12.

The fusogenic peptide HA2 impairs selectivity of CXCR4-targeted protein nanoparticles.

Sánchez-García L, Serna N, Mattanovich M, Cazzanelli P, Sánchez-Chardi A, Conchillo-Solé O, Cortés F, Daura X, Unzueta U, Mangues R, Villaverde A, Vázquez E.

Chem Commun (Camb). 2017 Apr 20;53(33):4565-4568. doi: 10.1039/c6cc09900a.

PMID:
28322369
13.

A combination of lactic acid bacteria regulates Escherichia coli infection and inflammation of the bovine endometrium.

Genís S, Sánchez-Chardi A, Bach À, Fàbregas F, Arís A.

J Dairy Sci. 2017 Jan;100(1):479-492. doi: 10.3168/jds.2016-11671. Epub 2016 Nov 9.

PMID:
27837977
14.

Bacterial mimetics of endocrine secretory granules as immobilized in vivo depots for functional protein drugs.

Céspedes MV, Fernández Y, Unzueta U, Mendoza R, Seras-Franzoso J, Sánchez-Chardi A, Álamo P, Toledo-Rubio V, Ferrer-Miralles N, Vázquez E, Schwartz S, Abasolo I, Corchero JL, Mangues R, Villaverde A.

Sci Rep. 2016 Oct 24;6:35765. doi: 10.1038/srep35765.

15.

Functional inclusion bodies produced in the yeast Pichia pastoris.

Rueda F, Gasser B, Sánchez-Chardi A, Roldán M, Villegas S, Puxbaum V, Ferrer-Miralles N, Unzueta U, Vázquez E, Garcia-Fruitós E, Mattanovich D, Villaverde A.

Microb Cell Fact. 2016 Oct 1;15(1):166.

16.

CXCR4(+)-targeted protein nanoparticles produced in the food-grade bacterium Lactococcus lactis.

Cano-Garrido O, Céspedes MV, Unzueta U, Saccardo P, Roldán M, Sánchez-Chardi A, Cubarsi R, Vázquez E, Mangues R, García-Fruitós E, Villaverde A.

Nanomedicine (Lond). 2016 Sep;11(18):2387-98. doi: 10.2217/nnm-2016-0200. Epub 2016 Aug 16.

17.

Functional protein-based nanomaterial produced in microorganisms recognized as safe: A new platform for biotechnology.

Cano-Garrido O, Sánchez-Chardi A, Parés S, Giró I, Tatkiewicz WI, Ferrer-Miralles N, Ratera I, Natalello A, Cubarsi R, Veciana J, Bach À, Villaverde A, Arís A, Garcia-Fruitós E.

Acta Biomater. 2016 Oct 1;43:230-239. doi: 10.1016/j.actbio.2016.07.038. Epub 2016 Jul 21.

PMID:
27452157
18.

Mycobacteria emulsified in olive oil-in-water trigger a robust immune response in bladder cancer treatment.

Noguera-Ortega E, Blanco-Cabra N, Rabanal RM, Sánchez-Chardi A, Roldán M, Guallar-Garrido S, Torrents E, Luquin M, Julián E.

Sci Rep. 2016 Jun 6;6:27232. doi: 10.1038/srep27232.

19.

Conformational and functional variants of CD44-targeted protein nanoparticles bio-produced in bacteria.

Pesarrodona M, Fernández Y, Foradada L, Sánchez-Chardi A, Conchillo-Solé O, Unzueta U, Xu Z, Roldán M, Villegas S, Ferrer-Miralles N, Schwartz S Jr, Rinas U, Daura X, Abasolo I, Vázquez E, Villaverde A.

Biofabrication. 2016 Apr 14;8(2):025001. doi: 10.1088/1758-5090/8/2/025001.

PMID:
27078873
20.

Structural and functional features of self-assembling protein nanoparticles produced in endotoxin-free Escherichia coli.

Rueda F, Céspedes MV, Sánchez-Chardi A, Seras-Franzoso J, Pesarrodona M, Ferrer-Miralles N, Vázquez E, Rinas U, Unzueta U, Mamat U, Mangues R, García-Fruitós E, Villaverde A.

Microb Cell Fact. 2016 Apr 8;15:59. doi: 10.1186/s12934-016-0457-z.

21.

Cellular uptake and intracellular fate of protein releasing bacterial amyloids in mammalian cells.

Seras-Franzoso J, Sánchez-Chardi A, Garcia-Fruitós E, Vázquez E, Villaverde A.

Soft Matter. 2016 Apr 14;12(14):3451-60. doi: 10.1039/c5sm02930a. Epub 2016 Mar 9.

PMID:
26956912
22.

Rational engineering of single-chain polypeptides into protein-only, BBB-targeted nanoparticles.

Serna N, Céspedes MV, Saccardo P, Xu Z, Unzueta U, Álamo P, Pesarrodona M, Sánchez-Chardi A, Roldán M, Mangues R, Vázquez E, Villaverde A, Ferrer-Miralles N.

Nanomedicine. 2016 Jul;12(5):1241-51. doi: 10.1016/j.nano.2016.01.004. Epub 2016 Mar 4.

PMID:
26949165
23.

Bottom-Up Instructive Quality Control in the Biofabrication of Smart Protein Materials.

Rueda F, Céspedes MV, Conchillo-Solé O, Sánchez-Chardi A, Seras-Franzoso J, Cubarsi R, Gallardo A, Pesarrodona M, Ferrer-Miralles N, Daura X, Vázquez E, García-Fruitós E, Mangues R, Unzueta U, Villaverde A.

Adv Mater. 2015 Dec 16;27(47):7816-22. doi: 10.1002/adma.201503676. Epub 2015 Oct 28.

PMID:
26509451
24.

Imaging of cellular aging in human retinal blood vessels.

Catita J, López-Luppo M, Ramos D, Nacher V, Navarro M, Carretero A, Sánchez-Chardi A, Mendes-Jorge L, Rodriguez-Baeza A, Ruberte J.

Exp Eye Res. 2015 Jun;135:14-25. doi: 10.1016/j.exer.2015.03.019. Epub 2015 Mar 27. Review.

PMID:
25818511
25.

In vivo architectonic stability of fully de novo designed protein-only nanoparticles.

Céspedes MV, Unzueta U, Tatkiewicz W, Sánchez-Chardi A, Conchillo-Solé O, Álamo P, Xu Z, Casanova I, Corchero JL, Pesarrodona M, Cedano J, Daura X, Ratera I, Veciana J, Ferrer-Miralles N, Vazquez E, Villaverde A, Mangues R.

ACS Nano. 2014 May 27;8(5):4166-76. doi: 10.1021/nn4055732. Epub 2014 Apr 14.

PMID:
24708510
26.

Histopathology related to cadmium and lead bioaccumulation in chronically exposed wood mice, Apodemus sylvaticus, around a former smelter.

Tête N, Durfort M, Rieffel D, Scheifler R, Sánchez-Chardi A.

Sci Total Environ. 2014 May 15;481:167-77. doi: 10.1016/j.scitotenv.2014.02.029. Epub 2014 Mar 2.

PMID:
24594745
27.

Chronic exposure to environmental stressors induces fluctuating asymmetry in shrews inhabiting protected Mediterranean sites.

Sánchez-Chardi A, García-Pando M, López-Fuster MJ.

Chemosphere. 2013 Oct;93(6):916-23. doi: 10.1016/j.chemosphere.2013.05.056. Epub 2013 Jun 22.

PMID:
23800592
28.

Differential interactions of virulent and non-virulent H. parasuis strains with naïve or swine influenza virus pre-infected dendritic cells.

Mussá T, Rodríguez-Cariño C, Sánchez-Chardi A, Baratelli M, Costa-Hurtado M, Fraile L, Domínguez J, Aragon V, Montoya M.

Vet Res. 2012 Nov 16;43:80. doi: 10.1186/1297-9716-43-80.

29.

Cyclopropanation of α-mycolic acids is not required for cording in Mycobacterium brumae and Mycobacterium fallax.

Brambilla C, Sánchez-Chardi A, Pérez-Trujillo M, Julián E, Luquin M.

Microbiology. 2012 Jun;158(Pt 6):1615-21. doi: 10.1099/mic.0.057919-0. Epub 2012 Apr 5.

PMID:
22493302
30.

Demonstration of cord formation by rough Mycobacterium abscessus variants: implications for the clinical microbiology laboratory.

Sánchez-Chardi A, Olivares F, Byrd TF, Julián E, Brambilla C, Luquin M.

J Clin Microbiol. 2011 Jun;49(6):2293-5. doi: 10.1128/JCM.02322-10. Epub 2011 Apr 13.

31.

Porcine circovirus type 2 morphogenesis in a clone derived from the l35 lymphoblastoid cell line.

Rodríguez-Cariño C, Duffy C, Sánchez-Chardi A, McNeilly F, Allan GM, Segalés J.

J Comp Pathol. 2011 Feb-Apr;144(2-3):91-102. doi: 10.1016/j.jcpa.2010.07.001. Epub 2010 Aug 30.

PMID:
20800239
32.

Microscopic cords, a virulence-related characteristic of Mycobacterium tuberculosis, are also present in nonpathogenic mycobacteria.

Julián E, Roldán M, Sánchez-Chardi A, Astola O, Agustí G, Luquin M.

J Bacteriol. 2010 Apr;192(7):1751-60. doi: 10.1128/JB.01485-09. Epub 2010 Jan 22.

33.

Subcellular immunolocalization of porcine circovirus type 2 (PCV2) in lymph nodes from pigs with post-weaning multisystemic wasting syndrome (PMWS).

Rodríguez-Cariño C, Sánchez-Chardi A, Segalés J.

J Comp Pathol. 2010 May;142(4):291-9. doi: 10.1016/j.jcpa.2009.12.001. Epub 2010 Jan 22.

PMID:
20096850
34.

Bioaccumulation of metals and effects of a landfill in small mammals Part III: Structural alterations.

Sánchez-Chardi A, Peñarroja-Matutano C, Borrás M, Nadal J.

Environ Res. 2009 Nov;109(8):960-7. doi: 10.1016/j.envres.2009.08.004. Epub 2009 Sep 15.

PMID:
19758588
35.

Metals in liver and kidneys and the effects of chronic exposure to pyrite mine pollution in the shrew Crocidura russula inhabiting the protected wetland of Doñana.

Sánchez-Chardi A, Ribeiro CA, Nadal J.

Chemosphere. 2009 Jul;76(3):387-94. doi: 10.1016/j.chemosphere.2009.03.036. Epub 2009 Apr 23.

PMID:
19394996
36.

Metal and metalloid accumulation in shrews (Soricomorpha, Mammalia) from two protected Mediterranean coastal sites.

Sánchez-Chardi A, López-Fuster MJ.

Environ Pollut. 2009 Apr;157(4):1243-8. doi: 10.1016/j.envpol.2008.11.047. Epub 2009 Jan 13.

PMID:
19144455
37.

Haematology, genotoxicity, enzymatic activity and histopathology as biomarkers of metal pollution in the shrew Crocidura russula.

Sánchez-Chardi A, Marques CC, Gabriel SI, Capela-Silva F, Cabrita AS, López-Fuster MJ, Nadal J, Mathias ML.

Environ Pollut. 2008 Dec;156(3):1332-9. doi: 10.1016/j.envpol.2008.02.026. Epub 2008 Apr 29.

PMID:
18448220
38.

Biochemical alterations in juvenile carp (Cyprinus carpio) exposed to zinc: glutathione reductase as a target.

Franco JL, Posser T, Mattos JJ, Sánchez-Chardi A, Trevisan R, Oliveira CS, Carvalho PS, Leal RB, Marques MR, Bainy AC, Dafre AL.

Mar Environ Res. 2008 Jul;66(1):88-9. doi: 10.1016/j.marenvres.2008.02.031. Epub 2008 Feb 26.

PMID:
18395787
39.

Bioaccumulation of metals and effects of a landfill in small mammals. Part II. The wood mouse, Apodemus sylvaticus.

Sánchez-Chardi A, Peñarroja-Matutano C, Ribeiro CA, Nadal J.

Chemosphere. 2007 Nov;70(1):101-9. Epub 2007 Aug 2.

PMID:
17681586
40.

Tissue, age, and sex distribution of thallium in shrews from Doñana, a protected area in SW Spain.

Sánchez-Chardi A.

Sci Total Environ. 2007 Sep 20;383(1-3):237-40. Epub 2007 Jun 13.

PMID:
17570462
41.
42.

How does the greater white-toothed shrew, Crocidura russula, responds to long-term heavy metal contamination? -- A case study.

Marques CC, Sánchez-Chardi A, Gabriel SI, Nadal J, Viegas-Crespo AM, da Luz Mathias M.

Sci Total Environ. 2007 Apr 15;376(1-3):128-33. Epub 2007 Feb 23.

PMID:
17321569
43.

Metal bioaccumulation in the greater white-toothed shrew, Crocidura russula, inhabiting an abandoned pyrite mine site.

Sánchez-Chardi A, Marques CC, Nadal J, da Luz Mathias M.

Chemosphere. 2007 Feb;67(1):121-30. Epub 2006 Nov 14.

PMID:
17107703
44.
45.
46.

Subchronic toxic effects of tributyltin (TBT) and inorganic lead (PbII) in rats.

da Silva de Assis HC, Sánchez-Chardi A, Dos Reis RC, Nicaretta L, Mencinauski C, Jakobi SC, da Silva PH, Zampronio AR, Pelletier E, de Oliveira Ribeiro CA.

Environ Toxicol Pharmacol. 2005 Jan;19(1):113-20. doi: 10.1016/j.etap.2004.05.006.

PMID:
21783467

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