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Items: 18

1.

Inhibitory effects of SEL201 in acute myeloid leukemia.

Kosciuczuk EM, Kar AK, Blyth GT, Fischietti M, Abedin S, Mina AA, Siliezar R, Rzymski T, Brzozka K, Eklund EA, Beauchamp EM, Eckerdt F, Saleiro D, Platanias LC.

Oncotarget. 2019 Dec 24;10(67):7112-7121. doi: 10.18632/oncotarget.27388. eCollection 2019 Dec 24.

2.

Synthesis of amide and sulfonamide substituted N-aryl 6-aminoquinoxalines as PFKFB3 inhibitors with improved physicochemical properties.

Boutard N, Białas A, Sabiniarz A, Guzik P, Banaszak K, Biela A, Bień M, Buda A, Bugaj B, Cieluch E, Cierpich A, Dudek Ł, Eggenweiler HM, Fogt J, Gaik M, Gondela A, Jakubiec K, Jurzak M, Kitlińska A, Kowalczyk P, Kujawa M, Kwiecińska K, Leś M, Lindemann R, Maciuszek M, Mikulski M, Niedziejko P, Obara A, Pawlik H, Rzymski T, Sieprawska-Lupa M, Sowińska M, Szeremeta-Spisak J, Stachowicz A, Tomczyk MM, Wiklik K, Włoszczak Ł, Ziemiańska S, Zarębski A, Brzózka K, Nowak M, Fabritius CH.

Bioorg Med Chem Lett. 2019 Feb 15;29(4):646-653. doi: 10.1016/j.bmcl.2018.12.034. Epub 2018 Dec 16.

PMID:
30626557
3.

Discovery and Structure-Activity Relationships of N-Aryl 6-Aminoquinoxalines as Potent PFKFB3 Kinase Inhibitors.

Boutard N, Białas A, Sabiniarz A, Guzik P, Banaszak K, Biela A, Bień M, Buda A, Bugaj B, Cieluch E, Cierpich A, Dudek Ł, Eggenweiler HM, Fogt J, Gaik M, Gondela A, Jakubiec K, Jurzak M, Kitlińska A, Kowalczyk P, Kujawa M, Kwiecińska K, Leś M, Lindemann R, Maciuszek M, Mikulski M, Niedziejko P, Obara A, Pawlik H, Rzymski T, Sieprawska-Lupa M, Sowińska M, Szeremeta-Spisak J, Stachowicz A, Tomczyk MM, Wiklik K, Włoszczak Ł, Ziemiańska S, Zarębski A, Brzózka K, Nowak M, Fabritius CH.

ChemMedChem. 2019 Jan 8;14(1):169-181. doi: 10.1002/cmdc.201800569. Epub 2018 Dec 6.

PMID:
30378281
4.

MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma.

Zhan Y, Guo J, Yang W, Goncalves C, Rzymski T, Dreas A, Żyłkiewicz E, Mikulski M, Brzózka K, Golas A, Kong Y, Ma M, Huang F, Huor B, Guo Q, da Silva SD, Torres J, Cai Y, Topisirovic I, Su J, Bijian K, Alaoui-Jamali MA, Huang S, Journe F, Ghanem GE, Miller WH Jr, Del Rincón SV.

J Clin Invest. 2017 Nov 1;127(11):4179-4192. doi: 10.1172/JCI91258. Epub 2017 Oct 16.

5.

SEL120-34A is a novel CDK8 inhibitor active in AML cells with high levels of serine phosphorylation of STAT1 and STAT5 transactivation domains.

Rzymski T, Mikula M, Żyłkiewicz E, Dreas A, Wiklik K, Gołas A, Wójcik K, Masiejczyk M, Wróbel A, Dolata I, Kitlińska A, Statkiewicz M, Kuklinska U, Goryca K, Sapała Ł, Grochowska A, Cabaj A, Szajewska-Skuta M, Gabor-Worwa E, Kucwaj K, Białas A, Radzimierski A, Combik M, Woyciechowski J, Mikulski M, Windak R, Ostrowski J, Brzózka K.

Oncotarget. 2017 May 16;8(20):33779-33795. doi: 10.18632/oncotarget.16810.

6.

Mitogen-activated Protein Kinase (MAPK) Interacting Kinases 1 and 2 (MNK1 and MNK2) as Targets for Cancer Therapy: Recent Progress in the Development of MNK Inhibitors.

Dreas A, Mikulski M, Milik M, Fabritius CH, Brzózka K, Rzymski T.

Curr Med Chem. 2017;24(28):3025-3053. doi: 10.2174/0929867324666170203123427. Review.

PMID:
28164761
7.

CDK8 kinase--An emerging target in targeted cancer therapy.

Rzymski T, Mikula M, Wiklik K, Brzózka K.

Biochim Biophys Acta. 2015 Oct;1854(10 Pt B):1617-29. doi: 10.1016/j.bbapap.2015.05.011. Epub 2015 May 22. Review.

PMID:
26006748
8.

The unfolded protein response controls induction and activation of ADAM17/TACE by severe hypoxia and ER stress.

Rzymski T, Petry A, Kračun D, Rieß F, Pike L, Harris AL, Görlach A.

Oncogene. 2012 Aug 2;31(31):3621-34. doi: 10.1038/onc.2011.522. Epub 2011 Nov 21.

PMID:
22105359
9.

Regulation of autophagy by ATF4 in response to severe hypoxia.

Rzymski T, Milani M, Pike L, Buffa F, Mellor HR, Winchester L, Pires I, Hammond E, Ragoussis I, Harris AL.

Oncogene. 2010 Aug 5;29(31):4424-35. doi: 10.1038/onc.2010.191. Epub 2010 May 31.

PMID:
20514020
10.

An oncogenic role of eIF3e/INT6 in human breast cancer.

Grzmil M, Rzymski T, Milani M, Harris AL, Capper RG, Saunders NJ, Salhan A, Ragoussis J, Norbury CJ.

Oncogene. 2010 Jul 15;29(28):4080-9. doi: 10.1038/onc.2010.152. Epub 2010 May 10.

PMID:
20453879
11.

Role of ATF4 in regulation of autophagy and resistance to drugs and hypoxia.

Rzymski T, Milani M, Singleton DC, Harris AL.

Cell Cycle. 2009 Dec;8(23):3838-47. Epub 2009 Dec 15. Review.

PMID:
19887912
12.

Hypoxic activation of the unfolded protein response (UPR) induces expression of the metastasis-associated gene LAMP3.

Mujcic H, Rzymski T, Rouschop KM, Koritzinsky M, Milani M, Harris AL, Wouters BG.

Radiother Oncol. 2009 Sep;92(3):450-9. doi: 10.1016/j.radonc.2009.08.017. Epub 2009 Aug 31.

PMID:
19726095
13.

The role of ATF4 stabilization and autophagy in resistance of breast cancer cells treated with Bortezomib.

Milani M, Rzymski T, Mellor HR, Pike L, Bottini A, Generali D, Harris AL.

Cancer Res. 2009 May 15;69(10):4415-23. doi: 10.1158/0008-5472.CAN-08-2839. Epub 2009 May 5.

14.

PHF5A represents a bridge protein between splicing proteins and ATP-dependent helicases and is differentially expressed during mouse spermatogenesis.

Rzymski T, Grzmil P, Meinhardt A, Wolf S, Burfeind P.

Cytogenet Genome Res. 2008;121(3-4):232-44. doi: 10.1159/000138890. Epub 2008 Aug 29.

PMID:
18758164
15.

Multiple pathways are involved in the anoxia response of SKIP3 including HuR-regulated RNA stability, NF-kappaB and ATF4.

Rzymski T, Paantjens A, Bod J, Harris AL.

Oncogene. 2008 Jul 31;27(33):4532-43. doi: 10.1038/onc.2008.100. Epub 2008 Apr 14.

PMID:
18408768
16.

The unfolded protein response and integrated stress response to anoxia.

Rzymski T, Harris AL.

Clin Cancer Res. 2007 May 1;13(9):2537-40.

17.

ADAM family genes testase 2alpha and 2beta are chromosomally linked and simultaneously expressed in male germ cells.

Bolcun E, Rzymski T, Nayernia K, Engel W.

Mol Reprod Dev. 2003 May;65(1):19-22.

PMID:
12658629
18.

The Caenorhabditis elegans ortholog of human PHF5a shows a muscle-specific expression domain and is essential for C. elegans morphogenetic development.

Trappe R, Schulze E, Rzymski T, Fröde S, Engel W.

Biochem Biophys Res Commun. 2002 Oct 4;297(4):1049-57.

PMID:
12359262

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