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Year Number of Results
1985 2
1986 4
1987 11
1988 23
1989 29
1990 43
1991 57
1992 84
1993 106
1994 136
1995 154
1996 158
1997 192
1998 215
1999 208
2000 274
2001 240
2002 299
2003 274
2004 315
2005 345
2006 361
2007 373
2008 336
2009 358
2010 310
2011 327
2012 370
2013 340
2014 340
2015 322
2016 299
2017 308
2018 297
2019 303
2020 333
2021 312
2022 334
2023 313
2024 62

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8,295 results

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[RyR2 mutation-linked arrhythmogenic diseases and its therapeutic strategies].
Kurebayashi N, Murayama T. Kurebayashi N, et al. Nihon Yakurigaku Zasshi. 2020;155(4):225-229. doi: 10.1254/fpj.20017. Nihon Yakurigaku Zasshi. 2020. PMID: 32612034 Review. Japanese.
The type 2 ryanodine receptor (RyR2) is a sarcoplasmic reticulum Ca(2+) release channel that plays a central role in cardiac excitation-contraction coupling. ...At present, the total number of disease-associated RyR2 mutations exceeds 300 …
The type 2 ryanodine receptor (RyR2) is a sarcoplasmic reticulum Ca(2+) release channel that plays a cent …
RYR2-ryanodinopathies: from calcium overload to calcium deficiency.
Steinberg C, Roston TM, van der Werf C, Sanatani S, Chen SRW, Wilde AAM, Krahn AD. Steinberg C, et al. Europace. 2023 Jun 2;25(6):euad156. doi: 10.1093/europace/euad156. Europace. 2023. PMID: 37387319 Free PMC article.
The sarcoplasmatic reticulum (SR) cardiac ryanodine receptor/calcium release channel RyR2 is an essential regulator of cardiac excitation-contraction coupling and intracellular calcium homeostasis. ...The pathophysiology of the dif …
The sarcoplasmatic reticulum (SR) cardiac ryanodine receptor/calcium release channel RyR2 is an es …
RyR2 Gain-of-Function and Not So Sudden Cardiac Death.
Hamilton S, Terentyev D. Hamilton S, et al. Circ Res. 2021 Jul 23;129(3):417-419. doi: 10.1161/CIRCRESAHA.121.319651. Epub 2021 Jul 22. Circ Res. 2021. PMID: 34292783 Free PMC article. No abstract available.
"Ryanopathies" and RyR2 dysfunctions: can we further decipher them using in vitro human disease models?
Sleiman Y, Lacampagne A, Meli AC. Sleiman Y, et al. Cell Death Dis. 2021 Nov 1;12(11):1041. doi: 10.1038/s41419-021-04337-9. Cell Death Dis. 2021. PMID: 34725342 Free PMC article. Review.
The ryanodine receptor (RyR), the largest intracellular calcium release channel located on the sarco/endoplasmic reticulum (SR/ER), plays a key role in the intracellular Ca(2+) handling. Abnormal type 2 ryanodine receptor (RyR2
The ryanodine receptor (RyR), the largest intracellular calcium release channel located on the sarco/endo …
RyR2 C-terminal truncating variants identified in patients with arrhythmic phenotypes exert a dominant negative effect through formation of wildtype-truncation heteromers.
Tian S, Zhong X, Wang H, Wei J, Guo W, Wang R, Paul Estillore J, Napolitano C, Duff HH, Ilhan E, Knight LM, Lloyd MS, Roberts JD, Priori SG, Chen SRW. Tian S, et al. Biochem J. 2023 Sep 13;480(17):1379-1395. doi: 10.1042/BCJ20230254. Biochem J. 2023. PMID: 37492947
Gain-of-function missense variants in the cardiac ryanodine receptor (RyR2) are linked to catecholaminergic polymorphic ventricular tachycardia (CPVT), whereas RyR2 loss-of-function missense variants cause Ca2+ release deficiency syndrome (CRDS) …
Gain-of-function missense variants in the cardiac ryanodine receptor (RyR2) are linked to catecholaminergic polymorphic …
RyR2 phosphorylation alters dyad architecture.
Short B. Short B. J Gen Physiol. 2024 Apr 1;156(4):e202413569. doi: 10.1085/jgp.202413569. Epub 2024 Mar 7. J Gen Physiol. 2024. PMID: 38451203 Free article.
Physiol.https://doi.org/10.1085/jgp.202213108) indicates that beta-adrenergic signaling enlarges dyads and reorganizes RyR2 tetramers in cardiomyocytes....
Physiol.https://doi.org/10.1085/jgp.202213108) indicates that beta-adrenergic signaling enlarges dyads and reorganizes RyR2 tetramers …
Ryanodine receptor 2 (RYR2) dysfunction activates the unfolded protein response and perturbs cardiomyocyte maturation.
Guo Y, Cao Y, Jardin BD, Zhang X, Zhou P, Guatimosim S, Lin J, Chen Z, Zhang Y, Mazumdar N, Lu F, Ma Q, Lu YW, Zhao M, Wang DZ, Dong E, Pu WT. Guo Y, et al. Cardiovasc Res. 2023 Mar 17;119(1):221-235. doi: 10.1093/cvr/cvac077. Cardiovasc Res. 2023. PMID: 35576474 Free PMC article.
AIMS: Calcium-handling capacity is a major gauge of cardiomyocyte maturity. Ryanodine receptor 2 (RYR2) is the pre-dominant calcium channel that releases calcium from the sarcoplasmic reticulum/endoplasmic reticulum (SR/ER) to acti …
AIMS: Calcium-handling capacity is a major gauge of cardiomyocyte maturity. Ryanodine receptor 2 (RYR2) is the p …
Direct regulation of the cardiac ryanodine receptor (RyR2) by O-GlcNAcylation.
Okolo CA, Khaing EP, Mereacre V, Wallace RS, Munro ML, Erickson JR, Jones PP. Okolo CA, et al. Cardiovasc Diabetol. 2023 Oct 13;22(1):276. doi: 10.1186/s12933-023-02010-3. Cardiovasc Diabetol. 2023. PMID: 37833717 Free PMC article.
We have previously shown that O-GlcNAcylation can trigger arrhythmias by indirectly increasing pathological Ca(2+) leak through the cardiac ryanodine receptor (RyR2) via Ca(2+)/calmodulin-dependent kinase II (CaMKII). ...The site of O-GlcNAcylation within …
We have previously shown that O-GlcNAcylation can trigger arrhythmias by indirectly increasing pathological Ca(2+) leak through the cardiac …
8,295 results