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The unfolded protein response in metazoan development.

Mitra S, Ryoo HD.

J Cell Sci. 2019 Feb 15;132(5). pii: jcs217216. doi: 10.1242/jcs.217216. Review.


highroad Is a Carboxypetidase Induced by Retinoids to Clear Mutant Rhodopsin-1 in Drosophila Retinitis Pigmentosa Models.

Huang HW, Brown B, Chung J, Domingos PM, Ryoo HD.

Cell Rep. 2018 Feb 6;22(6):1384-1391. doi: 10.1016/j.celrep.2018.01.032.


The GCN2-ATF4 Signaling Pathway Induces 4E-BP to Bias Translation and Boost Antimicrobial Peptide Synthesis in Response to Bacterial Infection.

Vasudevan D, Clark NK, Sam J, Cotham VC, Ueberheide B, Marr MT 2nd, Ryoo HD.

Cell Rep. 2017 Nov 21;21(8):2039-2047. doi: 10.1016/j.celrep.2017.10.096.


Two distinct nodes of translational inhibition in the Integrated Stress Response.

Ryoo HD, Vasudevan D.

BMB Rep. 2017 Nov;50(11):539-545. Review.


The requirement of IRE1 and XBP1 in resolving physiological stress during Drosophila development.

Huang HW, Zeng X, Rhim T, Ron D, Ryoo HD.

J Cell Sci. 2017 Sep 15;130(18):3040-3049. doi: 10.1242/jcs.203612. Epub 2017 Aug 3.


4E-BP is a target of the GCN2-ATF4 pathway during Drosophila development and aging.

Kang MJ, Vasudevan D, Kang K, Kim K, Park JE, Zhang N, Zeng X, Neubert TA, Marr MT 2nd, Ryoo HD.

J Cell Biol. 2017 Jan 2;216(1):115-129. doi: 10.1083/jcb.201511073. Epub 2016 Dec 15.


Long and short (timeframe) of endoplasmic reticulum stress-induced cell death.

Ryoo HD.

FEBS J. 2016 Oct;283(20):3718-3722. doi: 10.1111/febs.13755. Epub 2016 Jun 6. Review.


Detection of Cell Death in Drosophila Tissues.

Vasudevan D, Ryoo HD.

Methods Mol Biol. 2016;1419:131-44. doi: 10.1007/978-1-4939-3581-9_11.


Adaptive preconditioning in neurological diseases - therapeutic insights from proteostatic perturbations.

Mollereau B, Rzechorzek NM, Roussel BD, Sedru M, Van den Brink DM, Bailly-Maitre B, Palladino F, Medinas DB, Domingos PM, Hunot S, Chandran S, Birman S, Baron T, Vivien D, Duarte CB, Ryoo HD, Steller H, Urano F, Chevet E, Kroemer G, Ciechanover A, Calabrese EJ, Kaufman RJ, Hetz C.

Brain Res. 2016 Oct 1;1648(Pt B):603-616. doi: 10.1016/j.brainres.2016.02.033. Epub 2016 Mar 2. Review.


Regulation of Cell Death by IAPs and Their Antagonists.

Vasudevan D, Ryoo HD.

Curr Top Dev Biol. 2015;114:185-208. doi: 10.1016/bs.ctdb.2015.07.026. Epub 2015 Sep 11. Review.


Correction: Expression of Human Gaucher Disease Gene GBA Generates Neurodevelopmental Defects and ER Stress in Drosophila Eye.

Suzuki T, Shimoda M, Ito K, Hanai S, Aizawa H, Kato T, Kawasaki K, Yamaguchi T, Ryoo HD, Goto-Inoue N, Setou M, Tsuji S, Ishida N.

PLoS One. 2015 Aug 19;10(8):e0135619. doi: 10.1371/journal.pone.0135619. eCollection 2015. No abstract available.


Drosophila as a model for unfolded protein response research.

Ryoo HD.

BMB Rep. 2015 Aug;48(8):445-53. Review.


A Drosophila Reporter for the Translational Activation of ATF4 Marks Stressed Cells during Development.

Kang K, Ryoo HD, Park JE, Yoon JH, Kang MJ.

PLoS One. 2015 May 15;10(5):e0126795. doi: 10.1371/journal.pone.0126795. eCollection 2015.


PERK Limits Drosophila Lifespan by Promoting Intestinal Stem Cell Proliferation in Response to ER Stress.

Wang L, Ryoo HD, Qi Y, Jasper H.

PLoS Genet. 2015 May 6;11(5):e1005220. doi: 10.1371/journal.pgen.1005220. eCollection 2015 May.


Role of Drosophila EDEMs in the degradation of the alpha-1-antitrypsin Z variant.

Jang BY, Ryoo HD, Son J, Choi KC, Shin DM, Kang SW, Kang MJ.

Int J Mol Med. 2015 Apr;35(4):870-6. doi: 10.3892/ijmm.2015.2109. Epub 2015 Feb 25.


Integration of UPRER and oxidative stress signaling in the control of intestinal stem cell proliferation.

Wang L, Zeng X, Ryoo HD, Jasper H.

PLoS Genet. 2014 Aug 28;10(8):e1004568. doi: 10.1371/journal.pgen.1004568. eCollection 2014 Aug.


Hyperactivated Wnt signaling induces synthetic lethal interaction with Rb inactivation by elevating TORC1 activities.

Zhang T, Liao Y, Hsu FN, Zhang R, Searle JS, Pei X, Li X, Ryoo HD, Ji JY, Du W.

PLoS Genet. 2014 May 8;10(5):e1004357. doi: 10.1371/journal.pgen.1004357. eCollection 2014 May.


CDK7 regulates the mitochondrial localization of a tail-anchored proapoptotic protein, Hid.

Morishita J, Kang MJ, Fidelin K, Ryoo HD.

Cell Rep. 2013 Dec 26;5(6):1481-8. doi: 10.1016/j.celrep.2013.11.030. Epub 2013 Dec 19.


Xbp1-independent Ire1 signaling is required for photoreceptor differentiation and rhabdomere morphogenesis in Drosophila.

Coelho DS, CairrĂ£o F, Zeng X, Pires E, Coelho AV, Ron D, Ryoo HD, Domingos PM.

Cell Rep. 2013 Nov 14;5(3):791-801. doi: 10.1016/j.celrep.2013.09.046. Epub 2013 Oct 31.


Drosophila XBP1 expression reporter marks cells under endoplasmic reticulum stress and with high protein secretory load.

Ryoo HD, Li J, Kang MJ.

PLoS One. 2013 Sep 30;8(9):e75774. doi: 10.1371/journal.pone.0075774. eCollection 2013.


Expression of human Gaucher disease gene GBA generates neurodevelopmental defects and ER stress in Drosophila eye.

Suzuki T, Shimoda M, Ito K, Hanai S, Aizawa H, Kato T, Kawasaki K, Yamaguchi T, Ryoo HD, Goto-Inoue N, Setou M, Tsuji S, Ishida N.

PLoS One. 2013 Aug 2;8(8):e69147. doi: 10.1371/journal.pone.0069147. Print 2013. Erratum in: PLoS One. 2015;10(8):e0135619.


A modified UPR stress sensing system reveals a novel tissue distribution of IRE1/XBP1 activity during normal Drosophila development.

Sone M, Zeng X, Larese J, Ryoo HD.

Cell Stress Chaperones. 2013 May;18(3):307-19. doi: 10.1007/s12192-012-0383-x. Epub 2012 Nov 17.


Drosophila p53 isoforms differentially regulate apoptosis and apoptosis-induced proliferation.

Dichtel-Danjoy ML, Ma D, Dourlen P, Chatelain G, Napoletano F, Robin M, Corbet M, Levet C, Hafsi H, Hainaut P, Ryoo HD, Bourdon JC, Mollereau B.

Cell Death Differ. 2013 Jan;20(1):108-16. doi: 10.1038/cdd.2012.100. Epub 2012 Aug 17.


The role of apoptosis-induced proliferation for regeneration and cancer.

Ryoo HD, Bergmann A.

Cold Spring Harb Perspect Biol. 2012 Aug 1;4(8):a008797. doi: 10.1101/cshperspect.a008797. Review.


Compensatory proliferation and apoptosis-induced proliferation: a need for clarification.

Mollereau B, Perez-Garijo A, Bergmann A, Miura M, Gerlitz O, Ryoo HD, Steller H, Morata G.

Cell Death Differ. 2013 Jan;20(1):181. doi: 10.1038/cdd.2012.82. Epub 2012 Jun 22. No abstract available.


Pro-apoptotic signaling pathway by CDK5 and MEKK1.

Ryoo HD.

Cell Cycle. 2012 May 1;11(9):1746-7. doi: 10.4161/cc.20184. Epub 2012 May 1. No abstract available.


Drosophila BRUCE inhibits apoptosis through non-lysine ubiquitination of the IAP-antagonist REAPER.

Domingues C, Ryoo HD.

Cell Death Differ. 2012 Mar;19(3):470-7. doi: 10.1038/cdd.2011.116. Epub 2011 Sep 2.


Distinct death mechanisms in Drosophila development.

Ryoo HD, Baehrecke EH.

Curr Opin Cell Biol. 2010 Dec;22(6):889-95. doi: 10.1016/ Epub 2010 Sep 16. Review.


Drosophila IAP antagonists form multimeric complexes to promote cell death.

Sandu C, Ryoo HD, Steller H.

J Cell Biol. 2010 Sep 20;190(6):1039-52. doi: 10.1083/jcb.201004086. Epub 2010 Sep 13.


Impaired tissue growth is mediated by checkpoint kinase 1 (CHK1) in the integrated stress response.

Malzer E, Daly ML, Moloney A, Sendall TJ, Thomas SE, Ryder E, Ryoo HD, Crowther DC, Lomas DA, Marciniak SJ.

J Cell Sci. 2010 Sep 1;123(Pt 17):2892-900. doi: 10.1242/jcs.070078. Epub 2010 Aug 3.


Suppression of retinal degeneration in Drosophila by stimulation of ER-associated degradation.

Kang MJ, Ryoo HD.

Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):17043-8. doi: 10.1073/pnas.0905566106. Epub 2009 Sep 23.


Hyung Don Ryoo: a healthy career in cellular death.

Ryoo HD.

J Cell Biol. 2009 Jun 1;185(5):758-9. doi: 10.1083/jcb.1855pi. No abstract available.


ER stress protects from retinal degeneration.

Mendes CS, Levet C, Chatelain G, Dourlen P, Fouillet A, Dichtel-Danjoy ML, Gambis A, Ryoo HD, Steller H, Mollereau B.

EMBO J. 2009 May 6;28(9):1296-307. doi: 10.1038/emboj.2009.76. Epub 2009 Apr 2.


Regulation of the Drosophila apoptosome through feedback inhibition.

Shapiro PJ, Hsu HH, Jung H, Robbins ES, Ryoo HD.

Nat Cell Biol. 2008 Dec;10(12):1440-6. doi: 10.1038/ncb1803. Epub 2008 Nov 16.


Ero1L, a thiol oxidase, is required for Notch signaling through cysteine bridge formation of the Lin12-Notch repeats in Drosophila melanogaster.

Tien AC, Rajan A, Schulze KL, Ryoo HD, Acar M, Steller H, Bellen HJ.

J Cell Biol. 2008 Sep 22;182(6):1113-25. doi: 10.1083/jcb.200805001.


STAT92E is a positive regulator of Drosophila inhibitor of apoptosis 1 (DIAP/1) and protects against radiation-induced apoptosis.

Betz A, Ryoo HD, Steller H, Darnell JE Jr.

Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):13805-10. doi: 10.1073/pnas.0806291105. Epub 2008 Sep 8.


Unfolded protein response in Drosophila: why another model can make it fly.

Ryoo HD, Steller H.

Cell Cycle. 2007 Apr 1;6(7):830-5. Epub 2007 Apr 23. Review.


Regulation of the Drosophila ubiquitin ligase DIAP1 is mediated via several distinct ubiquitin system pathways.

Herman-Bachinsky Y, Ryoo HD, Ciechanover A, Gonen H.

Cell Death Differ. 2007 Apr;14(4):861-71. Epub 2007 Jan 5.


Unfolded protein response in a Drosophila model for retinal degeneration.

Ryoo HD, Domingos PM, Kang MJ, Steller H.

EMBO J. 2007 Jan 10;26(1):242-52. Epub 2006 Dec 14.


Hippo and its mission for growth control.

Ryoo HD, Steller H.

Nat Cell Biol. 2003 Oct;5(10):853-5. No abstract available.


Specificity of Distalless repression and limb primordia development by abdominal Hox proteins.

Gebelein B, Culi J, Ryoo HD, Zhang W, Mann RS.

Dev Cell. 2002 Oct;3(4):487-98.


Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1.

Ryoo HD, Bergmann A, Gonen H, Ciechanover A, Steller H.

Nat Cell Biol. 2002 Jun;4(6):432-8. Erratum in: Nat Cell Biol 2002 Jul;4(7):546.


Regulation of Hox target genes by a DNA bound Homothorax/Hox/Extradenticle complex.

Ryoo HD, Marty T, Casares F, Affolter M, Mann RS.

Development. 1999 Nov;126(22):5137-48.


The control of trunk Hox specificity and activity by Extradenticle.

Ryoo HD, Mann RS.

Genes Dev. 1999 Jul 1;13(13):1704-16.


Structure of a DNA-bound Ultrabithorax-Extradenticle homeodomain complex.

Passner JM, Ryoo HD, Shen L, Mann RS, Aggarwal AK.

Nature. 1999 Feb 25;397(6721):714-9.


Synergistic activation of a Drosophila enhancer by HOM/EXD and DPP signaling.

Grieder NC, Marty T, Ryoo HD, Mann RS, Affolter M.

EMBO J. 1997 Dec 15;16(24):7402-10.


Nuclear translocation of extradenticle requires homothorax, which encodes an extradenticle-related homeodomain protein.

Rieckhof GE, Casares F, Ryoo HD, Abu-Shaar M, Mann RS.

Cell. 1997 Oct 17;91(2):171-83.

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