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Items: 1 to 50 of 152

1.

Bardoxolone methyl as a novel potent antiviral agent against hepatitis B and C viruses in human hepatocyte cell culture systems.

Nio Y, Sasai M, Akahori Y, Okamura H, Hasegawa H, Oshima M, Watashi K, Wakita T, Ryo A, Tanaka Y, Hijikata M.

Antiviral Res. 2019 Sep;169:104537. doi: 10.1016/j.antiviral.2019.104537. Epub 2019 Jun 14.

PMID:
31207277
2.

Allosteric Regulation of HIV-1 Capsid Structure for Gag Assembly, Virion Production, and Viral Infectivity by a Disordered Interdomain Linker.

Koma T, Kotani O, Miyakawa K, Ryo A, Yokoyama M, Doi N, Adachi A, Sato H, Nomaguchi M.

J Virol. 2019 Aug 13;93(17). pii: e00381-19. doi: 10.1128/JVI.00381-19. Print 2019 Sep 1.

PMID:
31189701
3.

Variation of human norovirus GII genotypes detected in Ibaraki, Japan, during 2012-2018.

Motoya T, Umezawa M, Saito A, Goto K, Doi I, Fukaya S, Nagata N, Ikeda Y, Okayama K, Aso J, Matsushima Y, Ishioka T, Ryo A, Sasaki N, Katayama K, Kimura H.

Gut Pathog. 2019 May 24;11:26. doi: 10.1186/s13099-019-0303-z. eCollection 2019.

4.

PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation.

Miyakawa K, Matsunaga S, Yokoyama M, Nomaguchi M, Kimura Y, Nishi M, Kimura H, Sato H, Hirano H, Tamura T, Akari H, Miura T, Adachi A, Sawasaki T, Yamamoto N, Ryo A.

Nat Commun. 2019 Apr 23;10(1):1844. doi: 10.1038/s41467-019-09867-7.

5.

PI3K/AKT/mTOR Pathway Alterations Promote Malignant Progression and Xenograft Formation in Oligodendroglial Tumors.

Tateishi K, Nakamura T, Juratli TA, Williams EA, Matsushita Y, Miyake S, Nishi M, Miller JJ, Tummala SS, Fink AL, Lelic N, Koerner MVA, Miyake Y, Sasame J, Fujimoto K, Tanaka T, Minamimoto R, Matsunaga S, Mukaihara S, Shuto T, Taguchi H, Udaka N, Murata H, Ryo A, Yamanaka S, Curry WT, Dias-Santagata D, Yamamoto T, Ichimura K, Batchelor TT, Chi AS, Iafrate AJ, Wakimoto H, Cahill DP.

Clin Cancer Res. 2019 Jul 15;25(14):4375-4387. doi: 10.1158/1078-0432.CCR-18-4144. Epub 2019 Apr 11.

PMID:
30975663
6.

Epidermal growth factor receptor is a host-entry cofactor triggering hepatitis B virus internalization.

Iwamoto M, Saso W, Sugiyama R, Ishii K, Ohki M, Nagamori S, Suzuki R, Aizaki H, Ryo A, Yun JH, Park SY, Ohtani N, Muramatsu M, Iwami S, Tanaka Y, Sureau C, Wakita T, Watashi K.

Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8487-8492. doi: 10.1073/pnas.1811064116. Epub 2019 Apr 5.

PMID:
30952782
7.

Prolyl Isomerase Pin1 Suppresses Thermogenic Programs in Adipocytes by Promoting Degradation of Transcriptional Co-activator PRDM16.

Nakatsu Y, Matsunaga Y, Yamamotoya T, Ueda K, Inoue MK, Mizuno Y, Nakanishi M, Sano T, Yamawaki Y, Kushiyama A, Sakoda H, Fujishiro M, Ryo A, Ono H, Minamino T, Takahashi SI, Ohno H, Yoneda M, Takahashi K, Ishihara H, Katagiri H, Nishimura F, Kanematsu T, Yamada T, Asano T.

Cell Rep. 2019 Mar 19;26(12):3221-3230.e3. doi: 10.1016/j.celrep.2019.02.066.

8.

A novel inhibitor of tumorspheres reveals the activation of the serine biosynthetic pathway upon mitochondrial inhibition.

Subedi A, Muroi M, Futamura Y, Kawamura T, Aono H, Nishi M, Ryo A, Watanabe N, Osada H.

FEBS Lett. 2019 Apr;593(8):763-776. doi: 10.1002/1873-3468.13361. Epub 2019 Mar 23.

PMID:
30874300
9.

The Association Between Documentation of Koplik Spots and Laboratory Diagnosis of Measles and Other Rash Diseases in a National Measles Surveillance Program in Japan.

Kimura H, Shirabe K, Takeda M, Kobayashi M, Tsukagoshi H, Okayama K, Ryo A, Nagasawa K, Okabe N, Minagawa H, Kozawa K.

Front Microbiol. 2019 Feb 18;10:269. doi: 10.3389/fmicb.2019.00269. eCollection 2019.

10.

Molecular Evolutionary Analyses of the RNA-Dependent RNA Polymerase Region in Norovirus Genogroup II.

Ozaki K, Matsushima Y, Nagasawa K, Motoya T, Ryo A, Kuroda M, Katayama K, Kimura H.

Front Microbiol. 2018 Dec 18;9:3070. doi: 10.3389/fmicb.2018.03070. eCollection 2018.

11.

Production and characterization of monoclonal antibodies specific for major capsid VP1 protein of trichodysplasia spinulosa-associated polyomavirus.

Khatun H, Yamaoka Y, Matsushima Y, Matsunaga S, Kimura H, Ho J, Shuda M, Ryo A.

Microbiol Immunol. 2018 Dec;62(12):763-773. doi: 10.1111/1348-0421.12662.

PMID:
30537287
12.

TROY expression is associated with pathological stage and poor prognosis in patients treated with radical cystectomy.

Nomura M, Matsumoto K, Shimizu Y, Ikeda M, Amano N, Nishi M, Ryo A, Nagashio R, Sato Y, Iwamura M.

Cancer Biomark. 2019;24(1):91-96. doi: 10.3233/CBM-181911.

PMID:
30475756
13.

Recapitulation of hepatitis B virus-host interactions in liver organoids from human induced pluripotent stem cells.

Nie YZ, Zheng YW, Miyakawa K, Murata S, Zhang RR, Sekine K, Ueno Y, Takebe T, Wakita T, Ryo A, Taniguchi H.

EBioMedicine. 2018 Sep;35:114-123. doi: 10.1016/j.ebiom.2018.08.014. Epub 2018 Aug 16.

14.

Cocirculation of Influenza C Viruses with Distinct Internal Genome Constellations in Iwate Prefecture, Japan, in 2016.

Takahashi M, Obara T, Matsuzaki Y, Maisawa SI, Sasaki Y, Yoshino N, Shirasawa A, Iwabuchi K, Takahashi T, Kajita H, Ono Y, Ryo A, Kimura H, Muraki Y.

Jpn J Infect Dis. 2018 Sep 21;71(5):393-395. doi: 10.7883/yoken.JJID.2018.204. Epub 2018 Jul 31. No abstract available.

15.

Development of a cell-based assay to identify hepatitis B virus entry inhibitors targeting the sodium taurocholate cotransporting polypeptide.

Miyakawa K, Matsunaga S, Yamaoka Y, Dairaku M, Fukano K, Kimura H, Chimuro T, Nishitsuji H, Watashi K, Shimotohno K, Wakita T, Ryo A.

Oncotarget. 2018 May 4;9(34):23681-23694. doi: 10.18632/oncotarget.25348. eCollection 2018 May 4.

16.

A new strategy to identify hepatitis B virus entry inhibitors by AlphaScreen technology targeting the envelope-receptor interaction.

Saso W, Tsukuda S, Ohashi H, Fukano K, Morishita R, Matsunaga S, Ohki M, Ryo A, Park SY, Suzuki R, Aizaki H, Muramatsu M, Sureau C, Wakita T, Matano T, Watashi K.

Biochem Biophys Res Commun. 2018 Jun 22;501(2):374-379. doi: 10.1016/j.bbrc.2018.04.187. Epub 2018 May 11.

PMID:
29730285
17.

Lnc RNA H19 is associated with poor prognosis in breast cancer patients and promotes cancer stemness.

Shima H, Kida K, Adachi S, Yamada A, Sugae S, Narui K, Miyagi Y, Nishi M, Ryo A, Murata S, Taniguchi H, Ichikawa Y, Ishikawa T, Endo I.

Breast Cancer Res Treat. 2018 Aug;170(3):507-516. doi: 10.1007/s10549-018-4793-z. Epub 2018 Apr 24.

PMID:
29693231
18.

Molecular mechanisms of Streptococcus pneumoniae-targeted autophagy via pneumolysin, Golgi-resident Rab41, and Nedd4-1-mediated K63-linked ubiquitination.

Ogawa M, Matsuda R, Takada N, Tomokiyo M, Yamamoto S, Shizukusihi S, Yamaji T, Yoshikawa Y, Yoshida M, Tanida I, Koike M, Murai M, Morita H, Takeyama H, Ryo A, Guan JL, Yamamoto M, Inoue JI, Yanagawa T, Fukuda M, Kawabe H, Ohnishi M.

Cell Microbiol. 2018 Aug;20(8):e12846. doi: 10.1111/cmi.12846. Epub 2018 Apr 22.

PMID:
29582580
19.

Interferon sensitivity-determining region of hepatitis C virus influences virus production and interferon signaling.

Sugiyama R, Murayama A, Nitta S, Yamada N, Tasaka-Fujita M, Masaki T, Aly HH, Shiina M, Ryo A, Ishii K, Wakita T, Kato T.

Oncotarget. 2017 Dec 21;9(5):5627-5640. doi: 10.18632/oncotarget.23562. eCollection 2018 Jan 19.

20.

Chemical array system, a platform to identify novel hepatitis B virus entry inhibitors targeting sodium taurocholate cotransporting polypeptide.

Kaneko M, Futamura Y, Tsukuda S, Kondoh Y, Sekine T, Hirano H, Fukano K, Ohashi H, Saso W, Morishita R, Matsunaga S, Kawai F, Ryo A, Park SY, Suzuki R, Aizaki H, Ohtani N, Sureau C, Wakita T, Osada H, Watashi K.

Sci Rep. 2018 Feb 9;8(1):2769. doi: 10.1038/s41598-018-20987-w.

21.

Detailed genetic analyses of the HN gene in human respirovirus 3 detected in children with acute respiratory illness in the Iwate Prefecture, Japan.

Takahashi M, Nagasawa K, Saito K, Maisawa SI, Fujita K, Murakami K, Kuroda M, Ryo A, Kimura H.

Infect Genet Evol. 2018 Apr;59:155-162. doi: 10.1016/j.meegid.2018.01.021. Epub 2018 Feb 14.

PMID:
29408530
22.

Genetic Analysis of Human Norovirus Strains in Japan in 2016-2017.

Nagasawa K, Matsushima Y, Motoya T, Mizukoshi F, Ueki Y, Sakon N, Murakami K, Shimizu T, Okabe N, Nagata N, Shirabe K, Shinomiya H, Suzuki W, Kuroda M, Sekizuka T, Suzuki Y, Ryo A, Fujita K, Oishi K, Katayama K, Kimura H.

Front Microbiol. 2018 Jan 18;9:1. doi: 10.3389/fmicb.2018.00001. eCollection 2018.

23.

Phylogeny and Immunoreactivity of Norovirus GII.P16-GII.2, Japan, Winter 2016-17.

Nagasawa K, Matsushima Y, Motoya T, Mizukoshi F, Ueki Y, Sakon N, Murakami K, Shimizu T, Okabe N, Nagata N, Shirabe K, Shinomiya H, Suzuki W, Kuroda M, Sekizuka T, Ryo A, Fujita K, Oishi K, Katayama K, Kimura H.

Emerg Infect Dis. 2018 Jan;24(1):144-148. doi: 10.3201/eid2401.170284.

24.

Molecular Evolution of the VP1 Gene in Human Norovirus GII.4 Variants in 1974-2015.

Motoya T, Nagasawa K, Matsushima Y, Nagata N, Ryo A, Sekizuka T, Yamashita A, Kuroda M, Morita Y, Suzuki Y, Sasaki N, Katayama K, Kimura H.

Front Microbiol. 2017 Dec 5;8:2399. doi: 10.3389/fmicb.2017.02399. eCollection 2017.

25.

Salinomycin kills cancer stem cells by sequestering iron in lysosomes.

Mai TT, Hamaï A, Hienzsch A, Cañeque T, Müller S, Wicinski J, Cabaud O, Leroy C, David A, Acevedo V, Ryo A, Ginestier C, Birnbaum D, Charafe-Jauffret E, Codogno P, Mehrpour M, Rodriguez R.

Nat Chem. 2017 Oct;9(10):1025-1033. doi: 10.1038/nchem.2778. Epub 2017 May 16.

26.

Functional association of cellular microtubules with viral capsid assembly supports efficient hepatitis B virus replication.

Iwamoto M, Cai D, Sugiyama M, Suzuki R, Aizaki H, Ryo A, Ohtani N, Tanaka Y, Mizokami M, Wakita T, Guo H, Watashi K.

Sci Rep. 2017 Sep 6;7(1):10620. doi: 10.1038/s41598-017-11015-4.

27.

Inhibitory effects of metachromin A on hepatitis B virus production via impairment of the viral promoter activity.

Yamashita A, Tamaki M, Kasai H, Tanaka T, Otoguro T, Ryo A, Maekawa S, Enomoto N, de Voogd NJ, Tanaka J, Moriishi K.

Antiviral Res. 2017 Sep;145:136-145. doi: 10.1016/j.antiviral.2017.08.001. Epub 2017 Aug 4.

PMID:
28827084
28.

A method for detecting rash and fever illness-associated viruses using multiplex reverse transcription polymerase chain reaction.

Matsushima Y, Shimizu T, Doi I, Mizukoshi F, Nagasawa K, Ryo A, Shimizu H, Kobayashi M, Funatogawa K, Nagata N, Ishikawa M, Komane A, Okabe N, Mori Y, Takeda M, Kimura H.

Microbiol Immunol. 2017 Aug;61(8):337-344. doi: 10.1111/1348-0421.12502.

29.

Differences in Three-Dimensional Geometric Recognition by Non-Cancerous and Cancerous Epithelial Cells on Microgroove-Based Topography.

Kushiro K, Yaginuma T, Ryo A, Takai M.

Sci Rep. 2017 Jun 26;7(1):4244. doi: 10.1038/s41598-017-03779-6.

30.

Editorial: Perspectives for the Next Generation of Virus Research: Spearheading the Use of Innovative Technologies and Methodologies.

Yamamoto T, Honda A, Sato T, Ryo A.

Front Microbiol. 2017 May 11;8:758. doi: 10.3389/fmicb.2017.00758. eCollection 2017. No abstract available.

31.

Molecular Evolution of the RNA-Dependent RNA Polymerase and Capsid Genes of Human Norovirus Genotype GII.2 in Japan during 2004-2015.

Mizukoshi F, Nagasawa K, Doan YH, Haga K, Yoshizumi S, Ueki Y, Shinohara M, Ishikawa M, Sakon N, Shigemoto N, Okamoto-Nakagawa R, Ochi A, Murakami K, Ryo A, Suzuki Y, Katayama K, Kimura H.

Front Microbiol. 2017 Apr 25;8:705. doi: 10.3389/fmicb.2017.00705. eCollection 2017.

32.

Molecular evolution of the fusion protein (F) gene in human respiratory syncytial virus subgroup B.

Kimura H, Nagasawa K, Kimura R, Tsukagoshi H, Matsushima Y, Fujita K, Hirano E, Ishiwada N, Misaki T, Oishi K, Kuroda M, Ryo A.

Infect Genet Evol. 2017 Aug;52:1-9. doi: 10.1016/j.meegid.2017.04.015. Epub 2017 Apr 14.

PMID:
28414106
33.

Genetic analyses of the fusion protein genes in human parainfluenza virus types 1 and 3 among patients with acute respiratory infections in Eastern Japan from 2011 to 2015.

Tsutsui R, Tsukagoshi H, Nagasawa K, Takahashi M, Matsushima Y, Ryo A, Kuroda M, Takami H, Kimura H.

J Med Microbiol. 2017 Feb;66(2):160-168. doi: 10.1099/jmm.0.000431.

PMID:
28266286
34.

Mutations in genes encoding polycomb repressive complex 2 subunits cause Weaver syndrome.

Imagawa E, Higashimoto K, Sakai Y, Numakura C, Okamoto N, Matsunaga S, Ryo A, Sato Y, Sanefuji M, Ihara K, Takada Y, Nishimura G, Saitsu H, Mizuguchi T, Miyatake S, Nakashima M, Miyake N, Soejima H, Matsumoto N.

Hum Mutat. 2017 Jun;38(6):637-648. doi: 10.1002/humu.23200. Epub 2017 Mar 15.

PMID:
28229514
35.

The tumour suppressor APC promotes HIV-1 assembly via interaction with Gag precursor protein.

Miyakawa K, Nishi M, Matsunaga S, Okayama A, Anraku M, Kudoh A, Hirano H, Kimura H, Morikawa Y, Yamamoto N, Ono A, Ryo A.

Nat Commun. 2017 Jan 30;8:14259. doi: 10.1038/ncomms14259.

36.

Complete Genome Sequence of a Recombinant GII.P16-GII.4 Norovirus Detected in Kawasaki City, Japan, in 2016.

Matsushima Y, Shimizu T, Ishikawa M, Komane A, Okabe N, Ryo A, Kimura H, Katayama K, Shimizu H.

Genome Announc. 2016 Oct 6;4(5). pii: e01099-16. doi: 10.1128/genomeA.01099-16.

37.

Lyn Kinase Suppresses the Transcriptional Activity of IRF5 in the TLR-MyD88 Pathway to Restrain the Development of Autoimmunity.

Ban T, Sato GR, Nishiyama A, Akiyama A, Takasuna M, Umehara M, Suzuki S, Ichino M, Matsunaga S, Kimura A, Kimura Y, Yanai H, Miyashita S, Kuromitsu J, Tsukahara K, Yoshimatsu K, Endo I, Yamamoto T, Hirano H, Ryo A, Taniguchi T, Tamura T.

Immunity. 2016 Aug 16;45(2):319-32. doi: 10.1016/j.immuni.2016.07.015. Epub 2016 Aug 9.

38.

Inhibitory effect of CDK9 inhibitor FIT-039 on hepatitis B virus propagation.

Tanaka T, Okuyama-Dobashi K, Murakami S, Chen W, Okamoto T, Ueda K, Hosoya T, Matsuura Y, Ryo A, Tanaka Y, Hagiwara M, Moriishi K.

Antiviral Res. 2016 Sep;133:156-64. doi: 10.1016/j.antiviral.2016.08.008. Epub 2016 Aug 8.

PMID:
27515132
39.

Pathogen profiles and molecular epidemiology of respiratory viruses in Japanese inpatients with community-acquired pneumonia.

Kurai D, Sasaki Y, Saraya T, Ishii H, Tsukagoshi H, Kozawa K, Ryo A, Ishioka T, Kuroda M, Oishi K, Takizawa H, Kimura H.

Respir Investig. 2016 Jul;54(4):255-63. doi: 10.1016/j.resinv.2016.01.001. Epub 2016 Mar 17.

PMID:
27424825
40.

Molecular evolution of the capsid gene in human norovirus genogroup II.

Kobayashi M, Matsushima Y, Motoya T, Sakon N, Shigemoto N, Okamoto-Nakagawa R, Nishimura K, Yamashita Y, Kuroda M, Saruki N, Ryo A, Saraya T, Morita Y, Shirabe K, Ishikawa M, Takahashi T, Shinomiya H, Okabe N, Nagasawa K, Suzuki Y, Katayama K, Kimura H.

Sci Rep. 2016 Jul 7;6:29400. doi: 10.1038/srep29400.

41.

H11/HSPB8 Restricts HIV-2 Vpx to Restore the Anti-Viral Activity of SAMHD1.

Kudoh A, Miyakawa K, Matsunaga S, Matsushima Y, Kosugi I, Kimura H, Hayakawa S, Sawasaki T, Ryo A.

Front Microbiol. 2016 Jun 13;7:883. doi: 10.3389/fmicb.2016.00883. eCollection 2016.

42.

High-throughput screening identifies artesunate as selective inhibitor of cancer stemness: Involvement of mitochondrial metabolism.

Subedi A, Futamura Y, Nishi M, Ryo A, Watanabe N, Osada H.

Biochem Biophys Res Commun. 2016 Sep 2;477(4):737-742. doi: 10.1016/j.bbrc.2016.06.128. Epub 2016 Jun 27.

PMID:
27363336
43.

Molecular evolution of the fusion protein gene in human respiratory syncytial virus subgroup A.

Kimura H, Nagasawa K, Tsukagoshi H, Matsushima Y, Fujita K, Yoshida LM, Tanaka R, Ishii H, Shimojo N, Kuroda M, Ryo A.

Infect Genet Evol. 2016 Sep;43:398-406. doi: 10.1016/j.meegid.2016.06.019. Epub 2016 Jun 9.

PMID:
27291709
44.

Development of Monoclonal Antibody and Diagnostic Test for Middle East Respiratory Syndrome Coronavirus Using Cell-Free Synthesized Nucleocapsid Antigen.

Yamaoka Y, Matsuyama S, Fukushi S, Matsunaga S, Matsushima Y, Kuroyama H, Kimura H, Takeda M, Chimuro T, Ryo A.

Front Microbiol. 2016 Apr 20;7:509. doi: 10.3389/fmicb.2016.00509. eCollection 2016.

45.

Discovery of novel selenium derivatives as Pin1 inhibitors by high-throughput screening.

Subedi A, Shimizu T, Ryo A, Sanada E, Watanabe N, Osada H.

Biochem Biophys Res Commun. 2016 Jun 3;474(3):528-533. doi: 10.1016/j.bbrc.2016.04.124. Epub 2016 Apr 24.

PMID:
27120460
46.

Survey for human polyomaviruses in cancer.

Toptan T, Yousem SA, Ho J, Matsushima Y, Stabile LP, Fernández-Figueras MT, Bhargava R, Ryo A, Moore PS, Chang Y.

JCI Insight. 2016 Feb;1(2). pii: e85562. Epub 2016 Feb 25.

47.

Relationship between phosphorylation of sperm-specific antigen and prognosis of lung adenocarcinoma.

Okayama A, Kimura Y, Miyagi Y, Oshima T, Oshita F, Ito H, Nakayama H, Nagashima T, Rino Y, Masuda M, Ryo A, Hirano H.

J Proteomics. 2016 Apr 29;139:60-6. doi: 10.1016/j.jprot.2016.03.005. Epub 2016 Mar 3.

PMID:
26947549
48.

Eucommicin A, a β-truxinate lignan from Eucommia ulmoides, is a selective inhibitor of cancer stem cells.

Fujiwara A, Nishi M, Yoshida S, Hasegawa M, Yasuma C, Ryo A, Suzuki Y.

Phytochemistry. 2016 Feb;122:139-145. doi: 10.1016/j.phytochem.2015.11.017. Epub 2015 Dec 8.

PMID:
26678322
49.

The Hepatitis B Virus Genotype Affects the Persistence of Viral Replication in Immunodeficient NOG Mice.

Yokoyama Y, Miyagi T, Hikita H, Yoshioka T, Mukai K, Nawa T, Sakamori R, Ohkawa K, Hiramatsu N, Takahashi T, Suemizu H, Ryo A, Tatsumi T, Takehara T.

PLoS One. 2015 Dec 14;10(12):e0144775. doi: 10.1371/journal.pone.0144775. eCollection 2015.

50.

Hepatitis B virus efficiently infects non-adherent hepatoma cells via human sodium taurocholate cotransporting polypeptide.

Okuyama-Dobashi K, Kasai H, Tanaka T, Yamashita A, Yasumoto J, Chen W, Okamoto T, Maekawa S, Watashi K, Wakita T, Ryo A, Suzuki T, Matsuura Y, Enomoto N, Moriishi K.

Sci Rep. 2015 Nov 23;5:17047. doi: 10.1038/srep17047.

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