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Items: 29


Spontaneous transitions of actin-bound tropomyosin toward blocked and closed states.

Kiani FA, Lehman W, Fischer S, Rynkiewicz MJ.

J Gen Physiol. 2019 Jan 7;151(1):4-8. doi: 10.1085/jgp.201812188. Epub 2018 Nov 15.


Precise Binding of Tropomyosin on Actin Involves Sequence-Dependent Variance in Coiled-Coil Twisting.

Lehman W, Li X, Kiani FA, Moore JR, Campbell SG, Fischer S, Rynkiewicz MJ.

Biophys J. 2018 Sep 18;115(6):1082-1092. doi: 10.1016/j.bpj.2018.08.017. Epub 2018 Aug 18.


Lectin-mediated binding and sialoglycans of porcine surfactant protein D synergistically neutralize influenza A virus.

van Eijk M, Rynkiewicz MJ, Khatri K, Leymarie N, Zaia J, White MR, Hartshorn KL, Cafarella TR, van Die I, Hessing M, Seaton BA, Haagsman HP.

J Biol Chem. 2018 Jul 6;293(27):10646-10662. doi: 10.1074/jbc.RA117.001430. Epub 2018 May 16.


HCM and DCM cardiomyopathy-linked α-tropomyosin mutations influence off-state stability and crossbridge interaction on thin filaments.

Farman GP, Rynkiewicz MJ, Orzechowski M, Lehman W, Moore JR.

Arch Biochem Biophys. 2018 Jun 1;647:84-92. doi: 10.1016/ Epub 2018 Apr 5.


Tropomyosin Must Interact Weakly with Actin to Effectively Regulate Thin Filament Function.

Rynkiewicz MJ, Prum T, Hollenberg S, Kiani FA, Fagnant PM, Marston SB, Trybus KM, Fischer S, Moore JR, Lehman W.

Biophys J. 2017 Dec 5;113(11):2444-2451. doi: 10.1016/j.bpj.2017.10.004.


Distortion of the Actin A-Triad Results in Contractile Disinhibition and Cardiomyopathy.

Viswanathan MC, Schmidt W, Rynkiewicz MJ, Agarwal K, Gao J, Katz J, Lehman W, Cammarato A.

Cell Rep. 2017 Sep 12;20(11):2612-2625. doi: 10.1016/j.celrep.2017.08.070.


Differential Ligand Binding Specificities of the Pulmonary Collectins Are Determined by the Conformational Freedom of a Surface Loop.

Rynkiewicz MJ, Wu H, Cafarella TR, Nikolaidis NM, Head JF, Seaton BA, McCormack FX.

Biochemistry. 2017 Aug 8;56(31):4095-4105. doi: 10.1021/acs.biochem.6b01313. Epub 2017 Jul 31.


The propensity for tropomyosin twisting in the presence and absence of F-actin.

Rynkiewicz MJ, Fischer S, Lehman W.

Arch Biochem Biophys. 2016 Nov 1;609:51-58. doi: 10.1016/ Epub 2016 Sep 20.


Elucidation of Lipid Binding Sites on Lung Surfactant Protein A Using X-ray Crystallography, Mutagenesis, and Molecular Dynamics Simulations.

Goh BC, Wu H, Rynkiewicz MJ, Schulten K, Seaton BA, McCormack FX.

Biochemistry. 2016 Jul 5;55(26):3692-701. doi: 10.1021/acs.biochem.6b00048. Epub 2016 Jun 21.


Tropomyosin diffusion over actin subunits facilitates thin filament assembly.

Fischer S, Rynkiewicz MJ, Moore JR, Lehman W.

Struct Dyn. 2016 Jan 14;3(1):012002. doi: 10.1063/1.4940223. eCollection 2016 Jan.


Electrostatic interaction map reveals a new binding position for tropomyosin on F-actin.

Rynkiewicz MJ, Schott V, Orzechowski M, Lehman W, Fischer S.

J Muscle Res Cell Motil. 2015 Dec;36(6):525-33. doi: 10.1007/s10974-015-9419-z. Epub 2015 Aug 19.


Functional and structural characterization of Francisella tularensis O-antigen antibodies at the low end of antigen reactivity.

Lu Z, Rynkiewicz MJ, Yang CY, Madico G, Perkins HM, Roche MI, Seaton BA, Sharon J.

Monoclon Antib Immunodiagn Immunother. 2014 Aug;33(4):235-45. doi: 10.1089/mab.2014.0022.


B-cell epitopes in GroEL of Francisella tularensis.

Lu Z, Rynkiewicz MJ, Madico G, Li S, Yang CY, Perkins HM, Sompuram SR, Kodela V, Liu T, Morris T, Wang D, Roche MI, Seaton BA, Sharon J.

PLoS One. 2014 Jun 26;9(6):e99847. doi: 10.1371/journal.pone.0099847. eCollection 2014.


Molecular mechanisms of inhibition of influenza by surfactant protein D revealed by large-scale molecular dynamics simulation.

Goh BC, Rynkiewicz MJ, Cafarella TR, White MR, Hartshorn KL, Allen K, Crouch EC, Calin O, Seeberger PH, Schulten K, Seaton BA.

Biochemistry. 2013 Nov 26;52(47):8527-38. doi: 10.1021/bi4010683. Epub 2013 Nov 13.


Discovery of protective B-cell epitopes for development of antimicrobial vaccines and antibody therapeutics.

Sharon J, Rynkiewicz MJ, Lu Z, Yang CY.

Immunology. 2014 May;142(1):1-23. doi: 10.1111/imm.12213. Review.


The binding sites of monoclonal antibodies to the non-reducing end of Francisella tularensis O-antigen accommodate mainly the terminal saccharide.

Lu Z, Rynkiewicz MJ, Yang CY, Madico G, Perkins HM, Wang Q, Costello CE, Zaia J, Seaton BA, Sharon J.

Immunology. 2013 Nov;140(3):374-89. doi: 10.1111/imm.12150.


Structural analysis of a protective epitope of the Francisella tularensis O-polysaccharide.

Rynkiewicz MJ, Lu Z, Hui JH, Sharon J, Seaton BA.

Biochemistry. 2012 Jul 17;51(28):5684-94. Epub 2012 Jul 2.


A unique sugar-binding site mediates the distinct anti-influenza activity of pig surfactant protein D.

van Eijk M, Rynkiewicz MJ, White MR, Hartshorn KL, Zou X, Schulten K, Luo D, Crouch EC, Cafarella TR, Head JF, Haagsman HP, Seaton BA.

J Biol Chem. 2012 Aug 3;287(32):26666-77. doi: 10.1074/jbc.M112.368571. Epub 2012 Jun 8.


Mutagenesis of surfactant protein D informed by evolution and x-ray crystallography enhances defenses against influenza A virus in vivo.

Crouch E, Nikolaidis N, McCormack FX, McDonald B, Allen K, Rynkiewicz MJ, Cafarella TM, White M, Lewnard K, Leymarie N, Zaia J, Seaton BA, Hartshorn KL.

J Biol Chem. 2011 Nov 25;286(47):40681-92. doi: 10.1074/jbc.M111.300673. Epub 2011 Sep 30.


Introduction of N-linked glycans in the lectin domain of surfactant protein D: impact on interactions with influenza A viruses.

van Eijk M, Bruinsma L, Hartshorn KL, White MR, Rynkiewicz MJ, Seaton BA, Hemrika W, Romijn RA, van Balkom BW, Haagsman HP.

J Biol Chem. 2011 Jun 10;286(23):20137-51. doi: 10.1074/jbc.M111.224469. Epub 2011 Apr 13.


Crystallographic complexes of surfactant protein A and carbohydrates reveal ligand-induced conformational change.

Shang F, Rynkiewicz MJ, McCormack FX, Wu H, Cafarella TM, Head JF, Seaton BA.

J Biol Chem. 2011 Jan 7;286(1):757-65. doi: 10.1074/jbc.M110.175265. Epub 2010 Nov 3.


Design, synthesis, and biological evaluation of peptidomimetic inhibitors of factor XIa as novel anticoagulants.

Lin J, Deng H, Jin L, Pandey P, Quinn J, Cantin S, Rynkiewicz MJ, Gorga JC, Bibbins F, Celatka CA, Nagafuji P, Bannister TD, Meyers HV, Babine RE, Hayward NJ, Weaver D, Benjamin H, Stassen F, Abdel-Meguid SS, Strickler JE.

J Med Chem. 2006 Dec 28;49(26):7781-91.


Synthesis, SAR exploration, and X-ray crystal structures of factor XIa inhibitors containing an alpha-ketothiazole arginine.

Deng H, Bannister TD, Jin L, Babine RE, Quinn J, Nagafuji P, Celatka CA, Lin J, Lazarova TI, Rynkiewicz MJ, Bibbins F, Pandey P, Gorga J, Meyers HV, Abdel-Meguid SS, Strickler JE.

Bioorg Med Chem Lett. 2006 Jun 1;16(11):3049-54. Epub 2006 Mar 9.


Molecular recognition of the substrate diphosphate group governs product diversity in trichodiene synthase mutants.

Vedula LS, Rynkiewicz MJ, Pyun HJ, Coates RM, Cane DE, Christianson DW.

Biochemistry. 2005 Apr 26;44(16):6153-63.


The three-dimensional structure of the ZAP-70 kinase domain in complex with staurosporine: implications for the design of selective inhibitors.

Jin L, Pluskey S, Petrella EC, Cantin SM, Gorga JC, Rynkiewicz MJ, Pandey P, Strickler JE, Babine RE, Weaver DT, Seidl KJ.

J Biol Chem. 2004 Oct 8;279(41):42818-25. Epub 2004 Jul 29.


Structure of trichodiene synthase from Fusarium sporotrichioides provides mechanistic inferences on the terpene cyclization cascade.

Rynkiewicz MJ, Cane DE, Christianson DW.

Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13543-8. Epub 2001 Nov 6.


Crystal structure determination of aristolochene synthase from the blue cheese mold, Penicillium roqueforti.

Caruthers JM, Kang I, Rynkiewicz MJ, Cane DE, Christianson DW.

J Biol Chem. 2000 Aug 18;275(33):25533-9.


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