Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 52


The Interferon-Induced Exonuclease ISG20 Exerts Antiviral Activity through Upregulation of Type I Interferon Response Proteins.

Weiss CM, Trobaugh DW, Sun C, Lucas TM, Diamond MS, Ryman KD, Klimstra WB.

mSphere. 2018 Sep 19;3(5). pii: e00209-18. doi: 10.1128/mSphere.00209-18.


The Efficacy of the Interferon Alpha/Beta Response versus Arboviruses Is Temperature Dependent.

Lane WC, Dunn MD, Gardner CL, Lam LKM, Watson AM, Hartman AL, Ryman KD, Klimstra WB.

MBio. 2018 Apr 24;9(2). pii: e00535-18. doi: 10.1128/mBio.00535-18.


Gamma-interferon exerts a critical early restriction on replication and dissemination of yellow fever virus vaccine strain 17D-204.

Lam LKM, Watson AM, Ryman KD, Klimstra WB.

NPJ Vaccines. 2018 Jan 23;3:5. doi: 10.1038/s41541-017-0039-z. eCollection 2018.


Interplay between Keratinocytes and Myeloid Cells Drives Dengue Virus Spread in Human Skin.

Duangkhae P, Erdos G, Ryman KD, Watkins SC, Falo LD Jr, Marques ETA Jr, Barratt-Boyes SM.

J Invest Dermatol. 2018 Mar;138(3):618-626. doi: 10.1016/j.jid.2017.10.018. Epub 2017 Oct 26.


Antibody Preparations from Human Transchromosomic Cows Exhibit Prophylactic and Therapeutic Efficacy against Venezuelan Equine Encephalitis Virus.

Gardner CL, Sun C, Luke T, Raviprakash K, Wu H, Jiao JA, Sullivan E, Reed DS, Ryman KD, Klimstra WB.

J Virol. 2017 Jun 26;91(14). pii: e00226-17. doi: 10.1128/JVI.00226-17. Print 2017 Jul 15.


The 17D-204 Vaccine Strain-Induced Protection against Virulent Yellow Fever Virus Is Mediated by Humoral Immunity and CD4+ but not CD8+ T Cells.

Watson AM, Lam LK, Klimstra WB, Ryman KD.

PLoS Pathog. 2016 Jul 27;12(7):e1005786. doi: 10.1371/journal.ppat.1005786. eCollection 2016 Jul.


Insect-specific flavivirus infection is restricted by innate immunity in the vertebrate host.

Tree MO, McKellar DR, Kieft KJ, Watson AM, Ryman KD, Conway MJ.

Virology. 2016 Oct;497:81-91. doi: 10.1016/j.virol.2016.07.005. Epub 2016 Jul 21.


Host translation shutoff mediated by non-structural protein 2 is a critical factor in the antiviral state resistance of Venezuelan equine encephalitis virus.

Bhalla N, Sun C, Metthew Lam LK, Gardner CL, Ryman KD, Klimstra WB.

Virology. 2016 Sep;496:147-165. doi: 10.1016/j.virol.2016.06.005. Epub 2016 Jun 15.


Electroporation of Alphavirus RNA Translational Reporters into Fibroblastic and Myeloid Cells as a Tool to Study the Innate Immune System.

Gardner CL, Trobaugh DW, Ryman KD, Klimstra WB.

Methods Mol Biol. 2016;1428:127-37. doi: 10.1007/978-1-4939-3625-0_8.


Can understanding the virulence mechanisms of RNA viruses lead us to a vaccine against eastern equine encephalitis virus and other alphaviruses?

Trobaugh DW, Ryman KD, Klimstra WB.

Expert Rev Vaccines. 2014 Dec;13(12):1423-5. doi: 10.1586/14760584.2014.944168. Epub 2014 Jul 30.


In vivo imaging in an ABSL-3 regional biocontainment laboratory.

Scanga CA, Lopresti BJ, Tomko J, Frye LJ, Coleman TM, Fillmore D, Carney JP, Lin PL, Flynn JL, Gardner CL, Sun C, Klimstra WB, Ryman KD, Reed DS, Fisher DJ, Cole KS.

Pathog Dis. 2014 Jul;71(2):207-12. doi: 10.1111/2049-632X.12186. Epub 2014 Jun 18. Review.


Closing the gap between viral and noninfectious arthritis.

Ryman KD, Klimstra WB.

Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):5767-8. doi: 10.1073/pnas.1404206111. Epub 2014 Apr 14. No abstract available.


Deliberate attenuation of chikungunya virus by adaptation to heparan sulfate-dependent infectivity: a model for rational arboviral vaccine design.

Gardner CL, Hritz J, Sun C, Vanlandingham DL, Song TY, Ghedin E, Higgs S, Klimstra WB, Ryman KD.

PLoS Negl Trop Dis. 2014 Feb 20;8(2):e2719. doi: 10.1371/journal.pntd.0002719. eCollection 2014 Feb.


RNA viruses can hijack vertebrate microRNAs to suppress innate immunity.

Trobaugh DW, Gardner CL, Sun C, Haddow AD, Wang E, Chapnik E, Mildner A, Weaver SC, Ryman KD, Klimstra WB.

Nature. 2014 Feb 13;506(7487):245-8. doi: 10.1038/nature12869. Epub 2013 Dec 18.


Stable, high-level expression of reporter proteins from improved alphavirus expression vectors to track replication and dissemination during encephalitic and arthritogenic disease.

Sun C, Gardner CL, Watson AM, Ryman KD, Klimstra WB.

J Virol. 2014 Feb;88(4):2035-46. doi: 10.1128/JVI.02990-13. Epub 2013 Dec 4.


Comparison of the live attenuated yellow fever vaccine 17D-204 strain to its virulent parental strain Asibi by deep sequencing.

Beck A, Tesh RB, Wood TG, Widen SG, Ryman KD, Barrett AD.

J Infect Dis. 2014 Feb 1;209(3):334-44. doi: 10.1093/infdis/jit546. Epub 2013 Oct 17.


Mosquito saliva serine protease enhances dissemination of dengue virus into the mammalian host.

Conway MJ, Watson AM, Colpitts TM, Dragovic SM, Li Z, Wang P, Feitosa F, Shepherd DT, Ryman KD, Klimstra WB, Anderson JF, Fikrig E.

J Virol. 2014 Jan;88(1):164-75. doi: 10.1128/JVI.02235-13. Epub 2013 Oct 16.


Natural variation in the heparan sulfate binding domain of the eastern equine encephalitis virus E2 glycoprotein alters interactions with cell surfaces and virulence in mice.

Gardner CL, Choi-Nurvitadhi J, Sun C, Bayer A, Hritz J, Ryman KD, Klimstra WB.

J Virol. 2013 Aug;87(15):8582-90. doi: 10.1128/JVI.00937-13. Epub 2013 May 29.


Heparan sulfate binding by natural eastern equine encephalitis viruses promotes neurovirulence.

Gardner CL, Ebel GD, Ryman KD, Klimstra WB.

Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16026-31. doi: 10.1073/pnas.1110617108. Epub 2011 Sep 6.


Yellow fever: a reemerging threat.

Gardner CL, Ryman KD.

Clin Lab Med. 2010 Mar;30(1):237-60. doi: 10.1016/j.cll.2010.01.001. Review.


A mouse model for studying viscerotropic disease caused by yellow fever virus infection.

Meier KC, Gardner CL, Khoretonenko MV, Klimstra WB, Ryman KD.

PLoS Pathog. 2009 Oct;5(10):e1000614. doi: 10.1371/journal.ppat.1000614. Epub 2009 Oct 9.


Characteristics of alpha/beta interferon induction after infection of murine fibroblasts with wild-type and mutant alphaviruses.

Burke CW, Gardner CL, Steffan JJ, Ryman KD, Klimstra WB.

Virology. 2009 Dec 5;395(1):121-32. doi: 10.1016/j.virol.2009.08.039. Epub 2009 Sep 25.


Similarities and differences in antagonism of neuron alpha/beta interferon responses by Venezuelan equine encephalitis and Sindbis alphaviruses.

Yin J, Gardner CL, Burke CW, Ryman KD, Klimstra WB.

J Virol. 2009 Oct;83(19):10036-47. doi: 10.1128/JVI.01209-09. Epub 2009 Jul 29.


Type I interferon induction is correlated with attenuation of a South American eastern equine encephalitis virus strain in mice.

Gardner CL, Yin J, Burke CW, Klimstra WB, Ryman KD.

Virology. 2009 Aug 1;390(2):338-47. doi: 10.1016/j.virol.2009.05.030. Epub 2009 Jun 18.


Host responses to alphavirus infection.

Ryman KD, Klimstra WB.

Immunol Rev. 2008 Oct;225:27-45. doi: 10.1111/j.1600-065X.2008.00670.x. Review.


Eastern and Venezuelan equine encephalitis viruses differ in their ability to infect dendritic cells and macrophages: impact of altered cell tropism on pathogenesis.

Gardner CL, Burke CW, Tesfay MZ, Glass PJ, Klimstra WB, Ryman KD.

J Virol. 2008 Nov;82(21):10634-46. doi: 10.1128/JVI.01323-08. Epub 2008 Sep 3.


Alpha/beta interferon inhibits cap-dependent translation of viral but not cellular mRNA by a PKR-independent mechanism.

Tesfay MZ, Yin J, Gardner CL, Khoretonenko MV, Korneeva NL, Rhoads RE, Ryman KD, Klimstra WB.

J Virol. 2008 Mar;82(6):2620-30. Epub 2007 Dec 26.


Identification and characterization of interferon-induced proteins that inhibit alphavirus replication.

Zhang Y, Burke CW, Ryman KD, Klimstra WB.

J Virol. 2007 Oct;81(20):11246-55. Epub 2007 Aug 8.


Non-pathogenic Sindbis virus causes hemorrhagic fever in the absence of alpha/beta and gamma interferons.

Ryman KD, Meier KC, Gardner CL, Adegboyega PA, Klimstra WB.

Virology. 2007 Nov 25;368(2):273-85. Epub 2007 Aug 2.


Early restriction of alphavirus replication and dissemination contributes to age-dependent attenuation of systemic hyperinflammatory disease.

Ryman KD, Gardner CL, Meier KC, Biron CA, Johnston RE, Klimstra WB.

J Gen Virol. 2007 Feb;88(Pt 2):518-29.


Heparan sulfate binding can contribute to the neurovirulence of neuroadapted and nonneuroadapted Sindbis viruses.

Ryman KD, Gardner CL, Burke CW, Meier KC, Thompson JM, Klimstra WB.

J Virol. 2007 Apr;81(7):3563-73. Epub 2007 Jan 10.


Targeting Sindbis virus-based vectors to Fc receptor-positive cell types.

Klimstra WB, Williams JC, Ryman KD, Heidner HW.

Virology. 2005 Jul 20;338(1):9-21.


Sindbis virus translation is inhibited by a PKR/RNase L-independent effector induced by alpha/beta interferon priming of dendritic cells.

Ryman KD, Meier KC, Nangle EM, Ragsdale SL, Korneeva NL, Rhoads RE, MacDonald MR, Klimstra WB.

J Virol. 2005 Feb;79(3):1487-99.


DC-SIGN and L-SIGN can act as attachment receptors for alphaviruses and distinguish between mosquito cell- and mammalian cell-derived viruses.

Klimstra WB, Nangle EM, Smith MS, Yurochko AD, Ryman KD.

J Virol. 2003 Nov;77(22):12022-32. Erratum in: J Virol. 2004 Jul;78(14):7862.


Effects of PKR/RNase L-dependent and alternative antiviral pathways on alphavirus replication and pathogenesis.

Ryman KD, White LJ, Johnston RE, Klimstra WB.

Viral Immunol. 2002;15(1):53-76.


Interaction of yellow fever virus French neurotropic vaccine strain with monkey brain: characterization of monkey brain membrane receptor escape variants.

Ni H, Ryman KD, Wang H, Saeed MF, Hull R, Wood D, Minor PD, Watowich SJ, Barrett AD.

J Virol. 2000 Mar;74(6):2903-6.


Infection of neonatal mice with sindbis virus results in a systemic inflammatory response syndrome.

Klimstra WB, Ryman KD, Bernard KA, Nguyen KB, Biron CA, Johnston RE.

J Virol. 1999 Dec;73(12):10387-98.


Molecular and biological changes associated with HeLa cell attenuation of wild-type yellow fever virus.

Dunster LM, Wang H, Ryman KD, Miller BR, Watowich SJ, Minor PD, Barrett AD.

Virology. 1999 Sep 1;261(2):309-18.


Mutation in NS5 protein attenuates mouse neurovirulence of yellow fever 17D vaccine virus.

Xie H, Ryman KD, Campbell GA, Barrett AD.

J Gen Virol. 1998 Aug;79 ( Pt 8):1895-9.


Mutation in a 17D-204 vaccine substrain-specific envelope protein epitope alters the pathogenesis of yellow fever virus in mice.

Ryman KD, Ledger TN, Campbell GA, Watowich SJ, Barrett AD.

Virology. 1998 Apr 25;244(1):59-65.


Yellow fever virus envelope protein has two discrete type-specific neutralizing epitopes.

Ryman KD, Ledger TN, Weir RC, Schlesinger JJ, Barrett AD.

J Gen Virol. 1997 Jun;78 ( Pt 6):1353-6.


Genetic variation among strains of wild-type yellow fever virus from Senegal.

Wang H, Jennings AD, Ryman KD, Late CM, Wang E, Ni H, Minor PD, Barrett AD.

J Gen Virol. 1997 Jun;78 ( Pt 6):1349-52.


Antigenic variants of yellow fever virus with an altered neurovirulence phenotype in mice.

Ryman KD, Xie H, Ledger TN, Campbell GA, Barrett AD.

Virology. 1997 Apr 14;230(2):376-80.

Supplemental Content

Loading ...
Support Center