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Items: 1 to 50 of 111

1.

Transgene flow: facts, speculations and possible countermeasures.

Ryffel GU.

GM Crops Food. 2014;5(4):249-58. doi: 10.4161/21645698.2014.945883. Review.

2.

Orgenic plants: gene-manipulated plants compatible with organic farming.

Ryffel GU.

Biotechnol J. 2012 Nov;7(11):1328-31. doi: 10.1002/biot.201200225. Epub 2012 Aug 15.

PMID:
22893621
3.

The transcription factor encyclopedia.

Yusuf D, Butland SL, Swanson MI, Bolotin E, Ticoll A, Cheung WA, Zhang XY, Dickman CT, Fulton DL, Lim JS, Schnabl JM, Ramos OH, Vasseur-Cognet M, de Leeuw CN, Simpson EM, Ryffel GU, Lam EW, Kist R, Wilson MS, Marco-Ferreres R, Brosens JJ, Beccari LL, Bovolenta P, Benayoun BA, Monteiro LJ, Schwenen HD, Grontved L, Wederell E, Mandrup S, Veitia RA, Chakravarthy H, Hoodless PA, Mancarelli MM, Torbett BE, Banham AH, Reddy SP, Cullum RL, Liedtke M, Tschan MP, Vaz M, Rizzino A, Zannini M, Frietze S, Farnham PJ, Eijkelenboom A, Brown PJ, Laperrière D, Leprince D, de Cristofaro T, Prince KL, Putker M, del Peso L, Camenisch G, Wenger RH, Mikula M, Rozendaal M, Mader S, Ostrowski J, Rhodes SJ, Van Rechem C, Boulay G, Olechnowicz SW, Breslin MB, Lan MS, Nanan KK, Wegner M, Hou J, Mullen RD, Colvin SC, Noy PJ, Webb CF, Witek ME, Ferrell S, Daniel JM, Park J, Waldman SA, Peet DJ, Taggart M, Jayaraman PS, Karrich JJ, Blom B, Vesuna F, O'Geen H, Sun Y, Gronostajski RM, Woodcroft MW, Hough MR, Chen E, Europe-Finner GN, Karolczak-Bayatti M, Bailey J, Hankinson O, Raman V, LeBrun DP, Biswal S, Harvey CJ, DeBruyne JP, Hogenesch JB, Hevner RF, Héligon C, Luo XM, Blank MC, Millen KJ, Sharlin DS, Forrest D, Dahlman-Wright K, Zhao C, Mishima Y, Sinha S, Chakrabarti R, Portales-Casamar E, Sladek FM, Bradley PH, Wasserman WW.

Genome Biol. 2012;13(3):R24. doi: 10.1186/gb-2012-13-3-r24.

4.

Heat-shock mediated overexpression of HNF1β mutations has differential effects on gene expression in the Xenopus pronephric kidney.

Sauert K, Kahnert S, Roose M, Gull M, Brändli AW, Ryffel GU, Waldner C.

PLoS One. 2012;7(3):e33522. doi: 10.1371/journal.pone.0033522. Epub 2012 Mar 15.

5.

A systematic analysis of the 3'UTR of HNF4A mRNA reveals an interplay of regulatory elements including miRNA target sites.

Wirsing A, Senkel S, Klein-Hitpass L, Ryffel GU.

PLoS One. 2011;6(11):e27438. doi: 10.1371/journal.pone.0027438. Epub 2011 Nov 30.

6.

Double conditional human embryonic kidney cell line based on FLP and ΦC31 mediated transgene integration.

Waldner C, Rempel O, Schütte F, Yanik M, Solomentsew N, Ryffel GU.

BMC Res Notes. 2011 Oct 18;4:420. doi: 10.1186/1756-0500-4-420.

7.
8.

The nephrogenic potential of the transcription factors osr1, osr2, hnf1b, lhx1 and pax8 assessed in Xenopus animal caps.

Drews C, Senkel S, Ryffel GU.

BMC Dev Biol. 2011 Jan 31;11:5. doi: 10.1186/1471-213X-11-5.

9.

Aging of Xenopus tropicalis eggs leads to deadenylation of a specific set of maternal mRNAs and loss of developmental potential.

Kosubek A, Klein-Hitpass L, Rademacher K, Horsthemke B, Ryffel GU.

PLoS One. 2010 Oct 22;5(10):e13532. doi: 10.1371/journal.pone.0013532.

10.

Novel monogenic diabetes mutations in the P2 promoter of the HNF4A gene are associated with impaired function in vitro.

Wirsing A, Johnstone KA, Harries LW, Ellard S, Ryffel GU, Stanik J, Gasperikova D, Klimes I, Murphy R.

Diabet Med. 2010 Jun;27(6):631-5. doi: 10.1111/j.1464-5491.2010.03003.x.

PMID:
20546279
11.

Making the most of GM potatoes.

Ryffel GU.

Nat Biotechnol. 2010 Apr;28(4):318. doi: 10.1038/nbt0410-318. No abstract available.

PMID:
20379170
12.
13.

Red fluorescent Xenopus laevis: a new tool for grafting analysis.

Waldner C, Roose M, Ryffel GU.

BMC Dev Biol. 2009 Jun 23;9:37. doi: 10.1186/1471-213X-9-37.

14.

HNF1B mutations associate with hypomagnesemia and renal magnesium wasting.

Adalat S, Woolf AS, Johnstone KA, Wirsing A, Harries LW, Long DA, Hennekam RC, Ledermann SE, Rees L, van't Hoff W, Marks SD, Trompeter RS, Tullus K, Winyard PJ, Cansick J, Mushtaq I, Dhillon HK, Bingham C, Edghill EL, Shroff R, Stanescu H, Ryffel GU, Ellard S, Bockenhauer D.

J Am Soc Nephrol. 2009 May;20(5):1123-31. doi: 10.1681/ASN.2008060633. Epub 2009 Apr 23.

15.

Heat-shock inducible Cre strains to study organogenesis in transgenic Xenopus laevis.

Roose M, Sauert K, Turan G, Solomentsew N, Werdien D, Pramanik K, Senkel S, Ryffel GU, Waldner C.

Transgenic Res. 2009 Aug;18(4):595-605. doi: 10.1007/s11248-009-9253-4. Epub 2009 Mar 6.

PMID:
19266305
16.

Transcription factor HNF1beta and novel partners affect nephrogenesis.

Dudziak K, Mottalebi N, Senkel S, Edghill EL, Rosengarten S, Roose M, Bingham C, Ellard S, Ryffel GU.

Kidney Int. 2008 Jul;74(2):210-7. doi: 10.1038/ki.2008.149. Epub 2008 Apr 16.

17.

The protein tyrosine phosphatase-BL, modulates pancreatic beta-cell proliferation by interaction with the Wnt signalling pathway.

Welters HJ, Oknianska A, Erdmann KS, Ryffel GU, Morgan NG.

J Endocrinol. 2008 Jun;197(3):543-52. doi: 10.1677/JOE-07-0262. Epub 2008 Apr 15.

PMID:
18413347
18.

HNF4 alpha orchestrates a set of 14 genes to down-regulate cell proliferation in kidney cells.

Grigo K, Wirsing A, Lucas B, Klein-Hitpass L, Ryffel GU.

Biol Chem. 2008 Feb;389(2):179-87. doi: 10.1515/BC.2008.011.

PMID:
18163890
19.

Marking transgenic Xenopus froglets with passive micro transponders.

Waldner C, Roose M, Ryffel GU.

Transgenic Res. 2007 Aug;16(4):539-40. Epub 2007 Jan 16.

PMID:
17225070
20.

Tissue-specific transcription factor HNF4alpha inhibits cell proliferation and induces apoptosis in the pancreatic INS-1 beta-cell line.

Erdmann S, Senkel S, Arndt T, Lucas B, Lausen J, Klein-Hitpass L, Ryffel GU, Thomas H.

Biol Chem. 2007 Jan;388(1):91-106.

PMID:
17214554
21.

A Kir6.2 mutation causing neonatal diabetes impairs electrical activity and insulin secretion from INS-1 beta-cells.

Tarasov AI, Welters HJ, Senkel S, Ryffel GU, Hattersley AT, Morgan NG, Ashcroft FM.

Diabetes. 2006 Nov;55(11):3075-82.

22.

Conditional expression of hepatocyte nuclear factor-1beta, the maturity-onset diabetes of the young-5 gene product, influences the viability and functional competence of pancreatic beta-cells.

Welters HJ, Senkel S, Klein-Hitpass L, Erdmann S, Thomas H, Harries LW, Pearson ER, Bingham C, Hattersley AT, Ryffel GU, Morgan NG.

J Endocrinol. 2006 Jul;190(1):171-81.

PMID:
16837621
23.

Transgenic Xenopus laevis strain expressing cre recombinase in muscle cells.

Waldner C, Sakamaki K, Ueno N, Turan G, Ryffel GU.

Dev Dyn. 2006 Aug;235(8):2220-8.

24.

Identification of target genes of the transcription factor HNF1beta and HNF1alpha in a human embryonic kidney cell line.

Senkel S, Lucas B, Klein-Hitpass L, Ryffel GU.

Biochim Biophys Acta. 2005 Dec 20;1731(3):179-90. Epub 2005 Nov 2.

PMID:
16297991
25.

HNF4alpha reduces proliferation of kidney cells and affects genes deregulated in renal cell carcinoma.

Lucas B, Grigo K, Erdmann S, Lausen J, Klein-Hitpass L, Ryffel GU.

Oncogene. 2005 Sep 22;24(42):6418-31.

PMID:
16007190
26.

Pattern of genes influenced by conditional expression of the transcription factors HNF6, HNF4alpha and HNF1beta in a pancreatic beta-cell line.

Thomas H, Senkel S, Erdmann S, Arndt T, Turan G, Klein-Hitpass L, Ryffel GU.

Nucleic Acids Res. 2004 Nov 1;32(19):e150.

28.

Distinct molecular and morphogenetic properties of mutations in the human HNF1beta gene that lead to defective kidney development.

Bohn S, Thomas H, Turan G, Ellard S, Bingham C, Hattersley AT, Ryffel GU.

J Am Soc Nephrol. 2003 Aug;14(8):2033-41.

29.

What can a frog tell us about human kidney development.

Ryffel GU.

Nephron Exp Nephrol. 2003;94(2):e35-43. Review.

PMID:
12845229
30.

Tagging muscle cell lineages in development and tail regeneration using Cre recombinase in transgenic Xenopus.

Ryffel GU, Werdien D, Turan G, Gerhards A, Goosses S, Senkel S.

Nucleic Acids Res. 2003 Apr 15;31(8):e44.

31.

Evidence for haploinsufficiency of the human HNF1alpha gene revealed by functional characterization of MODY3-associated mutations.

Thomas H, Badenberg B, Bulman M, Lemm I, Lausen J, Kind L, Roosen S, Ellard S, Hattersley AT, Ryffel GU.

Biol Chem. 2002 Nov;383(11):1691-700.

PMID:
12530534
32.

Rare variants identified in the HNF- 4 alpha beta-cell-specific promoter and alternative exon 1 lack biological significance in maturity onset diabetes of the young and young onset Type II diabetes.

Mitchell SM, Vaxillaire M, Thomas H, Parrizas M, Benmezroua Y, Costa A, Hansen T, Owen KR, Tuomi T, Pirie F, Ryffel GU, Ferrer J, Froguel P, Hattersley AT, Frayling TM.

Diabetologia. 2002 Sep;45(9):1344-8. Epub 2002 Jul 19.

PMID:
12242469
33.

ERH (enhancer of rudimentary homologue), a conserved factor identical between frog and human, is a transcriptional repressor.

Pogge von Strandmann E, Senkel S, Ryffel GU.

Biol Chem. 2001 Sep;382(9):1379-85.

PMID:
11688721
34.

A distant upstream promoter of the HNF-4alpha gene connects the transcription factors involved in maturity-onset diabetes of the young.

Thomas H, Jaschkowitz K, Bulman M, Frayling TM, Mitchell SM, Roosen S, Lingott-Frieg A, Tack CJ, Ellard S, Ryffel GU, Hattersley AT.

Hum Mol Genet. 2001 Sep 15;10(19):2089-97.

PMID:
11590126
36.

FLP and Cre recombinase function in Xenopus embryos.

Werdien D, Peiler G, Ryffel GU.

Nucleic Acids Res. 2001 Jun 1;29(11):E53-3.

37.

Misexpression of Xsiah-2 induces a small eye phenotype in Xenopus.

Bogdan S, Senkel S, Esser F, Ryffel GU, Pogge v Strandmann E.

Mech Dev. 2001 May;103(1-2):61-9.

38.

Inhibitor of the tissue-specific transcription factor HNF4, a potential regulator in early Xenopus development.

Peiler G, Böckmann B, Nakhei H, Ryffel GU.

Mol Cell Biol. 2000 Dec;20(23):8676-83.

39.

Primary structure, chromosomal mapping, expression and transcriptional activity of murine hepatocyte nuclear factor 4gamma.

Taraviras S, Mantamadiotis T, Dong-Si T, Mincheva A, Lichter P, Drewes T, Ryffel GU, Monaghan AP, Schütz G.

Biochim Biophys Acta. 2000 Jan 31;1490(1-2):21-32.

PMID:
10786614
40.

The mutated human gene encoding hepatocyte nuclear factor 1beta inhibits kidney formation in developing Xenopus embryos.

Wild W, Pogge von Strandmann E, Nastos A, Senkel S, Lingott-Frieg A, Bulman M, Bingham C, Ellard S, Hattersley AT, Ryffel GU.

Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4695-700.

41.

Abnormal nephron development associated with a frameshift mutation in the transcription factor hepatocyte nuclear factor-1 beta.

Bingham C, Ellard S, Allen L, Bulman M, Shepherd M, Frayling T, Berry PJ, Clark PM, Lindner T, Bell GI, Ryffel GU, Nicholls AJ, Hattersley AT.

Kidney Int. 2000 Mar;57(3):898-907.

42.
43.

Naturally occurring mutations in the human HNF4alpha gene impair the function of the transcription factor to a varying degree.

Lausen J, Thomas H, Lemm I, Bulman M, Borgschulze M, Lingott A, Hattersley AT, Ryffel GU.

Nucleic Acids Res. 2000 Jan 15;28(2):430-7.

45.

Hepatocyte nuclear factor-4gamma: cDNA sequence, gene organization, and mutation screening in early-onset autosomal-dominant type 2 diabetes.

Plengvidhya N, Antonellis A, Wogan LT, Poleev A, Borgschulze M, Warram JH, Ryffel GU, Krolewski AS, Doria A.

Diabetes. 1999 Oct;48(10):2099-102.

PMID:
10512380
46.

Loss of function of the tissue specific transcription factor HNF1 alpha in renal cell carcinoma and clinical prognosis.

Anastasiadis AG, Lemm I, Radzewitz A, Lingott A, Ebert T, Ackermann R, Ryffel GU, Schulz WA.

Anticancer Res. 1999 May-Jun;19(3A):2105-10.

PMID:
10470156
47.

Loss of HNF1alpha function in human renal cell carcinoma: frequent mutations in the VHL gene but not the HNF1alpha gene.

Lemm I, Lingott A, Pogge v Strandmann E, Zoidl C, Bulman MP, Hattersley AT, Schulz WA, Ebert T, Ryffel GU.

Mol Carcinog. 1999 Apr;24(4):305-14.

PMID:
10326868
48.
50.

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