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Items: 1 to 50 of 488

1.

Secoeudesma sesquiterpenes lactone A alleviates inflammation and offers adjuvant protection in severe infection of carbapenem-resistant Klebsiella pneumoniae.

Jiang X, Chen Y, Liu D, Shi T, Cheng X, He W, Li Y, Ryffel B, Zheng SG, Zheng Y.

J Ethnopharmacol. 2020 Jan 22;252:112605. doi: 10.1016/j.jep.2020.112605. [Epub ahead of print]

PMID:
31981749
2.

Blockade of the NLRP3 inflammasome improves metabolic health and lifespan in obese mice.

Cañadas-Lozano D, Marín-Aguilar F, Castejón-Vega B, Ryffel B, Navarro-Pando JM, Ruiz-Cabello J, Alcocer-Gómez E, Bullón P, Cordero MD.

Geroscience. 2020 Jan 23. doi: 10.1007/s11357-019-00151-6. [Epub ahead of print]

PMID:
31975052
3.

The alternative cap-binding complex is required for antiviral defense in vivo.

Gebhardt A, Bergant V, Schnepf D, Moser M, Meiler A, Togbe D, Mackowiak C, Reinert LS, Paludan SR, Ryffel B, Stukalov A, Staeheli P, Pichlmair A.

PLoS Pathog. 2019 Dec 19;15(12):e1008155. doi: 10.1371/journal.ppat.1008155. eCollection 2019 Dec.

4.

CD3+ Macrophages Deliver Proinflammatory Cytokines by a CD3- and Transmembrane TNF-Dependent Pathway and Are Increased at the BCG-Infection Site.

Rodriguez-Cruz A, Vesin D, Ramon-Luing L, Zuñiga J, Quesniaux VFJ, Ryffel B, Lascurain R, Garcia I, Chávez-Galán L.

Front Immunol. 2019 Nov 7;10:2550. doi: 10.3389/fimmu.2019.02550. eCollection 2019.

5.

Muc5b-deficient mice develop early histological lung abnormalities.

Valque H, Gouyer V, Duez C, Leboeuf C, Marquillies P, Le Bert M, Plet S, Ryffel B, Janin A, Gottrand F, Desseyn JL.

Biol Open. 2019 Nov 7;8(11). pii: bio046359. doi: 10.1242/bio.046359.

6.

NLRP3 inflammasome suppression improves longevity and prevents cardiac aging in male mice.

Marín-Aguilar F, Lechuga-Vieco AV, Alcocer-Gómez E, Castejón-Vega B, Lucas J, Garrido C, Peralta-Garcia A, Pérez-Pulido AJ, Varela-López A, Quiles JL, Ryffel B, Flores I, Bullón P, Ruiz-Cabello J, Cordero MD.

Aging Cell. 2020 Jan;19(1):e13050. doi: 10.1111/acel.13050. Epub 2019 Oct 18.

7.

Self-DNA release and STING-dependent sensing drives inflammation to cigarette smoke in mice.

Nascimento M, Gombault A, Lacerda-Queiroz N, Panek C, Savigny F, Sbeity M, Bourinet M, Le Bert M, Riteau N, Ryffel B, Quesniaux VFJ, Couillin I.

Sci Rep. 2019 Oct 16;9(1):14848. doi: 10.1038/s41598-019-51427-y.

8.

Acute Respiratory Barrier Disruption by Ozone Exposure in Mice.

Sokolowska M, Quesniaux VFJ, Akdis CA, Chung KF, Ryffel B, Togbe D.

Front Immunol. 2019 Sep 13;10:2169. doi: 10.3389/fimmu.2019.02169. eCollection 2019. Review.

9.

NLRP3 inflammasome inhibition by MCC950 in aged mice improves health via enhanced autophagy and PPARα activity.

Marín-Aguilar F, Castejón-Vega B, Alcocer-Gómez E, Lendines-Cordero D, Cooper MA, de la Cruz P, Andújar-Pulido E, Pérez-Alegre M, Muntané J, Pérez-Pulido AJ, Ryffel B, Robertson AAB, Ruiz-Cabello J, Bullón P, Cordero MD.

J Gerontol A Biol Sci Med Sci. 2019 Oct 11. pii: glz239. doi: 10.1093/gerona/glz239. [Epub ahead of print]

PMID:
31603987
10.

ILC2s and Basophils Team Up to Orchestrate IL-33-Induced Atopic Dermatitis.

Ryffel B, Alves-Filho JC.

J Invest Dermatol. 2019 Oct;139(10):2077-2079. doi: 10.1016/j.jid.2019.06.118.

PMID:
31543211
11.

Microbial metabolites control the thymic development of mucosal-associated invariant T cells.

Legoux F, Bellet D, Daviaud C, El Morr Y, Darbois A, Niort K, Procopio E, Salou M, Gilet J, Ryffel B, Balvay A, Foussier A, Sarkis M, El Marjou A, Schmidt F, Rabot S, Lantz O.

Science. 2019 Oct 25;366(6464):494-499. doi: 10.1126/science.aaw2719. Epub 2019 Aug 29.

PMID:
31467190
12.

Self-DNA Sensing in Lung Inflammatory Diseases.

Benmerzoug S, Ryffel B, Togbe D, Quesniaux VFJ.

Trends Immunol. 2019 Aug;40(8):719-734. doi: 10.1016/j.it.2019.06.001. Epub 2019 Jun 28. Review.

PMID:
31262653
13.

Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring.

Darby MG, Chetty A, Mrjden D, Rolot M, Smith K, Mackowiak C, Sedda D, Nyangahu D, Jaspan H, Toellner KM, Waisman A, Quesniaux V, Ryffel B, Cunningham AF, Dewals BG, Brombacher F, Horsnell WGC.

Sci Adv. 2019 May 29;5(5):eaav3058. doi: 10.1126/sciadv.aav3058. eCollection 2019 May.

14.

Sterile Lung Inflammation Induced by Silica Exacerbates Mycobacterium tuberculosis Infection via STING-Dependent Type 2 Immunity.

Benmerzoug S, Bounab B, Rose S, Gosset D, Biet F, Cochard T, Xavier A, Rouxel N, Fauconnier L, Horsnell WGC, Ryffel B, Togbe D, Quesniaux VFJ.

Cell Rep. 2019 May 28;27(9):2649-2664.e5. doi: 10.1016/j.celrep.2019.04.110.

15.

Blockade of IL-33R/ST2 Signaling Attenuates Toxoplasma gondii Ileitis Depending on IL-22 Expression.

Ryffel B, Huang F, Robinet P, Panek C, Couillin I, Erard F, Piotet J, Le Bert M, Mackowiak C, Torres Arias M, Dimier-Poisson I, Zheng SG.

Front Immunol. 2019 Apr 18;10:702. doi: 10.3389/fimmu.2019.00702. eCollection 2019.

16.

Myeloid cell TNFR1 signaling dependent liver injury and inflammation upon BCG infection.

Chavez-Galan L, Vesin D, Blaser G, Uysal H, Benmerzoug S, Rose S, Ryffel B, Quesniaux VFJ, Garcia I.

Sci Rep. 2019 Mar 28;9(1):5297. doi: 10.1038/s41598-019-41629-9.

17.

A New Bifidobacteria Expression SysTem (BEST) to Produce and Deliver Interleukin-10 in Bifidobacterium bifidum.

Mauras A, Chain F, Faucheux A, Ruffié P, Gontier S, Ryffel B, Butel MJ, Langella P, Bermúdez-Humarán LG, Waligora-Dupriet AJ.

Front Microbiol. 2018 Dec 21;9:3075. doi: 10.3389/fmicb.2018.03075. eCollection 2018.

18.

Proteasomal degradation of NOD2 by NLRP12 in monocytes promotes bacterial tolerance and colonization by enteropathogens.

Normand S, Waldschmitt N, Neerincx A, Martinez-Torres RJ, Chauvin C, Couturier-Maillard A, Boulard O, Cobret L, Awad F, Huot L, Ribeiro-Ribeiro A, Lautz K, Ruez R, Delacre M, Bondu C, Guilliams M, Scott C, Segal A, Amselem S, Hot D, Karabina S, Bohn E, Ryffel B, Poulin LF, Kufer TA, Chamaillard M.

Nat Commun. 2018 Dec 17;9(1):5338. doi: 10.1038/s41467-018-07750-5.

19.

STING-dependent sensing of self-DNA drives silica-induced lung inflammation.

Benmerzoug S, Rose S, Bounab B, Gosset D, Duneau L, Chenuet P, Mollet L, Le Bert M, Lambers C, Geleff S, Roth M, Fauconnier L, Sedda D, Carvalho C, Perche O, Laurenceau D, Ryffel B, Apetoh L, Kiziltunc A, Uslu H, Albez FS, Akgun M, Togbe D, Quesniaux VFJ.

Nat Commun. 2018 Dec 6;9(1):5226. doi: 10.1038/s41467-018-07425-1.

20.

Correction: Interleukin-22-deficiency and microbiota contribute to the exacerbation of Toxoplasma gondii-induced intestinal inflammation.

Couturier-Maillard A, Froux N, Piotet-Morin J, Michaudel C, Brault L, Le Bérichel J, Sénéchal A, Robinet P, Chenuet P, Jejou S, Dumoutier L, Renauld JC, Iovanna J, Huber S, Chamaillard M, Quesniaux VFJ, Sokol H, Ryffel B.

Mucosal Immunol. 2019 Jan;12(1):290. doi: 10.1038/s41385-018-0112-6.

PMID:
30504789
21.

Interleukin-17/interleukin-17 receptor axis elicits intestinal neutrophil migration, restrains gut dysbiosis and lipopolysaccharide translocation in high-fat diet-induced metabolic syndrome model.

Pérez MM, Martins LMS, Dias MS, Pereira CA, Leite JA, Gonçalves ECS, de Almeida PZ, de Freitas EN, Tostes RC, Ramos SG, de Zoete MR, Ryffel B, Silva JS, Carlos D.

Immunology. 2019 Apr;156(4):339-355. doi: 10.1111/imm.13028. Epub 2018 Dec 27.

PMID:
30472727
22.

PD-1 Is Involved in the Dysregulation of Type 2 Innate Lymphoid Cells in a Murine Model of Obesity.

Oldenhove G, Boucquey E, Taquin A, Acolty V, Bonetti L, Ryffel B, Le Bert M, Englebert K, Boon L, Moser M.

Cell Rep. 2018 Nov 20;25(8):2053-2060.e4. doi: 10.1016/j.celrep.2018.10.091.

23.

Oxidized hemoglobin forms contribute to NLRP3 inflammasome-driven IL-1β production upon intravascular hemolysis.

Nyakundi BB, Tóth A, Balogh E, Nagy B, Erdei J, Ryffel B, Paragh G, Cordero MD, Jeney V.

Biochim Biophys Acta Mol Basis Dis. 2019 Feb 1;1865(2):464-475. doi: 10.1016/j.bbadis.2018.10.030. Epub 2018 Oct 30.

24.

Exclusive expression of transmembrane TNF aggravates acute glomerulonephritis despite reduced leukocyte infiltration and inflammation.

Müller MB, Hoppe JM, Bideak A, Lux M, Lindenmeyer MT, Müller S, Eltrich N, Ryffel B, Vielhauer V.

Kidney Int. 2019 Jan;95(1):75-93. doi: 10.1016/j.kint.2018.08.012. Epub 2018 Oct 30.

PMID:
30389199
25.

The regenerating family member 3 β instigates IL-17A-mediated neutrophil recruitment downstream of NOD1/2 signalling for controlling colonisation resistance independently of microbiota community structure.

Waldschmitt N, Kitamoto S, Secher T, Zacharioudaki V, Boulard O, Floquet E, Delacre M, Lamas B, Pham HP, Six A, Richard ML, Dagorn JC, Eberl G, Langella P, Chatel JM, Ryffel B, Iovanna JL, Poulin LF, Sokol H, Kamada N, Chamaillard M.

Gut. 2019 Jul;68(7):1190-1199. doi: 10.1136/gutjnl-2018-316757. Epub 2018 Oct 2.

PMID:
30279238
26.

Interleukin-33 contributes to disease severity in Dengue virus infection in mice.

Marques RE, Besnard AG, Maillet I, Fagundes CT, Souza DG, Ryffel B, Teixeira MM, Liew FY, Guabiraba R.

Immunology. 2018 Dec;155(4):477-490. doi: 10.1111/imm.12988. Epub 2018 Sep 10.

27.

Liver Immune Cells Release Type 1 Interferon Due to DNA Sensing and Amplify Liver Injury from Acetaminophen Overdose.

Araujo AM, Antunes MM, Mattos MS, Diniz AB, Alvarenga DM, Nakagaki BN, Carvalho É, Lacerda VAS, Carvalho-Gontijo R, Goulart J, Mafra K, Freitas-Lopes MA, Oliveira HMC, Dutra CM, David BA, Mendes Silva A, Quesniaux V, Ryffel B, Oliveira SC, Barber GN, Mansur DS, Cunha TM, Rezende RM, Oliveira AG, Menezes GB.

Cells. 2018 Jul 27;7(8). pii: E88. doi: 10.3390/cells7080088.

28.

The probiotic strain Escherichia coli Nissle 1917 prevents papain-induced respiratory barrier injury and severe allergic inflammation in mice.

Secher T, Maillet I, Mackowiak C, Le Bérichel J, Philippeau A, Panek C, Boury M, Oswald E, Saoudi A, Erard F, Le Bert M, Quesniaux V, Couturier-Maillard A, Ryffel B.

Sci Rep. 2018 Jul 26;8(1):11245. doi: 10.1038/s41598-018-29689-9.

29.

Gut Microbiota-Stimulated Innate Lymphoid Cells Support β-Defensin 14 Expression in Pancreatic Endocrine Cells, Preventing Autoimmune Diabetes.

Miani M, Le Naour J, Waeckel-Enée E, Verma SC, Straube M, Emond P, Ryffel B, van Endert P, Sokol H, Diana J.

Cell Metab. 2018 Oct 2;28(4):557-572.e6. doi: 10.1016/j.cmet.2018.06.012. Epub 2018 Jul 12.

30.

Functional and morphological differences of the lung upon acute and chronic ozone exposure in mice.

Michaudel C, Fauconnier L, Julé Y, Ryffel B.

Sci Rep. 2018 Jul 13;8(1):10611. doi: 10.1038/s41598-018-28261-9.

31.

The IL-33 Receptor ST2 Regulates Pulmonary Inflammation and Fibrosis to Bleomycin.

Fanny M, Nascimento M, Baron L, Schricke C, Maillet I, Akbal M, Riteau N, Le Bert M, Quesniaux V, Ryffel B, Gombault A, Même S, Même W, Couillin I.

Front Immunol. 2018 Jun 25;9:1476. doi: 10.3389/fimmu.2018.01476. eCollection 2018.

32.

Transmembrane TNF and Partially TNFR1 Regulate TNFR2 Expression and Control Inflammation in Mycobacterial-Induced Pleurisy.

Uysal H, Chavez-Galan L, Vesin D, Blaser G, Benkhoucha M, Ryffel B, Quesniaux VFJ, Garcia I.

Int J Mol Sci. 2018 Jul 4;19(7). pii: E1959. doi: 10.3390/ijms19071959.

33.

G-quadruplex DNA targeting alters class-switch recombination in B cells and attenuates allergic inflammation.

Dalloul Z, Chenuet P, Dalloul I, Boyer F, Aldigier JC, Laffleur B, El Makhour Y, Ryffel B, Quesniaux VFJ, Togbé D, Mergny JL, Cook-Moreau J, Cogné M.

J Allergy Clin Immunol. 2018 Oct;142(4):1352-1355. doi: 10.1016/j.jaci.2018.06.011. Epub 2018 Jun 20. No abstract available.

PMID:
29935221
34.

Succinate receptor deficiency attenuates arthritis by reducing dendritic cell traffic and expansion of Th17 cells in the lymph nodes.

Saraiva AL, Veras FP, Peres RS, Talbot J, de Lima KA, Luiz JP, Carballido JM, Cunha TM, Cunha FQ, Ryffel B, Alves-Filho JC.

FASEB J. 2018 Jun 12:fj201800285. doi: 10.1096/fj.201800285. [Epub ahead of print]

PMID:
29894669
35.

Smoking-induced aggravation of experimental arthritis is dependent of aryl hydrocarbon receptor activation in Th17 cells.

Talbot J, Peres RS, Pinto LG, Oliveira RDR, Lima KA, Donate PB, Silva JR, Ryffel B, Cunha TM, Alves-Filho JC, Liew FY, Louzada-Junior P, de Queiroz Cunha F.

Arthritis Res Ther. 2018 Jun 8;20(1):119. doi: 10.1186/s13075-018-1609-9.

36.

PD-1/PD-L1 pathway: an adaptive immune resistance mechanism to immunogenic chemotherapy in colorectal cancer.

Dosset M, Vargas TR, Lagrange A, Boidot R, Végran F, Roussey A, Chalmin F, Dondaine L, Paul C, Lauret Marie-Joseph E, Martin F, Ryffel B, Borg C, Adotévi O, Ghiringhelli F, Apetoh L.

Oncoimmunology. 2018 Mar 15;7(6):e1433981. doi: 10.1080/2162402X.2018.1433981. eCollection 2018.

37.

GM-CSF targeted immunomodulation affects host response to M. tuberculosis infection.

Benmerzoug S, Marinho FV, Rose S, Mackowiak C, Gosset D, Sedda D, Poisson E, Uyttenhove C, Van Snick J, Jacobs M, Garcia I, Ryffel B, Quesniaux VFJ.

Sci Rep. 2018 Jun 5;8(1):8652. doi: 10.1038/s41598-018-26984-3.

38.

Interleukin-1α Mediates Ozone-Induced Myeloid Differentiation Factor-88-Dependent Epithelial Tissue Injury and Inflammation.

Michaudel C, Maillet I, Fauconnier L, Quesniaux V, Chung KF, Wiegman C, Peter D, Ryffel B.

Front Immunol. 2018 May 7;9:916. doi: 10.3389/fimmu.2018.00916. eCollection 2018.

39.

The cGAS/STING Pathway Is Important for Dendritic Cell Activation but Is Not Essential to Induce Protective Immunity against Mycobacterium tuberculosis Infection.

Marinho FV, Benmerzoug S, Rose S, Campos PC, Marques JT, Báfica A, Barber G, Ryffel B, Oliveira SC, Quesniaux VFJ.

J Innate Immun. 2018;10(3):239-252. doi: 10.1159/000488952. Epub 2018 May 23.

40.

Induction of NLRP3 Inflammasome Activation by Heme in Human Endothelial Cells.

Erdei J, Tóth A, Balogh E, Nyakundi BB, Bányai E, Ryffel B, Paragh G, Cordero MD, Jeney V.

Oxid Med Cell Longev. 2018 Mar 20;2018:4310816. doi: 10.1155/2018/4310816. eCollection 2018.

41.

Interleukin-22-deficiency and microbiota contribute to the exacerbation of Toxoplasma gondii-induced intestinal inflammation.

Couturier-Maillard A, Froux N, Piotet-Morin J, Michaudel C, Brault L, Le Bérichel J, Sénéchal A, Robinet P, Chenuet P, Jejou S, Dumoutier L, Renauld JC, Iovanna J, Huber S, Chamaillard M, Quesniaux V, Sokol H, Chamaillard M, Ryffel B.

Mucosal Immunol. 2018 Jul;11(4):1181-1190. doi: 10.1038/s41385-018-0005-8. Epub 2018 May 4. Erratum in: Mucosal Immunol. 2019 Jan;12(1):290.

PMID:
29728643
42.

Interleukin-23 promotes intestinal T helper type17 immunity and ameliorates obesity-associated metabolic syndrome in a murine high-fat diet model.

Martins LMS, Perez MM, Pereira CA, Costa FRC, Dias MS, Tostes RC, Ramos SG, de Zoete MR, Ryffel B, Silva JS, Carlos D.

Immunology. 2018 May 2. doi: 10.1111/imm.12946. [Epub ahead of print]

43.

MyD88 as a therapeutic target for inflammatory lung diseases.

Di Padova F, Quesniaux VFJ, Ryffel B.

Expert Opin Ther Targets. 2018 May;22(5):401-408. doi: 10.1080/14728222.2018.1464139. Epub 2018 Apr 20. Review.

PMID:
29658361
44.

Gain of function mutation and inflammasome driven diseases in human and mouse models.

Cordero MD, Alcocer-Gómez E, Ryffel B.

J Autoimmun. 2018 Jul;91:13-22. doi: 10.1016/j.jaut.2018.03.002. Epub 2018 Mar 30. Review.

PMID:
29610014
45.

Humoral Responses Elicited by Adenovirus Displaying Epitopes Are Induced Independently of the Infection Process and Shaped by the Toll-Like Receptor/MyD88 Pathway.

Anchim A, Raddi N, Zig L, Perrieau P, Le Goffic R, Ryffel B, Benihoud K.

Front Immunol. 2018 Feb 5;9:124. doi: 10.3389/fimmu.2018.00124. eCollection 2018.

46.

Ozone exposure induces respiratory barrier biphasic injury and inflammation controlled by IL-33.

Michaudel C, Mackowiak C, Maillet I, Fauconnier L, Akdis CA, Sokolowska M, Dreher A, Tan HT, Quesniaux VF, Ryffel B, Togbe D.

J Allergy Clin Immunol. 2018 Sep;142(3):942-958. doi: 10.1016/j.jaci.2017.11.044. Epub 2018 Jan 10.

47.

Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway.

Holze C, Michaudel C, Mackowiak C, Haas DA, Benda C, Hubel P, Pennemann FL, Schnepf D, Wettmarshausen J, Braun M, Leung DW, Amarasinghe GK, Perocchi F, Staeheli P, Ryffel B, Pichlmair A.

Nat Immunol. 2018 Feb;19(2):130-140. doi: 10.1038/s41590-017-0013-y. Epub 2017 Dec 18.

48.

NLRP3-inflammasome inhibition prevents high fat and high sugar diets-induced heart damage through autophagy induction.

Pavillard LE, Cañadas-Lozano D, Alcocer-Gómez E, Marín-Aguilar F, Pereira S, Robertson AAB, Muntané J, Ryffel B, Cooper MA, Quiles JL, Bullón P, Ruiz-Cabello J, Cordero MD.

Oncotarget. 2017 Sep 8;8(59):99740-99756. doi: 10.18632/oncotarget.20763. eCollection 2017 Nov 21.

49.

Loss of vascular expression of nucleoside triphosphate diphosphohydrolase-1/CD39 in hypertension.

Roy C, Tabiasco J, Caillon A, Delneste Y, Merot J, Favre J, Guihot AL, Martin L, Nascimento DC, Ryffel B, Robson SC, Sévigny J, Henrion D, Kauffenstein G.

Purinergic Signal. 2018 Mar;14(1):73-82. doi: 10.1007/s11302-017-9597-9. Epub 2017 Dec 13.

50.

Tumor Necrosis Factor-Alpha Targeting Can Protect against Arthritis with Low Sensitization to Infection.

Belmellat N, Semerano L, Segueni N, Damotte D, Decker P, Ryffel B, Quesniaux V, Boissier MC, Assier E.

Front Immunol. 2017 Nov 14;8:1533. doi: 10.3389/fimmu.2017.01533. eCollection 2017.

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