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Items: 1 to 50 of 57

1.

KRAS Activation in Gastric Adenocarcinoma Stimulates Epithelial-to-Mesenchymal Transition to Cancer Stem-Like Cells and Promotes Metastasis.

Yoon C, Till J, Cho SJ, Chang KK, Lin JX, Huang CM, Ryeom S, Yoon SS.

Mol Cancer Res. 2019 Sep;17(9):1945-1957. doi: 10.1158/1541-7786.MCR-19-0077. Epub 2019 Jun 19.

PMID:
31217166
2.

Deletion of Calcineurin Promotes a Protumorigenic Fibroblast Phenotype.

Lieberman A, Barrett R, Kim J, Zhang KL, Avery D, Monslow J, Kim H, Kim BJ, Puré E, Ryeom S.

Cancer Res. 2019 Aug 1;79(15):3928-3939. doi: 10.1158/0008-5472.CAN-19-0056. Epub 2019 Jun 12.

PMID:
31189649
3.

Testicular endothelial cells promote self-renewal of spermatogonial stem cells in rats†.

Kim YH, Oh MG, Bhang DH, Kim BJ, Jung SE, Kim SM, Dohr G, Kim SU, Ryeom S, Ryu BY.

Biol Reprod. 2019 Aug 1;101(2):360-367. doi: 10.1093/biolre/ioz105.

PMID:
31187129
4.

H3K9 methyltransferases and demethylases control lung tumor-propagating cells and lung cancer progression.

Rowbotham SP, Li F, Dost AFM, Louie SM, Marsh BP, Pessina P, Anbarasu CR, Brainson CF, Tuminello SJ, Lieberman A, Ryeom S, Schlaeger TM, Aronow BJ, Watanabe H, Wong KK, Kim CF.

Nat Commun. 2018 Nov 19;9(1):4559. doi: 10.1038/s41467-018-07077-1.

5.

Extracellular cyclic adenosine monophosphate-dependent protein kinase A autoantibody and C-reactive protein as serum biomarkers for diagnosis of cancer in dogs.

Ryu MO, Kim BG, Choi US, Baek KH, Song YK, Li Q, Seo KW, Ryeom S, Youn HY, Bhang DH.

Vet Comp Oncol. 2019 Mar;17(1):99-106. doi: 10.1111/vco.12450. Epub 2018 Nov 28.

6.

Testicular endothelial cells are a critical population in the germline stem cell niche.

Bhang DH, Kim BJ, Kim BG, Schadler K, Baek KH, Kim YH, Hsiao W, Ding BS, Rafii S, Weiss MJ, Chou ST, Kolon TF, Ginsberg JP, Ryu BY, Ryeom S.

Nat Commun. 2018 Oct 22;9(1):4379. doi: 10.1038/s41467-018-06881-z.

7.

E-cadherin and K-ras: implications of a newly developed model of gastric cancer.

Till JE, Yoon SS, Ryeom S.

Oncoscience. 2017 Nov 28;4(11-12):162-163. doi: 10.18632/oncoscience.379. eCollection 2017 Nov. No abstract available.

8.

Oncogenic KRAS and p53 Loss Drive Gastric Tumorigenesis in Mice That Can Be Attenuated by E-Cadherin Expression.

Till JE, Yoon C, Kim BJ, Roby K, Addai P, Jonokuchi E, Tang LH, Yoon SS, Ryeom S.

Cancer Res. 2017 Oct 1;77(19):5349-5359. doi: 10.1158/0008-5472.CAN-17-0061. Epub 2017 Jul 31.

9.

Role of Rac1 Pathway in Epithelial-to-Mesenchymal Transition and Cancer Stem-like Cell Phenotypes in Gastric Adenocarcinoma.

Yoon C, Cho SJ, Chang KK, Park DJ, Ryeom SW, Yoon SS.

Mol Cancer Res. 2017 Aug;15(8):1106-1116. doi: 10.1158/1541-7786.MCR-17-0053. Epub 2017 May 1.

10.

Detection of Oncogene-Induced Senescence In Vivo.

Baek KH, Ryeom S.

Methods Mol Biol. 2017;1534:185-198.

11.

Tumor vessel normalization after aerobic exercise enhances chemotherapeutic efficacy.

Schadler KL, Thomas NJ, Galie PA, Bhang DH, Roby KC, Addai P, Till JE, Sturgeon K, Zaslavsky A, Chen CS, Ryeom S.

Oncotarget. 2016 Oct 4;7(40):65429-65440. doi: 10.18632/oncotarget.11748.

12.

Chemotherapy Resistance in Diffuse-Type Gastric Adenocarcinoma Is Mediated by RhoA Activation in Cancer Stem-Like Cells.

Yoon C, Cho SJ, Aksoy BA, Park DJ, Schultz N, Ryeom SW, Yoon SS.

Clin Cancer Res. 2016 Feb 15;22(4):971-83. doi: 10.1158/1078-0432.CCR-15-1356. Epub 2015 Oct 19.

13.
14.

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead.

Goodson WH 3rd, Lowe L, Carpenter DO, Gilbertson M, Manaf Ali A, Lopez de Cerain Salsamendi A, Lasfar A, Carnero A, Azqueta A, Amedei A, Charles AK, Collins AR, Ward A, Salzberg AC, Colacci A, Olsen AK, Berg A, Barclay BJ, Zhou BP, Blanco-Aparicio C, Baglole CJ, Dong C, Mondello C, Hsu CW, Naus CC, Yedjou C, Curran CS, Laird DW, Koch DC, Carlin DJ, Felsher DW, Roy D, Brown DG, Ratovitski E, Ryan EP, Corsini E, Rojas E, Moon EY, Laconi E, Marongiu F, Al-Mulla F, Chiaradonna F, Darroudi F, Martin FL, Van Schooten FJ, Goldberg GS, Wagemaker G, Nangami GN, Calaf GM, Williams G, Wolf GT, Koppen G, Brunborg G, Lyerly HK, Krishnan H, Ab Hamid H, Yasaei H, Sone H, Kondoh H, Salem HK, Hsu HY, Park HH, Koturbash I, Miousse IR, Scovassi AI, Klaunig JE, Vondráček J, Raju J, Roman J, Wise JP Sr, Whitfield JR, Woodrick J, Christopher JA, Ochieng J, Martinez-Leal JF, Weisz J, Kravchenko J, Sun J, Prudhomme KR, Narayanan KB, Cohen-Solal KA, Moorwood K, Gonzalez L, Soucek L, Jian L, D'Abronzo LS, Lin LT, Li L, Gulliver L, McCawley LJ, Memeo L, Vermeulen L, Leyns L, Zhang L, Valverde M, Khatami M, Romano MF, Chapellier M, Williams MA, Wade M, Manjili MH, Lleonart ME, Xia M, Gonzalez MJ, Karamouzis MV, Kirsch-Volders M, Vaccari M, Kuemmerle NB, Singh N, Cruickshanks N, Kleinstreuer N, van Larebeke N, Ahmed N, Ogunkua O, Krishnakumar PK, Vadgama P, Marignani PA, Ghosh PM, Ostrosky-Wegman P, Thompson PA, Dent P, Heneberg P, Darbre P, Sing Leung P, Nangia-Makker P, Cheng QS, Robey RB, Al-Temaimi R, Roy R, Andrade-Vieira R, Sinha RK, Mehta R, Vento R, Di Fiore R, Ponce-Cusi R, Dornetshuber-Fleiss R, Nahta R, Castellino RC, Palorini R, Abd Hamid R, Langie SA, Eltom SE, Brooks SA, Ryeom S, Wise SS, Bay SN, Harris SA, Papagerakis S, Romano S, Pavanello S, Eriksson S, Forte S, Casey SC, Luanpitpong S, Lee TJ, Otsuki T, Chen T, Massfelder T, Sanderson T, Guarnieri T, Hultman T, Dormoy V, Odero-Marah V, Sabbisetti V, Maguer-Satta V, Rathmell WK, Engström W, Decker WK, Bisson WH, Rojanasakul Y, Luqmani Y, Chen Z, Hu Z.

Carcinogenesis. 2015 Jun;36 Suppl 1:S254-96. doi: 10.1093/carcin/bgv039. Review. Erratum in: Carcinogenesis. 2016 Mar;37(3):344.

15.

The effect of environmental chemicals on the tumor microenvironment.

Casey SC, Vaccari M, Al-Mulla F, Al-Temaimi R, Amedei A, Barcellos-Hoff MH, Brown DG, Chapellier M, Christopher J, Curran CS, Forte S, Hamid RA, Heneberg P, Koch DC, Krishnakumar PK, Laconi E, Maguer-Satta V, Marongiu F, Memeo L, Mondello C, Raju J, Roman J, Roy R, Ryan EP, Ryeom S, Salem HK, Scovassi AI, Singh N, Soucek L, Vermeulen L, Whitfield JR, Woodrick J, Colacci A, Bisson WH, Felsher DW.

Carcinogenesis. 2015 Jun;36 Suppl 1:S160-83. doi: 10.1093/carcin/bgv035. Review.

16.

Translational Upregulation of an Individual p21Cip1 Transcript Variant by GCN2 Regulates Cell Proliferation and Survival under Nutrient Stress.

Lehman SL, Cerniglia GJ, Johannes GJ, Ye J, Ryeom S, Koumenis C.

PLoS Genet. 2015 Jun 23;11(6):e1005212. doi: 10.1371/journal.pgen.1005212. eCollection 2015 Jun.

17.

Cyclosporin A promotes tumor angiogenesis in a calcineurin-independent manner by increasing mitochondrial reactive oxygen species.

Zhou AY, Ryeom S.

Mol Cancer Res. 2014 Nov;12(11):1663-76. doi: 10.1158/1541-7786.MCR-14-0136. Epub 2014 Jul 9.

18.

Concomitant low-dose doxorubicin treatment and exercise.

Sturgeon K, Schadler K, Muthukumaran G, Ding D, Bajulaiye A, Thomas NJ, Ferrari V, Ryeom S, Libonati JR.

Am J Physiol Regul Integr Comp Physiol. 2014 Sep 15;307(6):R685-92. doi: 10.1152/ajpregu.00082.2014. Epub 2014 Jul 9.

19.

Immunosurveillance by antiangiogenesis: tumor growth arrest by T cell-derived thrombospondin-1.

Schadler KL, Crosby EJ, Zhou AY, Bhang DH, Braunstein L, Baek KH, Crawford D, Crawford A, Angelosanto J, Wherry EJ, Ryeom S.

Cancer Res. 2014 Apr 15;74(8):2171-81. doi: 10.1158/0008-5472.CAN-13-0094. Epub 2014 Mar 3.

20.

Lung stem cell differentiation in mice directed by endothelial cells via a BMP4-NFATc1-thrombospondin-1 axis.

Lee JH, Bhang DH, Beede A, Huang TL, Stripp BR, Bloch KD, Wagers AJ, Tseng YH, Ryeom S, Kim CF.

Cell. 2014 Jan 30;156(3):440-55. doi: 10.1016/j.cell.2013.12.039.

21.

Thrombospondin-1 mediates oncogenic Ras-induced senescence in premalignant lung tumors.

Baek KH, Bhang D, Zaslavsky A, Wang LC, Vachani A, Kim CF, Albelda SM, Evan GI, Ryeom S.

J Clin Invest. 2013 Oct;123(10):4375-89. doi: 10.1172/JCI67465. Epub 2013 Sep 9.

22.

The calcineurin-NFAT-angiopoietin-2 signaling axis in lung endothelium is critical for the establishment of lung metastases.

Minami T, Jiang S, Schadler K, Suehiro J, Osawa T, Oike Y, Miura M, Naito M, Kodama T, Ryeom S.

Cell Rep. 2013 Aug 29;4(4):709-23. doi: 10.1016/j.celrep.2013.07.021. Epub 2013 Aug 15.

23.

The calcineurin-NFAT pathway negatively regulates megakaryopoiesis.

Zaslavsky A, Chou ST, Schadler K, Lieberman A, Pimkin M, Kim YJ, Baek KH, Aird WC, Weiss MJ, Ryeom S.

Blood. 2013 Apr 18;121(16):3205-15. doi: 10.1182/blood-2012-04-421172. Epub 2013 Feb 27.

24.
25.

Circulating endothelial progenitor cells are up-regulated in a mouse model of endometriosis.

Becker CM, Beaudry P, Funakoshi T, Benny O, Zaslavsky A, Zurakowski D, Folkman J, D'Amato RJ, Ryeom S.

Am J Pathol. 2011 Apr;178(4):1782-91. doi: 10.1016/j.ajpath.2010.12.037.

26.

The cautionary tale of side effects of chronic Notch1 inhibition.

Ryeom SW.

J Clin Invest. 2011 Feb;121(2):508-9. doi: 10.1172/JCI45976. Epub 2011 Jan 25.

27.

CD4(+) T cells contribute to the remodeling of the microenvironment required for sustained tumor regression upon oncogene inactivation.

Rakhra K, Bachireddy P, Zabuawala T, Zeiser R, Xu L, Kopelman A, Fan AC, Yang Q, Braunstein L, Crosby E, Ryeom S, Felsher DW.

Cancer Cell. 2010 Nov 16;18(5):485-98. doi: 10.1016/j.ccr.2010.10.002. Epub 2010 Oct 28. Erratum in: Cancer Cell. 2010 Dec 14;18(6):696.

28.

Differential effects of VEGFR-1 and VEGFR-2 inhibition on tumor metastases based on host organ environment.

Lee YJ, Karl DL, Maduekwe UN, Rothrock C, Ryeom S, D'Amore PA, Yoon SS.

Cancer Res. 2010 Nov 1;70(21):8357-67. doi: 10.1158/0008-5472.CAN-10-1138. Epub 2010 Oct 26.

29.

Regional control of tumor growth.

Zaslavsky A, Chen C, Grillo J, Baek KH, Holmgren L, Yoon SS, Folkman J, Ryeom S.

Mol Cancer Res. 2010 Sep;8(9):1198-206. doi: 10.1158/1541-7786.MCR-10-0047. Epub 2010 Aug 24.

30.

Roles of arrest-defective protein 1(225) and hypoxia-inducible factor 1alpha in tumor growth and metastasis.

Lee MN, Lee SN, Kim SH, Kim B, Jung BK, Seo JH, Park JH, Choi JH, Yim SH, Lee MR, Park JG, Yoo JY, Kim JH, Lee ST, Kim HM, Ryeom S, Kim KW, Oh GT.

J Natl Cancer Inst. 2010 Mar 17;102(6):426-42. doi: 10.1093/jnci/djq026. Epub 2010 Mar 1.

31.

An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB.

Min J, Zaslavsky A, Fedele G, McLaughlin SK, Reczek EE, De Raedt T, Guney I, Strochlic DE, Macconaill LE, Beroukhim R, Bronson RT, Ryeom S, Hahn WC, Loda M, Cichowski K.

Nat Med. 2010 Mar;16(3):286-94. doi: 10.1038/nm.2100. Epub 2010 Feb 14.

32.

Variable inhibition of thrombospondin 1 against liver and lung metastases through differential activation of metalloproteinase ADAMTS1.

Lee YJ, Koch M, Karl D, Torres-Collado AX, Fernando NT, Rothrock C, Kuruppu D, Ryeom S, Iruela-Arispe ML, Yoon SS.

Cancer Res. 2010 Feb 1;70(3):948-56. doi: 10.1158/0008-5472.CAN-09-3094. Epub 2010 Jan 26.

33.

Platelet-derived thrombospondin-1 is a critical negative regulator and potential biomarker of angiogenesis.

Zaslavsky A, Baek KH, Lynch RC, Short S, Grillo J, Folkman J, Italiano JE Jr, Ryeom S.

Blood. 2010 Jun 3;115(22):4605-13. doi: 10.1182/blood-2009-09-242065. Epub 2010 Jan 19.

34.

Down's syndrome: protection against cancer and the therapeutic potential of DSCR1.

Ryeom S, Baek KH, Zaslavsky A.

Future Oncol. 2009 Oct;5(8):1185-8. doi: 10.2217/fon.09.88. Review. No abstract available.

35.

Role of endogenous angiogenesis inhibitors in Down syndrome.

Ryeom S, Folkman J.

J Craniofac Surg. 2009 Mar;20 Suppl 1:595-6. Erratum in: J Craniofac Surg. 2009 Sep;20(5):1629-30.

PMID:
19795527
36.

The Down syndrome critical region gene 1 short variant promoters direct vascular bed-specific gene expression during inflammation in mice.

Minami T, Yano K, Miura M, Kobayashi M, Suehiro J, Reid PC, Hamakubo T, Ryeom S, Aird WC, Kodama T.

J Clin Invest. 2009 Aug;119(8):2257-70. doi: 10.1172/JCI35738. Epub 2009 Jul 13.

37.

Efficacy of sunitinib and radiotherapy in genetically engineered mouse model of soft-tissue sarcoma.

Yoon SS, Stangenberg L, Lee YJ, Rothrock C, Dreyfuss JM, Baek KH, Waterman PR, Nielsen GP, Weissleder R, Mahmood U, Park PJ, Jacks T, Dodd RD, Fisher CJ, Ryeom S, Kirsch DG.

Int J Radiat Oncol Biol Phys. 2009 Jul 15;74(4):1207-16. doi: 10.1016/j.ijrobp.2009.02.052. Erratum in: Int J Radiat Oncol Biol Phys. 2010 Aug 1;77(5):1607.

38.

Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1.

Baek KH, Zaslavsky A, Lynch RC, Britt C, Okada Y, Siarey RJ, Lensch MW, Park IH, Yoon SS, Minami T, Korenberg JR, Folkman J, Daley GQ, Aird WC, Galdzicki Z, Ryeom S.

Nature. 2009 Jun 25;459(7250):1126-30. doi: 10.1038/nature08062. Epub 2009 May 20.

39.

Targeted deletion of the calcineurin inhibitor DSCR1 suppresses tumor growth.

Ryeom S, Baek KH, Rioth MJ, Lynch RC, Zaslavsky A, Birsner A, Yoon SS, McKeon F.

Cancer Cell. 2008 May;13(5):420-31. doi: 10.1016/j.ccr.2008.02.018.

40.

Tumor escape from endogenous, extracellular matrix-associated angiogenesis inhibitors by up-regulation of multiple proangiogenic factors.

Fernando NT, Koch M, Rothrock C, Gollogly LK, D'Amore PA, Ryeom S, Yoon SS.

Clin Cancer Res. 2008 Mar 1;14(5):1529-39. doi: 10.1158/1078-0432.CCR-07-4126.

41.

Potent antitumor effects of ZD6474 on neuroblastoma via dual targeting of tumor cells and tumor endothelium.

Beaudry P, Nilsson M, Rioth M, Prox D, Poon D, Xu L, Zweidler-Mckay P, Ryan A, Folkman J, Ryeom S, Heymach J.

Mol Cancer Ther. 2008 Feb;7(2):418-24. doi: 10.1158/1535-7163.MCT-07-0568. Epub 2008 Feb 1.

42.

TORC1 is essential for NF1-associated malignancies.

Johannessen CM, Johnson BW, Williams SM, Chan AW, Reczek EE, Lynch RC, Rioth MJ, McClatchey A, Ryeom S, Cichowski K.

Curr Biol. 2008 Jan 8;18(1):56-62. doi: 10.1016/j.cub.2007.11.066. Epub 2007 Dec 27.

43.

Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet alpha granules and differentially released.

Italiano JE Jr, Richardson JL, Patel-Hett S, Battinelli E, Zaslavsky A, Short S, Ryeom S, Folkman J, Klement GL.

Blood. 2008 Feb 1;111(3):1227-33. Epub 2007 Oct 25.

44.

Endothelial progenitor cells contribute to accelerated liver regeneration.

Beaudry P, Hida Y, Udagawa T, Alwayn IP, Greene AK, Arsenault D, Folkman J, Heymach JV, Ryeom S, Puder M.

J Pediatr Surg. 2007 Jul;42(7):1190-8.

PMID:
17618879
46.

Sustained regression of tumors upon MYC inactivation requires p53 or thrombospondin-1 to reverse the angiogenic switch.

Giuriato S, Ryeom S, Fan AC, Bachireddy P, Lynch RC, Rioth MJ, van Riggelen J, Kopelman AM, Passegué E, Tang F, Folkman J, Felsher DW.

Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16266-71. Epub 2006 Oct 20.

47.

Is oncogene addiction angiogenesis-dependent?

Folkman J, Ryeom S.

Cold Spring Harb Symp Quant Biol. 2005;70:389-97.

PMID:
16869776
48.

Angiogenic profile of soft tissue sarcomas based on analysis of circulating factors and microarray gene expression.

Yoon SS, Segal NH, Park PJ, Detwiller KY, Fernando NT, Ryeom SW, Brennan MF, Singer S.

J Surg Res. 2006 Oct;135(2):282-90.

PMID:
16603191
49.

Analysis of hypoxia-related gene expression in sarcomas and effect of hypoxia on RNA interference of vascular endothelial cell growth factor A.

Detwiller KY, Fernando NT, Segal NH, Ryeom SW, D'Amore PA, Yoon SS.

Cancer Res. 2005 Jul 1;65(13):5881-9.

50.

The threshold pattern of calcineurin-dependent gene expression is altered by loss of the endogenous inhibitor calcipressin.

Ryeom S, Greenwald RJ, Sharpe AH, McKeon F.

Nat Immunol. 2003 Sep;4(9):874-81. Epub 2003 Aug 17.

PMID:
12925851

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