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Items: 1 to 50 of 65


Membrane associated collagen XIII promotes cancer metastasis and enhances anoikis resistance.

Zhang H, Fredericks T, Xiong G, Qi Y, Rychahou PG, Li JD, Pihlajaniemi T, Xu W, Xu R.

Breast Cancer Res. 2018 Oct 1;20(1):116. doi: 10.1186/s13058-018-1030-y.


Development of murine bariatric surgery models: lessons learned.

Frohman HA, Rychahou PG, Li J, Gan T, Evers BM.

J Surg Res. 2018 Sep;229:302-310. doi: 10.1016/j.jss.2018.04.022. Epub 2018 May 10.


Preclinical evaluation of novel fatty acid synthase inhibitors in primary colorectal cancer cells and a patient-derived xenograft model of colorectal cancer.

Zaytseva YY, Rychahou PG, Le AT, Scott TL, Flight RM, Kim JT, Harris J, Liu J, Wang C, Morris AJ, Sivakumaran TA, Fan T, Moseley H, Gao T, Lee EY, Weiss HL, Heuer TS, Kemble G, Evers M.

Oncotarget. 2018 May 15;9(37):24787-24800. doi: 10.18632/oncotarget.25361. eCollection 2018 May 15.


Deptor Is a Novel Target of Wnt/β-Catenin/c-Myc and Contributes to Colorectal Cancer Cell Growth.

Wang Q, Zhou Y, Rychahou P, Harris JW, Zaytseva YY, Liu J, Wang C, Weiss HL, Liu C, Lee EY, Evers BM.

Cancer Res. 2018 Jun 15;78(12):3163-3175. doi: 10.1158/0008-5472.CAN-17-3107. Epub 2018 Apr 17.


Colorectal cancer lung metastasis treatment with polymer-drug nanoparticles.

Rychahou P, Bae Y, Reichel D, Zaytseva YY, Lee EY, Napier D, Weiss HL, Roller N, Frohman H, Le AT, Mark Evers B.

J Control Release. 2018 Apr 10;275:85-91. doi: 10.1016/j.jconrel.2018.02.008. Epub 2018 Feb 6.


The role of talin2 in breast cancer tumorigenesis and metastasis.

Li L, Li X, Qi L, Rychahou P, Jafari N, Huang C.

Oncotarget. 2017 Nov 6;8(63):106876-106887. doi: 10.18632/oncotarget.22449. eCollection 2017 Dec 5.


Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression.

Pi F, Binzel DW, Lee TJ, Li Z, Sun M, Rychahou P, Li H, Haque F, Wang S, Croce CM, Guo B, Evers BM, Guo P.

Nat Nanotechnol. 2018 Jan;13(1):82-89. doi: 10.1038/s41565-017-0012-z. Epub 2017 Dec 11.


Development of Halofluorochromic Polymer Nanoassemblies for the Potential Detection of Liver Metastatic Colorectal Cancer Tumors Using Experimental and Computational Approaches.

Reichel D, Curtis LT, Ehlman E, Mark Evers B, Rychahou P, Frieboes HB, Bae Y.

Pharm Res. 2017 Nov;34(11):2385-2402. doi: 10.1007/s11095-017-2245-9. Epub 2017 Aug 24.


Polymer nanoassemblies with hydrophobic pendant groups in the core induce false positive siRNA transfection in luciferase reporter assays.

Rheiner S, Reichel D, Rychahou P, Izumi T, Yang HS, Bae Y.

Int J Pharm. 2017 Aug 7;528(1-2):536-546. doi: 10.1016/j.ijpharm.2017.06.056. Epub 2017 Jun 16.


Fluorinated N,N'-Diarylureas As Novel Therapeutic Agents Against Cancer Stem Cells.

Kenlan DE, Rychahou P, Sviripa VM, Weiss HL, Liu C, Watt DS, Evers BM.

Mol Cancer Ther. 2017 May;16(5):831-837. doi: 10.1158/1535-7163.MCT-15-0634. Epub 2017 Mar 3.


Ketogenesis contributes to intestinal cell differentiation.

Wang Q, Zhou Y, Rychahou P, Fan TW, Lane AN, Weiss HL, Evers BM.

Cell Death Differ. 2017 Mar;24(3):458-468. doi: 10.1038/cdd.2016.142. Epub 2016 Dec 9.


A Computational/Experimental Assessment of Antitumor Activity of Polymer Nanoassemblies for pH-Controlled Drug Delivery to Primary and Metastatic Tumors.

Curtis LT, Rychahou P, Bae Y, Frieboes HB.

Pharm Res. 2016 Oct;33(10):2552-64. doi: 10.1007/s11095-016-1981-6. Epub 2016 Jun 29.


An obligatory role for neurotensin in high-fat-diet-induced obesity.

Li J, Song J, Zaytseva YY, Liu Y, Rychahou P, Jiang K, Starr ME, Kim JT, Harris JW, Yiannikouris FB, Katz WS, Nilsson PM, Orho-Melander M, Chen J, Zhu H, Fahrenholz T, Higashi RM, Gao T, Morris AJ, Cassis LA, Fan TW, Weiss HL, Dobner PR, Melander O, Jia J, Evers BM.

Nature. 2016 May 19;533(7603):411-5. doi: 10.1038/nature17662. Epub 2016 May 11.


Polymer nanoassemblies with solvato- and halo-fluorochromism for drug release monitoring and metastasis imaging.

Reichel D, Rychahou P, Bae Y.

Ther Deliv. 2015;6(10):1221-37. doi: 10.4155/tde.15.59. Epub 2015 Oct 8.


The role of ROS generation from magnetic nanoparticles in an alternating magnetic field on cytotoxicity.

Wydra RJ, Rychahou PG, Evers BM, Anderson KW, Dziubla TD, Hilt JZ.

Acta Biomater. 2015 Oct;25:284-90. doi: 10.1016/j.actbio.2015.06.037. Epub 2015 Jul 2. Erratum in: Acta Biomater. 2016 Mar;33:322-3.


RNA Nanoparticles Derived from Three-Way Junction of Phi29 Motor pRNA Are Resistant to I-125 and Cs-131 Radiation.

Li H, Rychahou PG, Cui Z, Pi F, Evers BM, Shu D, Guo P, Luo W.

Nucleic Acid Ther. 2015 Aug;25(4):188-97. Epub 2015 May 27.


Methods and assays for specific targeting and delivery of RNA nanoparticles to cancer metastases.

Rychahou P, Shu Y, Haque F, Hu J, Guo P, Evers BM.

Methods Mol Biol. 2015;1297:121-35. doi: 10.1007/978-1-4939-2562-9_9.


TSC2/mTORC1 signaling controls Paneth and goblet cell differentiation in the intestinal epithelium.

Zhou Y, Rychahou P, Wang Q, Weiss HL, Evers BM.

Cell Death Dis. 2015 Feb 5;6:e1631. doi: 10.1038/cddis.2014.588.


Delivery of RNA nanoparticles into colorectal cancer metastases following systemic administration.

Rychahou P, Haque F, Shu Y, Zaytseva Y, Weiss HL, Lee EY, Mustain W, Valentino J, Guo P, Evers BM.

ACS Nano. 2015 Feb 24;9(2):1108-16. doi: 10.1021/acsnano.5b00067. Epub 2015 Feb 10.


Activation of c-Met and upregulation of CD44 expression are associated with the metastatic phenotype in the colorectal cancer liver metastasis model.

Elliott VA, Rychahou P, Zaytseva YY, Evers BM.

PLoS One. 2014 May 13;9(5):e97432. doi: 10.1371/journal.pone.0097432. eCollection 2014.


Cancer cell-associated fatty acid synthase activates endothelial cells and promotes angiogenesis in colorectal cancer.

Zaytseva YY, Elliott VA, Rychahou P, Mustain WC, Kim JT, Valentino J, Gao T, O'Connor KL, Neltner JM, Lee EY, Weiss HL, Evers BM.

Carcinogenesis. 2014 Jun;35(6):1341-51. doi: 10.1093/carcin/bgu042. Epub 2014 Feb 7.


Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition.

Xiong G, Deng L, Zhu J, Rychahou PG, Xu R.

BMC Cancer. 2014 Jan 2;14:1. doi: 10.1186/1471-2407-14-1.


Engineered nanopore of Phi29 DNA-packaging motor for real-time detection of single colon cancer specific antibody in serum.

Wang S, Haque F, Rychahou PG, Evers BM, Guo P.

ACS Nano. 2013 Nov 26;7(11):9814-22. doi: 10.1021/nn404435v. Epub 2013 Oct 30.


Murine portal vein catheterization to analyze liver-directed therapies.

Valentino JD, Rychahou PG, Mustain WC, Elliott VA, Evers BM.

J Surg Res. 2013 Dec;185(2):690-6. doi: 10.1016/j.jss.2013.06.051. Epub 2013 Jul 17.


NFAT5 represses canonical Wnt signaling via inhibition of β-catenin acetylation and participates in regulating intestinal cell differentiation.

Wang Q, Zhou Y, Rychahou P, Liu C, Weiss HL, Evers BM.

Cell Death Dis. 2013 Jun 13;4:e671. doi: 10.1038/cddis.2013.202.


Ubiquitylation of phosphatidylinositol 4-phosphate 5-kinase type I γ by HECTD1 regulates focal adhesion dynamics and cell migration.

Li X, Zhou Q, Sunkara M, Kutys ML, Wu Z, Rychahou P, Morris AJ, Zhu H, Evers BM, Huang C.

J Cell Sci. 2013 Jun 15;126(Pt 12):2617-28. doi: 10.1242/jcs.117044. Epub 2013 Apr 9.


Deregulation of Wnt/β-catenin signaling through genetic or epigenetic alterations in human neuroendocrine tumors.

Kim JT, Li J, Jang ER, Gulhati P, Rychahou PG, Napier DL, Wang C, Weiss HL, Lee EY, Anthony L, Townsend CM Jr, Liu C, Evers BM.

Carcinogenesis. 2013 May;34(5):953-61. doi: 10.1093/carcin/bgt018. Epub 2013 Jan 25.


Ultrastable synergistic tetravalent RNA nanoparticles for targeting to cancers.

Haque F, Shu D, Shu Y, Shlyakhtenko LS, Rychahou PG, Evers BM, Guo P.

Nano Today. 2012 Aug;7(4):245-257.


Novel small interfering RNA cotargeting strategy as treatment for colorectal cancer.

Valentino JD, Elliott VA, Zaytseva YY, Rychahou PG, Mustain WC, Wang C, Gao T, Evers BM.

Surgery. 2012 Aug;152(2):277-85. doi: 10.1016/j.surg.2012.05.006.


PI3K p110α/Akt signaling negatively regulates secretion of the intestinal peptide neurotensin through interference of granule transport.

Li J, Song J, Cassidy MG, Rychahou P, Starr ME, Liu J, Li X, Epperly G, Weiss HL, Townsend CM Jr, Gao T, Evers BM.

Mol Endocrinol. 2012 Aug;26(8):1380-93. doi: 10.1210/me.2012-1024. Epub 2012 Jun 14.


Interaction with Suv39H1 is critical for Snail-mediated E-cadherin repression in breast cancer.

Dong C, Wu Y, Wang Y, Wang C, Kang T, Rychahou PG, Chi YI, Evers BM, Zhou BP.

Oncogene. 2013 Mar 14;32(11):1351-62. doi: 10.1038/onc.2012.169. Epub 2012 May 7.


G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer.

Dong C, Wu Y, Yao J, Wang Y, Yu Y, Rychahou PG, Evers BM, Zhou BP.

J Clin Invest. 2012 Apr;122(4):1469-86. doi: 10.1172/JCI57349. Epub 2012 Mar 12.


Inhibition of fatty acid synthase attenuates CD44-associated signaling and reduces metastasis in colorectal cancer.

Zaytseva YY, Rychahou PG, Gulhati P, Elliott VA, Mustain WC, O'Connor K, Morris AJ, Sunkara M, Weiss HL, Lee EY, Evers BM.

Cancer Res. 2012 Mar 15;72(6):1504-17. doi: 10.1158/0008-5472.CAN-11-4057. Epub 2012 Jan 19.


Regulation of the potential marker for intestinal cells, Bmi1, by β-catenin and the zinc finger protein KLF4: implications for colon cancer.

Yu T, Chen X, Zhang W, Colon D, Shi J, Napier D, Rychahou P, Lu W, Lee EY, Weiss HL, Evers BM, Liu C.

J Biol Chem. 2012 Feb 3;287(6):3760-8. doi: 10.1074/jbc.M111.316349. Epub 2011 Dec 14.


Inhibition of aldose reductase prevents colon cancer metastasis.

Tammali R, Reddy AB, Saxena A, Rychahou PG, Evers BM, Qiu S, Awasthi S, Ramana KV, Srivastava SK.

Carcinogenesis. 2011 Aug;32(8):1259-67. doi: 10.1093/carcin/bgr102. Epub 2011 Jun 3.


mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways.

Gulhati P, Bowen KA, Liu J, Stevens PD, Rychahou PG, Chen M, Lee EY, Weiss HL, O'Connor KL, Gao T, Evers BM.

Cancer Res. 2011 May 1;71(9):3246-56. doi: 10.1158/0008-5472.CAN-10-4058. Epub 2011 Mar 23.


Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression.

Zhang W, Sviripa V, Kril LM, Chen X, Yu T, Shi J, Rychahou P, Evers BM, Watt DS, Liu C.

J Med Chem. 2011 Mar 10;54(5):1288-97. doi: 10.1021/jm101248v. Epub 2011 Feb 3.


The role of neurotensin in physiologic and pathologic processes.

Mustain WC, Rychahou PG, Evers BM.

Curr Opin Endocrinol Diabetes Obes. 2011 Feb;18(1):75-82. doi: 10.1097/MED.0b013e3283419052. Review.


VEGFR-2 expression in carcinoid cancer cells and its role in tumor growth and metastasis.

Silva SR, Bowen KA, Rychahou PG, Jackson LN, Weiss HL, Lee EY, Townsend CM Jr, Evers BM.

Int J Cancer. 2011 Mar 1;128(5):1045-56. doi: 10.1002/ijc.25441.


Novel expression patterns of PI3K/Akt/mTOR signaling pathway components in colorectal cancer.

Johnson SM, Gulhati P, Rampy BA, Han Y, Rychahou PG, Doan HQ, Weiss HL, Evers BM.

J Am Coll Surg. 2010 May;210(5):767-76, 776-8. doi: 10.1016/j.jamcollsurg.2009.12.008.


Hydrodynamic delivery protocols.

Rychahou PG, Evers BM.

Methods Mol Biol. 2010;623:189-95. doi: 10.1007/978-1-60761-588-0_12.


PTEN loss induces epithelial--mesenchymal transition in human colon cancer cells.

Bowen KA, Doan HQ, Zhou BP, Wang Q, Zhou Y, Rychahou PG, Evers BM.

Anticancer Res. 2009 Nov;29(11):4439-49.


Targeted inhibition of mammalian target of rapamycin signaling inhibits tumorigenesis of colorectal cancer.

Gulhati P, Cai Q, Li J, Liu J, Rychahou PG, Qiu S, Lee EY, Silva SR, Bowen KA, Gao T, Evers BM.

Clin Cancer Res. 2009 Dec 1;15(23):7207-16. doi: 10.1158/1078-0432.CCR-09-1249. Epub 2009 Nov 24.


Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion.

Wu Y, Deng J, Rychahou PG, Qiu S, Evers BM, Zhou BP.

Cancer Cell. 2009 May 5;15(5):416-28. doi: 10.1016/j.ccr.2009.03.016.


Development and characterization of a novel in vivo model of carcinoid syndrome.

Jackson LN, Chen LA, Larson SD, Silva SR, Rychahou PG, Boor PJ, Li J, Defreitas G, Stafford WL, Townsend CM Jr, Evers BM.

Clin Cancer Res. 2009 Apr 15;15(8):2747-55. doi: 10.1158/1078-0432.CCR-08-2346. Epub 2009 Mar 31.


Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis.

Liu J, Weiss HL, Rychahou P, Jackson LN, Evers BM, Gao T.

Oncogene. 2009 Feb 19;28(7):994-1004. doi: 10.1038/onc.2008.450. Epub 2008 Dec 15.


Akt2 overexpression plays a critical role in the establishment of colorectal cancer metastasis.

Rychahou PG, Kang J, Gulhati P, Doan HQ, Chen LA, Xiao SY, Chung DH, Evers BM.

Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20315-20. doi: 10.1073/pnas.0810715105. Epub 2008 Dec 15.


Gastrin-releasing peptide receptor silencing suppresses the tumorigenesis and metastatic potential of neuroblastoma.

Qiao J, Kang J, Ishola TA, Rychahou PG, Evers BM, Chung DH.

Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12891-6. doi: 10.1073/pnas.0711861105. Epub 2008 Aug 27.


PI3K/Akt activation is critical for early hepatic regeneration after partial hepatectomy.

Jackson LN, Larson SD, Silva SR, Rychahou PG, Chen LA, Qiu S, Rajaraman S, Evers BM.

Am J Physiol Gastrointest Liver Physiol. 2008 Jun;294(6):G1401-10. doi: 10.1152/ajpgi.00062.2008. Epub 2008 Apr 3.


N-myc is a novel regulator of PI3K-mediated VEGF expression in neuroblastoma.

Kang J, Rychahou PG, Ishola TA, Mourot JM, Evers BM, Chung DH.

Oncogene. 2008 Jun 26;27(28):3999-4007. doi: 10.1038/onc.2008.15. Epub 2008 Feb 18.

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