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Items: 14


Photophysics of diphenyl-pyrazole compounds in solutions and α-synuclein aggregates.

Reiner AM, Schmidt F, Ryazanov S, Leonov A, Weckbecker D, Deeg AA, Griesinger C, Giese A, Zinth W.

Biochim Biophys Acta. 2018 Apr;1862(4):800-807. doi: 10.1016/j.bbagen.2017.12.007. Epub 2017 Dec 19.


3D molecular cartography using LC-MS facilitated by Optimus and 'ili software.

Protsyuk I, Melnik AV, Nothias LF, Rappez L, Phapale P, Aksenov AA, Bouslimani A, Ryazanov S, Dorrestein PC, Alexandrov T.

Nat Protoc. 2018 Jan;13(1):134-154. doi: 10.1038/nprot.2017.122. Epub 2017 Dec 21.


The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology.

Martinez Hernandez A, Urbanke H, Gillman AL, Lee J, Ryazanov S, Agbemenyah HY, Benito E, Jain G, Kaurani L, Grigorian G, Leonov A, Rezaei-Ghaleh N, Wilken P, Arce FT, Wagner J, Fuhrmann M, Caruana M, Camilleri A, Vassallo N, Zweckstetter M, Benz R, Giese A, Schneider A, Korte M, Lal R, Griesinger C, Eichele G, Fischer A.

EMBO Mol Med. 2018 Jan;10(1):32-47. doi: 10.15252/emmm.201707825.


The role of circadian rhythm and environmental factors in the regulation of sea urchin spawning.

Zhadan PM, Vaschenko MA, Ryazanov SD.

Dokl Biol Sci. 2017 Sep;476(1):191-195. doi: 10.1134/S0012496617050040. Epub 2017 Nov 4.


Treatment with diphenyl-pyrazole compound anle138b/c reveals that α-synuclein protects melanoma cells from autophagic cell death.

Turriani E, Lázaro DF, Ryazanov S, Leonov A, Giese A, Schön M, Schön MP, Griesinger C, Outeiro TF, Arndt-Jovin DJ, Becker D.

Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):E4971-E4977. doi: 10.1073/pnas.1700200114. Epub 2017 Jun 5.


Digitizing mass spectrometry data to explore the chemical diversity and distribution of marine cyanobacteria and algae.

Luzzatto-Knaan T, Garg N, Wang M, Glukhov E, Peng Y, Ackermann G, Amir A, Duggan BM, Ryazanov S, Gerwick L, Knight R, Alexandrov T, Bandeira N, Gerwick WH, Dorrestein PC.

Elife. 2017 May 11;6. pii: e24214. doi: 10.7554/eLife.24214.


The bacterial SRP receptor, FtsY, is activated on binding to the translocon.

Draycheva A, Bornemann T, Ryazanov S, Lakomek NA, Wintermeyer W.

Mol Microbiol. 2016 Oct;102(1):152-67. doi: 10.1111/mmi.13452. Epub 2016 Jul 19.


Anle138b Partly Ameliorates Motor Deficits Despite Failure of Neuroprotection in a Model of Advanced Multiple System Atrophy.

Fellner L, Kuzdas-Wood D, Levin J, Ryazanov S, Leonov A, Griesinger C, Giese A, Wenning GK, Stefanova N.

Front Neurosci. 2016 Mar 10;10:99. doi: 10.3389/fnins.2016.00099. eCollection 2016.


Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies.

Wagner J, Krauss S, Shi S, Ryazanov S, Steffen J, Miklitz C, Leonov A, Kleinknecht A, Göricke B, Weishaupt JH, Weckbecker D, Reiner AM, Zinth W, Levin J, Ehninger D, Remy S, Kretzschmar HA, Griesinger C, Giese A, Fuhrmann M.

Acta Neuropathol. 2015 Nov;130(5):619-31. doi: 10.1007/s00401-015-1483-3. Epub 2015 Oct 6.


Quantitative Real-Time Quaking-Induced Conversion Allows Monitoring of Disease-Modifying Therapy in the Urine of Prion-Infected Mice.

Shi S, Wagner J, Mitteregger-Kretzschmar G, Ryazanov S, Leonov A, Griesinger C, Giese A.

J Neuropathol Exp Neurol. 2015 Sep;74(9):924-33. doi: 10.1097/NEN.0000000000000233.


Anle138b and related compounds are aggregation specific fluorescence markers and reveal high affinity binding to α-synuclein aggregates.

Deeg AA, Reiner AM, Schmidt F, Schueder F, Ryazanov S, Ruf VC, Giller K, Becker S, Leonov A, Griesinger C, Giese A, Zinth W.

Biochim Biophys Acta. 2015 Sep;1850(9):1884-90. doi: 10.1016/j.bbagen.2015.05.021. Epub 2015 May 29.


Age specific survival rates of Steller sea lions at rookeries with divergent population trends in the Russian Far East.

Altukhov AV, Andrews RD, Calkins DG, Gelatt TS, Gurarie ED, Loughlin TR, Mamaev EG, Nikulin VS, Permyakov PA, Ryazanov SD, Vertyankin VV, Burkanov VN.

PLoS One. 2015 May 27;10(5):e0127292. doi: 10.1371/journal.pone.0127292. eCollection 2015.


The oligomer modulator anle138b inhibits disease progression in a Parkinson mouse model even with treatment started after disease onset.

Levin J, Schmidt F, Boehm C, Prix C, Bötzel K, Ryazanov S, Leonov A, Griesinger C, Giese A.

Acta Neuropathol. 2014 May;127(5):779-80. doi: 10.1007/s00401-014-1265-3. Epub 2014 Mar 11. No abstract available.


Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease.

Wagner J, Ryazanov S, Leonov A, Levin J, Shi S, Schmidt F, Prix C, Pan-Montojo F, Bertsch U, Mitteregger-Kretzschmar G, Geissen M, Eiden M, Leidel F, Hirschberger T, Deeg AA, Krauth JJ, Zinth W, Tavan P, Pilger J, Zweckstetter M, Frank T, Bähr M, Weishaupt JH, Uhr M, Urlaub H, Teichmann U, Samwer M, Bötzel K, Groschup M, Kretzschmar H, Griesinger C, Giese A.

Acta Neuropathol. 2013 Jun;125(6):795-813. doi: 10.1007/s00401-013-1114-9. Epub 2013 Apr 19.

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