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Chronic kidney disease exacerbates ischemic limb myopathy in mice via altered mitochondrial energetics.

Berru FN, Gray SE, Thome T, Kumar RA, Salyers ZR, Coleman M, Dennis Le, O'Malley K, Ferreira LF, Berceli SA, Scali ST, Ryan TE.

Sci Rep. 2019 Oct 29;9(1):15547. doi: 10.1038/s41598-019-52107-7.


Assessing mitochondrial energetics in vivo with molecular detail: the best of both worlds using mitoRACE.

Ryan TE.

J Physiol. 2019 Nov;597(22):5319-5320. doi: 10.1113/JP278897. Epub 2019 Oct 30. No abstract available.


Mitochondrial PE potentiates respiratory enzymes to amplify skeletal muscle aerobic capacity.

Heden TD, Johnson JM, Ferrara PJ, Eshima H, Verkerke ARP, Wentzler EJ, Siripoksup P, Narowski TM, Coleman CB, Lin CT, Ryan TE, Reidy PT, de Castro Brás LE, Karner CM, Burant CF, Maschek JA, Cox JE, Mashek DG, Kardon G, Boudina S, Zeczycki TN, Rutter J, Shaikh SR, Vance JE, Drummond MJ, Neufer PD, Funai K.

Sci Adv. 2019 Sep 11;5(9):eaax8352. doi: 10.1126/sciadv.aax8352. eCollection 2019 Sep.


Vitamin C and Thiamine for Sepsis and Septic Shock.

Mitchell AB, Ryan TE, Gillion AR, Wells LD, Muthiah MP.

Am J Med. 2019 Aug 27. pii: S0002-9343(19)30699-0. doi: 10.1016/j.amjmed.2019.07.054. [Epub ahead of print]


High-intensity exercise to promote accelerated improvements in cardiorespiratory fitness (HI-PACE): study protocol for a randomized controlled trial.

McGee JE, Barefoot SG, Gniewek NR, Brophy PM, Clark A, Dubis GS, Ryan TE, Houmard JA, Vos P, Raedeke TD, Swift DL.

Trials. 2019 Aug 8;20(1):484. doi: 10.1186/s13063-019-3611-1.


Mitochondrial respiration and H2O2 emission in saponin-permeabilized murine diaphragm fibers: optimization of fiber separation and comparison to limb muscle.

Hahn D, Kumar RA, Ryan TE, Ferreira LF.

Am J Physiol Cell Physiol. 2019 Oct 1;317(4):C665-C673. doi: 10.1152/ajpcell.00184.2019. Epub 2019 Jul 17.


Uremic metabolites impair skeletal muscle mitochondrial energetics through disruption of the electron transport system and matrix dehydrogenase activity.

Thome T, Salyers ZR, Kumar RA, Hahn D, Berru FN, Ferreira LF, Scali ST, Ryan TE.

Am J Physiol Cell Physiol. 2019 Oct 1;317(4):C701-C713. doi: 10.1152/ajpcell.00098.2019. Epub 2019 Jul 10.


Chronic high-fat diet decreased detrusor mitochondrial respiration and increased nerve-mediated contractions.

Powers SA, Ryan TE, Pak ES, Fraser MO, McClung JM, Hannan JL.

Neurourol Urodyn. 2019 Aug;38(6):1524-1532. doi: 10.1002/nau.24015. Epub 2019 May 10.


Morphing mitochondria: understanding the development of the mitochondrial reticulum in skeletal muscle.

Ryan TE.

J Physiol. 2019 May;597(10):2619-2620. doi: 10.1113/JP278057. Epub 2019 Apr 23. No abstract available.


Induced in vivo knockdown of the Brca1 gene in skeletal muscle results in skeletal muscle weakness.

Tarpey MD, Valencia AP, Jackson KC, Amorese AJ, Balestrieri NP, Renegar RH, Pratt SJP, Ryan TE, McClung JM, Lovering RM, Spangenburg EE.

J Physiol. 2019 Feb;597(3):869-887. doi: 10.1113/JP276863. Epub 2018 Dec 16.


Extensive skeletal muscle cell mitochondriopathy distinguishes critical limb ischemia patients from claudicants.

Ryan TE, Yamaguchi DJ, Schmidt CA, Zeczycki TN, Shaikh SR, Brophy P, Green TD, Tarpey MD, Karnekar R, Goldberg EJ, Sparagna GC, Torres MJ, Annex BH, Neufer PD, Spangenburg EE, McClung JM.

JCI Insight. 2018 Nov 2;3(21). pii: 123235. doi: 10.1172/jci.insight.123235.


Impact of 17β-estradiol on complex I kinetics and H2O2 production in liver and skeletal muscle mitochondria.

Torres MJ, Ryan TE, Lin CT, Zeczycki TN, Neufer PD.

J Biol Chem. 2018 Oct 26;293(43):16889-16898. doi: 10.1074/jbc.RA118.005148. Epub 2018 Sep 14.


Characterization and utilization of the flexor digitorum brevis for assessing skeletal muscle function.

Tarpey MD, Amorese AJ, Balestrieri NP, Ryan TE, Schmidt CA, McClung JM, Spangenburg EE.

Skelet Muscle. 2018 Apr 17;8(1):14. doi: 10.1186/s13395-018-0160-3.


Strain-Dependent Variation in Acute Ischemic Muscle Injury.

Schmidt CA, Amorese AJ, Ryan TE, Goldberg EJ, Tarpey MD, Green TD, Karnekar RR, Yamaguchi DJ, Spangenburg EE, McClung JM.

Am J Pathol. 2018 May;188(5):1246-1262. doi: 10.1016/j.ajpath.2018.01.008. Epub 2018 Feb 16.


Near-infrared spectroscopy detects age-related differences in skeletal muscle oxidative function: promising implications for geroscience.

Chung S, Rosenberry R, Ryan TE, Munson M, Dombrowsky T, Park S, Nasirian A, Haykowsky MJ, Nelson MD.

Physiol Rep. 2018 Feb;6(3). doi: 10.14814/phy2.13588.


Commentaries on Viewpoint: Principles, insights, and potential pitfalls of the noninvasive determination of muscle oxidative capacity by near-infrared spectroscopy.

Chung S, Nelson MD, Hamaoka T, Jacobs RA, Pearson J, Subudhi AW, Jenkins NT, Bartlett MF, Fitzgerald LF, Miehm JD, Kent JA, Lucero AA, Rowlands DS, Stoner L, McCully KK, Call J, Rodriguez-Miguelez P, Harris RA, Porcelli S, Rasica L, Marzorati M, Quaresima V, Ryan TE, Vernillo G, Millet GP, Malatesta D, Millet GY, Zuo L, Chuang CC.

J Appl Physiol (1985). 2018 Jan 1;124(1):249-255. doi: 10.1152/japplphysiol.00857.2017. No abstract available.


17β-Estradiol Directly Lowers Mitochondrial Membrane Microviscosity and Improves Bioenergetic Function in Skeletal Muscle.

Torres MJ, Kew KA, Ryan TE, Pennington ER, Lin CT, Buddo KA, Fix AM, Smith CA, Gilliam LA, Karvinen S, Lowe DA, Spangenburg EE, Zeczycki TN, Shaikh SR, Neufer PD.

Cell Metab. 2018 Jan 9;27(1):167-179.e7. doi: 10.1016/j.cmet.2017.10.003. Epub 2017 Nov 2.


Greater Oxidative Capacity in Primary Myotubes from Endurance-trained Women.

Heden TD, Ryan TE, Ferrara PJ, Hickner RC, Brophy PM, Neufer PD, McClung JM, Funai K.

Med Sci Sports Exerc. 2017 Nov;49(11):2151-2157. doi: 10.1249/MSS.0000000000001352.


BAG3 (Bcl-2-Associated Athanogene-3) Coding Variant in Mice Determines Susceptibility to Ischemic Limb Muscle Myopathy by Directing Autophagy.

McClung JM, McCord TJ, Ryan TE, Schmidt CA, Green TD, Southerland KW, Reinardy JL, Mueller SB, Venkatraman TN, Lascola CD, Keum S, Marchuk DA, Spangenburg EE, Dokun A, Annex BH, Kontos CD.

Circulation. 2017 Jul 18;136(3):281-296. doi: 10.1161/CIRCULATIONAHA.116.024873. Epub 2017 Apr 25.


Diminished force production and mitochondrial respiratory deficits are strain-dependent myopathies of subacute limb ischemia.

Schmidt CA, Ryan TE, Lin CT, Inigo MMR, Green TD, Brault JJ, Spangenburg EE, McClung JM.

J Vasc Surg. 2017 May;65(5):1504-1514.e11. doi: 10.1016/j.jvs.2016.04.041. Epub 2016 Dec 23.


Endurance neuromuscular electrical stimulation training improves skeletal muscle oxidative capacity in individuals with motor-complete spinal cord injury.

Erickson ML, Ryan TE, Backus D, McCully KK.

Muscle Nerve. 2017 May;55(5):669-675. doi: 10.1002/mus.25393. Epub 2017 Jan 11.


A Direct Comparison of Metabolic Responses to High-Fat Diet in C57BL/6J and C57BL/6NJ Mice.

Fisher-Wellman KH, Ryan TE, Smith CD, Gilliam LA, Lin CT, Reese LR, Torres MJ, Neufer PD.

Diabetes. 2016 Nov;65(11):3249-3261. Epub 2016 Aug 5.


Direct real-time quantification of mitochondrial oxidative phosphorylation efficiency in permeabilized skeletal muscle myofibers.

Lark DS, Torres MJ, Lin CT, Ryan TE, Anderson EJ, Neufer PD.

Am J Physiol Cell Physiol. 2016 Aug 1;311(2):C239-45. doi: 10.1152/ajpcell.00124.2016. Epub 2016 Jun 22.


Targeted overexpression of mitochondrial catalase protects against cancer chemotherapy-induced skeletal muscle dysfunction.

Gilliam LA, Lark DS, Reese LR, Torres MJ, Ryan TE, Lin CT, Cathey BL, Neufer PD.

Am J Physiol Endocrinol Metab. 2016 Aug 1;311(2):E293-301. doi: 10.1152/ajpendo.00540.2015. Epub 2016 Jun 21.


Targeted Expression of Catalase to Mitochondria Protects Against Ischemic Myopathy in High-Fat Diet-Fed Mice.

Ryan TE, Schmidt CA, Green TD, Spangenburg EE, Neufer PD, McClung JM.

Diabetes. 2016 Sep;65(9):2553-68. doi: 10.2337/db16-0387. Epub 2016 Jun 9.


Mitochondrial therapy improves limb perfusion and myopathy following hindlimb ischemia.

Ryan TE, Schmidt CA, Alleman RJ, Tsang AM, Green TD, Neufer PD, Brown DA, McClung JM.

J Mol Cell Cardiol. 2016 Aug;97:191-6. doi: 10.1016/j.yjmcc.2016.05.015. Epub 2016 Jun 1.


Ceramide-tamoxifen regimen targets bioenergetic elements in acute myelogenous leukemia.

Morad SA, Ryan TE, Neufer PD, Zeczycki TN, Davis TS, MacDougall MR, Fox TE, Tan SF, Feith DJ, Loughran TP Jr, Kester M, Claxton DF, Barth BM, Deering TG, Cabot MC.

J Lipid Res. 2016 Jul;57(7):1231-42. doi: 10.1194/jlr.M067389. Epub 2016 May 2.


Exercise-induced protection against reperfusion arrhythmia involves stabilization of mitochondrial energetics.

Alleman RJ, Tsang AM, Ryan TE, Patteson DJ, McClung JM, Spangenburg EE, Shaikh SR, Neufer PD, Brown DA.

Am J Physiol Heart Circ Physiol. 2016 May 15;310(10):H1360-70. doi: 10.1152/ajpheart.00858.2015. Epub 2016 Mar 4.


Mitochondrial Regulation of the Muscle Microenvironment in Critical Limb Ischemia.

Ryan TE, Schmidt CA, Green TD, Brown DA, Neufer PD, McClung JM.

Front Physiol. 2015 Nov 18;6:336. doi: 10.3389/fphys.2015.00336. eCollection 2015. Review.


Protein Kinase A Governs Oxidative Phosphorylation Kinetics and Oxidant Emitting Potential at Complex I.

Lark DS, Reese LR, Ryan TE, Torres MJ, Smith CD, Lin CT, Neufer PD.

Front Physiol. 2015 Nov 17;6:332. doi: 10.3389/fphys.2015.00332. eCollection 2015.


Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells.

Ferdaoussi M, Dai X, Jensen MV, Wang R, Peterson BS, Huang C, Ilkayeva O, Smith N, Miller N, Hajmrle C, Spigelman AF, Wright RC, Plummer G, Suzuki K, Mackay JP, van de Bunt M, Gloyn AL, Ryan TE, Norquay LD, Brosnan MJ, Trimmer JK, Rolph TP, Kibbey RG, Manning Fox JE, Colmers WF, Shirihai OS, Neufer PD, Yeh ET, Newgard CB, MacDonald PE.

J Clin Invest. 2015 Oct 1;125(10):3847-60. doi: 10.1172/JCI82498. Epub 2015 Sep 21.


Subacute limb ischemia induces skeletal muscle injury in genetically susceptible mice independent of vascular density.

McClung JM, McCord TJ, Southerland K, Schmidt CA, Padgett ME, Ryan TE, Kontos CD.

J Vasc Surg. 2016 Oct;64(4):1101-1111.e2. doi: 10.1016/j.jvs.2015.06.139. Epub 2015 Aug 5.


Muscle cell derived angiopoietin-1 contributes to both myogenesis and angiogenesis in the ischemic environment.

McClung JM, Reinardy JL, Mueller SB, McCord TJ, Kontos CD, Brown DA, Hussain SN, Schmidt CA, Ryan TE, Green TD.

Front Physiol. 2015 May 19;6:161. doi: 10.3389/fphys.2015.00161. eCollection 2015.


Effects of Low-Volume, High-Intensity Whole-Body Calisthenics on Army ROTC Cadets.

Gist NH, Freese EC, Ryan TE, Cureton KJ.

Mil Med. 2015 May;180(5):492-8. doi: 10.7205/MILMED-D-14-00277.


Reduced skeletal muscle oxidative capacity and impaired training adaptations in heart failure.

Southern WM, Ryan TE, Kepple K, Murrow JR, Nilsson KR, McCully KK.

Physiol Rep. 2015 Apr;3(4). pii: e12353. doi: 10.14814/phy2.12353.


Pyruvate dehydrogenase complex and nicotinamide nucleotide transhydrogenase constitute an energy-consuming redox circuit.

Fisher-Wellman KH, Lin CT, Ryan TE, Reese LR, Gilliam LA, Cathey BL, Lark DS, Smith CD, Muoio DM, Neufer PD.

Biochem J. 2015 Apr 15;467(2):271-80. doi: 10.1042/BJ20141447.


Androgen modulation of Foxp1 and Foxp2 in the developing rat brain: impact on sex specific vocalization.

Bowers JM, Perez-Pouchoulen M, Roby CR, Ryan TE, McCarthy MM.

Endocrinology. 2014 Dec;155(12):4881-94. doi: 10.1210/en.2014-1486. Epub 2014 Sep 23.


Assessment of in vivo skeletal muscle mitochondrial respiratory capacity in humans by near-infrared spectroscopy: a comparison with in situ measurements.

Ryan TE, Brophy P, Lin CT, Hickner RC, Neufer PD.

J Physiol. 2014 Aug 1;592(15):3231-41. doi: 10.1113/jphysiol.2014.274456. Epub 2014 Jun 20.


Reproducibility of near-infrared spectroscopy measurements of oxidative function and postexercise recovery kinetics in the medial gastrocnemius muscle.

Southern WM, Ryan TE, Reynolds MA, McCully K.

Appl Physiol Nutr Metab. 2014 May;39(5):521-9. doi: 10.1139/apnm-2013-0347. Epub 2013 Nov 20.


Skeletal muscle oxidative capacity in amyotrophic lateral sclerosis.

Ryan TE, Erickson ML, Verma A, Chavez J, Rivner MH, Mccully KK.

Muscle Nerve. 2014 Nov;50(5):767-74. doi: 10.1002/mus.24223. Epub 2014 Sep 29.


A cross-validation of near-infrared spectroscopy measurements of skeletal muscle oxidative capacity with phosphorus magnetic resonance spectroscopy.

Ryan TE, Southern WM, Reynolds MA, McCully KK.

J Appl Physiol (1985). 2013 Dec;115(12):1757-66. doi: 10.1152/japplphysiol.00835.2013. Epub 2013 Oct 17.


Identification and target strength of orange roughy (Hoplostethus atlanticus) measured in situ.

Kloser RJ, Macaulay GJ, Ryan TE, Lewis M.

J Acoust Soc Am. 2013 Jul;134(1):97-108. doi: 10.1121/1.4807748.


Case report: endurance electrical stimulation training improves skeletal muscle oxidative capacity in chronic spinal cord injury.

Ryan TE, Erickson ML, Young HJ, McCully KK.

Arch Phys Med Rehabil. 2013 Dec;94(12):2559-61. doi: 10.1016/j.apmr.2013.06.014. Epub 2013 Jun 28.


Electrically induced resistance training in individuals with motor complete spinal cord injury.

Ryan TE, Brizendine JT, Backus D, McCully KK.

Arch Phys Med Rehabil. 2013 Nov;94(11):2166-73. doi: 10.1016/j.apmr.2013.06.016. Epub 2013 Jun 28.


Near-infrared assessments of skeletal muscle oxidative capacity in persons with spinal cord injury.

Erickson ML, Ryan TE, Young HJ, McCully KK.

Eur J Appl Physiol. 2013 Sep;113(9):2275-83. doi: 10.1007/s00421-013-2657-0. Epub 2013 May 24.


Activity-induced changes in skeletal muscle metabolism measured with optical spectroscopy.

Ryan TE, Southern WM, Brizendine JT, McCully KK.

Med Sci Sports Exerc. 2013 Dec;45(12):2346-52. doi: 10.1249/MSS.0b013e31829a726a.


Skeletal muscle metabolism in endurance athletes with near-infrared spectroscopy.

Brizendine JT, Ryan TE, Larson RD, McCully KK.

Med Sci Sports Exerc. 2013 May;45(5):869-75. doi: 10.1249/MSS.0b013e31827e0eb6. Erratum in: Med Sci Sports Exerc. 2013 Aug;45(8):1640-1.


A comparison of exercise type and intensity on the noninvasive assessment of skeletal muscle mitochondrial function using near-infrared spectroscopy.

Ryan TE, Brizendine JT, McCully KK.

J Appl Physiol (1985). 2013 Jan 15;114(2):230-7. doi: 10.1152/japplphysiol.01043.2012. Epub 2012 Nov 15.


Noninvasive evaluation of skeletal muscle mitochondrial capacity with near-infrared spectroscopy: correcting for blood volume changes.

Ryan TE, Erickson ML, Brizendine JT, Young HJ, McCully KK.

J Appl Physiol (1985). 2012 Jul;113(2):175-83. doi: 10.1152/japplphysiol.00319.2012. Epub 2012 May 10.


von Willebrand factor (VWF) propeptide binding to VWF D'D3 domain attenuates platelet activation and adhesion.

Madabhushi SR, Shang C, Dayananda KM, Rittenhouse-Olson K, Murphy M, Ryan TE, Montgomery RR, Neelamegham S.

Blood. 2012 May 17;119(20):4769-78. doi: 10.1182/blood-2011-10-387548. Epub 2012 Mar 27.

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