Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 37

1.

Pediatric asthma severity scores distinguish suitable inpatient level of care for children admitted for status asthmaticus.

Ryan KS, Son S, Roddy M, Siraj S, McKinley SD, Nakagawa TA, Sochet AA.

J Asthma. 2019 Oct 26:1-9. doi: 10.1080/02770903.2019.1680998. [Epub ahead of print]

PMID:
31608716
2.

The Biosynthetic Gene Cluster of Pyrazomycin-A C-Nucleoside Antibiotic with a Rare Pyrazole Moiety.

Zhao G, Yao S, Rothchild KW, Liu T, Liu Y, Lian J, He HY, Ryan KS, Du YL.

Chembiochem. 2019 Sep 3. doi: 10.1002/cbic.201900449. [Epub ahead of print]

PMID:
31482654
3.

Convergent biosynthetic transformations to a bacterial specialized metabolite.

Du YL, Higgins MA, Zhao G, Ryan KS.

Nat Chem Biol. 2019 Nov;15(11):1043-1048. doi: 10.1038/s41589-019-0331-5. Epub 2019 Aug 12.

PMID:
31406372
4.

A Longitudinal and Sustainability Assessment of Pediatric Interfacility Transport Handover Standardization.

Sochet AA, Ryan KS, Miller W, Bartlett JL, Nakagawa TA, Bingham L.

Pediatr Qual Saf. 2018 Nov 8;3(6):e118. doi: 10.1097/pq9.0000000000000118. eCollection 2018 Nov-Dec.

5.

An Asymmetric Reductase That Intercepts Acyclic Imino Acids Produced in Situ by a Partner Oxidase.

Guo J, Higgins MA, Daniel-Ivad P, Ryan KS.

J Am Chem Soc. 2019 Aug 7;141(31):12258-12267. doi: 10.1021/jacs.9b03307. Epub 2019 Jul 25.

PMID:
31298853
6.

In vitro Reconstitution of the Biosynthetic Pathway to the Nitroimidazole Antibiotic Azomycin.

Hedges JB, Ryan KS.

Angew Chem Int Ed Engl. 2019 Aug 19;58(34):11647-11651. doi: 10.1002/anie.201903500. Epub 2019 Jul 17.

PMID:
31231913
7.

Stress ulcer prophylaxis in children with status asthmaticus receiving systemic corticosteroids: a descriptive study assessing frequency of clinically important bleeding.

Sochet AA, Son S, Ryan KS, Roddy M, Barrie E, Wilsey M, McKinley SD, Nakagawa TA.

J Asthma. 2019 May 30:1-8. doi: 10.1080/02770903.2019.1614617. [Epub ahead of print]

PMID:
31046509
8.

Piperazic acid-containing natural products: structures and biosynthesis.

Morgan KD, Andersen RJ, Ryan KS.

Nat Prod Rep. 2019 Apr 5. doi: 10.1039/c8np00076j. [Epub ahead of print] Review.

PMID:
30949650
9.

Two-Enzyme Pathway Links l-Arginine to Nitric Oxide in N-Nitroso Biosynthesis.

He HY, Henderson AC, Du YL, Ryan KS.

J Am Chem Soc. 2019 Mar 6;141(9):4026-4033. doi: 10.1021/jacs.8b13049. Epub 2019 Feb 21.

PMID:
30763082
10.

Pyridoxal phosphate-dependent reactions in the biosynthesis of natural products.

Du YL, Ryan KS.

Nat Prod Rep. 2019 Mar 20;36(3):430-457. doi: 10.1039/c8np00049b. Review.

PMID:
30183796
11.

Metalloenzymes in natural product biosynthetic pathways.

Ryan KS, Drennan CL.

Nat Prod Rep. 2018 Jul 18;35(7):612-614. doi: 10.1039/c8np90023j. No abstract available.

PMID:
30009301
12.

Snapshots of the Catalytic Cycle of an O2, Pyridoxal Phosphate-Dependent Hydroxylase.

Hedges JB, Kuatsjah E, Du YL, Eltis LD, Ryan KS.

ACS Chem Biol. 2018 Apr 20;13(4):965-974. doi: 10.1021/acschembio.8b00039. Epub 2018 Feb 28.

PMID:
29466666
13.

Standardization of Pediatric Interfacility Transport Handover: Measuring the Development of a Shared Mental Model.

Sochet AA, Ryan KS, Bartlett JL, Nakagawa TA, Bingham L.

Pediatr Crit Care Med. 2018 Feb;19(2):e72-e79. doi: 10.1097/PCC.0000000000001396.

PMID:
29206726
14.

A heme-dependent enzyme forms the nitrogen-nitrogen bond in piperazate.

Du YL, He HY, Higgins MA, Ryan KS.

Nat Chem Biol. 2017 Aug;13(8):836-838. doi: 10.1038/nchembio.2411. Epub 2017 Jun 19.

PMID:
28628093
15.

Synthetic Biology Approaches to New Bisindoles.

Alkhalaf LM, Du YL, Ryan KS.

Methods Enzymol. 2016;575:21-37. doi: 10.1016/bs.mie.2016.02.017. Epub 2016 Mar 24.

PMID:
27417923
16.

Catalytic repertoire of bacterial bisindole formation.

Du YL, Ryan KS.

Curr Opin Chem Biol. 2016 Apr;31:74-81. doi: 10.1016/j.cbpa.2016.01.017. Epub 2016 Feb 6. Review.

PMID:
26855265
17.

A pyridoxal phosphate-dependent enzyme that oxidizes an unactivated carbon-carbon bond.

Du YL, Singh R, Alkhalaf LM, Kuatsjah E, He HY, Eltis LD, Ryan KS.

Nat Chem Biol. 2016 Mar;12(3):194-9. doi: 10.1038/nchembio.2009. Epub 2016 Jan 25.

PMID:
26807714
18.

Reduced deformability of parasitized red blood cells as a biomarker for anti-malarial drug efficacy.

Deng X, Duffy SP, Myrand-Lapierre ME, Matthews K, Santoso AT, Du YL, Ryan KS, Ma H.

Malar J. 2015 Oct 31;14:428. doi: 10.1186/s12936-015-0957-z.

19.

Biosynthetic manipulation of tryptophan in bacteria: pathways and mechanisms.

Alkhalaf LM, Ryan KS.

Chem Biol. 2015 Mar 19;22(3):317-28. doi: 10.1016/j.chembiol.2015.02.005. Review.

20.

In vitro reconstitution of indolmycin biosynthesis reveals the molecular basis of oxazolinone assembly.

Du YL, Alkhalaf LM, Ryan KS.

Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2717-22. doi: 10.1073/pnas.1419964112. Epub 2015 Feb 17.

21.

Expansion of bisindole biosynthetic pathways by combinatorial construction.

Du YL, Ryan KS.

ACS Synth Biol. 2015 Jun 19;4(6):682-8. doi: 10.1021/sb5003218. Epub 2015 Jan 2.

22.

Reconstruction of cladoniamide biosynthesis reveals nonenzymatic routes to bisindole diversity.

Du YL, Williams DE, Patrick BO, Andersen RJ, Ryan KS.

ACS Chem Biol. 2014 Dec 19;9(12):2748-54. doi: 10.1021/cb500728h. Epub 2014 Oct 24.

23.

Metal binding properties of Escherichia coli YjiA, a member of the metal homeostasis-associated COG0523 family of GTPases.

Sydor AM, Jost M, Ryan KS, Turo KE, Douglas CD, Drennan CL, Zamble DB.

Biochemistry. 2013 Mar 12;52(10):1788-1801. Erratum in: Biochemistry. 2013 Jun 11;52(23):4105.

24.

Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A.

Yamanaka K, Reynolds KA, Kersten RD, Ryan KS, Gonzalez DJ, Nizet V, Dorrestein PC, Moore BS.

Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):1957-62. doi: 10.1073/pnas.1319584111. Epub 2014 Jan 21.

25.

N-carbamoylation of 2,4-diaminobutyrate reroutes the outcome in padanamide biosynthesis.

Du YL, Dalisay DS, Andersen RJ, Ryan KS.

Chem Biol. 2013 Aug 22;20(8):1002-11. doi: 10.1016/j.chembiol.2013.06.013. Epub 2013 Aug 1.

26.

Biosynthetic O-methylation protects cladoniamides from self-destruction.

Du YL, Ding T, Ryan KS.

Org Lett. 2013 May 17;15(10):2538-41. doi: 10.1021/ol401036f. Epub 2013 May 2.

PMID:
23639001
27.

An unusual role for a mobile flavin in StaC-like indolocarbazole biosynthetic enzymes.

Goldman PJ, Ryan KS, Hamill MJ, Howard-Jones AR, Walsh CT, Elliott SJ, Drennan CL.

Chem Biol. 2012 Jul 27;19(7):855-65. doi: 10.1016/j.chembiol.2012.05.016.

28.

Flavoenzyme-catalyzed atropo-selective N,C-bipyrrole homocoupling in marinopyrrole biosynthesis.

Yamanaka K, Ryan KS, Gulder TA, Hughes CC, Moore BS.

J Am Chem Soc. 2012 Aug 1;134(30):12434-7. doi: 10.1021/ja305670f. Epub 2012 Jul 18.

29.

Introducing the parvome: bioactive compounds in the microbial world.

Davies J, Ryan KS.

ACS Chem Biol. 2012 Feb 17;7(2):252-9. doi: 10.1021/cb200337h. Epub 2011 Nov 17. Review.

PMID:
22074935
30.

Biosynthetic gene cluster for the cladoniamides, bis-indoles with a rearranged scaffold.

Ryan KS.

PLoS One. 2011;6(8):e23694. doi: 10.1371/journal.pone.0023694. Epub 2011 Aug 18.

31.

Total (bio)synthesis: strategies of nature and of chemists.

Roberts AA, Ryan KS, Moore BS, Gulder TA.

Top Curr Chem. 2010;297:149-203. Review.

32.

Divergent pathways in the biosynthesis of bisindole natural products.

Ryan KS, Drennan CL.

Chem Biol. 2009 Apr 24;16(4):351-64. doi: 10.1016/j.chembiol.2009.01.017.

33.

Alkaloid biosynthesis takes root.

Ryan KS, Moore BS.

Nat Chem Biol. 2009 Mar;5(3):140-1. doi: 10.1038/nchembio0309-140. No abstract available.

PMID:
19219013
34.

The FAD cofactor of RebC shifts to an IN conformation upon flavin reduction.

Ryan KS, Chakraborty S, Howard-Jones AR, Walsh CT, Ballou DP, Drennan CL.

Biochemistry. 2008 Dec 23;47(51):13506-13. doi: 10.1021/bi801229w.

35.

The violacein biosynthetic enzyme VioE shares a fold with lipoprotein transporter proteins.

Ryan KS, Balibar CJ, Turo KE, Walsh CT, Drennan CL.

J Biol Chem. 2008 Mar 7;283(10):6467-75. doi: 10.1074/jbc.M708573200. Epub 2008 Jan 2.

36.

Crystallographic trapping in the rebeccamycin biosynthetic enzyme RebC.

Ryan KS, Howard-Jones AR, Hamill MJ, Elliott SJ, Walsh CT, Drennan CL.

Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15311-6. Epub 2007 Sep 14.

37.

Environmental regulation of lateral root initiation in Arabidopsis.

Malamy JE, Ryan KS.

Plant Physiol. 2001 Nov;127(3):899-909.

Supplemental Content

Support Center